The importance of serine metabolism in cancer

Metabolic Heterogeneity in Human Lung Tumors

(2016) Christopher T. Hensley et al.   CELL

Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway

(2016) Gregory S. Ducker et al.   Cell Metabolism

Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer

(2016) Shawn M. Davidson et al.   Cell Metabolism

Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells

(2016) Aaron M. Hosios et al.   DEVELOPMENTAL CELL

Targeting MTHFD2 in acute myeloid leukemia

(2016) Yana Pikman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Serine Metabolism Supports the Methionine Cycle and DNA/RNA Methylation through De Novo ATP Synthesis in Cancer Cells

(2016) Oliver D.K. Maddocks et al.   MOLECULAR CELL

Serine biosynthesis and transport defects

(2016) Ayman W. El-Hattab   MOLECULAR GENETICS AND METABOLISM

A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate

(2016) Michael E Pacold et al.   Nature Chemical Biology

Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers

(2016) Edouard Mullarky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle

(2016) I. Ben-Sahra et al.   SCIENCE

Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor

(2016) Abigail S. Krall et al.   Nature Communications

Mitochondrial dysfunction remodels one-carbon metabolism in human cells

(2016) Xiaoyan Robert Bao et al.   eLife

Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells

(2015) Lucas B. Sullivan et al.   CELL

Pyruvate Kinase Isoform Expression Alters Nucleotide Synthesis to Impact Cell Proliferation

(2015) Sophia Y. Lunt et al.   MOLECULAR CELL

SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance

(2015) Dohoon Kim et al.   NATURE

Oxidative stress inhibits distant metastasis by human melanoma cells

(2015) Elena Piskounova et al.   NATURE

NRF2 regulates serine biosynthesis in non–small cell lung cancer

(2015) Gina M DeNicola et al.   NATURE GENETICS

Pyruvate kinase: Function, regulation and role in cancer

(2015) William J. Israelsen et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Famine versus feast: understanding the metabolism of tumors in vivo

(2015) Jared R. Mayers et al.   TRENDS IN BIOCHEMICAL SCIENCES

Phosphoglycerate dehydrogenase is dispensable for breast tumor maintenance and growth

(2015) Jinyun Chen et al.   Oncotarget

Human Phosphoglycerate Dehydrogenase Produces the Oncometabolite d-2-Hydroxyglutarate

(2014) Jing Fan et al.   ACS Chemical Biology

Neu-Laxova Syndrome Is a Heterogeneous Metabolic Disorder Caused by Defects in Enzymes of the L-Serine Biosynthesis Pathway

(2014) Rocio Acuna-Hidalgo et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Tracing Compartmentalized NADPH Metabolism in the Cytosol and Mitochondria of Mammalian Cells

(2014) Caroline A. Lewis et al.   MOLECULAR CELL

Quantitative flux analysis reveals folate-dependent NADPH production

(2014) Jing Fan et al.   NATURE

Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer

(2014) Roland Nilsson et al.   Nature Communications

Serine Catabolism Regulates Mitochondrial Redox Control during Hypoxia

(2014) J. Ye et al.   Cancer Discovery

Serine, but Not Glycine, Supports One-Carbon Metabolism and Proliferation of Cancer Cells

(2014) Christiaan F. Labuschagne et al.   Cell Reports

Phosphoglycerate Dehydrogenase: Potential Therapeutic Target and Putative Metabolic Oncogene

(2014) Cheryl K. Zogg   Journal of Oncology

PKM2 Isoform-Specific Deletion Reveals a Differential Requirement for Pyruvate Kinase in Tumor Cells

(2013) William J. Israelsen et al.   CELL

The Histone H3 Methyltransferase G9A Epigenetically Activates the Serine-Glycine Synthesis Pathway to Sustain Cancer Cell Survival and Proliferation

(2013) Jane Ding et al.   Cell Metabolism

Exploiting the bad eating habits of Ras-driven cancers

(2013) E. White   GENES & DEVELOPMENT

Expression and Clinical Significance of Phosphoglycerate Dehydrogenase and Squamous Cell Carcinoma Antigen in Cervical Cancer

(2013) Zhang Jing et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

An update on serine deficiency disorders

(2013) S. N. van der Crabben et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Allosteric Regulation of PKM2 Allows Cellular Adaptation to Different Physiological States

(2013) D. Y. Gui et al.   Science Signaling

Small Molecule Activation of PKM2 in Cancer Cells Induces Serine Auxotrophy

(2012) Charles Kung et al.   CHEMISTRY & BIOLOGY

Phosphoglycerate dehydrogenase induces glioma cells proliferation and invasion by stabilizing forkhead box M1

(2012) Jinlong Liu et al.   JOURNAL OF NEURO-ONCOLOGY

Serine is a natural ligand and allosteric activator of pyruvate kinase M2

(2012) Barbara Chaneton et al.   NATURE

Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells

(2012) Oliver D. K. Maddocks et al.   NATURE

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

(2012) Dimitrios Anastasiou et al.   Nature Chemical Biology

Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation

(2012) J. Ye et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation

(2012) M. Jain et al.   SCIENCE

Mouse Genetics Suggests Cell-Context Dependency for Myc-Regulated Metabolic Enzymes during Tumorigenesis

(2012) Lisa M. Nilsson et al.   PLoS Genetics

Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation

(2011) Sophia Y. Lunt et al.   Annual Review of Cell and Developmental Biology

Imaging Cytosolic NADH-NAD+ Redox State with a Genetically Encoded Fluorescent Biosensor

(2011) Yin Pun Hung et al.   Cell Metabolism

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

(2011) Richard Possemato et al.   NATURE

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

(2011) Jason W Locasale et al.   NATURE GENETICS

Targeting cancer metabolism: a therapeutic window opens

(2011) Matthew G. Vander Heiden   NATURE REVIEWS DRUG DISCOVERY

PHGDH amplification and altered glucose metabolism in human melanoma

(2011) Edouard Mullarky et al.   Pigment Cell & Melanoma Research

Compartmentalization of Mammalian Folate-Mediated One-Carbon Metabolism

(2010) Anne S. Tibbetts et al.   Annual Review of Nutrition

Enhanced serine production by bone metastatic breast cancer cells stimulates osteoclastogenesis

(2010) Sirkku Pollari et al.   BREAST CANCER RESEARCH AND TREATMENT

The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate

(2010) Patrick S. Ward et al.   CANCER CELL

The landscape of somatic copy-number alteration across human cancers

(2010) Rameen Beroukhim et al.   NATURE

Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment

(2009) Zachary T. Schafer et al.   NATURE

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2009) Lenny Dang et al.   NATURE

Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer

(2009) R J DeBerardinis et al.   ONCOGENE

Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth

(2009) T. Hitosugi et al.   Science Signaling

Pyruvate kinase M2 is a phosphotyrosine-binding protein

(2008) Heather R. Christofk et al.   NATURE

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE