Regulation of branched-chain amino acid metabolism by hypoxia-inducible factor in glioblastoma

ZMYND8 acetylation mediates HIF-dependent breast cancer progression and metastasis

(2018) Yan Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Methylation of hypoxia-inducible factor (HIF)-1α by G9a/GLP inhibits HIF-1 transcriptional activity and cell migration

(2018) Lei Bao et al.   NUCLEIC ACIDS RESEARCH

Cancer progression by reprogrammed BCAA metabolism in myeloid leukaemia

(2017) Ayuna Hattori et al.   NATURE

BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation

(2017) Simon Raffel et al.   NATURE

The branched-chain amino acid transaminase 1 sustains growth of antiestrogen-resistant and ERα-negative breast cancer

(2017) V Thewes et al.   ONCOGENE

Differential Glutamate Metabolism in Proliferating and Quiescent Mammary Epithelial Cells

(2016) Jonathan L. Coloff et al.   Cell Metabolism

Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation

(2016) Min Pan et al.   NATURE CELL BIOLOGY

Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers

(2016) J. R. Mayers et al.   SCIENCE

The Warburg Effect: How Does it Benefit Cancer Cells?

(2016) Maria V. Liberti et al.   TRENDS IN BIOCHEMICAL SCIENCES

PRDX2 and PRDX4 are negative regulators of hypoxia-inducible factors under conditions of prolonged hypoxia

(2016) Weibo Luo et al.   Oncotarget

BCAT1 expression associates with ovarian cancer progression: possible implications in altered disease metabolism

(2015) Zhi-Qiang Wang et al.   Oncotarget

Cytosolic Branched Chain Aminotransferase (BCATc) Regulates mTORC1 Signaling and Glycolytic Metabolism in CD4+T Cells

(2014) Elitsa A. Ananieva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

JPH203, an L-Type Amino Acid Transporter 1–Selective Compound, Induces Apoptosis of YD-38 Human Oral Cancer Cells

(2014) Dae-Woong Yun et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Glutamine Oxidation Maintains the TCA Cycle and Cell Survival during Impaired Mitochondrial Pyruvate Transport

(2014) Chendong Yang et al.   MOLECULAR CELL

The Branched-Chain Aminotransferase Proteins: Novel Redox Chaperones for Protein Disulfide Isomerase–Implications in Alzheimer's Disease

(2013) Maya El Hindy et al.   ANTIOXIDANTS & REDOX SIGNALING

Glutamine and cancer: cell biology, physiology, and clinical opportunities

(2013) Christopher T. Hensley et al.   JOURNAL OF CLINICAL INVESTIGATION

BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1

(2013) Martje Tönjes et al.   NATURE MEDICINE

The small SLC43 family: Facilitator system l amino acid transporters and the orphan EEG1

(2012) Susanna Bodoy et al.   MOLECULAR ASPECTS OF MEDICINE

HIF2α Acts as an mTORC1 Activator through the Amino Acid Carrier SLC7A5

(2012) Ainara Elorza et al.   MOLECULAR CELL

Differential redox potential between the human cytosolic and mitochondrial branched-chain aminotransferase

(2011) Steven J. Coles et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq

(2011) J. Schodel et al.   BLOOD

Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1

(2011) Weibo Luo et al.   CELL

Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme

(2011) Amparo Wolf et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

(2011) Christian M. Metallo et al.   NATURE

Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of  -ketoglutarate to citrate to support cell growth and viability

(2011) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

(2010) A. Le et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

S-Nitrosoglutathione Inactivation of the Mitochondrial and Cytosolic BCAT Proteins: S-Nitrosation and S-Thiolation†

(2009) Steven J. Coles et al.   BIOCHEMISTRY

Regulatory Control of Human Cytosolic Branched-Chain Aminotransferase by Oxidation and S-Glutathionylation and Its Interactions with Redox Sensitive Neuronal Proteins†

(2008) Myra E. Conway et al.   BIOCHEMISTRY