The DNA damage-induced cell death response: a roadmap to kill cancer cells

Cellular senescence: from growth arrest to immunogenic conversion

(2015) D. G. A. Burton et al.   AGE

How cancer cells hijack DNA double-strand break repair pathways to gain genomic instability

(2015) P. A. Jeggo et al.   BIOCHEMICAL JOURNAL

The tumor-modulatory effects of Caspase-2 and Pidd1 do not require the scaffold protein Raidd

(2015) L Peintner et al.   CELL DEATH AND DIFFERENTIATION

HIPK2 restricts SIRT1 activity upon severe DNA damage by a phosphorylation-controlled mechanism

(2015) E Conrad et al.   CELL DEATH AND DIFFERENTIATION

Characterization of RIPK3-mediated phosphorylation of the activation loop of MLKL during necroptosis

(2015) D A Rodriguez et al.   CELL DEATH AND DIFFERENTIATION

Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics

(2015) Gi-Bang Koo et al.   CELL RESEARCH

The Tyrosine Kinase c-Abl Promotes Homeodomain-interacting Protein Kinase 2 (HIPK2) Accumulation and Activation in Response to DNA Damage

(2015) Nina Reuven et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pin1-Induced Proline Isomerization in Cytosolic p53 Mediates BAX Activation and Apoptosis

(2015) Ariele Viacava Follis et al.   MOLECULAR CELL

Targeting the DNA Damage Response in Cancer

(2015) Mark J. O’Connor   MOLECULAR CELL

Necroptosis and its role in inflammation

(2015) Manolis Pasparakis et al.   NATURE

The diverse role of RIP kinases in necroptosis and inflammation

(2015) John Silke et al.   NATURE IMMUNOLOGY

Live to die another way: modes of programmed cell death and the signals emanating from dying cells

(2015) Yaron Fuchs et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Involvement of ATM in homologous recombination after end resection and RAD51 nucleofilament formation

(2015) A. Bakr et al.   NUCLEIC ACIDS RESEARCH

Absence of RIPK3 predicts necroptosis resistance in malignant melanoma

(2015) P Geserick et al.   Cell Death & Disease

DNA-PK: A dynamic enzyme in a versatile DSB repair pathway

(2014) Anthony J. Davis et al.   DNA REPAIR

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

(2014) Huayi Wang et al.   MOLECULAR CELL

Stem cell aging: mechanisms, regulators and therapeutic opportunities

(2014) Juhyun Oh et al.   NATURE MEDICINE

Drugging the p53 pathway: understanding the route to clinical efficacy

(2014) Kian Hoe Khoo et al.   NATURE REVIEWS DRUG DISCOVERY

Regulated necrosis: the expanding network of non-apoptotic cell death pathways

(2014) Tom Vanden Berghe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Necroptosis

(2014) Andreas Linkermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

XAF1 directs apoptotic switch of p53 signaling through activation of HIPK2 and ZNF313

(2014) M.-G. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ShaPINg Cell Fate Upon DNA Damage: Role of Pin1 Isomerase in DNA Damage-Induced Cell Death and Repair

(2014) Tilman Polonio-Vallon et al.   Frontiers in Oncology

HIPK2 catalytic activity and subcellular localization are regulated by activation-loop Y354 autophosphorylation

(2013) Francesca Siepi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Src kinase modulates the apoptotic p53 pathway by altering HIPK2 localization

(2013) Timan Polonio-Vallon et al.   CELL CYCLE

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

(2013) James M. Murphy et al.   IMMUNITY

Posttranslational modifications regulate HIPK2, a driver of proliferative diseases

(2013) Vera V. Saul et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Regulation of DNA Damage Responses by Ubiquitin and SUMO

(2013) Stephen P. Jackson et al.   MOLECULAR CELL

Push back to respond better: regulatory inhibition of the DNA double-strand break response

(2013) Stephanie Panier et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The ATM protein kinase: regulating the cellular response to genotoxic stress and more

(2013) Yosef Shiloh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

(2013) Peter E. Czabotar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Rotational positioning of nucleosomes facilitates selective binding of p53 to response elements associated with cell cycle arrest

(2013) F. Cui et al.   NUCLEIC ACIDS RESEARCH

CYLD Deubiquitinates RIP1 in the TNFα-Induced Necrosome to Facilitate Kinase Activation and Programmed Necrosis

(2013) David M. Moquin et al.   PLoS One

Induction of amphiregulin by p53 promotes apoptosis via control of microRNA biogenesis in response to DNA damage

(2013) N. Taira et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophosphorylation and Pin1 binding coordinate DNA damage-induced HIPK2 activation and cell death

(2013) N. Bitomsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA Damage Sensing by the ATM and ATR Kinases

(2013) A. Marechal et al.   Cold Spring Harbor Perspectives in Biology

Death of p53-defective cells triggered by forced mitotic entry in the presence of DNA damage is not uniquely dependent on Caspase-2 or the PIDDosome

(2013) C Manzl et al.   Cell Death & Disease

HIPK2: A tumour suppressor that controls DNA damage-induced cell fate and cytokinesis

(2012) Thomas G. Hofmann et al.   BIOESSAYS

DNA damage-induced cell death: From specific DNA lesions to the DNA damage response and apoptosis

(2012) Wynand P. Roos et al.   CANCER LETTERS

p53 Opens the Mitochondrial Permeability Transition Pore to Trigger Necrosis

(2012) Angelina V. Vaseva et al.   CELL

The prolyl-isomerase Pin1 activates the mitochondrial death program of p53

(2012) G Sorrentino et al.   CELL DEATH AND DIFFERENTIATION

Caspase-2 deficiency promotes aberrant DNA-damage response and genetic instability

(2012) L Dorstyn et al.   CELL DEATH AND DIFFERENTIATION

DAI/ZBP1/DLM-1 Complexes with RIP3 to Mediate Virus-Induced Programmed Necrosis that Is Targeted by Murine Cytomegalovirus vIRA

(2012) Jason W. Upton et al.   Cell Host & Microbe

p63/p73 in the control of cell cycle and cell death

(2012) N. Allocati et al.   EXPERIMENTAL CELL RESEARCH

Mutant p53: one name, many proteins

(2012) W. A. Freed-Pastor et al.   GENES & DEVELOPMENT

Updates on HIPK2: a resourceful oncosuppressor for clearing cancer

(2012) Gabriella D’Orazi et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

PIDD Death-Domain Phosphorylation by ATM Controls Prodeath versus Prosurvival PIDDosome Signaling

(2012) Kiyohiro Ando et al.   MOLECULAR CELL

A Redox-Regulated SUMO/Acetylation Switch of HIPK2 Controls the Survival Threshold to Oxidative Stress

(2012) Laureano de la Vega et al.   MOLECULAR CELL

Identification of the molecular basis of doxorubicin-induced cardiotoxicity

(2012) Sui Zhang et al.   NATURE MEDICINE

A telomere-dependent DNA damage checkpoint induced by prolonged mitotic arrest

(2012) Makoto T Hayashi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

HIPK2 kinase activity depends on cis-autophosphorylation of its activation loop

(2012) Vera V. Saul et al.   Journal of Molecular Cell Biology

Regulation of p73 activity by post-translational modifications

(2012) F Conforti et al.   Cell Death & Disease

FOXO3 signalling links ATM to the p53 apoptotic pathway following DNA damage

(2012) Young Min Chung et al.   Nature Communications

Zyxin Is a Critical Regulator of the Apoptotic HIPK2-p53 Signaling Axis

(2011) J. Crone et al.   CANCER RESEARCH

NEMO and RIP1 Control Cell Fate in Response to Extensive DNA Damage via TNF-α Feedforward Signaling

(2011) Sharon Biton et al.   CELL

The PIDDosome, DNA-damage-induced apoptosis and beyond

(2011) S Janssens et al.   CELL DEATH AND DIFFERENTIATION

Mechanisms and pathways of growth failure in primordial dwarfism

(2011) A. Klingseisen et al.   GENES & DEVELOPMENT

A Cytosolic ATM/NEMO/RIP1 Complex Recruits TAK1 To Mediate the NF- B and p38 Mitogen-Activated Protein Kinase (MAPK)/MAPK-Activated Protein 2 Responses to DNA Damage

(2011) Y. Yang et al.   MOLECULAR AND CELLULAR BIOLOGY

XIAP-associated factor 1 (XAF1), a novel target of p53, enhances p53-mediated apoptosis via post-translational modification

(2011) Bing Zou et al.   MOLECULAR CARCINOGENESIS

The ATM Kinase Induces MicroRNA Biogenesis in the DNA Damage Response

(2011) Xinna Zhang et al.   MOLECULAR CELL

Cutaneous HPV23 E6 Prevents p53 Phosphorylation through Interaction with HIPK2

(2011) Dorothea Muschik et al.   PLoS One

Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway

(2011) S. He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ser46 phosphorylation and prolyl-isomerase Pin1-mediated isomerization of p53 are key events in p53-dependent apoptosis induced by mutant huntingtin

(2011) A. Grison et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Requirement of ATM for Rapid p53 Phosphorylation at Ser46 without Ser/Thr-Gln Sequences

(2010) M. Kodama et al.   MOLECULAR AND CELLULAR BIOLOGY

ATM- and NEMO-Dependent ELKS Ubiquitination Coordinates TAK1-Mediated IKK Activation in Response to Genotoxic Stress

(2010) Zhao-Hui Wu et al.   MOLECULAR CELL

A Cytoplasmic ATM-TRAF6-cIAP1 Module Links Nuclear DNA Damage Signaling to Ubiquitin-Mediated NF-κB Activation

(2010) Michael Hinz et al.   MOLECULAR CELL

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondria and cell death: outer membrane permeabilization and beyond

(2010) Stephen W. G. Tait et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

p63 and p73, the Ancestors of p53

(2010) V. Dotsch et al.   Cold Spring Harbor Perspectives in Biology

Stabilization of HIPK2 by escape from proteasomal degradation mediated by the E3 ubiquitin ligase Siah1

(2009) Se-Yong Kim et al.   CANCER LETTERS

cIAP1, cIAP2, and XIAP Act Cooperatively via Nonredundant Pathways to Regulate Genotoxic Stress-Induced Nuclear Factor- B Activation

(2009) H.-S. Jin et al.   CANCER RESEARCH

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

(2009) Sudan He et al.   CELL

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

Apoptosis and autophagy: Regulation of apoptosis by DNA damage signalling - roles of p53, p73 and HIPK2

(2009) Nadja Bitomsky et al.   FEBS Journal

A Nuclear Poly(ADP-Ribose)-Dependent Signalosome Confers DNA Damage-Induced IκB Kinase Activation

(2009) Michael Stilmann et al.   MOLECULAR CELL

Modulation of microRNA processing by p53

(2009) Hiroshi I. Suzuki et al.   NATURE

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Axin determines cell fate by controlling the p53 activation threshold after DNA damage

(2009) Qinxi Li et al.   NATURE CELL BIOLOGY

Death receptor signal transducers: nodes of coordination in immune signaling networks

(2009) Nicholas S Wilson et al.   NATURE IMMUNOLOGY

DNA Damage, Aging, and Cancer

(2009) Jan H.J. Hoeijmakers   NEW ENGLAND JOURNAL OF MEDICINE

A tumor suppressor function for caspase-2

(2009) L. H. Ho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of nuclear bodies in apoptosis signalling

(2008) Eva Krieghoff-Henning et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

How cells switch HIPK2 on and off

(2008) D Sombroek et al.   CELL DEATH AND DIFFERENTIATION

Yap1 Phosphorylation by c-Abl Is a Critical Step in Selective Activation of Proapoptotic Genes in Response to DNA Damage

(2008) Dan Levy et al.   MOLECULAR CELL

ATM Signaling Facilitates Repair of DNA Double-Strand Breaks Associated with Heterochromatin

(2008) Aaron A. Goodarzi et al.   MOLECULAR CELL

Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR

(2008) Melanie Winter et al.   NATURE CELL BIOLOGY

Noncanonical NF-κB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK

(2008) Brian J Zarnegar et al.   NATURE IMMUNOLOGY

Regulation of apoptosis by PML and the PML-NBs

(2008) R Bernardi et al.   ONCOGENE

MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death

(2008) R Schickel et al.   ONCOGENE

Functional evolution of the p53 regulatory network through its target response elements

(2008) A. G. Jegga et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Oncogene-Induced DNA Damage Model for Cancer Development

(2008) T. D. Halazonetis et al.   SCIENCE

The impact of p53 and p73 on aneuploidy and cancer

(2008) Richard Tomasini et al.   TRENDS IN CELL BIOLOGY

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY