Journal
ONCOGENE
Volume 39, Issue 44, Pages 6747-6756Publisher
SPRINGERNATURE
DOI: 10.1038/s41388-020-01480-z
Keywords
-
Funding
- NIH [R01AG066166, R35GM124693, R01CA222393]
- CPRIT [RP190358]
- Mary Kay Foundation [08-19]
- Welch Foundation [I-1903-20190330]
- UTSW startup funds
Ask authors/readers for more resources
Metabolic reprogramming fulfils increased nutrient demands and regulates numerous oncogenic processes in tumors, leading to tumor malignancy. Branched-chain amino acids (BCAAs, i.e., valine, leucine, and isoleucine) function as nitrogen donors to generate macromolecules such as nucleotides and are indispensable for human cancer cell growth. The cell-autonomous and non-autonomous roles of altered BCAA metabolism have been implicated in cancer progression and the key proteins in the BCAA metabolic pathway serve as possible prognostic and diagnostic biomarkers in human cancers. Here we summarize how BCAA metabolic reprogramming is regulated in cancer cells and how it influences cancer progression.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available