Review
Cell Biology
Noorzaileen Eileena Zaidi, Nur Aima Hafiza Shazali, Thean-Chor Leow, Mohd Azuraidi Osman, Kamariah Ibrahim, Wan-Hee Cheng, Kok-Song Lai, Nik Mohd Afizan Nik Abd Rahman
Summary: Tumour heterogeneity refers to the complex interactions between different cell subpopulations within the tumour microenvironment. The interactions between cancer cells and the surrounding microenvironment are closely related to metabolic reprogramming, which can modulate immune cell functions and initiate anti-tumour responses.
Review
Cell Biology
Jacob P. Veenstra, Lucas Felipe Fernandes Bittencourt, Katherine M. Aird
Summary: Ovarian cancer is a highly aggressive disease, often diagnosed late after it has spread. Inflammatory signals and cellular senescence play important roles in ovarian cancer dissemination. Recent studies have shown that platinum-based or PARP inhibitor therapies, standard treatments for ovarian cancer, can induce senescence in ovarian cancer cells, leading to an inflammatory response known as the senescence-associated secretory phenotype (SASP). The SASP may promote metastasis in ovarian cancer.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Li Li, Cheng Chen, Chengyao Chiang, Tian Xiao, Yangchao Chen, Yongxiang Zhao, Duo Zheng
Summary: TRPV1, a transmembrane protein activated by various stimuli, is associated with pain transmission and has been found to play crucial roles in cancer tumorigenesis and development. Studies have shown direct links between TRPV1 and cancer cell proliferation, death, and metastasis, with TRPV1 being a potential target for treating diseases. Research is focusing on the effects of TRPV1 agonists/antagonists on cancer, with both types of drugs potentially having anti-cancer effects.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Immunology
Soumik Pal, Amit Sharma, Sam Padalumavunkal Mathew, Bithiah Grace Jaganathan
Summary: Cancer is a heterogeneous disease characterized by various genetic and phenotypic aberrations, and cancer cells meet their uncontrolled proliferation demands through metabolic reprogramming. Despite increasing understanding of tumor metabolism, therapeutic interventions targeting these specific dysregulations have been largely ineffective in clinical trials.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Engineering, Biomedical
Ravi Chandra Yada, Danielle E. Desa, Amani A. Gillette, Emmett Bartels, Paul M. Harari, Melissa C. Skala, David J. Beebe, Sheena C. Kerr
Summary: The study created a microphysiological system using primary patient cells to investigate the metastasis of head and neck cancer. It was found that lymphatic endothelial cells secrete macrophage migration inhibitory factor (MIF) in the tumor microenvironment. The study also observed patient-to-patient heterogeneity in cancer cell migration. This multicellular, microfluidic platform expands the tools available for studying head and neck cancer biology in vitro.
Review
Biochemistry & Molecular Biology
Flavia Martino, Mariadomenica Lupi, Enrico Giraudo, Letizia Lanzetti
Summary: Breast cancer is a highly prevalent and deadly disease, with a significant number of patients succumbing to it each year. The phenomenon of metastatic dormancy, in which cancer cells remain dormant before becoming active and initiating metastatic disease, is a major challenge in breast cancer management. Understanding cancers as ecosystems and studying the impact of non-cancer-cell-autonomous events can greatly enhance our knowledge of the natural history of cancer, including aspects related to metabolism. In breast cancer, metabolic pathways play a crucial role and their study can shed new light on the development of effective therapies.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Review
Cell Biology
Jang Bae Moon, Su Woong Yoo, Changho Lee, Dong-Yeon Kim, Ayoung Pyo, Seong Young Kwon
Summary: Bone metastasis is a common malignant bone tumor that significantly affects the morbidity and mortality of cancer patients. Precise assessment of the tumor microenvironment in bone metastasis is essential for optimizing patient care. Imaging techniques offer advantages for visualizing the tumor microenvironment without the need for biopsy.
Article
Chemistry, Multidisciplinary
Zebin Yang, Yu Luo, Huizhu Yu, Kaicheng Liang, Miao Wang, Qigang Wang, Bo Yin, Hangrong Chen
Summary: This study has constructed a novel nanomaterial to reshape the immunosuppressive tumor microenvironment. The nanomaterial can generate reactive oxygen species to alleviate tumor hypoxia and promote the polarization of tumor-associated macrophages. The light-activated nanoplatform can activate and recruit immune cells in combination with radiotherapy, reversing the immunosuppressive tumor microenvironment and enhancing immune responses.
ADVANCED MATERIALS
(2022)
Review
Cell Biology
William W. Feng, Hannah T. Zuppe, Manabu Kurokawa
Summary: Cluster of differentiation 36 (CD36) is a cell surface scavenger receptor that plays critical roles in various cancers, and its functions include fatty acid uptake, cellular adhesion regulation, immune response modulation, and apoptosis induction. CD36 is involved in mediating metastasis, drug resistance, and immune evasion in cancer, making it a potential therapeutic target. The clinical implications of CD36-targeted therapy extend beyond cancer due to its roles in metabolic disorders.
Review
Biochemistry & Molecular Biology
Hsiang-Hao Chuang, Yen-Yi Zhen, Yu-Chen Tsai, Cheng-Hao Chuang, Michael Hsiao, Ming-Shyan Huang, Chih-Jen Yang
Summary: In this review, the authors summarize the mechanisms of FAK-mediated signaling networks during tumor development and the recent progress of FAK-targeted small-molecule compounds for anticancer activity from preclinical and clinical evidence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Gaohong Sheng, Yuan Gao, Yong Yang, Hua Wu
Summary: Osteosarcoma, the most common primary bone malignancy in adolescents, has a high propensity to metastasize leading to treatment failure and poor prognosis. Despite advancements in research, knowledge and therapy strategies targeting metastatic progression are still limited. Comprehensive understanding at molecular, cellular, and animal levels is needed to develop innovative therapies for metastatic osteosarcoma.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Tai-Na Wu, Hui-Ming Chen, Lie-Fen Shyur
Summary: Triple-negative breast cancer is typically treated with chemotherapy, but drug resistance often leads to poor prognosis. Abnormal tumor metabolism and immune cells in the tumor microenvironment may impact tumor growth and resistance to treatment. Phytochemicals have the potential to alter tumor metabolism and reprogram the tumor microenvironment, potentially suppressing cancer metastasis and overcoming chemoresistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Marie-Therese Haider, Daniel J. Smit, Hanna Taipaleenmaeki
Summary: This article summarizes the recent research progress on miRNAs in breast cancer bone metastasis. MiRNAs not only affect the function of cancer cells, but also play an important role in key cells of the bone microenvironment. In addition, the article discusses the potential application of miRNAs as therapeutic targets and elaborates on the advantages and challenges of miRNA treatment.
Article
Multidisciplinary Sciences
Othman Benchama, Sergiy Tyukhtenko, Michael S. Malamas, Mark K. Williams, Alexandros Makriyannis, Hava Karsenty Avraham
Summary: This study found that the use of MAGL inhibitor AM9928 can effectively block the adhesion and migration of TNBC cells, reduce the secretion of pro-inflammatory factors by cells, and inhibit the activation of HBMECs and cytokine secretion caused by TNBC. Animal experiments showed that AM9928 can inhibit the growth of mammary tumors in the mammary fat pads and reduce the permeability changes of the blood brain barrier, thus reducing the metastasis of TNBC in the brain. These findings suggest that MAGL inhibitors have the potential to be a novel strategy for TNBC treatment.
SCIENTIFIC REPORTS
(2022)
Review
Oncology
Qiu-Luo Liu, Huijie Zhou, Zong-Guang Zhou, Hai-Ning Chen
Summary: Colorectal cancer (CRC) patients often suffer from liver metastases, resulting in high mortality rates. The molecular basis and management of colorectal liver metastases (CRLMs) pose significant challenges in the clinic. Recent genomic evidence has revealed liver tropism in CRC and a stricter evolutionary bottleneck in the liver compared to lymph nodes. This organ-specific bottleneck challenges CRC cells and necessitates adaptation at both the genetic and phenotypic levels to interact with the hepatic microenvironment. Here, we review emerging evidence on the clonal evolution of CRLM and discuss recent insights into the molecular mechanisms behind the bidirectional interactions between metastatic CRC cells and the unique liver microenvironment.
CANCER AND METASTASIS REVIEWS
(2023)
Article
Oncology
Ulrike Wokoun, Martin Hellriegel, Guenter Emons, Carsten Gruendker
Review
Endocrinology & Metabolism
Carsten Gruendker, Guenter Emons
FRONTIERS IN ENDOCRINOLOGY
(2017)
Article
Oncology
Rainer Girgert, Guenter Emons, Carsten Gruendker
Review
Endocrinology & Metabolism
Rainer Girgert, Guenter Emons, Carsten Gruendker
FRONTIERS IN ENDOCRINOLOGY
(2019)
Review
Obstetrics & Gynecology
Carsten Gruendker, Matthias Laesche, JohannaW. Hellinger, Guenter Emons
GEBURTSHILFE UND FRAUENHEILKUNDE
(2019)
Article
Obstetrics & Gynecology
Carsten Gruendker, Ulrike Wokoun, Martin Hellriegel, Guenter Emons
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2019)
Article
Oncology
Johanna W. Hellinger, Silke Huechel, Lena Goetz, Gerd Bauerschmitz, Guenter Emons, Carsten Gruendker
FRONTIERS IN ONCOLOGY
(2019)
Article
Multidisciplinary Sciences
Johanna W. Hellinger, Franziska Schoemel, Judith Buse, Christof Lenz, Gerd Bauerschmitz, Guenter Emons, Carsten Gruendker
SCIENTIFIC REPORTS
(2020)
Article
Cell Biology
Katharina Kolb, Johanna Hellinger, Maike Kansy, Florian Wegwitz, Gerd Bauerschmitz, Guenter Emons, Carsten Gruendker
Review
Cell Biology
Carsten Gruendker, Guenter Emons
Summary: The HPG axis regulates the female menstrual cycle through GnRH, which can impact ovarian cancer either indirectly through the HPG axis or directly through receptors on the surface of tumor cells.
Review
Cell Biology
Gunter Emons, Carsten Gruendker
Summary: Endometrial cancer expresses GnRH and its receptor, which can regulate proliferation, the cell cycle, and apoptosis. GnRH agonists are used in fertility preserving therapy for early EC, but show limited activity in advanced or recurrent EC. Further clinical trials exploring the GnRH-system in EC may be beneficial.
Review
Cell Biology
Matthias Laesche, Horst Urban, Julia Gallwas, Carsten Gruendker
Summary: Cervical cancer is mainly caused by long-term infection of HPV virus, with weakened immune system and damaged cervical mucosa being crucial factors for carcinogenesis. Aberrant microbial microenvironment, immune and metabolic signalling are pathological mechanisms of cervical cancer.
Article
Cell Biology
Friederike Steifensand, Julia Gallwas, Gerd Bauerschmitz, Carsten Gruendker
Summary: Increased glucose requirement and upregulated glutaminolysis play crucial roles in cancer cell survival, making combined metabolic treatments a potentially effective strategy for improving therapy outcomes in estrogen receptor alpha-positive breast cancer.
Review
Biochemistry & Molecular Biology
Matthias Laesche, Julia Gallwas, Carsten Gruendker
Summary: Despite precautionary measures and vaccinations, HPV-related cancers still remain a significant concern. Research and therapy efforts are needed to address the challenges posed by this disease. HPV infection has the ability to evade immune recognition and utilize host cells for replication. Understanding the effects of HPV infection on metabolic, hormonal, and immune signaling pathways can provide insights into the development of cervical cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)