Cell Fate Regulation upon DNA Damage: p53 Serine 46 Kinases Pave the Cell Death Road
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Cell Fate Regulation upon DNA Damage: p53 Serine 46 Kinases Pave the Cell Death Road
Authors
Keywords
-
Journal
BIOESSAYS
Volume 41, Issue 12, Pages 1900127
Publisher
Wiley
Online
2019-10-17
DOI
10.1002/bies.201900127
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Ser46 phosphorylation of p53 is an essential event in prolyl-isomerase Pin1-mediated p53-independent apoptosis in response to heat stress
- (2019) Li Li et al. Cell Death & Disease
- The multiple mechanisms that regulate p53 activity and cell fate
- (2019) Antonina Hafner et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- AMP-activated protein kinase: the current landscape for drug development
- (2019) Gregory R. Steinberg et al. NATURE REVIEWS DRUG DISCOVERY
- The SIAH1–HIPK2–p53ser46 Damage Response Pathway is Involved in Temozolomide-Induced Glioblastoma Cell Death
- (2019) Yang He et al. MOLECULAR CANCER RESEARCH
- The functional roles of PML nuclear bodies in genome maintenance
- (2018) Hae Ryung Chang et al. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
- Genotoxic Damage Activates the AMPK-α1 Isoform in the Nucleus via Ca 2+ /CaMKK2 Signaling to Enhance Tumor Cell Survival
- (2017) Diana Vara-Ciruelos et al. MOLECULAR CANCER RESEARCH
- AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance
- (2017) Daniel Garcia et al. MOLECULAR CELL
- The RNA processing factors THRAP3 and BCLAF1 promote the DNA damage response through selective mRNA splicing and nuclear export
- (2017) Jekaterina Vohhodina et al. NUCLEIC ACIDS RESEARCH
- Loss of tumour-specific ATM protein expression is an independent prognostic factor in early resected NSCLC
- (2017) Lars F. Petersen et al. Oncotarget
- The p53 Pathway: Origins, Inactivation in Cancer, and Emerging Therapeutic Approaches
- (2016) Andreas C. Joerger et al. Annual Review of Biochemistry
- Transcriptional induction of protein kinase C delta by p53 tumor suppressor in the apoptotic response to DNA damage
- (2016) Nurmaa Dashzeveg et al. CANCER LETTERS
- The DNA damage-induced cell death response: a roadmap to kill cancer cells
- (2016) Sonja Matt et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- An African-specific polymorphism in theTP53gene impairs p53 tumor suppressor function in a mouse model
- (2016) Matthew Jennis et al. GENES & DEVELOPMENT
- Downregulated DYRK2 expression is associated with poor prognosis and Oxaliplatin resistance in hepatocellular carcinoma
- (2016) Xiubing Zhang et al. PATHOLOGY RESEARCH AND PRACTICE
- Multifunctional roles of PKCδ: Opportunities for targeted therapy in human disease
- (2016) Mary E. Reyland et al. PHARMACOLOGY & THERAPEUTICS
- AMPKα Is Suppressed in Bladder Cancer through Macrophage-Mediated Mechanisms
- (2016) Stavros Kopsiaftis et al. Translational Oncology
- Low Expression of DYRK2 (Dual Specificity Tyrosine Phosphorylation Regulated Kinase 2) Correlates with Poor Prognosis in Colorectal Cancer
- (2016) Haiyan Yan et al. PLoS One
- The Stress Kinase p38 as a Target for Cancer Therapy
- (2015) A. Igea et al. CANCER RESEARCH
- HIPK2 restricts SIRT1 activity upon severe DNA damage by a phosphorylation-controlled mechanism
- (2015) E Conrad et al. CELL DEATH AND DIFFERENTIATION
- Molecular Pathways: Is AMPK a Friend or a Foe in Cancer?
- (2015) D. G. Hardie CLINICAL CANCER RESEARCH
- DYRK protein kinases
- (2015) Ulf Soppa et al. CURRENT BIOLOGY
- The Tyrosine Kinase c-Abl Promotes Homeodomain-interacting Protein Kinase 2 (HIPK2) Accumulation and Activation in Response to DNA Damage
- (2015) Nina Reuven et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Pin1-Induced Proline Isomerization in Cytosolic p53 Mediates BAX Activation and Apoptosis
- (2015) Ariele Viacava Follis et al. MOLECULAR CELL
- A New p53 Target Gene, RKIP, Is Essential for DNA Damage-Induced Cellular Senescence and Suppression of ERK Activation
- (2015) Su-Jin Lee et al. NEOPLASIA
- Irreparable telomeric DNA damage and persistent DDR signalling as a shared causative mechanism of cellular senescence and ageing
- (2014) Francesca Rossiello et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- Inhibiting Tyrosine Phosphorylation of Protein Kinase Cδ (PKCδ) Protects the Salivary Gland from Radiation Damage
- (2014) Sten M. Wie et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- AMP-Activated Protein Kinase Suppresses the In Vitro and In Vivo Proliferation of Hepatocellular Carcinoma
- (2014) Jidong Cheng et al. PLoS One
- ShaPINg Cell Fate Upon DNA Damage: Role of Pin1 Isomerase in DNA Damage-Induced Cell Death and Repair
- (2014) Tilman Polonio-Vallon et al. Frontiers in Oncology
- Human Papillomavirus Load in Eyebrow Hair Follicles and Risk of Cutaneous Squamous Cell Carcinoma
- (2013) R. E. Neale et al. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
- DYRK2 controls the epithelial–mesenchymal transition in breast cancer by degrading Snail
- (2013) Rei Mimoto et al. CANCER LETTERS
- Src kinase modulates the apoptotic p53 pathway by altering HIPK2 localization
- (2013) Timan Polonio-Vallon et al. CELL CYCLE
- The ATM protein kinase: regulating the cellular response to genotoxic stress and more
- (2013) Yosef Shiloh et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Autophosphorylation and Pin1 binding coordinate DNA damage-induced HIPK2 activation and cell death
- (2013) N. Bitomsky et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Myc-induced AMPK-phospho p53 pathway activates Bak to sensitize mitochondrial apoptosis
- (2013) A. I. Nieminen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- HIPK2: A tumour suppressor that controls DNA damage-induced cell fate and cytokinesis
- (2012) Thomas G. Hofmann et al. BIOESSAYS
- The prolyl-isomerase Pin1 activates the mitochondrial death program of p53
- (2012) G Sorrentino et al. CELL DEATH AND DIFFERENTIATION
- Nuclear Localization of p38 MAPK in Response to DNA Damage
- (2012) C. David Wood et al. International Journal of Biological Sciences
- Mutual regulation between SIAH2 and DYRK2 controls hypoxic and genotoxic signaling pathways
- (2012) Moisés Pérez et al. Journal of Molecular Cell Biology
- The impact of phosphorylated AMP-activated protein kinase expression on lung cancer survival
- (2011) W. N. William et al. ANNALS OF ONCOLOGY
- Zyxin Is a Critical Regulator of the Apoptotic HIPK2-p53 Signaling Axis
- (2011) J. Crone et al. CANCER RESEARCH
- Regulated Binding of Importin-α to Protein Kinase Cδ in Response to Apoptotic Signals Facilitates Nuclear Import
- (2011) Tariq S. Adwan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cutaneous HPV23 E6 Prevents p53 Phosphorylation through Interaction with HIPK2
- (2011) Dorothea Muschik et al. PLoS One
- Ser46 phosphorylation and prolyl-isomerase Pin1-mediated isomerization of p53 are key events in p53-dependent apoptosis induced by mutant huntingtin
- (2011) A. Grison et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mechanisms and functions of p38 MAPK signalling
- (2010) Ana Cuadrado et al. BIOCHEMICAL JOURNAL
- Increased SIAH expression predicts ductal carcinoma in situ (DCIS) progression to invasive carcinoma
- (2010) Kathryn C. Behling et al. BREAST CANCER RESEARCH AND TREATMENT
- Prognostic significance of AMP-activated protein kinase expression and modifying effect of MAPK3/1 in colorectal cancer
- (2010) Y Baba et al. BRITISH JOURNAL OF CANCER
- Siah2-Dependent Concerted Activity of HIF and FoxA2 Regulates Formation of Neuroendocrine Phenotype and Neuroendocrine Prostate Tumors
- (2010) Jianfei Qi et al. CANCER CELL
- Dyrk1A Phosphorylates p53 and Inhibits Proliferation of Embryonic Neuronal Cells
- (2010) Joongkyu Park et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Requirement of ATM for Rapid p53 Phosphorylation at Ser46 without Ser/Thr-Gln Sequences
- (2010) M. Kodama et al. MOLECULAR AND CELLULAR BIOLOGY
- Histological evaluation of AMPK signalling in primary breast cancer
- (2009) Sirwan M Hadad et al. BMC CANCER
- Hypoxia suppresses chemotherapeutic drug-induced p53 Serine 46 phosphorylation by triggering HIPK2 degradation
- (2009) Jutta Moehlenbrink et al. CANCER LETTERS
- Blinded by the Light: The Growing Complexity of p53
- (2009) Karen H. Vousden et al. CELL
- Modes of p53 Regulation
- (2009) Jan-Philipp Kruse et al. CELL
- ATM Augments Nuclear Stabilization of DYRK2 by Inhibiting MDM2 in the Apoptotic Response to DNA Damage
- (2009) Naoe Taira et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Effect of Disrupting Seven-in-Absentia Homolog 2 Function on Lung Cancer Cell Growth
- (2008) Atique U. Ahmed et al. JNCI-Journal of the National Cancer Institute
- PML Activates Transcription by Protecting HIPK2 and p300 from SCFFbx3-Mediated Degradation
- (2008) Y. Shima et al. MOLECULAR AND CELLULAR BIOLOGY
- UVB-induced Senescence in Human Keratinocytes Requires a Functional Insulin-like Growth Factor-1 Receptor and p53
- (2008) Davina A. Lewis et al. MOLECULAR BIOLOGY OF THE CELL
- Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR
- (2008) Melanie Winter et al. NATURE CELL BIOLOGY
- An inducible autoregulatory loop between HIPK2 and Siah2 at the apex of the hypoxic response
- (2008) Marco A. Calzado et al. NATURE CELL BIOLOGY
- Loss of p53 synthesis in zebrafish tumors with ribosomal protein gene mutations
- (2008) A. W. MacInnes et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started