Mechanisms of Metabolic Reprogramming in Cancer Cells Supporting Enhanced Growth and Proliferation

Phase I assessment of safety and therapeutic activity of BAY1436032 in patients with IDH1-mutant solid tumors

(2021) Antje Wick et al.   CLINICAL CANCER RESEARCH

Emerging Roles for Branched-Chain Amino Acid Metabolism in Cancer

(2020) Sharanya Sivanand et al.   CANCER CELL

Regulation of branched-chain amino acid metabolism by hypoxia-inducible factor in glioblastoma

(2020) Bo Zhang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Pentose Phosphate Pathway and Its Involvement in Cisplatin Resistance

(2020) Isabella Giacomini et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structure-Based Design and Identification of FT-2102 (Olutasidenib), a Potent Mutant-Selective IDH1 Inhibitor

(2020) Justin A. Caravella et al.   JOURNAL OF MEDICINAL CHEMISTRY

BCAT2-mediated BCAA catabolism is critical for development of pancreatic ductal adenocarcinoma

(2020) Jin-Tao Li et al.   NATURE CELL BIOLOGY

Vorasidenib (AG-881): A First-in-Class, Brain-Penetrant Dual Inhibitor of Mutant IDH1 and 2 for Treatment of Glioma

(2020) Zenon Konteatis et al.   ACS Medicinal Chemistry Letters

Phenformin Inhibits Hedgehog-Dependent Tumor Growth through a Complex I-Independent Redox/Corepressor Module

(2020) Laura Di Magno et al.   Cell Reports

Cholesterol and beyond - The role of the mevalonate pathway in cancer biology

(2020) Andy Göbel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Pemetrexed sensitizes human lung cancer cells to cytotoxic immune cells

(2020) Tamio Okimoto et al.   CANCER SCIENCE

Ivosidenib in IDH1-mutant, chemotherapy-refractory cholangiocarcinoma (ClarIDHy): a multicentre, randomised, double-blind, placebo-controlled, phase 3 study

(2020) Ghassan K Abou-Alfa et al.   LANCET ONCOLOGY

A shift in glutamine nitrogen metabolism contributes to the malignant progression of cancer

(2020) Manabu Kodama et al.   Nature Communications

COX6B2 drives metabolic reprogramming toward oxidative phosphorylation to promote metastasis in pancreatic ductal cancer cells

(2020) Ke Nie et al.   Oncogenesis

Metabolic Heterogeneity of Cancer Cells: An Interplay between HIF-1, GLUTs, and AMPK

(2020) Nurbubu T. Moldogazieva et al.   Cancers

Shedding New Light on Cancer Metabolism: A Metabolic Tightrope Between Life and Death

(2020) Matthias Läsche et al.   Frontiers in Oncology

Non-Coding RNAs Operate in the Crosstalk Between Cancer Metabolic Reprogramming and Metastasis

(2020) Ziyi Li et al.   Frontiers in Oncology

Methionine Dependence of Cancer

(2020) Peter Kaiser   Biomolecules

Safety and efficacy of BAY1436032 in IDH1-mutant AML: phase I study results

(2020) Michael Heuser et al.   LEUKEMIA

In Silico Study Identified Methotrexate Analog as Potential Inhibitor of Drug Resistant Human Dihydrofolate Reductase for Cancer Therapeutics

(2020) Rabia Mukhtar Rana et al.   MOLECULES

Cysteine as a Carbon Source, a Hot Spot in Cancer Cells Survival

(2020) Jacinta Serpa   Frontiers in Oncology

The Pentose Phosphate Pathway Dynamics in Cancer and Its Dependency on Intracellular pH

(2020) Khalid O. Alfarouk et al.   Metabolites

Digging deeper through glucose metabolism and its regulators in cancer and metastasis

(2020) Majid Ghanavat et al.   LIFE SCIENCES

Multifaceted role of branched-chain amino acid metabolism in cancer

(2020) Hui Peng et al.   ONCOGENE

The Warburg Effect 97 Years after Its Discovery

(2020) Rosa Maria Pascale et al.   Cancers

Cancer Metabolism: Phenotype, Signaling and Therapeutic Targets

(2020) Jae Hyung Park et al.   Cells

The Warburg Effect in Yeast: Repression of Mitochondrial Metabolism Is Not a Prerequisite to Promote Cell Proliferation

(2020) Cyrielle L. Bouchez et al.   Frontiers in Oncology

Mitochondrial oxidative phosphorylation in cutaneous melanoma

(2020) Prakrit R. Kumar et al.   BRITISH JOURNAL OF CANCER

Serine, glycine and one‑carbon metabolism in cancer (Review)

(2020) Sijing Pan et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Two high-rate pentose-phosphate pathways in cancer cells

(2020) Vanessa Cossu et al.   Scientific Reports

Capecitabine for the treatment of pancreatic cancer

(2019) Nauman S. Siddiqui et al.   EXPERT OPINION ON PHARMACOTHERAPY

HIF-1-Dependent Reprogramming of Glucose Metabolic Pathway of Cancer Cells and Its Therapeutic Significance

(2019) Ayako Nagao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Crucial role of the pentose phosphate pathway in malignant tumors (Review)

(2019) Lin Jin et al.   Oncology Letters

Enasidenib: First Mutant IDH2 Inhibitor for the Treatment of Refractory and Relapsed Acute Myeloid Leukemia

(2019) Raghav Dogra et al.   Anti-Cancer Agents in Medicinal Chemistry

Dual inhibition of glutaminase and carnitine palmitoyltransferase decreases growth and migration of glutaminase inhibition–resistant triple-negative breast cancer cells

(2019) Larissa Menezes dos Reis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enasidenib, an inhibitor of mutant IDH2 proteins, induces durable remissions in older patients with newly diagnosed acute myeloid leukemia

(2019) Daniel A. Pollyea et al.   LEUKEMIA

Methionine is a metabolic dependency of tumor-initiating cells

(2019) Zhenxun Wang et al.   NATURE MEDICINE

The Diverse Functions of Non-Essential Amino Acids in Cancer

(2019) Bo-Hyun Choi et al.   Cancers

Novel pyrrolo[3,2-d]pyrimidine compounds target mitochondrial and cytosolic one-carbon metabolism with broad-spectrum antitumor efficacy

(2019) Aamod S. Dekhne et al.   MOLECULAR CANCER THERAPEUTICS

Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis

(2019) Gang Cheng et al.   Nature Communications

Elevated level of mitochondrial reactive oxygen species via fatty acid β-oxidation in cancer stem cells promotes cancer metastasis by inducing epithelial–mesenchymal transition

(2019) Caihua Wang et al.   Stem Cell Research & Therapy

Ketogenic diet in the treatment of cancer – Where do we stand?

(2019) Daniela D. Weber et al.   Molecular Metabolism

A Phase III open-label trial to evaluate efficacy and safety of CPI-613 plus modified FOLFIRINOX (mFFX) versus FOLFIRINOX (FFX) in patients with metastatic adenocarcinoma of the pancreas

(2019) Philip A Philip et al.   Future Oncology

The Role of Non-coding RNAs in Oncology

(2019) Frank J. Slack et al.   CELL

Novel IDH1-Targeted Glioma Therapies

(2019) Georg Karpel-Massler et al.   CNS DRUGS

The complexity of the serine glycine one-carbon pathway in cancer

(2019) Miguel Reina-Campos et al.   JOURNAL OF CELL BIOLOGY

Adapt and conquer: Metabolic flexibility in cancer growth, invasion and evasion

(2019) Peter Kreuzaler et al.   Molecular Metabolism

Current perspectives on statins as potential anti-cancer therapeutics: clinical outcomes and underlying molecular mechanisms

(2019) Ali Fatehi Hassanabad   Translational Lung Cancer Research

The Tricarboxylic Acid Cycle at the Crossroad Between Cancer and Immunity

(2019) Alessandra Scagliola et al.   ANTIOXIDANTS & REDOX SIGNALING

Reprogramming of fatty acid metabolism in cancer

(2019) Nikos Koundouros et al.   BRITISH JOURNAL OF CANCER

Dysregulation of glutaminase and glutamine synthetase in cancer

(2019) José M. Matés et al.   CANCER LETTERS

Dysregulation of de novo nucleotide biosynthetic pathway enzymes in cancer and targeting opportunities

(2019) Alyncia D. Robinson et al.   CANCER LETTERS

Greasing the Wheels of the Cancer Machine: The Role of Lipid Metabolism in Cancer

(2019) Marteinn Thor Snaebjornsson et al.   Cell Metabolism

Crucial players in glycolysis: Cancer progress

(2019) Zaka Abbaszadeh et al.   GENE

Phase III Trial of Adjuvant Capecitabine After Standard Neo-/Adjuvant Chemotherapy in Patients With Early Triple-Negative Breast Cancer (GEICAM/2003-11_CIBOMA/2004-01)

(2019) Ana Lluch et al.   JOURNAL OF CLINICAL ONCOLOGY

Randomized Phase III Study of Continuation Maintenance Bevacizumab With or Without Pemetrexed in Advanced Nonsquamous Non–Small-Cell Lung Cancer: COMPASS (WJOG5610L)

(2019) Takashi Seto et al.   JOURNAL OF CLINICAL ONCOLOGY

Rescue of TCA Cycle Dysfunction for Cancer Therapy

(2019) Jubert Marquez et al.   Journal of Clinical Medicine

Glutamate production from ammonia via glutamate dehydrogenase 2 activity supports cancer cell proliferation under glutamine depletion

(2018) Yukiko Takeuchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lipid metabolism and lipophagy in cancer

(2018) Meenu Maan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Pentose Phosphate Pathway as a Potential Target for Cancer Therapy

(2018) Eunae Sandra Cho et al.   Biomolecules & Therapeutics

LPL protein in Chronic Lymphocytic Leukaemia have different origins in Mutated and Unmutated patients. Advances for a new prognostic marker in CLL

(2018) Daniel Prieto et al.   BRITISH JOURNAL OF HAEMATOLOGY

Non-coding RNAs in the reprogramming of glucose metabolism in cancer

(2018) Ram C. Shankaraiah et al.   CANCER LETTERS

A Phase I Study of CPI-613 in Combination with High-Dose Cytarabine and Mitoxantrone for Relapsed or Refractory Acute Myeloid Leukemia

(2018) Timothy S. Pardee et al.   CLINICAL CANCER RESEARCH

Oxidative Phosphorylation as an Emerging Target in Cancer Therapy

(2018) Thomas M. Ashton et al.   CLINICAL CANCER RESEARCH

Branched-chain amino acid metabolism in cancer

(2018) Elitsa A. Ananieva et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Orlistat as a FASN inhibitor and multitargeted agent for cancer therapy

(2018) Alejandro Schcolnik-Cabrera et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Evolution of GAPDH as a druggable target of tumor glycolysis?

(2018) Shanmugasundaram Ganapathy-Kanniappan   EXPERT OPINION ON THERAPEUTIC TARGETS

Molecular targeting of glutaminase sensitizes ovarian cancer cells to chemotherapy

(2018) Chioniso P. Masamha et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The apple polyphenol phloretin inhibits breast cancer cell migration and proliferation via inhibition of signals by type 2 glucose transporter

(2018) Kuan-Hsun Wu et al.   JOURNAL OF FOOD AND DRUG ANALYSIS

Statins: a role in breast cancer therapy?

(2018) S. Borgquist et al.   JOURNAL OF INTERNAL MEDICINE

Grasping for aspartate in tumour metabolism

(2018) Accalia Fu et al.   NATURE CELL BIOLOGY

p53 and glucose metabolism: an orchestra to be directed in cancer therapy

(2018) Ana Sara Gomes et al.   PHARMACOLOGICAL RESEARCH

A new inhibitor of glucose-6-phosphate dehydrogenase blocks pentose phosphate pathway and suppresses malignant proliferation and metastasis in vivo

(2018) Luigi Mele et al.   Cell Death & Disease

Discovery of AG-120 (Ivosidenib): A First-in-Class Mutant IDH1 Inhibitor for the Treatment of IDH1 Mutant Cancers

(2018) Janeta Popovici-Muller et al.   ACS Medicinal Chemistry Letters

Inhibition of Glucose-6-Phosphate Dehydrogenase Reverses Cisplatin Resistance in Lung Cancer Cells via the Redox System

(2018) Weipeng Hong et al.   Frontiers in Pharmacology

Influence of the Tumor Microenvironment on Cancer Cells Metabolic Reprogramming

(2018) Victoire Gouirand et al.   Frontiers in Oncology

Fatty acid oxidation: An emerging facet of metabolic transformation in cancer

(2018) Yibao Ma et al.   CANCER LETTERS

Cytosolic Aspartate Availability Determines Cell Survival When Glutamine Is Limiting

(2018) H. Furkan Alkan et al.   Cell Metabolism

Immunometabolism in cancer at a glance

(2018) Katrin Singer et al.   Disease Models & Mechanisms

OUP accepted manuscript

(2018)   JNCI-Journal of the National Cancer Institute

Lipid Droplets in Cancer: Guardians of Fat in a Stressful World

(2018) Toni Petan et al.   MOLECULES

Transketolase like 1 (TKTL1) expression alterations in prostate cancer tumorigenesis

(2018) Inês Anselmo da Costa et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

The evolving role of pemetrexed disodium for the treatment of non-small cell lung cancer

(2018) Giovanni Rossi et al.   EXPERT OPINION ON PHARMACOTHERAPY

Fuelling cancer cells

(2018) Alexander R. Terry et al.   Nature Reviews Endocrinology

Astragalin Reduces Hexokinase 2 through Increasing miR-125b to Inhibit the Proliferation of Hepatocellular Carcinoma Cells in Vitro and in Vivo

(2017) Wei Li et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Chrysin inhibited tumor glycolysis and induced apoptosis in hepatocellular carcinoma by targeting hexokinase-2

(2017) Dong Xu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Molecular docking and molecular dynamics simulation analyses of urea with ammoniated and ammoxidized lignin

(2017) Wenzhuo Li et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Pan-mutant-IDH1 inhibitor BAY1436032 is highly effective against human IDH1 mutant acute myeloid leukemia in vivo

(2017) A Chaturvedi et al.   LEUKEMIA

Overexpression of lncRNA IGFBP4–1 reprograms energy metabolism to promote lung cancer progression

(2017) Binyao Yang et al.   Molecular Cancer

Cancer progression by reprogrammed BCAA metabolism in myeloid leukaemia

(2017) Ayuna Hattori et al.   NATURE

Glucose feeds the TCA cycle via circulating lactate

(2017) Sheng Hui et al.   NATURE

Metabolic coupling and the Reverse Warburg Effect in cancer: Implications for novel biomarker and anticancer agent development

(2017) Lindsay Wilde et al.   SEMINARS IN ONCOLOGY

Metabolic Interactions in the Tumor Microenvironment

(2017) Costas A. Lyssiotis et al.   TRENDS IN CELL BIOLOGY

Simvastatin and Atorvastatin inhibit DNA replication licensing factor MCM7 and effectively suppress RB-deficient tumors growth

(2017) Juan Li et al.   Cell Death & Disease

Discovery and Evaluation of Clinical Candidate IDH305, a Brain Penetrant Mutant IDH1 Inhibitor

(2017) Young Shin Cho et al.   ACS Medicinal Chemistry Letters

The natural product carolacton inhibits folate-dependent C1 metabolism by targeting FolD/MTHFD

(2017) Chengzhang Fu et al.   Nature Communications

One-carbon metabolism and nucleotide biosynthesis as attractive targets for anticancer therapy

(2017) Oleg Shuvalov et al.   Oncotarget

The emerging role and targetability of the TCA cycle in cancer metabolism

(2017) Nicole M. Anderson et al.   Protein & Cell

BCKDK of BCAA Catabolism Cross-talking With the MAPK Pathway Promotes Tumorigenesis of Colorectal Cancer

(2017) Peipei Xue et al.   EBioMedicine

Glycine inhibits angiogenesis in colorectal cancer: role of endothelial cells

(2016) Helge Bruns et al.   AMINO ACIDS

Effects of G6PD activity inhibition on the viability, ROS generation and mechanical properties of cervical cancer cells

(2016) Zishui Fang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mechanism of antineoplastic activity of lonidamine

(2016) Kavindra Nath et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Curcumin directly inhibits the transport activity of GLUT1

(2016) Leesha K. Gunnink et al.   BIOCHIMIE

Metabolic Heterogeneity in Human Lung Tumors

(2016) Christopher T. Hensley et al.   CELL

Hypoxia‐inducible factors: coupling glucose metabolism and redox regulation with induction of the breast cancer stem cell phenotype

(2016) Gregg L Semenza   EMBO JOURNAL

Apple Polyphenol Phloretin Inhibits Colorectal Cancer Cell Growth via Inhibition of the Type 2 Glucose Transporter and Activation of p53-Mediated Signaling

(2016) Sheng-Tsai Lin et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The importance of serine metabolism in cancer

(2016) Katherine R. Mattaini et al.   JOURNAL OF CELL BIOLOGY

Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion

(2016) Cristovão M. Sousa et al.   NATURE

Cancer metabolism: a therapeutic perspective

(2016) Ubaldo E. Martinez-Outschoorn et al.   Nature Reviews Clinical Oncology

Fatty acid oxidation is required for the respiration and proliferation of malignant glioma cells

(2016) Hua Lin et al.   NEURO-ONCOLOGY

Glutamine activates STAT3 to control cancer cell proliferation independently of glutamine metabolism

(2016) A Cacace et al.   ONCOGENE

Transketolase counteracts oxidative stress to drive cancer development

(2016) Iris Ming-Jing Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blockage of glutaminolysis enhances the sensitivity of ovarian cancer cells to PI3K/mTOR inhibition involvement of STAT3 signaling

(2016) Lili Guo et al.   TUMOR BIOLOGY

Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor

(2016) Abigail S. Krall et al.   Nature Communications

Repurposing atovaquone: Targeting mitochondrial complex III and OXPHOS to eradicate cancer stem cells

(2016) Marco Fiorillo et al.   Oncotarget

Fatty Acid Oxidation-Driven Src Links Mitochondrial Energy Reprogramming and Oncogenic Properties in Triple-Negative Breast Cancer

(2016) Jun Hyoung Park et al.   Cell Reports

Anticancer activity of koningic acid and semisynthetic derivatives

(2015) Nicolas J. Rahier et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Targeting glutaminolysis has antileukemic activity in acute myeloid leukemia and synergizes with BCL-2 inhibition

(2015) N. Jacque et al.   BLOOD

The Warburg effect in tumor progression: Mitochondrial oxidative metabolism as an anti-metastasis mechanism

(2015) Jianrong Lu et al.   CANCER LETTERS

Molecular Pathways: Fatty Acid Synthase

(2015) S. F. Jones et al.   CLINICAL CANCER RESEARCH

Akt inhibitors in cancer treatment: The long journey from drug discovery to clinical use (Review)

(2015) GEORGE MIHAI NITULESCU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

A phase I open-labeled, single-arm, dose-escalation, study of dichloroacetate (DCA) in patients with advanced solid tumors

(2015) Quincy Siu-Chung Chu et al.   INVESTIGATIONAL NEW DRUGS

Inhibition of Mitochondrial Complex II by the Anticancer Agent Lonidamine

(2015) Lili Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H+ symporters

(2015) Ibtissam Marchiq et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

PEPCK Coordinates the Regulation of Central Carbon Metabolism to Promote Cancer Cell Growth

(2015) Emily D. Montal et al.   MOLECULAR CELL

DHFR-mediated effects of methotrexate in medulloblastoma and osteosarcoma cells: The same outcome of treatment with different doses in sensitive cell lines

(2015) Jakub Neradil et al.   ONCOLOGY REPORTS

Differential regulation of mTORC1 by leucine and glutamine

(2015) J. L. Jewell et al.   SCIENCE

Inhibition of glucose-6-phosphate dehydrogenase sensitizes cisplatin-resistant cells to death

(2015) Daniela Catanzaro et al.   Oncotarget

By reducing hexokinase 2, resveratrol induces apoptosis in HCC cells addicted to aerobic glycolysis and inhibits tumor growth in mice

(2015) Weiqi Dai et al.   Oncotarget

Modeling the interplay between the HIF-1 and p53 pathways in hypoxia

(2015) Chun-Hong Zhou et al.   Scientific Reports

Comprehensive Review on Betulin as a Potent Anticancer Agent

(2015) Sylwia Katarzyna Król et al.   Biomed Research International

Nitric Oxide And Oxygen: Actions And Interactions In Health And Disease

(2015) Professor Sir Salvador Moncada   Redox Biology

Glutaminase: A Hot Spot For Regulation Of Cancer Cell Metabolism?

(2015)   Oncotarget

Glutaminase 2 negatively regulates the PI3K/AKT signaling and shows tumor suppression activity in human hepatocellular carcinoma

(2015) Juan Liu et al.   Oncotarget

Chemical inhibition of acetyl-CoA carboxylase suppresses self-renewal growth of cancer stem cells

(2015) Bruna Corominas-Faja et al.   Oncotarget

Metabolic Targeting of Lactate Efflux by Malignant Glioma Inhibits Invasiveness and Induces Necrosis: An In Vivo Study

(2015) Chaim B Colen et al.   NEOPLASIA

The return of metabolism: biochemistry and physiology of the pentose phosphate pathway

(2014) Anna Stincone et al.   BIOLOGICAL REVIEWS

Protein and Nucleotide Biosynthesis Are Coupled by a Single Rate-Limiting Enzyme, PRPS2, to Drive Cancer

(2014) John T. Cunningham et al.   CELL

Acetate Fuels the Cancer Engine

(2014) Costas A. Lyssiotis et al.   CELL

Systemic Delivery of Microencapsulated 3-Bromopyruvate for the Therapy of Pancreatic Cancer

(2014) J. Chapiro et al.   CLINICAL CANCER RESEARCH

Targeting the Metabolic Plasticity of Multiple Myeloma with FDA-Approved Ritonavir and Metformin

(2014) S. Dalva-Aydemir et al.   CLINICAL CANCER RESEARCH

Picking the Point of Inhibition: A Comparative Review of PI3K/AKT/mTOR Pathway Inhibitors

(2014) R. Dienstmann et al.   MOLECULAR CANCER THERAPEUTICS

Lipid Catabolism via CPT1 as a Therapeutic Target for Prostate Cancer

(2014) I. R. Schlaepfer et al.   MOLECULAR CANCER THERAPEUTICS

Fatostatin Displays High Antitumor Activity in Prostate Cancer by Blocking SREBP-Regulated Metabolic Pathways and Androgen Receptor Signaling

(2014) X. Li et al.   MOLECULAR CANCER THERAPEUTICS

PCK2 activation mediates an adaptive response to glucose depletion in lung cancer

(2014) K Leithner et al.   ONCOGENE

6-Thioguanine: A Drug With Unrealized Potential for Cancer Therapy

(2014) Pashna N. Munshi et al.   ONCOLOGIST

Dichloroacetate Enhances Adriamycin-Induced Hepatoma Cell Toxicity In Vitro and In Vivo by Increasing Reactive Oxygen Species Levels

(2014) Yunhai Dai et al.   PLoS One

Serine and glycine metabolism in cancer

(2014) Ivano Amelio et al.   TRENDS IN BIOCHEMICAL SCIENCES

The pentose phosphate pathway and cancer

(2014) Krushna C. Patra et al.   TRENDS IN BIOCHEMICAL SCIENCES

Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer

(2014) Roland Nilsson et al.   Nature Communications

Regulation of the pentose phosphate pathway in cancer

(2014) Peng Jiang et al.   Protein & Cell

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

(2014) William W Wheaton et al.   eLife

Safety and outcome of treatment of metastatic melanoma using 3-bromopyruvate: a concise literature review and case study

(2014) Salah Mohamed El Sayed et al.   Chinese Journal of Cancer

MicroRNA-433 negatively regulates the expression of thymidylate synthase (TYMS) responsible for 5-fluorouracil sensitivity in HeLa cells

(2013) Keisuke Gotanda et al.   BMC CANCER

Cellular Fatty Acid Metabolism and Cancer

(2013) Erin Currie et al.   Cell Metabolism

Glutaminase Isoenzymes as Key Regulators in Metabolic and Oxidative Stress Against Cancer

(2013) J.M. Mates et al.   CURRENT MOLECULAR MEDICINE

Enhanced antitumor activity of cerulenin combined with oxaliplatin in human colon cancer cells

(2013) RISA SHIRAGAMI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors

(2013) E. M. Dunbar et al.   INVESTIGATIONAL NEW DRUGS

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

(2013) Jaekyoung Son et al.   NATURE

Lipoprotein lipase in non-small cell lung cancer tissue is highly expressed in a subpopulation of tumor-associated macrophages

(2013) Helena Podgornik et al.   PATHOLOGY RESEARCH AND PRACTICE

STAT1 Regulates Human Glutaminase 1 Promoter Activity through Multiple Binding Sites in HIV-1 Infected Macrophages

(2013) Lixia Zhao et al.   PLoS One

Catabolism of Exogenous Lactate Reveals It as a Legitimate Metabolic Substrate in Breast Cancer

(2013) Kelly M. Kennedy et al.   PLoS One

Strengthened glycolysis under hypoxia supports tumor symbiosis and hexosamine biosynthesis in pancreatic adenocarcinoma

(2013) F. Guillaumond et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipogenesis and lipolysis: The pathways exploited by the cancer cells to acquire fatty acids

(2013) Nousheen Zaidi et al.   PROGRESS IN LIPID RESEARCH

Targeting cellular metabolism to improve cancer therapeutics

(2013) Y Zhao et al.   Cell Death & Disease

Activating oxidative phosphorylation by a pyruvate dehydrogenase kinase inhibitor overcomes sorafenib resistance of hepatocellular carcinoma

(2012) Y-C Shen et al.   BRITISH JOURNAL OF CANCER

Overexpression of the Mitochondrial Folate and Glycine-Serine Pathway: A New Determinant of Methotrexate Selectivity in Tumors

(2012) A. Vazquez et al.   CANCER RESEARCH

Lipid metabolism in cancer

(2012) Claudio R. Santos et al.   FEBS Journal

The pentose phosphate pathway: An antioxidant defense and a crossroad in tumor cell fate

(2012) Chiara Riganti et al.   FREE RADICAL BIOLOGY AND MEDICINE

A translational study “case report” on the small molecule “energy blocker” 3-bromopyruvate (3BP) as a potent anticancer agent: from bench side to bedside

(2012) Y. H. Ko et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

A Small-Molecule Inhibitor of Glucose Transporter 1 Downregulates Glycolysis, Induces Cell-Cycle Arrest, and Inhibits Cancer Cell Growth In Vitro and In Vivo

(2012) Y. Liu et al.   MOLECULAR CANCER THERAPEUTICS

Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells

(2012) Oliver D. K. Maddocks et al.   NATURE

Interferon-α Regulates Glutaminase 1 Promoter through STAT1 Phosphorylation: Relevance to HIV-1 Associated Neurocognitive Disorders

(2012) Lixia Zhao et al.   PLoS One

Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism

(2012) K. Thangavelu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic reprogramming in cancer: Unraveling the role of glutamine in tumorigenesis

(2012) Dania Daye et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Tumor cell metabolism

(2011) Susana Romero-Garcia et al.   CANCER BIOLOGY & THERAPY

Identification of transaldolase as a novel serum biomarker for hepatocellular carcinoma metastasis using xenografted mouse model and clinic samples

(2011) Cun Wang et al.   CANCER LETTERS

Arsenic Trioxide Treatment Decreases the Oxygen Consumption Rate of Tumor Cells and Radiosensitizes Solid Tumors

(2011) C. Diepart et al.   CANCER RESEARCH

The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

(2011) Stephanos Pavlides et al.   CELL CYCLE

Induction of the Mitochondrial NDUFA4L2 Protein by HIF-1α Decreases Oxygen Consumption by Inhibiting Complex I Activity

(2011) Daniel Tello et al.   Cell Metabolism

Altered cancer cell metabolism in gliomas with mutant IDH1 or IDH2

(2011) Alexandra Borodovsky et al.   CURRENT OPINION IN ONCOLOGY

The monocarboxylate transporter family-Structure and functional characterization

(2011) Andrew P. Halestrap   IUBMB LIFE

l-3-Phosphoserine phosphatase (PSPH) regulates cutaneous squamous cell carcinoma proliferation independent of l-serine biosynthesis

(2011) Michael A. Bachelor et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Non-redox-active lipoate derivates disrupt cancer cell mitochondrial metabolism and are potent anticancer agents in vivo

(2011) Zuzana Zachar et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Cancer Cell Dependence on Unsaturated Fatty Acids Implicates Stearoyl-CoA Desaturase as a Target for Cancer Therapy

(2011) U. V. Roongta et al.   MOLECULAR CANCER RESEARCH

Lipoprotein Lipase Links Dietary Fat to Solid Tumor Cell Proliferation

(2011) N. B. Kuemmerle et al.   MOLECULAR CANCER THERAPEUTICS

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

(2011) Richard Possemato et al.   NATURE

p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase

(2011) Peng Jiang et al.   NATURE CELL BIOLOGY

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

(2011) Jason W Locasale et al.   NATURE GENETICS

Pyruvate carboxylase is required for glutamine-independent growth of tumor cells

(2011) T. Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting GLUT1 and the Warburg Effect in Renal Cell Carcinoma by Chemical Synthetic Lethality

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(2010) W. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

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(2010) A. Le et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

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(2009) Javier A. Menendez   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

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Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction

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Mitaplatin, a potent fusion of cisplatin and the orphan drug dichloroacetate

(2009) Shanta Dhar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

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(2009) M. G. Vander Heiden et al.   SCIENCE

Thymidylate Synthase and Methylenetetrahydrofolate Reductase Gene Polymorphisms and Toxicity to Capecitabine in Advanced Colorectal Cancer Patients

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TKTL1 is overexpressed in a large portion of non-small cell lung cancer specimens

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Overexpression of phosphoserine aminotransferase PSAT1 stimulates cell growth and increases chemoresistance of colon cancer cells

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A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death

(2008) T. E. Wood et al.   MOLECULAR CANCER THERAPEUTICS

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(2008) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

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