The role of transforming growth factor β in T helper 17 differentiation

When worlds collide: Th17 and Treg cells in cancer and autoimmunity

(2018) Hannah M. Knochelmann et al.   Cellular & Molecular Immunology

Dietary salt promotes neurovascular and cognitive dysfunction through a gut-initiated TH17 response

(2018) Giuseppe Faraco et al.   NATURE NEUROSCIENCE

Metabolic Adaptations of CD4+ T Cells in Inflammatory Disease

(2018) Cristina Dumitru et al.   Frontiers in Immunology

Transforming Growth Factor-β Signaling in Regulatory T Cells Controls T Helper-17 Cells and Tissue-Specific Immune Responses

(2017) Joanne E. Konkel et al.   IMMUNITY

Reversing SKI–SMAD4-mediated suppression is essential for TH17 cell differentiation

(2017) Song Zhang et al.   NATURE

Sensing relative signal in the Tgf-β/Smad pathway

(2017) Christopher L. Frick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolism Controls the Balance of Th17/T-Regulatory Cells

(2017) Licheng Sun et al.   Frontiers in Immunology

Revisiting the regulatory roles of the TGF-β family of cytokines

(2016) Keshi Fujio et al.   AUTOIMMUNITY REVIEWS

IL‐1 signaling is critical for expansion but not generation of autoreactive GM‐CSF + Th17 cells

(2016) Ilgiz A Mufazalov et al.   EMBO JOURNAL

Fine-Tuning Th17 Cells: To Be or Not To Be Pathogenic?

(2016) Chrysi Kanellopoulou et al.   IMMUNITY

The search for the target antigens of multiple sclerosis, part 1: autoreactive CD4+ T lymphocytes as pathogenic effectors and therapeutic targets

(2016) Reinhard Hohlfeld et al.   LANCET NEUROLOGY

Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells

(2016) Sylvia Heink et al.   NATURE IMMUNOLOGY

Tumour suppressor death-associated protein kinase targets cytoplasmic HIF-1α for Th17 suppression

(2016) Ting-Fang Chou et al.   Nature Communications

Analysis of TGF-β1 and TGF-β3 as regulators of encephalitogenic Th17 cells: Implications for multiple sclerosis

(2015) Priscilla W. Lee et al.   BRAIN BEHAVIOR AND IMMUNITY

CD5L/AIM Regulates Lipid Biosynthesis and Restrains Th17 Cell Pathogenicity

(2015) Chao Wang et al.   CELL

TGF-β converts Th1 cells into Th17 cells through stimulation of Runx1 expression

(2015) Hou-Pu Liu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A Critical Role for Transcription Factor Smad4 in T Cell Function that Is Independent of Transforming Growth Factor β Receptor Signaling

(2015) Ai-Di Gu et al.   IMMUNITY

The Energy Sensor AMPK Regulates T Cell Metabolic Adaptation and Effector Responses In Vivo

(2015) Julianna Blagih et al.   IMMUNITY

Th17 Cell Pathway in Human Immunity: Lessons from Genetics and Therapeutic Interventions

(2015) Dhavalkumar D. Patel et al.   IMMUNITY

The Cytokine GM-CSF Drives the Inflammatory Signature of CCR2+ Monocytes and Licenses Autoimmunity

(2015) Andrew L. Croxford et al.   IMMUNITY

Pouring fuel on the fire: Th17 cells, the environment, and autoimmunity

(2015) Patrick R. Burkett et al.   JOURNAL OF CLINICAL INVESTIGATION

Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation

(2015) Nicola Gagliani et al.   NATURE

Phosphorylation status determines the opposing functions of Smad2/Smad3 as STAT3 cofactors in TH17 differentiation

(2015) Jeong-Hwan Yoon et al.   Nature Communications

PI3K/mTORC2 regulates TGF-β/Activin signalling by modulating Smad2/3 activity via linker phosphorylation

(2015) Jason S. L. Yu et al.   Nature Communications

Small-Molecule RORγt Antagonists Inhibit T Helper 17 Cell Transcriptional Network by Divergent Mechanisms

(2014) Sheng Xiao et al.   IMMUNITY

The Transcription Factor IRF8 Activates Integrin-Mediated TGF-β Signaling and Promotes Neuroinflammation

(2014) Yuko Yoshida et al.   IMMUNITY

The Transcription Factors T-bet and Runx Are Required for the Ontogeny of Pathogenic Interferon-γ-Producing T Helper 17 Cells

(2014) Yan Wang et al.   IMMUNITY

T-bet and Eomesodermin Play Critical Roles in Directing T Cell Differentiation to Th1 versus Th17

(2014) Y. Yang et al.   JOURNAL OF IMMUNOLOGY

IL-23 Promotes Maintenance but Not Commitment to the Th17 Lineage

(2014) G. L. Stritesky et al.   JOURNAL OF IMMUNOLOGY

Excess IL-1 Signaling Enhances the Development of Th17 Cells by Downregulating TGF- -Induced Foxp3 Expression

(2014) S. Ikeda et al.   JOURNAL OF IMMUNOLOGY

Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells

(2014) Sascha Rutz et al.   NATURE

The cytokine TGF-β co-opts signaling via STAT3-STAT4 to promote the differentiation of human TFH cells

(2014) Nathalie Schmitt et al.   NATURE IMMUNOLOGY

De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells

(2014) Luciana Berod et al.   NATURE MEDICINE

TGF-β Activation and Function in Immunity

(2013) Mark A. Travis et al.   Annual Review of Immunology

Does dietary salt induce autoimmunity?

(2013) Andrew L Croxford et al.   CELL RESEARCH

Metabolic control of the Treg/Th17 axis

(2013) Joseph Barbi et al.   IMMUNOLOGICAL REVIEWS

Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1

(2013) Chuan Wu et al.   NATURE

Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells

(2013) Markus Kleinewietfeld et al.   NATURE

Plasticity of TH17 cells in Peyer's patches is responsible for the induction of T cell–dependent IgA responses

(2013) Keiji Hirota et al.   NATURE IMMUNOLOGY

A Validated Regulatory Network for Th17 Cell Specification

(2012) Maria Ciofani et al.   CELL

BATF–JUN is critical for IRF4-mediated transcription in T cells

(2012) Peng Li et al.   NATURE

Induction and molecular signature of pathogenic TH17 cells

(2012) Youjin Lee et al.   NATURE IMMUNOLOGY

TRIM28 prevents autoinflammatory T cell development in vivo

(2012) Shunsuke Chikuma et al.   NATURE IMMUNOLOGY

TGFβ signalling in context

(2012) Joan Massagué   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Requirements of transcription factor Smad-dependent and -independent TGF-  signaling to control discrete T-cell functions

(2012) A.-D. Gu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PI3K-Akt-mTORC1-S6K1/2 Axis Controls Th17 Differentiation by Regulating Gfi1 Expression and Nuclear Translocation of RORγ

(2012) Yutaka Kurebayashi et al.   Cell Reports

Characterization of Gliadin-Specific Th17 Cells from the Mucosa of Celiac Disease Patients

(2011) Silvia Fernández et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

(2011) Eric V. Dang et al.   CELL

c-Ski in health and disease

(2011) Carine Bonnon et al.   CELL AND TISSUE RESEARCH

Preferential Expression of Integrin αvβ8 Promotes Generation of Regulatory T Cells by Mouse CD103+ Dendritic Cells

(2011) Helena Païdassi et al.   GASTROENTEROLOGY

Intestinal Dendritic Cells Specialize to Activate Transforming Growth Factor-β and Induce Foxp3+ Regulatory T Cells via Integrin αvβ8

(2011) John J. Worthington et al.   GASTROENTEROLOGY

Priming Microenvironments Dictate Cytokine Requirements for T Helper 17 Cell Lineage Commitment

(2011) Wei Hu et al.   IMMUNITY

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

(2011) Ruoning Wang et al.   IMMUNITY

Transcription Factor Smad-Independent T Helper 17 Cell Induction by Transforming-Growth Factor-β Is Mediated by Suppression of Eomesodermin

(2011) Kenji Ichiyama et al.   IMMUNITY

CD4+CD25+Foxp3+ Regulatory T Cells Promote Th17 Cells In Vitro and Enhance Host Resistance in Mouse Candida albicans Th17 Cell Infection Model

(2011) Pushpa Pandiyan et al.   IMMUNITY

Foxp3+ Regulatory T Cells Promote T Helper 17 Cell Development In Vivo through Regulation of Interleukin-2

(2011) Yi Chen et al.   IMMUNITY

Autocrine Transforming Growth Factor-β1 Promotes In Vivo Th17 Cell Differentiation

(2011) Ilona Gutcher et al.   IMMUNITY

An Essential Role of the Transcription Factor GATA-3 for the Function of Regulatory T Cells

(2011) Yunqi Wang et al.   IMMUNITY

Smad4 deficiency in T cells leads to the Th17-associated development of premalignant gastroduodenal lesions in mice

(2011) Jennifer Nancy Hahn et al.   JOURNAL OF CLINICAL INVESTIGATION

GATA3 controls Foxp3+ regulatory T cell fate during inflammation in mice

(2011) Elizabeth A. Wohlfert et al.   JOURNAL OF CLINICAL INVESTIGATION

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells

(2011) Lewis Z. Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Latent TGF-β structure and activation

(2011) Minlong Shi et al.   NATURE

Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity

(2011) Jun R. Huh et al.   NATURE

Transcription factor c-Maf mediates the TGF-β-dependent suppression of IL-22 production in TH17 cells

(2011) Sascha Rutz et al.   NATURE IMMUNOLOGY

RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation

(2011) Laura Codarri et al.   NATURE IMMUNOLOGY

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

(2011) Greg M Delgoffe et al.   NATURE IMMUNOLOGY

The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF

(2011) Mohamed El-Behi et al.   NATURE IMMUNOLOGY

TRAF6 inhibits Th17 differentiation and TGF- -mediated suppression of IL-2

(2010) P. J. Cejas et al.   BLOOD

Th17 and Regulatory T Cells in Mediating and Restraining Inflammation

(2010) Dan R. Littman et al.   CELL

CD161 is a marker of all human IL-17-producing T-cell subsets and is induced by RORC

(2010) Laura Maggi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Smad2 Positively Regulates the Generation of Th17 Cells

(2010) Gustavo J. Martinez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SMAD2 Is Essential for TGFβ-mediated Th17 Cell Generation

(2010) Nidhi Malhotra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice

(2010) Partha S. Biswas et al.   JOURNAL OF CLINICAL INVESTIGATION

TGF-  Enhances Effector Th1 Cell Activation but Promotes Self-Regulation via IL-10

(2010) D. J. Huss et al.   JOURNAL OF IMMUNOLOGY

TGF-  Induces IL-9 Production from Human Th17 Cells

(2010) G. Beriou et al.   JOURNAL OF IMMUNOLOGY

Smad2 and Smad3 Are Redundantly Essential for the TGF- -Mediated Regulation of Regulatory T Plasticity and Th1 Development

(2010) T. Takimoto et al.   JOURNAL OF IMMUNOLOGY

Role of SMAD and Non-SMAD Signals in the Development of Th17 and Regulatory T Cells

(2010) L. Lu et al.   JOURNAL OF IMMUNOLOGY

Generation of pathogenic TH17 cells in the absence of TGF-β signalling

(2010) Kamran Ghoreschi et al.   NATURE

The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27

(2010) Lionel Apetoh et al.   NATURE IMMUNOLOGY

T-bet represses TH17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγt

(2010) Vanja Lazarevic et al.   NATURE IMMUNOLOGY

Renal fibrosis: novel insights into mechanisms and therapeutic targets

(2010) Peter Boor et al.   Nature Reviews Nephrology

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

TGF-β indirectly favors the development of human Th17 cells by inhibiting Th1 cells

(2009) Veronica Santarlasci et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Plasticity of CD4+ T Cell Lineage Differentiation

(2009) Liang Zhou et al.   IMMUNITY

Critical Regulation of Early Th17 Cell Differentiation by Interleukin-1 Signaling

(2009) Yeonseok Chung et al.   IMMUNITY

Smad3 Differentially Regulates the Induction of Regulatory and Inflammatory T Cell Differentiation

(2009) Gustavo J. Martinez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

T-bet is essential for encephalitogenicity of both Th1 and Th17 cells

(2009) Yuhong Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Transforming growth factor β is dispensable for the molecular orchestration of Th17 cell differentiation

(2009) Jyoti Das et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Down-regulation of Gfi-1 expression by TGF-β is important for differentiation of Th17 and CD103+inducible regulatory T cells

(2009) Jinfang Zhu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Activin A Promotes the TGF- -Induced Conversion of CD4+CD25- T Cells into Foxp3+ Induced Regulatory T Cells

(2009) S. Huber et al.   JOURNAL OF IMMUNOLOGY

IL-17 Signaling-Independent Central Nervous System Autoimmunity Is Negatively Regulated by TGF- 

(2009) I. Gonzalez-Garcia et al.   JOURNAL OF IMMUNOLOGY

TGF-  Promotes Th17 Cell Development through Inhibition of SOCS3

(2009) H. Qin et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: IL-23 Receptor GFP Reporter Mice Reveal Distinct Populations of IL-17-Producing Cells

(2009) Amit Awasthi et al.   JOURNAL OF IMMUNOLOGY

The AP-1 transcription factor Batf controls TH17 differentiation

(2009) Barbara U. Schraml et al.   NATURE

The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17–producing effector T helper cells in vivo

(2009) Mandy J McGeachy et al.   NATURE IMMUNOLOGY

Interaction between the aryl hydrocarbon receptor and transforming growth factor-β signaling pathways: Evidence of an asymmetrical relationship in rat granulosa cells

(2008) Ursula A. Bussmann et al.   BIOCHEMICAL PHARMACOLOGY

Specific Microbiota Direct the Differentiation of IL-17-Producing T-Helper Cells in the Mucosa of the Small Intestine

(2008) Ivaylo I. Ivanov et al.   Cell Host & Microbe

Ski and SnoN, potent negative regulators of TGF-β signaling

(2008) Julien Deheuninck et al.   CELL RESEARCH

Non-Smad pathways in TGF-β signaling

(2008) Ying E Zhang   CELL RESEARCH

Molecular Antagonism and Plasticity of Regulatory and Inflammatory T Cell Programs

(2008) Xuexian O. Yang et al.   IMMUNITY

Th17 cells in human disease

(2008) Laura A. Tesmer et al.   IMMUNOLOGICAL REVIEWS

Foxp3 Inhibits RORγt-mediatedIL-17AmRNA Transcription through Direct Interaction with RORγt

(2008) Kenji Ichiyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human interleukin 17–producing cells originate from a CD161+CD4+T cell precursor

(2008) Lorenzo Cosmi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

(2008) Marc Veldhoen et al.   NATURE

Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor

(2008) Francisco J. Quintana et al.   NATURE

TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function

(2008) Liang Zhou et al.   NATURE

IL-21 and TGF-β are required for differentiation of human TH17 cells

(2008) Li Yang et al.   NATURE

Interactions among the transcription factors Runx1, RORγt and Foxp3 regulate the differentiation of interleukin 17–producing T cells

(2008) Fuping Zhang et al.   NATURE IMMUNOLOGY

A critical function for transforming growth factor-β, interleukin 23 and proinflammatory cytokines in driving and modulating human TH-17 responses

(2008) Elisabetta Volpe et al.   NATURE IMMUNOLOGY

The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt

(2008) Nicolas Manel et al.   NATURE IMMUNOLOGY

IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype

(2008) M. Huber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA