Extracellular vesicles as delivery systems at nano-/micro-scale

Exosomes induce endolysosomal permeabilization as a gateway by which exosomal tau seeds escape into the cytosol

(2021) Juan Carlos Polanco et al.   ACTA NEUROPATHOLOGICA

Engineering exosomes for pulmonary delivery of peptides and drugs to inflammatory lung cells by inhalation

(2021) GyeungYun Kim et al.   JOURNAL OF CONTROLLED RELEASE

A call for the standardised reporting of factors affecting the exogenous loading of extracellular vesicles with therapeutic cargos

(2021) Stephanie Rankin-Turner et al.   ADVANCED DRUG DELIVERY REVIEWS

MiR-199a-modified exosomes from adipose tissue-derived mesenchymal stem cells improve hepatocellular carcinoma chemosensitivity through mTOR pathway

(2020) Guohua Lou et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The entry of nanoparticles into solid tumours

(2020) Shrey Sindhwani et al.   NATURE MATERIALS

Matrix mechanics and water permeation regulate extracellular vesicle transport

(2020) Stephen Lenzini et al.   Nature Nanotechnology

Engineered exosomes for targeted co-delivery of miR-21 inhibitor and chemotherapeutics to reverse drug resistance in colon cancer

(2020) Gaofeng Liang et al.   JOURNAL OF NANOBIOTECHNOLOGY

Altered biodistribution of deglycosylated extracellular vesicles through enhanced cellular uptake

(2020) Nao Nishida-Aoki et al.   Journal of Extracellular Vesicles

Exosomes derived from HeLa cells break down vascular integrity by triggering endoplasmic reticulum stress in endothelial cells

(2020) Yinuo Lin et al.   Journal of Extracellular Vesicles

Tumor‐exocytosed exosome/AIEgen hybrid nano‐vesicles facilitate efficient tumor penetration and photodynamic therapy

(2020) Daoming Zhu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Native and bioengineered extracellular vesicles for cardiovascular therapeutics

(2020) Ricardo Cerqueira de Abreu et al.   Nature Reviews Cardiology

Effectiveness of convalescent plasma therapy in severe COVID-19 patients

(2020) Kai Duan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mesenchymal Stem Cell-Derived Extracellular Vesicles: Challenges in Clinical Applications

(2020) Austin Gowen et al.   Frontiers in Cell and Developmental Biology

Supramolecular Nanofibers Containing Arginine-Glycine-Aspartate (RGD) Peptides Boost Therapeutic Efficacy of Extracellular Vesicles in Kidney Repair

(2020) Chuyue Zhang et al.   ACS Nano

AFM-Based High-Throughput Nanomechanical Screening of Single Extracellular Vesicles

(2020) Andrea Ridolfi et al.   ANALYTICAL CHEMISTRY

Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers

(2020) Ayuko Hoshino et al.   CELL

Extracellular vesicles for tumor targeting delivery based on five features principle

(2020) Tuying Yong et al.   JOURNAL OF CONTROLLED RELEASE

RAB31 marks and controls an ESCRT-independent exosome pathway

(2020) Denghui Wei et al.   CELL RESEARCH

Pluripotent Stem Cell-Based Cell Therapy—Promise and Challenges

(2020) Shinya Yamanaka   Cell Stem Cell

Extracellular Vesicles in the Development of Cancer Therapeutics

(2020) Haoyao Sun et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effects of extracellular matrix viscoelasticity on cellular behaviour

(2020) Ovijit Chaudhuri et al.   NATURE

A framework for designing delivery systems

(2020) Wilson Poon et al.   Nature Nanotechnology

Exosome-based candidates move into the clinic

(2020) Megan Cully   NATURE REVIEWS DRUG DISCOVERY

Engineering precision nanoparticles for drug delivery

(2020) Michael J. Mitchell et al.   NATURE REVIEWS DRUG DISCOVERY

Public needs to prep for vaccine side effects

(2020) Meredith Wadman   SCIENCE

Extracellular vesicles: A bright star of nanomedicine

(2020) Peipei Wu et al.   BIOMATERIALS

Advances in nanocarriers enabled brain targeted drug delivery across blood brain barrier

(2019) Garima Sharma et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Elimination Pathways of Nanoparticles

(2019) Wilson Poon et al.   ACS Nano

Cell death: a review of the major forms of apoptosis, necrosis and autophagy

(2019) Mark S D’Arcy   CELL BIOLOGY INTERNATIONAL

Manufacturing and characterization of extracellular vesicles from umbilical cord–derived mesenchymal stromal cells for clinical testing

(2019) Eva Rohde et al.   CYTOTHERAPY

Oligodepsipeptide (nano)carriers: Computational design and analysis of enhanced drug loading

(2019) Nadia Brunacci et al.   JOURNAL OF CONTROLLED RELEASE

Reversal of Osteoporotic Activity by Endothelial Cell-Secreted Bone Targeting and Biocompatible Exosomes

(2019) Hongyuan Song et al.   NANO LETTERS

Extracellular Vesicles: Exosomes and Microvesicles, Integrators of Homeostasis

(2019) Philip D. Stahl et al.   PHYSIOLOGY

Dynamic filopodial forces induce accumulation, damage, and plastic remodeling of 3D extracellular matrices

(2019) Andrea Malandrino et al.   PLoS Computational Biology

Chain-Length- and Saturation-Tuned Mechanics of Fluid Nanovesicles Direct Tumor Delivery

(2019) Zhuo Dai et al.   ACS Nano

Subchronic and chronic toxicity evaluation of inorganic nanoparticles for delivery applications

(2019) Raziye Mohammadpour et al.   ADVANCED DRUG DELIVERY REVIEWS

Exosome manufacturing status

(2019) William Whitford et al.   Future Medicinal Chemistry

Tumor-Derived Extracellular Vesicles Breach the Intact Blood–Brain Barrier via Transcytosis

(2019) Golnaz Morad et al.   ACS Nano

Intranasal Delivery of Mesenchymal Stem Cell Derived Exosomes Loaded with Phosphatase and Tensin Homolog siRNA Repairs Complete Spinal Cord Injury

(2019) Shaowei Guo et al.   ACS Nano

Lipid-based nanoparticle formulations for small molecules and RNA drugs

(2019) Ludger M. Ickenstein et al.   Expert Opinion on Drug Delivery

Extracellular Vesicles as Drug Delivery Vehicles to the Central Nervous System

(2019) Farah Shahjin et al.   Journal of Neuroimmune Pharmacology

Microvesicle-mediated delivery of minicircle DNA results in effective gene-directed enzyme prodrug cancer therapy

(2019) Masamitsu Kanada et al.   MOLECULAR CANCER THERAPEUTICS

Systemic Exosomal Delivery of shRNA Minicircles Prevents Parkinsonian Pathology

(2019) María Izco et al.   MOLECULAR THERAPY

Gene Editing: Friend or Foe? Evidence Indicates Endogenous Exosomes Can Deliver Functional gRNA and Cas9 Protein (Small 38/2019)

(2019) Ran Chen et al.   Small

Extracellular vesicles or exosomes? On primacy, precision, and popularity influencing a choice of nomenclature

(2019) Kenneth W. Witwer et al.   Journal of Extracellular Vesicles

Targeted exosome‐encapsulated erastin induced ferroptosis in triple negative breast cancer cells

(2019) Mengyu Yu et al.   CANCER SCIENCE

Engineered extracellular vesicles with synthetic lipids via membrane fusion to establish efficient gene delivery

(2019) Yong-Yu Jhan et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Exosome-like nanoplatform modified with targeting ligand improves anti-cancer and anti-inflammation effects of imperialine

(2019) Qing Lin et al.   JOURNAL OF CONTROLLED RELEASE

SPION‐Decorated Exosome Delivered BAY55‐9837 Targeting the Pancreas through Magnetism to Improve the Blood GLC Response

(2019) Manjiao Zhuang et al.   Small

Extracellular Vesicles: Catching the Light in Zebrafish

(2019) Frederik J. Verweij et al.   TRENDS IN CELL BIOLOGY

Linkage between endosomal escape of LNP-mRNA and loading into EVs for transport to other cells

(2019) Marco Maugeri et al.   Nature Communications

Tumor exosome-based nanoparticles are efficient drug carriers for chemotherapy

(2019) Tuying Yong et al.   Nature Communications

Gold-DNA nanosunflowers for efficient gene silencing with controllable transformation

(2019) Shuaidong Huo et al.   Science Advances

Gemcitabine loaded autologous exosomes for effective and safe chemotherapy of pancreatic cancer

(2019) Yong-Jiang Li et al.   Acta Biomaterialia

Extracellular vesicle (ECV)-modified polyethylenimine (PEI) complexes for enhanced siRNA delivery in vitro and in vivo

(2019) Petro Zhupanyn et al.   JOURNAL OF CONTROLLED RELEASE

Exosome-mediated siRNA delivery to suppress postoperative breast cancer metastasis

(2019) Liuwan Zhao et al.   JOURNAL OF CONTROLLED RELEASE

Eliminating blood oncogenic exosomes into the small intestine with aptamer-functionalized nanoparticles

(2019) Xiaodong Xie et al.   Nature Communications

Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation

(2019) Zhaogang Yang et al.   Nature Biomedical Engineering

Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy

(2018) Tian Tian et al.   BIOMATERIALS

Characterization of the mechanical properties of cancer cells in 3D matrices in response to collagen concentration and cytoskeletal inhibitors

(2018) Jessica E. Kim et al.   Integrative Biology

Engineered exosome-mediated delivery of functionally active miR-26a and its enhanced suppression effect in HepG2 cells

(2018) Gaofeng Liang et al.   International Journal of Nanomedicine

Formation and Characterization of Protein Corona Around Nanoparticles: A Review

(2018) Vikram Pareek et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Role of Extracellular Vesicle Surface Proteins in the Pharmacokinetics of Extracellular Vesicles

(2018) Chonlada Charoenviriyakul et al.   MOLECULAR PHARMACEUTICS

Smart Nanoreactors for pH-Responsive Tumor Homing, Mitochondria-Targeting, and Enhanced Photodynamic-Immunotherapy of Cancer

(2018) Guangbao Yang et al.   NANO LETTERS

Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation

(2018) Haiying Zhang et al.   NATURE CELL BIOLOGY

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Manufacturing Exosomes: A Promising Therapeutic Platform

(2018) Ivano Luigi Colao et al.   TRENDS IN MOLECULAR MEDICINE

Designer exosomes produced by implanted cells intracerebrally deliver therapeutic cargo for Parkinson’s disease treatment

(2018) Ryosuke Kojima et al.   Nature Communications

Lipid Nanoparticles Enabling Gene Therapies: From Concepts to Clinical Utility

(2018) Jayesh A. Kulkarni et al.   Nucleic Acid Therapeutics

Deep Insight into PEGylation of Bioadhesive Chitosan Nanoparticles: Sensitivity Study for the Key Parameters Through Artificial Neural Network Model

(2018) Ugur Bozuyuk et al.   ACS Applied Materials & Interfaces

PEGylation of model drug carriers enhances phagocytosis by primary human neutrophils

(2018) William J. Kelley et al.   Acta Biomaterialia

Neutrophil membrane-coated nanoparticles inhibit synovial inflammation and alleviate joint damage in inflammatory arthritis

(2018) Qiangzhe Zhang et al.   Nature Nanotechnology

Nanomechanics of Extracellular Vesicles Reveals Vesiculation Pathways

(2018) Raya Sorkin et al.   Small

Enhanced Mechanical Properties of Polymer Nanocomposites Using Dopamine-Modified Polymers at Nanoparticle Surfaces in Very Low Molecular Weight Polymers

(2018) Na Kyung Kwon et al.   ACS Macro Letters

Transport and interactions of nanoparticles in the kidneys

(2018) Bujie Du et al.   Nature Reviews Materials

Apoptosis and apoptotic body: disease message and therapeutic target potentials

(2018) Xuebo Xu et al.   BIOSCIENCE REPORTS

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

(2018) Mathilde Mathieu et al.   NATURE CELL BIOLOGY

In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment

(2018) Qian Chen et al.   Nature Nanotechnology

Matrix mechanical plasticity regulates cancer cell migration through confining microenvironments

(2018) Katrina M. Wisdom et al.   Nature Communications

The fluid membrane determines mechanics of erythrocyte extracellular vesicles and is softened in hereditary spherocytosis

(2018) Daan Vorselen et al.   Nature Communications

Replication study: Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

(2018) Jeewon Kim et al.   eLife

Exosomes derived from siRNA against GRP78 modified bone-marrow-derived mesenchymal stem cells suppress Sorafenib resistance in hepatocellular carcinoma

(2018) Hongdan Li et al.   JOURNAL OF NANOBIOTECHNOLOGY

Surface Charge-Dependent Cellular Uptake of Polystyrene Nanoparticles

(2018) Soyeon Jeon et al.   Nanomaterials

Macrophage conditioned medium induced cellular network formation in MCF-7 cells through enhanced tunneling nanotube formation and tunneling nanotube mediated release of viable cytoplasmic fragments

(2017) Pooja Patheja et al.   EXPERIMENTAL CELL RESEARCH

Manufacturing of Human Extracellular Vesicle-Based Therapeutics for Clinical Use

(2017) Mario Gimona et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exosomes derived from miR-181-5p-modified adipose-derived mesenchymal stem cells prevent liver fibrosis via autophagy activation

(2017) Ying Qu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Gene therapy for monogenic liver diseases: clinical successes, current challenges and future prospects

(2017) Julien Baruteau et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Pharmacokinetics of Exosomes—An Important Factor for Elucidating the Biological Roles of Exosomes and for the Development of Exosome-Based Therapeutics

(2017) Masaki Morishita et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Mechanical Properties of Membranes Composed of Gel-Phase or Fluid-Phase Phospholipids Probed on Liposomes by Atomic Force Spectroscopy

(2017) Oumaima Et-Thakafy et al.   LANGMUIR

Rescue of Hearing by Gene Delivery to Inner-Ear Hair Cells Using Exosome-Associated AAV

(2017) Bence György et al.   MOLECULAR THERAPY

Milk-derived exosomes for oral delivery of paclitaxel

(2017) Ashish K. Agrawal et al.   Nanomedicine-Nanotechnology Biology and Medicine

Fluorescence labelling of extracellular vesicles using a novel thiol-based strategy for quantitative analysis of cellular delivery and intracellular traffic

(2017) H. D. Roberts-Dalton et al.   Nanoscale

Effect of partial PEGylation on particle uptake by macrophages

(2017) Lucero Sanchez et al.   Nanoscale

Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer

(2017) Sushrut Kamerkar et al.   NATURE

Overcoming cellular barriers for RNA therapeutics

(2017) Steven F Dowdy   NATURE BIOTECHNOLOGY

Lipids in exosomes: Current knowledge and the way forward

(2017) Tore Skotland et al.   PROGRESS IN LIPID RESEARCH

Exosome-associated AAV2 vector mediates robust gene delivery into the murine retina upon intravitreal injection

(2017) Sarah J. Wassmer et al.   Scientific Reports

3,3′-Diindolylmethane stimulates exosomal Wnt11 autocrine signaling in human umbilical cord mesenchymal stem cells to enhance wound healing

(2017) Hui Shi et al.   Theranostics

Progress in Exosome Isolation Techniques

(2017) Pin Li et al.   Theranostics

Oncogene Knockdown via Active Loading of Small RNAs into Extracellular Vesicles by Sonication

(2016) Tek N. Lamichhane et al.   Cellular and Molecular Bioengineering

Focus on Extracellular Vesicles: Exosomes and Their Role in Protein Trafficking and Biomarker Potential in Alzheimer’s and Parkinson’s Disease

(2016) Laura Vella et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extracellular vesicle isolation and characterization: toward clinical application

(2016) Rong Xu et al.   JOURNAL OF CLINICAL INVESTIGATION

The biology and function of exosomes in cancer

(2016) Raghu Kalluri   JOURNAL OF CLINICAL INVESTIGATION

Ultrasmall Magnetically Engineered Ag2Se Quantum Dots for Instant Efficient Labeling and Whole-Body High-Resolution Multimodal Real-Time Tracking of Cell-Derived Microvesicles

(2016) Jing-Ya Zhao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Exosome-mediated Delivery of Hydrophobically Modified siRNA for Huntingtin mRNA Silencing

(2016) Marie-Cécile Didiot et al.   MOLECULAR THERAPY

Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells

(2016) Myung Soo Kim et al.   Nanomedicine-Nanotechnology Biology and Medicine

Biophysical insight into mechanisms of sonoporation

(2016) Brandon Helfield et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

 -cell-mimetic designer cells provide closed-loop glycemic control

(2016) M. Xie et al.   SCIENCE

Interplay of active processes modulates tension and drives phase transition in self-renewing, motor-driven cytoskeletal networks

(2016) Michael Mak et al.   Nature Communications

Tuning the Mechanical Properties of Polymer Nanocomposites Filled with Grafted Nanoparticles by Varying the Grafted Chain Length and Flexibility

(2016) Zixuan Wang et al.   Polymers

Bioresponsive materials

(2016) Yue Lu et al.   Nature Reviews Materials

Biodistribution and delivery efficiency of unmodified tumor-derived exosomes

(2015) Tyson Smyth et al.   JOURNAL OF CONTROLLED RELEASE

Exosomes as drug delivery vehicles for Parkinson's disease therapy

(2015) Matthew J. Haney et al.   JOURNAL OF CONTROLLED RELEASE

Exosomes derived from miR-122-modified adipose tissue-derived MSCs increase chemosensitivity of hepatocellular carcinoma

(2015) Guohua Lou et al.   Journal of Hematology & Oncology

Quantitative Analysis of Tissue Distribution of the B16BL6-Derived Exosomes Using a Streptavidin-Lactadherin Fusion Protein and Iodine-125-Labeled Biotin Derivative After Intravenous Injection in Mice

(2015) Masaki Morishita et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Investigating cell mechanics with atomic force microscopy

(2015) K. Haase et al.   Journal of the Royal Society Interface

Differential fates of biomolecules delivered to target cells via extracellular vesicles

(2015) Masamitsu Kanada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic Biodistribution of Extracellular Vesicles in Vivo Using a Multimodal Imaging Reporter

(2014) Charles P. Lai et al.   ACS Nano

Tunable Rigidity of (Polymeric Core)-(Lipid Shell) Nanoparticles for Regulated Cellular Uptake

(2014) Jiashu Sun et al.   ADVANCED MATERIALS

Probing the Stochastic, Motor-Driven Properties of the Cytoplasm Using Force Spectrum Microscopy

(2014) Ming Guo et al.   CELL

Water Permeation Drives Tumor Cell Migration in Confined Microenvironments

(2014) Kimberly M. Stroka et al.   CELL

Extracellular vesicles as drug delivery systems: Lessons from the liposome field

(2014) Roy van der Meel et al.   JOURNAL OF CONTROLLED RELEASE

Systemic exosomal siRNA delivery reduced alpha-synuclein aggregates in brains of transgenic mice

(2014) J. Mark Cooper et al.   MOVEMENT DISORDERS

Impact of Dimensionality and Network Disruption on Microrheology of Cancer Cells in 3D Environments

(2014) Michael Mak et al.   PLoS Computational Biology

Exosomes are natural carriers of exogenous siRNA to human cells in vitro

(2013) Tatyana A Shtam et al.   Cell Communication and Signaling

Polymeric nanoparticles of different sizes overcome the cell membrane barrier

(2013) Simone Lerch et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

P-glycoprotein Mediates Drug Resistance via a Novel Mechanism Involving Lysosomal Sequestration

(2013) Tetsuo Yamagishi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physical limits of cell migration: Control by ECM space and nuclear deformation and tuning by proteolysis and traction force

(2013) Katarina Wolf et al.   JOURNAL OF CELL BIOLOGY

The cytoplasm of living cells behaves as a poroelastic material

(2013) Emad Moeendarbary et al.   NATURE MATERIALS

The Effect of Nanoparticle Size, Shape, and Surface Chemistry on Biological Systems

(2012) Alexandre Albanese et al.   Annual Review of Biomedical Engineering

Microbubble-induced sonoporation involved in ultrasound-mediated DNA transfection in vitro at low acoustic pressures

(2012) Yuanyuan Qiu et al.   JOURNAL OF BIOMECHANICS

Influence of nanoparticle size, loading, and shape on the mechanical properties of polymer nanocomposites

(2012) Aki Kutvonen et al.   JOURNAL OF CHEMICAL PHYSICS

Elucidating mechanical transition effects of invading cancer cells with a subnucleus-scaled microfluidic serial dimensional modulation device

(2012) Michael Mak et al.   LAB ON A CHIP

Fluorescent labeling of nano-sized vesicles released by cells and subsequent quantitative and qualitative analysis by high-resolution flow cytometry

(2012) Els J van der Vlist et al.   Nature Protocols

MVB vesicle formation: ESCRT-dependent, ESCRT-independent and everything in between

(2011) Markus Babst   CURRENT OPINION IN CELL BIOLOGY

Treatment of Brain Inflammatory Diseases by Delivering Exosome Encapsulated Anti-inflammatory Drugs From the Nasal Region to the Brain

(2011) Xiaoying Zhuang et al.   MOLECULAR THERAPY

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

A Novel Nanoparticle Drug Delivery System: The Anti-inflammatory Activity of Curcumin Is Enhanced When Encapsulated in Exosomes

(2010) Dongmei Sun et al.   MOLECULAR THERAPY

Microenvironmental pH Is a Key Factor for Exosome Traffic in Tumor Cells

(2009) Isabella Parolini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protease-dependent versus -independent cancer cell invasion programs: three-dimensional amoeboid movement revisited

(2009) Farideh Sabeh et al.   JOURNAL OF CELL BIOLOGY