Proteasome machinery is instrumental in a common gain-of-function program of the p53 missense mutants in cancer

Mitochondrial dysfunctions in cancer: Genetic defects and oncogenic signaling impinging on TCA cycle activity

(2015) Enrico Desideri et al.   CANCER LETTERS

Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth

(2015) Jiajun Zhu et al.   NATURE

Integrative genomic analysis reveals widespread enhancer regulation by p53 in response to DNA damage

(2015) Scott T. Younger et al.   NUCLEIC ACIDS RESEARCH

Proteome-wide analysis of mutant p53 targets in breast cancer identifies new levels of gain-of-function that influence PARP, PCNA, and MCM4

(2015) Alla Polotskaia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of nucleotide metabolism by mutant p53 contributes to its gain-of-function activities

(2015) Madhusudhan Kollareddy et al.   Nature Communications

Genome-wide analysis of p53 transcriptional programs in B cells upon exposure to genotoxic stress in vivo

(2015) Claudia Tonelli et al.   Oncotarget

Mutant p53: One, No One, and One Hundred Thousand

(2015) Dawid Walerych et al.   Frontiers in Oncology

Building Predictive Models inRUsing thecaretPackage

(2015) Max Kuhn   Journal of Statistical Software

Gain-of-function p53 mutants have widespread genomic locations partially overlapping with p63.

(2015) Elena Martynova et al.   Oncotarget

Mutant p53 Drives Pancreatic Cancer Metastasis through Cell-Autonomous PDGF Receptor β Signaling

(2014) Susann Weissmueller et al.   CELL

The ubiquitin–proteasome system: opportunities for therapeutic intervention in solid tumors

(2014) Daniel E Johnson   ENDOCRINE-RELATED CANCER

Mutant p53 reactivation by small molecules makes its way to the clinic

(2014) Vladimir J.N. Bykov et al.   FEBS LETTERS

Efficacy of therapy with bortezomib in solid tumors: a review based on 32 clinical trials

(2014) Zebo Huang et al.   Future Oncology

Regulation of PSMB5 Protein and β Subunits of Mammalian Proteasome by Constitutively Activated Signal Transducer and Activator of Transcription 3 (STAT3)

(2014) Janakiram Reddy Vangala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multi-enzyme digestion FASP and the ‘Total Protein Approach’-based absolute quantification of the Escherichia coli proteome

(2014) Jacek R. Wiśniewski et al.   Journal of Proteomics

Mutant p53 Reprograms TNF Signaling in Cancer Cells through Interaction with the Tumor Suppressor DAB2IP

(2014) Giulio Di Minin et al.   MOLECULAR CELL

A mutant p53/let-7i-axis-regulated gene network drives cell migration, invasion and metastasis

(2014) M Subramanian et al.   ONCOGENE

iRegulon: From a Gene List to a Gene Regulatory Network Using Large Motif and Track Collections

(2014) Rekin's Janky et al.   PLoS Computational Biology

Global analysis of p53-regulated transcription identifies its direct targets and unexpected regulatory mechanisms

(2014) Mary Ann Allen et al.   eLife

A Genome-wide siRNA Screen Identifies Proteasome Addiction as a Vulnerability of Basal-like Triple-Negative Breast Cancer Cells

(2013) Fabio Petrocca et al.   CANCER CELL

The Major Reverse Transcriptase-Incompetent Splice Variant of the Human Telomerase Protein Inhibits Telomerase Activity but Protects from Apoptosis

(2013) I. Listerman et al.   CANCER RESEARCH

Targeting triple negative breast cancer: Is p53 the answer?

(2013) Natalie Turner et al.   CANCER TREATMENT REVIEWS

The emerging role of the Nrf2-Keap1 signaling pathway in cancer

(2013) M. C. Jaramillo et al.   GENES & DEVELOPMENT

Mutational landscape and significance across 12 major cancer types

(2013) Cyriac Kandoth et al.   NATURE

Gain-of-function mutant p53 downregulates miR-223 contributing to chemoresistance of cultured tumor cells

(2013) S Masciarelli et al.   ONCOGENE

Disarming mutant p53 oncogenic function

(2013) Javier E. Girardini et al.   PHARMACOLOGICAL RESEARCH

Differential regulation of the REGγ–proteasome pathway by p53/TGF-β signalling and mutant p53 in cancer cells

(2013) Amjad Ali et al.   Nature Communications

Mitochondrial Dysfunction in Cancer

(2013) Michelle L. Boland et al.   Frontiers in Oncology

Consecutive Proteolytic Digestion in an Enzyme Reactor Increases Depth of Proteomic and Phosphoproteomic Analysis

(2012) Jacek R. Wiśniewski et al.   ANALYTICAL CHEMISTRY

The CCAAT box-binding transcription factor NF-Y regulates basal expression of human proteasome genes

(2012) Haiming Xu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The rebel angel: mutant p53 as the driving oncogene in breast cancer

(2012) D. Walerych et al.   CARCINOGENESIS

Cancer Vulnerabilities Unveiled by Genomic Loss

(2012) Deepak Nijhawan et al.   CELL

Mutant p53 Disrupts Mammary Tissue Architecture via the Mevalonate Pathway

(2012) William A. Freed-Pastor et al.   CELL

Mutant p53 cooperates with ETS2 to promote etoposide resistance

(2012) P. M. Do et al.   GENES & DEVELOPMENT

Mutant p53: one name, many proteins

(2012) W. A. Freed-Pastor et al.   GENES & DEVELOPMENT

Mutant p53R273Hattenuates the expression of phase 2 detoxifying enzymes and promotes the survival of cells with high levels of reactive oxygen species

(2012) Eyal Kalo et al.   JOURNAL OF CELL SCIENCE

Targeting p53 in Vivo: A First-in-Human Study With p53-Targeting Compound APR-246 in Refractory Hematologic Malignancies and Prostate Cancer

(2012) Sören Lehmann et al.   JOURNAL OF CLINICAL ONCOLOGY

Inhibition of the Nrf2 transcription factor by the alkaloid trigonelline renders pancreatic cancer cells more susceptible to apoptosis through decreased proteasomal gene expression and proteasome activity

(2012) A Arlt et al.   ONCOGENE

Mutant p53 drives invasion in breast tumors through up-regulation of miR-155

(2012) P M Neilsen et al.   ONCOGENE

A Pin1/Mutant p53 Axis Promotes Aggressiveness in Breast Cancer

(2011) Javier E. Girardini et al.   CANCER CELL

SAHA shows preferential cytotoxicity in mutant p53 cancer cells by destabilizing mutant p53 through inhibition of the HDAC6-Hsp90 chaperone axis

(2011) D Li et al.   CELL DEATH AND DIFFERENTIATION

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

(2011) Gina M. DeNicola et al.   NATURE

Modulation of the Vitamin D3 Response by Cancer-Associated Mutant p53

(2010) Perry Stambolsky et al.   CANCER CELL

Dishevelled-KSRP complex regulates Wnt signaling through post-transcriptional stabilization of  -catenin mRNA

(2010) R. K. Bikkavilli et al.   JOURNAL OF CELL SCIENCE

Transcription Factor Nrf1 Mediates the Proteasome Recovery Pathway after Proteasome Inhibition in Mammalian Cells

(2010) Senthil K. Radhakrishnan et al.   MOLECULAR CELL

Proteasomal Degradation Is Transcriptionally Controlled by TCF11 via an ERAD-Dependent Feedback Loop

(2010) Janos Steffen et al.   MOLECULAR CELL

BRD7 is a candidate tumour suppressor gene required for p53 function

(2010) Jarno Drost et al.   NATURE CELL BIOLOGY

The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function

(2010) David Warde-Farley et al.   NUCLEIC ACIDS RESEARCH

Pharmacological reactivation of mutant p53: from protein structure to the cancer patient

(2010) K G Wiman   ONCOGENE

ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks

(2009) Gabriela Bindea et al.   BIOINFORMATICS

PRIMA-1 Reactivates Mutant p53 by Covalent Binding to the Core Domain

(2009) Jeremy M.R. Lambert et al.   CANCER CELL

Mutant p53 Drives Invasion by Promoting Integrin Recycling

(2009) Patricia A.J. Muller et al.   CELL

A Mutant-p53/Smad Complex Opposes p63 to Empower TGFβ-Induced Metastasis

(2009) Maddalena Adorno et al.   CELL

Therapeutic strategies within the ubiquitin proteasome system

(2009) A G Eldridge et al.   CELL DEATH AND DIFFERENTIATION

MicroRNAs: Predictors and modifiers of chemo- and radiotherapy in different tumour types

(2009) Richard Hummel et al.   EUROPEAN JOURNAL OF CANCER

Direct Interaction between Nrf2 and p21Cip1/WAF1 Upregulates the Nrf2-Mediated Antioxidant Response

(2009) Weimin Chen et al.   MOLECULAR CELL

The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs

(2009) Michele Trabucchi et al.   NATURE

The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancer

(2009) Alessandra Rustighi et al.   NATURE CELL BIOLOGY

CD40 Induces Antigen Transporter and Immunoproteasome Gene Expression in Carcinomas via the Coordinated Action of NF- B and of NF- B-Mediated De Novo Synthesis of IRF-1

(2008) A. Moschonas et al.   MOLECULAR AND CELLULAR BIOLOGY