The Impact of Mutant p53 in the Non-Coding RNA World

PIWI-interacting RNA-36712 restrains breast cancer progression and chemoresistance by interaction with SEPW1 pseudogene SEPW1P RNA

(2019) Liping Tan et al.   Molecular Cancer

Treating Disease at the RNA Level with Oligonucleotides

(2019) Arthur A. Levin   NEW ENGLAND JOURNAL OF MEDICINE

MicroRNA-34 family: a potential tumor suppressor and therapeutic candidate in cancer

(2019) Lu Zhang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

MiR-223-3p functions as a tumor suppressor in lung squamous cell carcinoma by miR-223-3p-mutant p53 regulatory feedback loop

(2019) Peng Luo et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Wild type- and mutant p53 proteins in mitochondrial dysfunction: emerging insights in cancer disease

(2019) Giovanni Blandino et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Targeting mutant p53 in cancer: the latest insights

(2019) Silvia Di Agostino et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Integrated Analysis of TP53 Gene and Pathway Alterations in The Cancer Genome Atlas

(2019) Lawrence A. Donehower et al.   Cell Reports

The circular RNA circ-Ccnb1 dissociates Ccnb1/Cdk1 complex suppressing cell invasion and tumorigenesis

(2019) Ling Fang et al.   CANCER LETTERS

P53-R273H mutation enhances colorectal cancer stemness through regulating specific lncRNAs

(2019) Yuechao Zhao et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The biogenesis, biology and characterization of circular RNAs

(2019) Lasse S. Kristensen et al.   NATURE REVIEWS GENETICS

Intrinsic adriamycin resistance in p53-mutated breast cancer is related to the miR-30c/FANCF/REV1-mediated DNA damage response

(2019) Shu Lin et al.   Cell Death & Disease

The miR-205-5p/BRCA1/RAD17 Axis Promotes Genomic Instability in Head and Neck Squamous Cell Carcinomas

(2019) Fabio Valenti et al.   Cancers

Noncoding RNAs in Extracellular Fluids as Cancer Biomarkers: The New Frontier of Liquid Biopsies

(2019) Barbara Pardini et al.   Cancers

The Role of Non-coding RNAs in Oncology

(2019) Frank J. Slack et al.   CELL

Towards the overcoming of anticancer drug resistance mediated by p53 mutations

(2019) Xin Cao et al.   DRUG RESISTANCE UPDATES

MicroRNA-Based Combinatorial Cancer Therapy: Effects of MicroRNAs on the Efficacy of Anti-Cancer Therapies

(2019) Hyun Ah Seo et al.   Cells

Metazoan MicroRNAs

(2018) David P. Bartel   CELL

Enhanced breast cancer progression by mutant p53 is inhibited by the circular RNA circ-Ccnb1

(2018) Ling Fang et al.   CELL DEATH AND DIFFERENTIATION

New therapeutic strategies to treat human cancers expressing mutant p53 proteins

(2018) Giovanni Blandino et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Secretory microRNAs as biomarkers of cancer

(2018) Kazuharu Kai et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Computational Strategies for Exploring Circular RNAs

(2018) Yuan Gao et al.   TRENDS IN GENETICS

Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246

(2018) Tomer Cooks et al.   Nature Communications

Long Non-coding MIR205HG Depletes Hsa-miR-590-3p Leading to Unrestrained Proliferation in Head and Neck Squamous Cell Carcinoma

(2018) Silvia Di Agostino et al.   Theranostics

Zinc Metallochaperones as Mutant p53 Reactivators: A New Paradigm in Cancer Therapeutics

(2018) Samuel Kogan et al.   Cancers

Intrathecal administration of nusinersen in adolescent and adult SMA type 2 and 3 patients

(2018) Claudia D. Wurster et al.   JOURNAL OF NEUROLOGY

Quantitative proteomics reveals that long non-coding RNA MALAT1 interacts with DBC1 to regulate p53 acetylation

(2017) Ruibing Chen et al.   NUCLEIC ACIDS RESEARCH

Circular RNAs in cancer: opportunities and challenges in the field

(2017) L S Kristensen et al.   ONCOGENE

The Dimensions, Dynamics, and Relevance of the Mammalian Noncoding Transcriptome

(2017) Ira W. Deveson et al.   TRENDS IN GENETICS

InheritedTP53Mutations and the Li–Fraumeni Syndrome

(2017) Tanya Guha et al.   Cold Spring Harbor Perspectives in Medicine

Circular RNAs: analysis, expression and potential functions

(2016) Steven P. Barrett et al.   DEVELOPMENT

Noncoding RNA: Current Deep Sequencing Data Analysis Approaches and Challenges

(2016) Dario Veneziano et al.   HUMAN MUTATION

Mutant p53 proteins counteract autophagic mechanism sensitizing cancer cells to mTOR inhibition

(2016) Marco Cordani et al.   Molecular Oncology

Proteasome machinery is instrumental in a common gain-of-function program of the p53 missense mutants in cancer

(2016) Dawid Walerych et al.   NATURE CELL BIOLOGY

Mutant p53 inhibits miRNA biogenesis by interfering with the microprocessor complex

(2016) F Garibaldi et al.   ONCOGENE

Differential regulated microRNA by wild type and mutant p53 in induced pluripotent stem cells

(2016) Francesca Grespi et al.   Cell Death & Disease

Gain-of-function miRNA signature by mutant p53 associates with poor cancer outcome

(2016) Yao Zhang et al.   Oncotarget

Oncogenic Intra-p53 Family Member Interactions in Human Cancers

(2016) Maria Ferraiuolo et al.   Frontiers in Oncology

An overview of microRNAs

(2015) Scott M. Hammond   ADVANCED DRUG DELIVERY REVIEWS

Mutant p53 stimulates chemoresistance of pancreatic adenocarcinoma cells to gemcitabine

(2015) Claudia Fiorini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

YAP enhances the pro‐proliferative transcriptional activity of mutant p53 proteins

(2015) Silvia Di Agostino et al.   EMBO REPORTS

Integrative analysis of 111 reference human epigenomes

(2015) Anshul Kundaje et al.   NATURE

Comprehensive genomic characterization of head and neck squamous cell carcinomas

(2015)   NATURE

The landscape of long noncoding RNAs in the human transcriptome

(2015) Matthew K Iyer et al.   NATURE GENETICS

Mutant p53: One, No One, and One Hundred Thousand

(2015) Dawid Walerych et al.   Frontiers in Oncology

Gain of function mutant p53 proteins cooperate with E2F4 to transcriptionally downregulate RAD17 and BRCA1 gene expression

(2015) Fabio Valenti et al.   Oncotarget

Mutant p53 in Cancer: New Functions and Therapeutic Opportunities

(2014) Patricia A.J. Muller et al.   CANCER CELL

Aberrant Regulation and Function of MicroRNAs in Cancer

(2014) Brian D. Adams et al.   CURRENT BIOLOGY

The ENCODE Project and Perspectives on Pathways

(2014) Vinicius Tragante et al.   GENETIC EPIDEMIOLOGY

A mutant p53/let-7i-axis-regulated gene network drives cell migration, invasion and metastasis

(2014) M Subramanian et al.   ONCOGENE

Exploring the Wnt Pathway-Associated LncRNAs and Genes Involved in Pancreatic Carcinogenesis Driven by Tp53 Mutation

(2014) Qi Wang et al.   PHARMACEUTICAL RESEARCH

RNAi Therapies: Drugging the Undruggable

(2014) S. Y. Wu et al.   Science Translational Medicine

Degradation of mutant p53H175 protein by Zn(II) through autophagy

(2014) A Garufi et al.   Cell Death & Disease

Expression of TP53 mutation-associated microRNAs predicts clinical outcome in head and neck squamous cell carcinoma patients

(2013) F. Ganci et al.   ANNALS OF ONCOLOGY

Recent progress in pancreatic cancer

(2013) Christopher L. Wolfgang et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Mutant p53 Regulates Dicer through p63-dependent and -independent Mechanisms to Promote an Invasive Phenotype

(2013) Patricia A. J. Muller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MALAT1 — a paradigm for long noncoding RNA function in cancer

(2013) Tony Gutschner et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Mutational landscape and significance across 12 major cancer types

(2013) Cyriac Kandoth et al.   NATURE

Gain-of-function mutant p53 downregulates miR-223 contributing to chemoresistance of cultured tumor cells

(2013) S Masciarelli et al.   ONCOGENE

Computational identification of a transiently open L1/S3 pocket for reactivation of mutant p53

(2013) Christopher D. Wassman et al.   Nature Communications

Tumour-associated mutant p53 drives the Warburg effect

(2013) Cen Zhang et al.   Nature Communications

miRNA-34 Prevents Cancer Initiation and Progression in a Therapeutically Resistant K-ras and p53-Induced Mouse Model of Lung Adenocarcinoma

(2012) A. L. Kasinski et al.   CANCER RESEARCH

Mutant p53 Disrupts Mammary Tissue Architecture via the Mevalonate Pathway

(2012) William A. Freed-Pastor et al.   CELL

Landscape of transcription in human cells

(2012) Sarah Djebali et al.   NATURE

Mutant p53 drives invasion in breast tumors through up-regulation of miR-155

(2012) P M Neilsen et al.   ONCOGENE

Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer

(2012) P. Tucci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNAs, wild-type and mutant p53: More questions than answers

(2012) Matthew Fletcher Jones et al.   RNA Biology

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

MicroRNA-128-2 targets the transcriptional repressor E2F5 enhancing mutant p53 gain of function

(2011) S Donzelli et al.   CELL DEATH AND DIFFERENTIATION

TP53 Disruptive Mutations Lead to Head and Neck Cancer Treatment Failure through Inhibition of Radiation-Induced Senescence

(2011) H. D. Skinner et al.   CLINICAL CANCER RESEARCH

Prognostic Significance of Truncating TP53 Mutations in Head and Neck Squamous Cell Carcinoma

(2011) M. Lindenbergh-van der Plas et al.   CLINICAL CANCER RESEARCH

Molecular Mechanisms of Long Noncoding RNAs

(2011) Kevin C. Wang et al.   MOLECULAR CELL

Integrated genomic analyses of ovarian carcinoma

(2011) D. Bell et al.   NATURE

Non-coding RNAs in human disease

(2011) Manel Esteller   NATURE REVIEWS GENETICS

The Mutational Landscape of Head and Neck Squamous Cell Carcinoma

(2011) N. Stransky et al.   SCIENCE

MicroRNAs: Synthesis, mechanism, function, and recent clinical trials

(2010) Fazli Wahid et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Modulation of the Vitamin D3 Response by Cancer-Associated Mutant p53

(2010) Perry Stambolsky et al.   CANCER CELL

Development of a Lung Cancer Therapeutic Based on the Tumor Suppressor MicroRNA-34

(2010) J. F. Wiggins et al.   CANCER RESEARCH

A Large Intergenic Noncoding RNA Induced by p53 Mediates Global Gene Repression in the p53 Response

(2010) Maite Huarte et al.   CELL

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

MicroRNA Expression Differentiates Histology and Predicts Survival of Lung Cancer

(2010) M. T. Landi et al.   CLINICAL CANCER RESEARCH

Frequent Downregulation of miR-34 Family in Human Ovarian Cancers

(2010) D. C. Corney et al.   CLINICAL CANCER RESEARCH

A long nuclear-retained non-coding RNA regulates synaptogenesis by modulating gene expression

(2010) Delphine Bernard et al.   EMBO JOURNAL

The role of mutant p53 in human cancer

(2010) Amanda M Goh et al.   JOURNAL OF PATHOLOGY

Reactivation of p53: from peptides to small molecules

(2010) Christopher J. Brown et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

A transcriptional sketch of a primary human breast cancer by 454 deep sequencing

(2009) Alessandro Guffanti et al.   BMC GENOMICS

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer

(2009) J. P. Morton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA