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Title
The Role of p53 Signaling in Colorectal Cancer
Authors
Keywords
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Journal
Cancers
Volume 13, Issue 9, Pages 2125
Publisher
MDPI AG
Online
2021-04-28
DOI
10.3390/cancers13092125
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Related references
Note: Only part of the references are listed.- DAZAP2 acts as specifier of the p53 response to DNA damage
- (2021) Magdalena C Liebl et al. NUCLEIC ACIDS RESEARCH
- Targeting a neoantigen derived from a common TP53 mutation
- (2021) Emily Han-Chung Hsiue et al. SCIENCE
- Cancer type-dependent correlations between TP53 mutations and antitumor immunity
- (2020) Lin Li et al. DNA REPAIR
- The Impact of Mutant p53 in the Non-Coding RNA World
- (2020) Silvia Di Agostino Biomolecules
- The gut microbiome switches mutant p53 from tumour-suppressive to oncogenic
- (2020) Eliran Kadosh et al. NATURE
- Targeting p53 for the treatment of cancer
- (2020) Michael J. Duffy et al. SEMINARS IN CANCER BIOLOGY
- Landscape of somatic single nucleotide variants and indels in colorectal cancer and impact on survival
- (2020) Syed H. Zaidi et al. Nature Communications
- Mutant p53 Drives Cancer Metastasis via RCP-Mediated Hsp90α Secretion
- (2020) Shaosen Zhang et al. Cell Reports
- UFMylation maintains tumour suppressor p53 stability by antagonizing its ubiquitination
- (2020) Jiang Liu et al. NATURE CELL BIOLOGY
- Pancreatic Ductal Adenocarcinoma (PDAC) Organoids: The Shining Light at the End of the Tunnel for Drug Response Prediction and Personalized Medicine
- (2020) Pierre-Olivier Frappart et al. Cancers
- Molecular Mechanisms of Colon Cancer Progression and Metastasis: Recent Insights and Advancements
- (2020) Ahmed Malki et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Rising incidence of early-onset colorectal cancer — a call to action
- (2020) Naohiko Akimoto et al. Nature Reviews Clinical Oncology
- Immunologic Recognition of a Shared p53 Mutated Neoantigen in a Patient with Metastatic Colorectal Cancer
- (2019) Winifred Lo et al. Cancer Immunology Research
- miRNA‑766 induces apoptosis of human colon cancer cells through the p53/Bax signaling pathway by MDM4
- (2019) Weirong Chen et al. Experimental and Therapeutic Medicine
- The multiple mechanisms that regulate p53 activity and cell fate
- (2019) Antonina Hafner et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Comprehensive Genomic Landscapes in Early and Later Onset Colorectal Cancer
- (2019) Christopher H Lieu et al. CLINICAL CANCER RESEARCH
- Analysis of KRAS , NRAS , BRAF , PIK3CA and TP53 mutations in a large prospective series of locally advanced rectal cancer patients
- (2019) Francesco Sclafani et al. INTERNATIONAL JOURNAL OF CANCER
- Trp53 null and R270H mutant alleles have comparable effects in regulating invasion, metastasis, and gene expression in mouse colon tumorigenesis
- (2019) Jinyu Tang et al. LABORATORY INVESTIGATION
- Integrated Analysis of TP53 Gene and Pathway Alterations in The Cancer Genome Atlas
- (2019) Lawrence A. Donehower et al. Cell Reports
- Morphology and Molecular Features of Rare Colorectal Carcinoma Histotypes
- (2019) Andrea Remo et al. Cancers
- Global patterns and trends in colorectal cancer incidence in young adults
- (2019) Rebecca L Siegel et al. GUT
- P53-R273H mutation enhances colorectal cancer stemness through regulating specific lncRNAs
- (2019) Yuechao Zhao et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Global burden of colorectal cancer: emerging trends, risk factors and prevention strategies
- (2019) NaNa Keum et al. Nature Reviews Gastroenterology & Hepatology
- iASPP mediates p53 selectivity through a modular mechanism fine-tuning DNA recognition
- (2019) Shuo Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A dominant-negative effect drives selection of TP53 missense mutations in myeloid malignancies
- (2019) Steffen Boettcher et al. SCIENCE
- Expression of circZNF609 is Down-Regulated in Colorectal Cancer Tissue and Promotes Apoptosis in Colorectal Cancer Cells by Upregulating p53
- (2019) Xiaoyun Zhang et al. MEDICAL SCIENCE MONITOR
- Cell Fate Regulation upon DNA Damage: p53 Serine 46 Kinases Pave the Cell Death Road
- (2019) Magdalena C. Liebl et al. BIOESSAYS
- Mutant p53 drives cancer chemotherapy resistance due to loss of function on activating transcription of PUMA
- (2019) Yuan Huang et al. CELL CYCLE
- Targeting the Oncogenic p53 Mutants in Colorectal Cancer and Other Solid Tumors
- (2019) Hui Li et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- How the Other Half Lives: What p53 Does When It Is Not Being a Transcription Factor
- (2019) Teresa Ho et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Paradoxical Role for Wild-Type p53 in Driving Therapy Resistance in Melanoma
- (2019) Marie R. Webster et al. MOLECULAR CELL
- Predictive Gene Signatures Determine Tumor Sensitivity to MDM2 Inhibition
- (2018) Jo Ishizawa et al. CANCER RESEARCH
- Mutant p53 regulates enhancer-associated H3K4 monomethylation through interactions with the methyltransferase MLL4
- (2018) Homa Rahnamoun et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- DNA repair processes are critical mediators of p53-dependent tumor suppression
- (2018) Ana Janic et al. NATURE MEDICINE
- Mutant p53 gain of function underlies high expression levels of colorectal cancer stem cells markers
- (2018) Hilla Solomon et al. ONCOGENE
- Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246
- (2018) Tomer Cooks et al. Nature Communications
- Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
- (2018) Freddie Bray et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Therapeutic Ablation of Gain-of-Function Mutant p53 in Colorectal Cancer Inhibits Stat3-Mediated Tumor Growth and Invasion
- (2018) Ramona Schulz-Heddergott et al. CANCER CELL
- Mutational processes shape the landscape of TP53 mutations in human cancer
- (2018) Andrew O. Giacomelli et al. NATURE GENETICS
- p53 Isoforms and Their Implications in Cancer
- (2018) Maximilian Vieler et al. Cancers
- Primate-specific miR-944 activates p53-dependent tumor suppression in human colorectal cancers
- (2018) Yoon-Jin Kim et al. CANCER LETTERS
- p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression
- (2018) Sung-Hwan Moon et al. CELL
- p53 mutants cooperate with HIF-1 in transcriptional regulation of extracellular matrix components to promote tumor progression
- (2018) Ivano Amelio et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Colorectal Carcinoma: A General Overview and Future Perspectives in Colorectal Cancer
- (2017) Inés Mármol et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Mutant p53 Gains Its Function via c-Myc Activation upon CDK4 Phosphorylation at Serine 249 and Consequent PIN1 Binding
- (2017) Peng Liao et al. MOLECULAR CELL
- Therapeutic targeting of p53: all mutants are equal, but some mutants are more equal than others
- (2017) Kanaga Sabapathy et al. Nature Reviews Clinical Oncology
- p53 pulses lead to distinct patterns of gene expression albeit similar DNA-binding dynamics
- (2017) Antonina Hafner et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Census and evaluation of p53 target genes
- (2017) M Fischer ONCOGENE
- p53 pulses lead to distinct patterns of gene expression albeit similar DNA-binding dynamics
- (2017) Antonina Hafner et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Exploiting the p53 Pathway for Therapy
- (2017) Chit Fang Cheok et al. Cold Spring Harbor Perspectives in Medicine
- Deleterious Effect of RAS and Evolutionary High-risk TP53 Double Mutation in Colorectal Liver Metastases
- (2017) Yun Shin Chun et al. ANNALS OF SURGERY
- MicroRNA-214 suppresses growth, migration and invasion through a novel target, high mobility group AT-hook 1, in human cervical and colorectal cancer cells
- (2016) Karthik Subramanian Chandrasekaran et al. BRITISH JOURNAL OF CANCER
- Cell-to-Cell Variation in p53 Dynamics Leads to Fractional Killing
- (2016) Andrew L. Paek et al. CELL
- Reactivation of mutant p53 by a dietary-related compound phenethyl isothiocyanate inhibits tumor growth
- (2016) M Aggarwal et al. CELL DEATH AND DIFFERENTIATION
- The DNA damage-induced cell death response: a roadmap to kill cancer cells
- (2016) Sonja Matt et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Global patterns and trends in colorectal cancer incidence and mortality
- (2016) Melina Arnold et al. GUT
- Proteasome machinery is instrumental in a common gain-of-function program of the p53 missense mutants in cancer
- (2016) Dawid Walerych et al. NATURE CELL BIOLOGY
- DNAJA1 controls the fate of misfolded mutant p53 through the mevalonate pathway
- (2016) Alejandro Parrales et al. NATURE CELL BIOLOGY
- TP53 mutations, expression and interaction networks in human cancers
- (2016) Xiaosheng Wang et al. Oncotarget
- microRNA-1827 represses MDM2 to positively regulate tumor suppressor p53 and suppress tumorigenesis
- (2016) Cen Zhang et al. Oncotarget
- The role of p53 in cancer drug resistance and targeted chemotherapy
- (2016) Karin Hientz et al. Oncotarget
- p53 Isoforms: Key Regulators of the Cell Fate Decision
- (2016) Sebastien M. Joruiz et al. Cold Spring Harbor Perspectives in Medicine
- Transcriptional Regulation by Wild-Type and Cancer-Related Mutant Forms of p53
- (2016) Neil T. Pfister et al. Cold Spring Harbor Perspectives in Medicine
- p53 Pulses Diversify Target Gene Expression Dynamics in an mRNA Half-Life-Dependent Manner and Delineate Co-regulated Target Gene Subnetworks
- (2016) Joshua R. Porter et al. Cell Systems
- MDM2 antagonist clinical response association with a gene expression signature in acute myeloid leukaemia
- (2015) Hua Zhong et al. BRITISH JOURNAL OF HAEMATOLOGY
- Pontin, a new mutant p53-binding protein, promotes gain-of-function of mutant p53
- (2015) Y Zhao et al. CELL DEATH AND DIFFERENTIATION
- DNA damage-induced ephrin-B2 reverse signaling promotes chemoresistance and drives EMT in colorectal carcinoma harboring mutant p53
- (2015) S K Alam et al. CELL DEATH AND DIFFERENTIATION
- YAP enhances the pro‐proliferative transcriptional activity of mutant p53 proteins
- (2015) Silvia Di Agostino et al. EMBO REPORTS
- Mutant p53 cooperates with the SWI/SNF chromatin remodeling complex to regulateVEGFR2in breast cancer cells
- (2015) Neil T. Pfister et al. GENES & DEVELOPMENT
- Mutant p53 Promotes Tumor Cell Malignancy by Both Positive and Negative Regulation of the Transforming Growth Factor β (TGF-β) Pathway
- (2015) Lei Ji et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Pin1-Induced Proline Isomerization in Cytosolic p53 Mediates BAX Activation and Apoptosis
- (2015) Ariele Viacava Follis et al. MOLECULAR CELL
- The p53 C Terminus Controls Site-Specific DNA Binding and Promotes Structural Changes within the Central DNA Binding Domain
- (2015) Oleg Laptenko et al. MOLECULAR CELL
- Improving survival by exploiting tumour dependence on stabilized mutant p53 for treatment
- (2015) E. M. Alexandrova et al. NATURE
- Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth
- (2015) Jiajun Zhu et al. NATURE
- Ferroptosis as a p53-mediated activity during tumour suppression
- (2015) Le Jiang et al. NATURE
- Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer
- (2015) Shuo Wei et al. NATURE MEDICINE
- The consensus molecular subtypes of colorectal cancer
- (2015) Justin Guinney et al. NATURE MEDICINE
- Proteome-wide analysis of mutant p53 targets in breast cancer identifies new levels of gain-of-function that influence PARP, PCNA, and MCM4
- (2015) Alla Polotskaia et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A distinct p53 target gene set predicts for response to the selective p53–HDM2 inhibitor NVP-CGM097
- (2015) Sébastien Jeay et al. eLife
- Expression signature based on TP53 target genes doesn't predict response to TP53-MDM2 inhibitor in wild type TP53 tumors
- (2015) Dmitriy Sonkin eLife
- Targeting Oncogenic Mutant p53 for Cancer Therapy
- (2015) Alejandro Parrales et al. Frontiers in Oncology
- Heterogeneity of Li-Fraumeni Syndrome links to unequal gain-of-function effects of p53 mutations
- (2014) Jie Xu et al. Scientific Reports
- DNA damage strength modulates a bimodal switch of p53 dynamics for cell-fate control
- (2013) Xi Chen et al. BMC BIOLOGY
- Mutant p53 Prolongs NF-κB Activation and Promotes Chronic Inflammation and Inflammation-Associated Colorectal Cancer
- (2013) Tomer Cooks et al. CANCER CELL
- Another fork in the road—life or death decisions by the tumour suppressor p53
- (2013) Luis A Carvajal et al. EMBO REPORTS
- Mutational landscape and significance across 12 major cancer types
- (2013) Cyriac Kandoth et al. NATURE
- Gain-of-function mutant p53 downregulates miR-223 contributing to chemoresistance of cultured tumor cells
- (2013) S Masciarelli et al. ONCOGENE
- Autophosphorylation and Pin1 binding coordinate DNA damage-induced HIPK2 activation and cell death
- (2013) N. Bitomsky et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal
- (2013) J. Gao et al. Science Signaling
- Tumour-associated mutant p53 drives the Warburg effect
- (2013) Cen Zhang et al. Nature Communications
- Mutant p53 Disrupts Mammary Tissue Architecture via the Mevalonate Pathway
- (2012) William A. Freed-Pastor et al. CELL
- Mutant p53 cooperates with ETS2 to promote etoposide resistance
- (2012) P. M. Do et al. GENES & DEVELOPMENT
- Targeting Chk1 in p53-deficient triple-negative breast cancer is therapeutically beneficial in human-in-mouse tumor models
- (2012) Cynthia X. Ma et al. JOURNAL OF CLINICAL INVESTIGATION
- p53 mutations in cancer
- (2012) Patricia A. J. Muller et al. NATURE CELL BIOLOGY
- p53 Dynamics Control Cell Fate
- (2012) J. E. Purvis et al. SCIENCE
- The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.
- (2012) Ethan Cerami et al. Cancer Discovery
- A Pin1/Mutant p53 Axis Promotes Aggressiveness in Breast Cancer
- (2011) Javier E. Girardini et al. CANCER CELL
- SAHA shows preferential cytotoxicity in mutant p53 cancer cells by destabilizing mutant p53 through inhibition of the HDAC6-Hsp90 chaperone axis
- (2011) D Li et al. CELL DEATH AND DIFFERENTIATION
- Immunological and Clinical Effects of Vaccines Targeting p53-Overexpressing Malignancies
- (2011) R. Vermeij et al. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
- TopBP1 Mediates Mutant p53 Gain of Function through NF-Y and p63/p73
- (2011) K. Liu et al. MOLECULAR AND CELLULAR BIOLOGY
- Functional Inactivation of Endogenous MDM2 and CHIP by HSP90 Causes Aberrant Stabilization of Mutant p53 in Human Cancer Cells
- (2011) D. Li et al. MOLECULAR CANCER RESEARCH
- PRIMA-1 Reactivates Mutant p53 by Covalent Binding to the Core Domain
- (2009) Jeremy M.R. Lambert et al. CANCER CELL
- Blinded by the Light: The Growing Complexity of p53
- (2009) Karen H. Vousden et al. CELL
- Modes of p53 Regulation
- (2009) Jan-Philipp Kruse et al. CELL
- A Mutant-p53/Smad Complex Opposes p63 to Empower TGFβ-Induced Metastasis
- (2009) Maddalena Adorno et al. CELL
- The execution of the transcriptional axis mutant p53, E2F1 and ID4 promotes tumor neo-angiogenesis
- (2009) Giulia Fontemaggi et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53
- (2009) S. Sur et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Acetylation Is Indispensable for p53 Activation
- (2008) Yi Tang et al. CELL
- Genomic and Epigenetic Instability in Colorectal Cancer Pathogenesis
- (2008) William M. Grady et al. GASTROENTEROLOGY
- Regulation of MDMX Expression by Mitogenic Signaling
- (2008) D. M. Gilkes et al. MOLECULAR AND CELLULAR BIOLOGY
- MDM2 Gene Amplification Is Correlated to Tumor Progression but not to the Presence of SNP309 or TP53 Mutational Status in Primary Colorectal Cancers
- (2008) A. Forslund et al. MOLECULAR CANCER RESEARCH
- A complex barcode underlies the heterogeneous response of p53 to stress
- (2008) Fiona Murray-Zmijewski et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway
- (2008) J. E. Kravchenko et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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