Journal
CANCERS
Volume 11, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/cancers11071036
Keywords
colorectal cancer histotypes; signet ring cell carcinoma; medullary carcinoma; lymphoepitelioma-like carcinoma; cribriform/comedo-type carcinoma; micropapillary carcinoma; clear cell carcinoma; hepatoid carcinoma; adenocarcinoma with osseous metaplasia; rhabdoid carcinoma
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Funding
- University of Genova
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Several histopathological variants of colorectal carcinoma can be distinguished, some associated with specific molecular profiles. However, in routine practice, ninety/ninety-five percent of all large bowel tumors are diagnosed as conventional adenocarcinoma, even though they are a heterogeneous group including rare histotypes, which are often under-recognized. Indeed, colorectal cancer exhibits differences in incidence, location of tumor, pathogenesis, molecular pathways and outcome depending on histotype. The aim is therefore to review the morphological and molecular features of these rare variants of intestinal carcinomas which may hold the key to differences in prognosis and treatment.
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