Extracellular Vesicles in the Development of Cancer Therapeutics

The biology, function, and biomedical applications of exosomes

(2020) Raghu Kalluri et al.   SCIENCE

Progress in extracellular vesicle biology and their application in cancer medicine

(2020) Akhil Srivastava et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Extracellular vesicles as drug delivery systems: Why and how?

(2020) Omnia M. Elsharkasy et al.   ADVANCED DRUG DELIVERY REVIEWS

RNA delivery by extracellular vesicles in mammalian cells and its applications

(2020) Killian O’Brien et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Role of Extracellular Vesicles in the Hallmarks of Cancer and Drug Resistance

(2020) Cristina P. R. Xavier et al.   Cells

Anti-PD-1 Therapy Response Predicted by the Combination of Exosomal PD-L1 and CD28

(2020) Chaoxu Zhang et al.   Frontiers in Oncology

CKAP4, a DKK1 receptor, is a biomarker in exosomes derived from pancreatic cancer and a molecular target for therapy

(2019) Hirokazu Kimura et al.   CLINICAL CANCER RESEARCH

Drug-loaded exosomal preparations from different cell types exhibit distinctive loading capability, yield, and antitumor efficacies: a comparative analysis

(2019) Rajashekhar Kanchanapally et al.   International Journal of Nanomedicine

Inhibition of multiple myeloma‑derived exosomes uptake suppresses the functional response in bone marrow stromal cell

(2019) Yongjiang Zheng et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Extracellular Microvesicles as New Industrial Therapeutic Frontiers

(2019) Vivek Agrahari et al.   TRENDS IN BIOTECHNOLOGY

The origin of exosomal miR-1246 in human cancer cells

(2019) Yi-Fan Xu et al.   RNA Biology

Clinical cancer nanomedicine

(2019) Joy Wolfram et al.   Nano Today

Phenotypical and functional evaluation of dendritic cells after exosomal delivery of miRNA-155

(2019) Ali Asadirad et al.   LIFE SCIENCES

Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory

(2019) Mauro Poggio et al.   CELL

exRNA Atlas Analysis Reveals Distinct Extracellular RNA Cargo Types and Their Carriers Present across Human Biofluids

(2019) Oscar D. Murillo et al.   CELL

Exosome-Mediated Metastasis: Communication from a Distance

(2019) Inbal Wortzel et al.   DEVELOPMENTAL CELL

Tumor-derived extracellular vesicles: reliable tools for Cancer diagnosis and clinical applications

(2019) Reza Rahbarghazi et al.   Cell Communication and Signaling

Exosomes and their role in tumorigenesis and anticancer drug resistance

(2019) Neta Milman et al.   DRUG RESISTANCE UPDATES

Latest advances in extracellular vesicles: from bench to bedside

(2019) Tomofumi Yamamoto et al.   SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS

Glioblastoma-Associated Microglia Reprogramming Is Mediated by Functional Transfer of Extracellular miR-21

(2019) Erik R. Abels et al.   Cell Reports

Small extracellular vesicle loading systems in cancer therapy: Current status and the way forward

(2019) Yue-Feng Zhang et al.   CYTOTHERAPY

Extracellular Vesicles As Nanomedicine: Hopes And Hurdles In Clinical Translation

(2019) Thierry Burnouf et al.   International Journal of Nanomedicine

The role of exosomal PD-L1 in tumor progression and immunotherapy

(2019) Feiting Xie et al.   Molecular Cancer

Gemcitabine loaded autologous exosomes for effective and safe chemotherapy of pancreatic cancer

(2019) Yong-Jiang Li et al.   Acta Biomaterialia

Extracellular vesicles as biomarkers and therapeutic targets for cancer

(2019) Fumihiko Urabe et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Eliminating blood oncogenic exosomes into the small intestine with aptamer-functionalized nanoparticles

(2019) Xiaodong Xie et al.   Nature Communications

Ovatodiolide Suppresses Oral Cancer Malignancy by Down-Regulating Exosomal Mir-21/STAT3/β-Catenin Cargo and Preventing Oncogenic Transformation of Normal Gingival Fibroblasts

(2019) Jia-Hong Chen et al.   Cancers

Apoptotic Cell-Derived Extracellular Vesicles Promote Malignancy of Glioblastoma Via Intercellular Transfer of Splicing Factors

(2018) Marat S. Pavlyukov et al.   CANCER CELL

Hypoxic tumor-derived exosomal miR-301a mediates M2 macrophage polarization via PTEN/PI3Kγ to promote pancreatic cancer metastasis

(2018) Xiaofeng Wang et al.   CANCER RESEARCH

Regulation and mechanisms of extracellular vesicle biogenesis and secretion

(2018) Crislyn D’Souza-Schorey et al.   Essays in Biochemistry

Exosome-mediated transfer of lncRNA‑SNHG14 promotes trastuzumab chemoresistance in breast cancer

(2018) Huaying Dong et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Extracellular vesicle therapeutics for liver disease

(2018) David A. Borrelli et al.   JOURNAL OF CONTROLLED RELEASE

Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation

(2018) Haiying Zhang et al.   NATURE CELL BIOLOGY

CRISPR/Cas9 genome editing in human hematopoietic stem cells

(2018) Rasmus O Bak et al.   Nature Protocols

Metastasis-associated miR-23a from nasopharyngeal carcinoma-derived exosomes mediates angiogenesis by repressing a novel target gene TSGA10

(2018) Lili Bao et al.   ONCOGENE

Exosomes in cancer: Use them or target them?

(2018) Nuno Bastos et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Effect of pH, temperature and freezing-thawing on quantity changes and cellular uptake of exosomes

(2018) Yirui Cheng et al.   Protein & Cell

Transfer of miRNA in Macrophage-Derived Exosomes Induces Drug Resistance in Pancreatic Adenocarcinoma

(2018) Yoav Binenbaum et al.   CANCER RESEARCH

Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response

(2018) Gang Chen et al.   NATURE

A New Approach for Loading Anticancer Drugs Into Mesenchymal Stem Cell-Derived Exosome Mimetics for Cancer Therapy

(2018) Senthilkumar Kalimuthu et al.   Frontiers in Pharmacology

Internalization of Exosomes through Receptor-mediated Endocytosis

(2018) Amber Gonda et al.   MOLECULAR CANCER RESEARCH

Endocytosis Pathways of Endothelial Cell Derived Exosomes

(2018) Anna B. Banizs et al.   MOLECULAR PHARMACEUTICS

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

(2018) Mathilde Mathieu et al.   NATURE CELL BIOLOGY

A potential gain-of-function variant of SLC9A6 leads to endosomal alkalinization and neuronal atrophy associated with Christianson Syndrome

(2018) Alina Ilie et al.   NEUROBIOLOGY OF DISEASE

Recent advancements in the use of exosomes as drug delivery systems

(2018) Edwin J. Bunggulawa et al.   JOURNAL OF NANOBIOTECHNOLOGY

Cell type-specific and common characteristics of exosomes derived from mouse cell lines: Yield, physicochemical properties, and pharmacokinetics

(2017) Chonlada Charoenviriyakul et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Doxorubicin-loaded cell-derived nanovesicles: an alternative targeted approach for anti-tumor therapy

(2017) Wei Jiang Goh et al.   International Journal of Nanomedicine

Disruption of Circulating Extracellular Vesicles as a Novel Therapeutic Strategy against Cancer Metastasis

(2017) Nao Nishida-Aoki et al.   MOLECULAR THERAPY

Functional Delivery of Lipid-Conjugated siRNA by Extracellular Vesicles

(2017) Aisling J. O’Loughlin et al.   MOLECULAR THERAPY

Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer

(2017) Sushrut Kamerkar et al.   NATURE

exoRBase: a database of circRNA, lncRNA and mRNA in human blood exosomes

(2017) Shengli Li et al.   NUCLEIC ACIDS RESEARCH

miRandola 2017: a curated knowledge base of non-invasive biomarkers

(2017) Francesco Russo et al.   NUCLEIC ACIDS RESEARCH

Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer

(2017) Pasquale Sansone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell-based therapy using miR-302-367 expressing cells represses glioblastoma growth

(2017) Mohamed Fareh et al.   Cell Death & Disease

Coding and noncoding landscape of extracellular RNA released by human glioma stem cells

(2017) Zhiyun Wei et al.   Nature Communications

Plasma exosome miR-196a and miR-1246 are potential indicators of localized pancreatic cancer

(2017) Yi-Fan Xu et al.   Oncotarget

Anti-Donor Immune Responses Elicited by Allogeneic Mesenchymal Stem Cells and Their Extracellular Vesicles: Are We Still Learning?

(2017) Paul Lohan et al.   Frontiers in Immunology

MicroRNA-155 Controls Exosome Synthesis and Promotes Gemcitabine Resistance in Pancreatic Ductal Adenocarcinoma

(2017) Manabu Mikamori et al.   Scientific Reports

Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis

(2016) Annette Becker et al.   CANCER CELL

Reversing drug resistance of soft tumor-repopulating cells by tumor cell-derived chemotherapeutic microparticles

(2016) Jingwei Ma et al.   CELL RESEARCH

Nano carriers for drug transport across the blood–brain barrier

(2016) Xinming Li et al.   JOURNAL OF DRUG TARGETING

ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins

(2016) Carolina Villarroya-Beltri et al.   Nature Communications

Tetherin is an exosomal tether

(2016) James R Edgar et al.   eLife

Engineering hybrid exosomes by membrane fusion with liposomes

(2016) Yuko T. Sato et al.   Scientific Reports

Exosomes as drug delivery vehicles for Parkinson's disease therapy

(2015) Matthew J. Haney et al.   JOURNAL OF CONTROLLED RELEASE

Active loading into extracellular vesicles significantly improves the cellular uptake and photodynamic effect of porphyrins

(2015) Gregor Fuhrmann et al.   JOURNAL OF CONTROLLED RELEASE

Exosomes derived from miR-122-modified adipose tissue-derived MSCs increase chemosensitivity of hepatocellular carcinoma

(2015) Guohua Lou et al.   Journal of Hematology & Oncology

Exosome-mediated microRNA signaling from breast cancer cells is altered by the anti-angiogenesis agent docosahexaenoic acid (DHA)

(2015) Bethany N. Hannafon et al.   Molecular Cancer

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis

(2015) Miranda Y. Fong et al.   NATURE CELL BIOLOGY

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

(2015) Bruno Costa-Silva et al.   NATURE CELL BIOLOGY

Extracellular vesicle-mediated transfer of CLIC1 protein is a novel mechanism for the regulation of glioblastoma growth

(2015) Matteo Setti et al.   Oncotarget

Dendritic cell-derived exosomes as maintenance immunotherapy after first line chemotherapy in NSCLC

(2015) Benjamin Besse et al.   OncoImmunology

Placenta-Derived Exosomes and Syncytiotrophoblast Microparticles and their Role in Human Reproduction: Immune Modulation for Pregnancy Success

(2014) Lucia Mincheva-Nilsson et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Examination of the specificity of tumor cell derived exosomes with tumor cells in vitro

(2014) Tyson J. Smyth et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis

(2014) Sonia A. Melo et al.   CANCER CELL

Double-stranded DNA in exosomes: a novel biomarker in cancer detection

(2014) Basant Kumar Thakur et al.   CELL RESEARCH

Regulation of exosome release by glycosphingolipids and flotillins

(2014) Santosh Phuyal et al.   FEBS Journal

Molecular Mechanisms of Cellular Cholesterol Efflux

(2014) Michael C. Phillips   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Double-stranded Genomic DNA Spanning All Chromosomes with MutatedKRASandp53DNA in the Serum Exosomes of Patients with Pancreatic Cancer

(2014) Christoph Kahlert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exosome Uptake through Clathrin-mediated Endocytosis and Macropinocytosis and Mediating miR-21 Delivery

(2014) Tian Tian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Paclitaxel is incorporated by mesenchymal stromal cells and released in exosomes that inhibit in vitro tumor growth: A new approach for drug delivery

(2014) Luisa Pascucci et al.   JOURNAL OF CONTROLLED RELEASE

Exosomes As a Short-Range Mechanism to Spread Alloantigen between Dendritic Cells during T Cell Allorecognition

(2014) A. Montecalvo et al.   JOURNAL OF IMMUNOLOGY

MSC-derived exosomes: a novel tool to treat therapy-refractory graft-versus-host disease

(2014) L Kordelas et al.   LEUKEMIA

Maximizing exosome colloidal stability following electroporation

(2013) Joshua L. Hood et al.   ANALYTICAL BIOCHEMISTRY

Immune Modulation in Cancer with Antibodies

(2013) David B. Page et al.   Annual Review of Medicine

A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy

(2013) Yanhua Tian et al.   BIOMATERIALS

Exosomes from marrow stromal cells expressing miR-146b inhibit glioma growth

(2013) Mark Katakowski et al.   CANCER LETTERS

Exosomes are natural carriers of exogenous siRNA to human cells in vitro

(2013) Tatyana A Shtam et al.   Cell Communication and Signaling

Oncology Meets Immunology: The Cancer-Immunity Cycle

(2013) Daniel S. Chen et al.   IMMUNITY

Intercellular Communication by Exosome-Derived microRNAs in Cancer

(2013) Bethany Hannafon et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exosome Uptake Depends on ERK1/2-Heat Shock Protein 27 Signaling and Lipid Raft-mediated Endocytosis Negatively Regulated by Caveolin-1

(2013) Katrin J. Svensson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neutral Sphingomyelinase 2 (nSMase2)-dependent Exosomal Transfer of Angiogenic MicroRNAs Regulate Cancer Cell Metastasis

(2013) Nobuyoshi Kosaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exosomes Derived from Epstein-Barr Virus-Infected Cells Are Internalized via Caveola-Dependent Endocytosis and Promote Phenotypic Modulation in Target Cells

(2013) A. Nanbo et al.   JOURNAL OF VIROLOGY

Extracellular vesicles: biology and emerging therapeutic opportunities

(2013) Samir EL Andaloussi et al.   NATURE REVIEWS DRUG DISCOVERY

Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity

(2013) H. C. Christianson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Delivery of therapeutic agents by nanoparticles made of grapefruit-derived lipids

(2013) Qilong Wang et al.   Nature Communications

Delivery of Functional Anti-miR-9 by Mesenchymal Stem Cell–derived Exosomes to Glioblastoma Multiforme Cells Conferred Chemosensitivity

(2013) Jessian L Munoz et al.   Molecular Therapy-Nucleic Acids

Tumor cell-derived exosomes: A message in a bottle

(2012) Pedram Kharaziha et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Macrophage microvesicles induce macrophage differentiation and miR-223 transfer

(2012) N. Ismail et al.   BLOOD

Rab27a Supports Exosome-Dependent and -Independent Mechanisms That Modify the Tumor Microenvironment and Can Promote Tumor Progression

(2012) A. Bobrie et al.   CANCER RESEARCH

Sphingolipid-modulated Exosome Secretion Promotes Clearance of Amyloid-β by Microglia

(2012) Kohei Yuyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exosome removal as a therapeutic adjuvant in cancer

(2012) Annette M Marleau et al.   Journal of Translational Medicine

Syndecan–syntenin–ALIX regulates the biogenesis of exosomes

(2012) Maria Francesca Baietti et al.   NATURE CELL BIOLOGY

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

(2012) Héctor Peinado et al.   NATURE MEDICINE

Delivery of chemotherapeutic drugs in tumour cell-derived microparticles

(2012) Ke Tang et al.   Nature Communications

Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation

(2012) Hina Kalra et al.   PLOS BIOLOGY

Role of Exosomes/Microvesicles in the Nervous System and Use in Emerging Therapies

(2012) Charles Pin-Kuang Lai et al.   Frontiers in Physiology

Hepatic metabolism of retinoids and disease associations

(2011) Yohei Shirakami et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes

(2011) A. Montecalvo et al.   BLOOD

Interaction and uptake of exosomes by ovarian cancer cells

(2011) Cristina Escrevente et al.   BMC CANCER

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Proteolipidic Composition of Exosomes Changes during Reticulocyte Maturation

(2011) Kévin Carayon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Matrix vesicles are carriers of bone morphogenetic proteins (BMPs), vascular endothelial growth factor (VEGF), and noncollagenous matrix proteins

(2011) Niru N. Nahar et al.   JOURNAL OF BONE AND MINERAL METABOLISM

Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis

(2011) D. Fitzner et al.   JOURNAL OF CELL SCIENCE

Treatment of Brain Inflammatory Diseases by Delivering Exosome Encapsulated Anti-inflammatory Drugs From the Nasal Region to the Brain

(2011) Xiaoying Zhuang et al.   MOLECULAR THERAPY

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

Cancer cell-derived microvesicles induce transformation by transferring tissue transglutaminase and fibronectin to recipient cells

(2011) M. A. Antonyak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A–C

(2010) Chieh Hsu et al.   JOURNAL OF CELL BIOLOGY

Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells

(2010) Fanny Chalmin et al.   JOURNAL OF CLINICAL INVESTIGATION

Functional delivery of viral miRNAs via exosomes

(2010) D. M. Pegtel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular Internalization of Exosomes Occurs Through Phagocytosis

(2010) Du Feng et al.   TRAFFIC

Tumor markers in pancreatic cancer: a European Group on Tumor Markers (EGTM) status report

(2009) M. J. Duffy et al.   ANNALS OF ONCOLOGY

Reduction of Hepatitis C Virus Using Lectin Affinity Plasmapheresis in Dialysis Patients

(2009) Richard H. Tullis et al.   BLOOD PURIFICATION

Microenvironmental pH Is a Key Factor for Exosome Traffic in Tumor Cells

(2009) Isabella Parolini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rab27a and Rab27b control different steps of the exosome secretion pathway

(2009) Matias Ostrowski et al.   NATURE CELL BIOLOGY

Nedd4 Family-interacting Protein 1 (Ndfip1) Is Required for the Exosomal Secretion of Nedd4 Family Proteins

(2008) Ulrich Putz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phase I Clinical Trial of Autologous Ascites-derived Exosomes Combined With GM-CSF for Colorectal Cancer

(2008) Shengming Dai et al.   MOLECULAR THERAPY

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

(2008) Johan Skog et al.   NATURE CELL BIOLOGY

The Paradoxical Dynamism of Marrow Stem Cells: Considerations of Stem Cells, Niches, and Microvesicles

(2008) Peter J. Quesenberry et al.   Stem Cell Reviews and Reports

Itinerant exosomes: emerging roles in cell and tissue polarity

(2008) Aparna Lakkaraju et al.   TRENDS IN CELL BIOLOGY