Cytokines that Modulate the Differentiation of Th17 Cells in Autoimmune Uveitis

Tear IL-6 and IL-10 levels in HLA-B27-Associated Uveitis and Its clinical Implications

(2020) Aman Kumar et al.   OCULAR IMMUNOLOGY AND INFLAMMATION

Translating IL-6 biology into effective treatments

(2020) Ernest H. Choy et al.   Nature Reviews Rheumatology

Cytokine Profiling in Aqueous Humor Samples From Patients With Non-Infectious Uveitis Associated With Systemic Inflammatory Diseases

(2020) Martina Bonacini et al.   Frontiers in Immunology

Regulatory T cells and their derived cytokine, interleukin-35, reduce pain in experimental autoimmune encephalomyelitis

(2019) Samuel S Duffy et al.   JOURNAL OF NEUROSCIENCE

IL-6, IL-12, and IL-23 STAT-Pathway Genetic Risk and Responsiveness of Lymphocytes in Patients with Multiple Sclerosis

(2019) Marina von Essen et al.   Cells

The right place of interleukin-1 inhibitors in the treatment of Behçet’s syndrome: a systematic review

(2019) Alessandra Bettiol et al.   RHEUMATOLOGY INTERNATIONAL

Poor Control of Sarcoidosis-Related Panuveitis with an Antibody to IL-23

(2019) Akshay S. Thomas et al.   OCULAR IMMUNOLOGY AND INFLAMMATION

Expression of interleukin (IL)-10 family cytokines in aqueous humour of patients with specific endogenous uveitic entities: elevated levels of IL-19 in human leucocyte antigen-B27-associated uveitis

(2019) Ahmed M. Abu El-Asrar et al.   ACTA OPHTHALMOLOGICA

The γc Family of Cytokines: Basic Biology to Therapeutic Ramifications

(2019) Warren J. Leonard et al.   IMMUNITY

Pleiotropy and Specificity: Insights from the Interleukin 6 Family of Cytokines

(2019) Masaaki Murakami et al.   IMMUNITY

Targeting SOCS Proteins to Control JAK-STAT Signalling in Disease

(2019) Gillian A. Durham et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Long term outcome of ustekinumab therapy for Behçet's disease

(2019) Adrien Mirouse et al.   Arthritis & Rheumatology

Inactivation of MTOR promotes autophagy-mediated epithelial injury in particulate matter-induced airway inflammation

(2019) Yin-Fang Wu et al.   Autophagy

SKI and SMAD4 are essential for IL-21-induced Th17 differentiation

(2019) Song Zhang et al.   MOLECULAR IMMUNOLOGY

Dysregulations of follicular helper T cells through IL-21 pathway in age-related macular degeneration

(2019) Qiaowei Wu et al.   MOLECULAR IMMUNOLOGY

ERα Signaling Increased IL-17A Production in Th17 Cells by Upregulating IL-23R Expression, Mitochondrial Respiration, and Proliferation

(2019) Hubaida Fuseini et al.   Frontiers in Immunology

JAK/STAT Cytokine Signaling at the Crossroad of NK Cell Development and Maturation

(2019) Dagmar Gotthardt et al.   Frontiers in Immunology

IL-6 dysregulation originates in dendritic cells and mediates graft-versus-host disease via classical signaling

(2019) Andrew N. Wilkinson et al.   BLOOD

miR-223-3p promotes autoreactive Th17 cell responses in experimental autoimmune uveitis (EAU) by inhibiting transcription factor FOXO3 expression

(2019) Yankai Wei et al.   FASEB JOURNAL

Short-term and low-dose IL-2 therapy restores the Th17/Treg balance in the peripheral blood of patients with primary Sjögren’s syndrome

(2018) Miao Miao et al.   ANNALS OF THE RHEUMATIC DISEASES

T helper 17.1 cells associate with multiple sclerosis disease activity: perspectives for early intervention

(2018) Jamie van Langelaar et al.   BRAIN

Reassessing Th1 versus Th17.1 in sarcoidosis: new tricks for old dogma

(2018) Edward S. Chen   EUROPEAN RESPIRATORY JOURNAL

Structural Activation of Pro-inflammatory Human Cytokine IL-23 by Cognate IL-23 Receptor Enables Recruitment of the Shared Receptor IL-12Rβ1

(2018) Yehudi Bloch et al.   IMMUNITY

The role of transforming growth factor β in T helper 17 differentiation

(2018) Song Zhang   IMMUNOLOGY

Use of Gevokizumab in Patients with Behçet’s Disease Uveitis: An International, Randomized, Double-Masked, Placebo-Controlled Study and Open-Label Extension Study

(2018) Ilknur Tugal-Tutkun et al.   OCULAR IMMUNOLOGY AND INFLAMMATION

Targeting Interleukin-23 in the Treatment of Noninfectious Uveitis

(2018) Kathryn L. Pepple et al.   OPHTHALMOLOGY

The immunopathogenesis of chronic and relapsing autoimmune uveitis – Lessons from experimental rat models

(2018) Maria Diedrichs-Möhring et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Anti-interleukin 6 receptor tocilizumab in refractory uveitis associated with Behçet’s disease: multicentre retrospective study

(2018) Belén Atienza-Mateo et al.   RHEUMATOLOGY

Interferon γ and Its Important Roles in Promoting and Inhibiting Spontaneous and Therapeutic Cancer Immunity

(2018) Elise Alspach et al.   Cold Spring Harbor Perspectives in Biology

IL-6/STAT3 pathway induced deficiency of RFX1 contributes to Th17-dependent autoimmune diseases via epigenetic regulation

(2018) Ming Zhao et al.   Nature Communications

Act1 is a negative regulator in T and B cells via direct inhibition of STAT3

(2018) Cun-Jin Zhang et al.   Nature Communications

IL-23 and IL-1β Drive Human Th17 Cell Differentiation and Metabolic Reprogramming in Absence of CD28 Costimulation

(2018) Shankar Revu et al.   Cell Reports

Immunoglobulin E-Mediated Autoimmunity

(2018) Marcus Maurer et al.   Frontiers in Immunology

Whodunit? The Contribution of Interleukin (IL)-17/IL-22-Producing γδ T Cells, αβ T Cells, and Innate Lymphoid Cells to the Pathogenesis of Spondyloarthritis

(2018) Annika Reinhardt et al.   Frontiers in Immunology

Tuning the Cytokine Responses: An Update on Interleukin (IL)-4 and IL-13 Receptor Complexes

(2018) Ilkka S. Junttila   Frontiers in Immunology

Insight Into Non-Pathogenic Th17 Cells in Autoimmune Diseases

(2018) Xinyu Wu et al.   Frontiers in Immunology

IL-1R signaling promotes STAT3 and NF-κB factor recruitment to distal cis-regulatory elements that regulateIl17a/ftranscription

(2018) Sarah K. Whitley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BCAP links IL-1R to the PI3K–mTOR pathway and regulates pathogenic Th17 cell differentiation

(2018) Krystin Deason et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Presence of Uveitis Is Associated with a Sustained Response to the Interleukin (IL)-1 Inhibitors Anakinra and Canakinumab in Behçet’s Disease

(2018) Claudia Fabiani et al.   OCULAR IMMUNOLOGY AND INFLAMMATION

Immunological and clinical effects of low-dose interleukin-2 across 11 autoimmune diseases in a single, open clinical trial

(2018) Michelle Rosenzwajg et al.   ANNALS OF THE RHEUMATIC DISEASES

Insights into Local Orbital Immunity: Evidence for the Involvement of the Th17 Cell Pathway in Thyroid-Associated Ophthalmopathy

(2018) Sijie Fang et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Nonredundant Roles of IL-21 and IL-4 in the Phased Initiation of Germinal Center B Cells and Subsequent Self-Renewal Transitions

(2018) David G. Gonzalez et al.   JOURNAL OF IMMUNOLOGY

Efficacy and Safety of Sarilumab for the Treatment of Posterior Segment Noninfectious Uveitis (SARIL-NIU): the Phase 2 SATURN Study

(2018) Jarmila Heissigerová et al.   OPHTHALMOLOGY

ROCK2, but not ROCK1 interacts with phosphorylated STAT3 and co-occupies TH17/TFH gene promoters in TH17-activated human T cells

(2018) Wei Chen et al.   Scientific Reports

An elevated pro-inflammatory cytokines profile in Behcet’s disease: A multiplex analysis

(2017) Nasser Gholijani et al.   IMMUNOLOGY LETTERS

PTEN drives Th17 cell differentiation by preventing IL-2 production

(2017) Hyeong Su Kim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Reversing SKI–SMAD4-mediated suppression is essential for TH17 cell differentiation

(2017) Song Zhang et al.   NATURE

The association between genetic polymorphisms of the interleukin-23 receptor gene and susceptibility to uveitis: a meta-analysis

(2017) Jae Hyun Jung et al.   BMC Ophthalmology

IL-12p35 induces expansion of IL-10 and IL-35-expressing regulatory B cells and ameliorates autoimmune disease

(2017) Ivy M. Dambuza et al.   Nature Communications

Aberrant DNA methylation of GATA binding protein 3 (GATA3), interleukin-4 (IL-4), and transforming growth factor-β (TGF-β) promoters in Behcet’s disease

(2017) Yunyun Zhu et al.   Oncotarget

IL-23R and IL-17A polymorphisms correlate with susceptibility of ankylosing spondylitis in a Southwest Chinese population

(2017) Bin Yang et al.   Oncotarget

Diagnostic Value of Serum-Soluble Interleukin 2 Receptor Levels vs Angiotensin-Converting Enzyme in Patients With Sarcoidosis-Associated Uveitis

(2017) Fahriye Groen-Hakan et al.   JAMA Ophthalmology

Anti-Interleukin-6 Receptor Tocilizumab for Severe Juvenile Idiopathic Arthritis-Associated Uveitis Refractory to Anti-Tumor Necrosis Factor Therapy: A Multicenter Study of Twenty-Five Patients

(2017) Vanesa Calvo-Río et al.   Arthritis & Rheumatology

IL-12p35 Inhibits Neuroinflammation and Ameliorates Autoimmune Encephalomyelitis

(2017) Jin Kyeong Choi et al.   Frontiers in Immunology

Serum Profiles of Cytokines in Behcet’s Disease

(2017) Alireza Sadeghi et al.   Journal of Clinical Medicine

Cytokine and chemokine tear levels in patients with uveitis

(2016) Ester Carreño et al.   ACTA OPHTHALMOLOGICA

Interleukin (IL)-1 inhibition with anakinra and canakinumab in Behçet’s disease-related uveitis: a multicenter retrospective observational study

(2016) Claudia Fabiani et al.   CLINICAL RHEUMATOLOGY

A novel IL-23p19/Ebi3 (IL-39) cytokine mediates inflammation in Lupus-like mice

(2016) Xiaoqian Wang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The MicroRNA-183-96-182 Cluster Promotes T Helper 17 Cell Pathogenicity by Negatively Regulating Transcription Factor Foxo1 Expression

(2016) Kenji Ichiyama et al.   IMMUNITY

Interleukin-23-Induced Transcription Factor Blimp-1 Promotes Pathogenicity of T Helper 17 Cells

(2016) Renu Jain et al.   IMMUNITY

Safety, PK, and PD of recombinant anti-interleukin-21 monoclonal antibody in a first-in-human trial

(2016) Stanislav Ignatenko et al.   INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS

Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells

(2016) Sylvia Heink et al.   NATURE IMMUNOLOGY

Safety and Efficacy of Gevokizumab in Patients with Behçet’s Disease Uveitis: Results of an Exploratory Phase 2 Study

(2016) Ilknur Tugal-Tutkun et al.   OCULAR IMMUNOLOGY AND INFLAMMATION

IL-21 and T Cell Differentiation: Consider the Context

(2016) Yuan Tian et al.   TRENDS IN IMMUNOLOGY

TGF-β Family Signaling in the Control of Cell Proliferation and Survival

(2016) Yun Zhang et al.   Cold Spring Harbor Perspectives in Biology

TGF-β and the TGF-β Family: Context-Dependent Roles in Cell and Tissue Physiology

(2016) Masato Morikawa et al.   Cold Spring Harbor Perspectives in Biology

Expanding Diversity in Molecular Structures and Functions of the IL-6/IL-12 Heterodimeric Cytokine Family

(2016) Hideaki Hasegawa et al.   Frontiers in Immunology

Analysis of TGF-β1 and TGF-β3 as regulators of encephalitogenic Th17 cells: Implications for multiple sclerosis

(2015) Priscilla W. Lee et al.   BRAIN BEHAVIOR AND IMMUNITY

Cytokine Expression Profile in Aqueous Humor and Sera of Patients with Acute Anterior Uveitis

(2015) W. Chen et al.   CURRENT MOLECULAR MEDICINE

Interleukin 35: Critical regulator of immunity and lymphocyte-mediated diseases

(2015) Charles E. Egwuagu et al.   CYTOKINE & GROWTH FACTOR REVIEWS

A Critical Role for Transcription Factor Smad4 in T Cell Function that Is Independent of Transforming Growth Factor β Receptor Signaling

(2015) Ai-Di Gu et al.   IMMUNITY

Mesenchymal stem cells inhibit Th17 cells differentiation via IFN-γ-mediated SOCS3 activation

(2015) Xingxia Liu et al.   IMMUNOLOGIC RESEARCH

Elevated follicular helper T Cells and expression of IL-21 in thyroid tissues are involved in the pathogenesis of Graves’ disease

(2015) Jin Zhang et al.   IMMUNOLOGIC RESEARCH

TLR3 drives IRF6-dependent IL-23p19 expression and p19/EBI3 heterodimer formation in keratinocytes

(2015) Divya Ramnath et al.   IMMUNOLOGY AND CELL BIOLOGY

IL-21R signaling is critical for induction of spontaneous experimental autoimmune encephalomyelitis

(2015) Youjin Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

NK-DC crosstalk controls the autopathogenic Th17 response through an innate IFN-γ–IL-27 axis

(2015) Wai Po Chong et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: IL-1 Receptor Signaling is Critical for the Development of Autoimmune Uveitis

(2015) Chi-Keung Wan et al.   JOURNAL OF IMMUNOLOGY

IL-27 Induces Th17 Differentiation in the Absence of STAT1 Signaling

(2015) Anneli Peters et al.   JOURNAL OF IMMUNOLOGY

The preclinical pharmacology of the high affinity anti-IL-6R Nanobody® ALX-0061 supports its clinical development in rheumatoid arthritis

(2015) Maarten Van Roy et al.   ARTHRITIS RESEARCH & THERAPY

Phosphorylation status determines the opposing functions of Smad2/Smad3 as STAT3 cofactors in TH17 differentiation

(2015) Jeong-Hwan Yoon et al.   Nature Communications

IL-1β promotes Th17 differentiation by inducing alternative splicing of FOXP3

(2015) Reiner K. W. Mailer et al.   Scientific Reports

Diagnosis and classification of autoimmune uveitis

(2014) Carlo Selmi   AUTOIMMUNITY REVIEWS

EBI3 is pivotal for the initiation of experimental autoimmune uveitis

(2014) Atsunobu Takeda et al.   EXPERIMENTAL EYE RESEARCH

The Transcription Factors T-bet and Runx Are Required for the Ontogeny of Pathogenic Interferon-γ-Producing T Helper 17 Cells

(2014) Yan Wang et al.   IMMUNITY

Suppressor of Cytokine Signaling 1 (SOCS1) Mitigates Anterior Uveitis and Confers Protection Against Ocular HSV-1 Infection

(2014) Cheng-Rong Yu et al.   INFLAMMATION

Guselkumab (an IL-23–specific mAb) demonstrates clinical and molecular response in patients with moderate-to-severe psoriasis

(2014) Howard Sofen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Counter-regulation of T cell effector function by differentially activated p38

(2014) Muhammad S. Alam et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Loss of STAT3 in CD4 + T Cells Prevents Development of Experimental Autoimmune Diseases

(2014) Xuebin Liu et al.   JOURNAL OF IMMUNOLOGY

Proinflammatory Cytokines and C-Reactive Protein in Uveitis Associated with Behçet’s Disease

(2014) Marina Mesquida et al.   MEDIATORS OF INFLAMMATION

Interleukin-35 induces regulatory B cells that suppress autoimmune disease

(2014) Ren-Xi Wang et al.   NATURE MEDICINE

An Anti-Interleukin-2 Receptor Drug Attenuates T- Helper 1 Lymphocytes-Mediated Inflammation in an Acute Model of Endotoxin-Induced Uveitis

(2014) Salvador Mérida et al.   PLoS One

Opposing actions of IL-2 and IL-21 on Th9 differentiation correlate with their differential regulation of BCL6 expression

(2014) Wei Liao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Decreased interleukin 27 expression is associated with active uveitis in Behçet’s disease

(2014) Chaokui Wang et al.   ARTHRITIS RESEARCH & THERAPY

Interleukin 21, Interleukin 23, and Transforming Growth Factor β1 in HLA-A29-Associated Birdshot Retinochoroidopathy

(2013) Paul Yang et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Long-term daclizumab therapy for the treatment of noninfectious ocular inflammatory disease

(2013) Keith Wroblewski et al.   CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE

The Interleukin-1 Family: Back to the Future

(2013) Cecilia Garlanda et al.   IMMUNITY

Interleukin-2 at the Crossroads of Effector Responses, Tolerance, and Immunotherapy

(2013) Wei Liao et al.   IMMUNITY

Breakdown of immune privilege and spontaneous autoimmunity in mice expressing a transgenic T cell receptor specific for a retinal autoantigen

(2013) Reiko Horai et al.   JOURNAL OF AUTOIMMUNITY

IL-27p28 inhibits central nervous system autoimmunity by concurrently antagonizing Th1 and Th17 responses

(2013) Wai Po Chong et al.   JOURNAL OF AUTOIMMUNITY

The interleukin-1 receptor family

(2013) Diana Boraschi et al.   SEMINARS IN IMMUNOLOGY

Inactivation of the Enzyme GSK3α by the Kinase IKKi Promotes AKT-mTOR Signaling Pathway that Mediates Interleukin-1-Induced Th17 Cell Maintenance

(2012) Muhammet F. Gulen et al.   IMMUNITY

Interleukin-27 Priming of T Cells Controls IL-17 Production In trans via Induction of the Ligand PD-L1

(2012) Kiyoshi Hirahara et al.   IMMUNITY

Novel IL27p28/IL12p40 Cytokine Suppressed Experimental Autoimmune Uveitis by Inhibiting Autoreactive Th1/Th17 Cells and Promoting Expansion of Regulatory T Cells

(2012) Ren-Xi Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IL-4 in the Brain: A Cytokine To Remember

(2012) Sachin P. Gadani et al.   JOURNAL OF IMMUNOLOGY

Induction and molecular signature of pathogenic TH17 cells

(2012) Youjin Lee et al.   NATURE IMMUNOLOGY

The composition and signaling of the IL-35 receptor are unconventional

(2012) Lauren W Collison et al.   NATURE IMMUNOLOGY

IL-12 family cytokines: immunological playmakers

(2012) Dario A A Vignali et al.   NATURE IMMUNOLOGY

Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases

(2012) Charles A. Dinarello et al.   NATURE REVIEWS DRUG DISCOVERY

Elevated levels of interleukin-27 and effect on production of interferon-γ and interleukin-17 in patients with Behçet’s disease

(2012) H Shen et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

IL-21 and Sjögren's syndrome

(2012) R Hal Scofield   ARTHRITIS RESEARCH & THERAPY

IL-6/IL-6 receptor system and its role in physiological and pathological conditions

(2011) Masahiko Mihara et al.   CLINICAL SCIENCE

Persistence of IL-2 expressing Th17 cells in healthy humans and experimental autoimmune uveitis

(2011) Cheng-Rong Yu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Retinal cells suppress intraocular inflammation (uveitis) through production of interleukin-27 and interleukin-10

(2011) Yun Sang Lee et al.   IMMUNOLOGY

Critical role of IL-21 in modulating TH17 and regulatory T cells in Behçet disease

(2011) Guillaume Geri et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Sensitivity and Resistance to Regulation by IL-4 during Th17 Maturation

(2011) L. A. Cooney et al.   JOURNAL OF IMMUNOLOGY

Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages

(2011) Wei Liao et al.   NATURE IMMUNOLOGY

Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5

(2011) Xiang-Ping Yang et al.   NATURE IMMUNOLOGY

Upregulation of Interleukin 21 and Promotion of Interleukin 17 Production in Chronic or Recurrent Vogt-Koyanagi-Harada Disease

(2010) Fuzhen Li   ARCHIVES OF OPHTHALMOLOGY

Blockade of interleukin-6 signaling suppresses experimental autoimmune uveoretinitis by the inhibition of inflammatory Th17 responses

(2010) Satoshi Hohki et al.   EXPERIMENTAL EYE RESEARCH

Regulation of the T helper cell type 2 (Th2)/T regulatory cell (Treg) balance by IL-4 and STAT6

(2010) Svetlana Chapoval et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Generation of pathogenic TH17 cells in the absence of TGF-β signalling

(2010) Kamran Ghoreschi et al.   NATURE

A role for IL-27p28 as an antagonist of gp130-mediated signaling

(2010) Jason S Stumhofer et al.   NATURE IMMUNOLOGY

T-bet represses TH17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγt

(2010) Vanja Lazarevic et al.   NATURE IMMUNOLOGY

High-dose Daclizumab for the Treatment of Juvenile Idiopathic Arthritis–Associated Active Anterior Uveitis

(2009) H. Nida Sen et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Inhibitory effect of Cyclosporin A and corticosteroids on the production of IFN-γ and IL-17 by T cells in Vogt–Koyanagi–Harada syndrome

(2009) Xiaoli Liu et al.   CLINICAL IMMUNOLOGY

The Current STATus of lymphocyte signaling: new roles for old players

(2009) Adewole S Adamson et al.   CURRENT OPINION IN IMMUNOLOGY

Critical Regulation of Early Th17 Cell Differentiation by Interleukin-1 Signaling

(2009) Yeonseok Chung et al.   IMMUNITY

Involvement of Th17 cells and the effect of anti-IL-6 therapy in autoimmune uveitis

(2009) T. Yoshimura et al.   RHEUMATOLOGY

Enforced expression of GATA3 allows differentiation of IL-17-producing cells, but constrains Th17-mediated pathology

(2008) Jan Piet van Hamburg et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

High-dose humanized anti-IL-2 receptor alpha antibody (daclizumab) for the treatment of active, non-infectious uveitis

(2008) Steven Yeh et al.   JOURNAL OF AUTOIMMUNITY

Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category

(2008) Dror Luger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function

(2008) Liang Zhou et al.   NATURE

IL-21 and TGF-β are required for differentiation of human TH17 cells

(2008) Li Yang et al.   NATURE