Review
Medicine, General & Internal
Athina Dimosiari, Dimitrios Patoulias, George D. Kitas, Theodoros Dimitroulas
Summary: Cardiovascular disease (CVD) is a global pandemic of the 21st century, with high morbidity, mortality, and economic burden. Inflammation plays a crucial role in the development and progression of CVD, particularly the NLRP3 inflammasome-IL-1/IL-6 pathway, which has been studied as a potential treatment target. However, evidence on the cardiovascular safety of IL-1 and IL-6 antagonists in patients without rheumatic disease is limited and conflicting. This review summarizes and critically presents the available evidence from randomized controlled trials and observational studies regarding the use of IL-1 and IL-6 antagonists in the treatment of CVD.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Masaru Takeuchi, Yoshihiko Usui, Kenichi Namba, Hiroshi Keino, Masaki Takeuchi, Hiroshi Takase, Koju Kamoi, Keitaro Hase, Takako Ito, Kei Nakai, Kazuichi Maruyama, Eri Kobayashi, Hisashi Mashimo, Tomohito Sato, Nobuyuki Ohguro, Junko Hori, Annabelle A. Okada, Koh-hei Sonoda, Nobuhisa Mizuki, Hiroshi Goto
Summary: This retrospective study evaluated the 10-year outcome of infliximab (IFX) treatment for uveitis in Behcet disease patients. The results showed that approximately 75% of patients continued IFX treatment for 10 years, and their visual acuity significantly improved and remained stable. Although half of the patients experienced recurrence of uveitis after treatment, there was no significant difference in visual acuity compared to those without recurrence.
FRONTIERS IN MEDICINE
(2023)
Article
Dermatology
Riko Takimoto-Ito, Naotomo Kambe, Toshiaki Kogame, Atsushi Otsuka, Takashi Nomura, Kazushi Izawa, Yuya Tabuchi, Hajime Yoshifuji, Yohei Takeuchi, Kenji Kabashima
Summary: Schnitzler syndrome is a rare condition characterized by chronic urticarial rash, recurrent fever, and bone pain. The pathophysiology is not well understood and treatment options are limited, but IL-1 and IL-6 targeted therapies may provide some symptomatic relief. Further research and long-term follow-up are needed to determine the impact of these treatments on preventing progression to hematopoietic disorders.
JOURNAL OF DERMATOLOGY
(2021)
Article
Dermatology
Angel Luis Salcedo-Mingoarranz, Maria Dorado-Fernandez, Sofia Garcia-Martinez, Paz Collado-Ramos, Nicolas Silvestre-Torner
Summary: Schnitzler syndrome (SchS) is a rare autoimmune and inflammatory disease mediated by interleukin-1 beta (IL-1β). Diagnosis requires recurrent monoclonal gammopathy and chronic urticarial rash according to the Strasbourg criteria. Treatment with canakinumab has been successful in a case of SchS after intolerance to anakinra and failure of other therapies. Canakinumab, an anti-IL-1β antibody, has proven to be an effective alternative to anakinra in SchS.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2023)
Review
Pharmacology & Pharmacy
Nicholas C. Schwier
Summary: Rilonacept is a safe IL-1 trap administered weekly subcutaneously, with proven efficacy in reducing the risk of recurrent pericarditis and promoting clinical response. It may be considered for patients needing weaning from standard background therapy.
ANNALS OF PHARMACOTHERAPY
(2022)
Article
Medicine, General & Internal
Shao-Huan Lan, Chi-Kuei Hsu, Shen-Peng Chang, Li-Chin Lu, Chih-Cheng Lai
Summary: This study evaluated the clinical efficacy and safety of interleukin-1 (IL-1) blockade for patients with COVID-19. The results showed that IL-1 blockade does not provide increased survival benefits in hospitalized patients with COVID-19, but it may reduce the need for mechanical ventilation. Furthermore, IL-1 blockade is a safe agent for use in the treatment of COVID-19.
ANNALS OF MEDICINE
(2023)
Review
Medicine, General & Internal
Marie-Eve Brien, Virginie Gaudreault, Katia Hughes, Dexter J. L. Hayes, Alexander E. P. Heazell, Sylvie Girard
Summary: This systematic review evaluates the safety and perinatal outcomes of IL-1 blockade during pregnancy. The findings suggest that IL-1 blockade is not associated with increased adverse perinatal outcomes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Rheumatology
Berkay Kilic, Yelin Guler, Feyza N. Azman, Ece Bostanci, Serdal Ugurlu
Summary: This study aimed to evaluate the efficacy and safety of anti-IL-1 agents in FMF patients. The results showed that anti-IL-1 agents significantly decreased levels of inflammatory markers and demonstrated good efficacy and low adverse events in adult and pediatric FMF patients.
Article
Rheumatology
Yusuf Karabulut, Halise Hande Gezer, Mehmet Tuncay Duruoez
Summary: This study presented the real-life experience of using canakinumab in adult patients with Familial Mediterranean fever resistant to standard therapy from two rheumatology clinics. The research found that canakinumab is effective and tolerable in reducing attacks in resistant FMF patients, suggesting it may be another treatment option for those who are non-responsive to colchicine and/or anakinra. Further studies with larger patient samples are needed to validate these findings.
RHEUMATOLOGY INTERNATIONAL
(2022)
Article
Pediatrics
Ilaria Maccora, Sarah Abu Rumeileh, Franco Curci, Cinzia de Libero, Edoardo Marrani, Maria Vincenza Mastrolia, Ilaria Pagnini, Gabriele Simonini
Summary: This study evaluated the efficacy of Tocilizumab and Abatacept for treating anti-TNF refractory CCU. The results showed a significantly higher remission rate for Tocilizumab compared to Abatacept.
FRONTIERS IN PEDIATRICS
(2022)
Review
Dermatology
Hakim Ben Abdallah, Karsten Fogh, Christian Vestergaard, Rikke Bech
Summary: Interleukin inhibitors have shown promising effectiveness in treating Pyoderma gangrenosum in adults, with response rates of 70% and complete response rates of 57%. Further studies are required to investigate the efficacy and underlying disease importance of different interleukin inhibitors for the treatment of PG.
Review
Immunology
Dennis D. Arnold, Ayla Yalamanoglu, Onur Boyman
Summary: This systematic review evaluates the safety and efficacy of anakinra, canakinumab, rilonacept, gevokizumab, and bermekimab compared to placebo, standard-of-care treatment or other biologics for the treatment of immune-mediated disorders. The review finds that these biologics have varying safety and efficacy profiles in treating specific diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Rheumatology
Alba Herrero-Morant, Jose Luis Martin-Varillas, Santos Castaneda, Olga Maiz, Julio Sanchez, Norberto Ortego, Enrique Raya, Agueda Prior-Espanol, Clara Moriano, Rafael B. Melero-Gonzalez, Jenaro Grana-Gil, Ana Urruticoechea-Arana, Angel Ramos-Calvo, Marta Loredo-Martinez, Eva Salgado-Perez, Francisca Sivera, Ignacio Torre, Javier Narvaez, Jose Luis Andreu, Olga Martinez-Gonzalez, Ricardo Gomez-de la Torre, Sabela Fernandez-Aguado, Susana Romero-Yuste, Inigo Gonzalez-Mazon, Carmen Alvarez-Reguera, Jose Luis Hernandez, Miguel angel Gonzalez-Gay, Ricardo Blanco
Summary: Biologic therapy appears to be effective and relatively safe in refractory neurobehcet's disease.
Review
Immunology
Stefano Rodolfi, Irene Nasone, Marco Folci, Carlo Selmi, Enrico Brunetta
Summary: Autoinflammatory diseases are immune-mediated conditions characterized by uncontrolled activation of the innate immune system. They share common clinical features and are typically treated with glucocorticoids and colchicine. However, targeting hyperinflammation via interleukin 1 has shown promise in the treatment of these diseases as well as non-immune-mediated diseases.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2022)
Review
Immunology
Caroline Vinit, Sophie Georgin-Lavialle, Aikaterini Theodoropoulou, Catherine Barbier, Alexandre Belot, Manel Mejbri, Pascal Pillet, Jana Pachlopnik, Sylvaine Poignant, Charlotte Rebelle, Andreas Woerner, Isabelle Kone-Paut, Veronique Hentgen
Summary: The main reasons for initiating IL-1 inhibitors in patients with familial Mediterranean fever, mevalonate kinase deficiency, and tumor necrosis factor receptor-associated periodic syndrome include treatment failure, continued disease activity, severe complications or comorbidities, and deterioration in quality of life.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Ophthalmology
Maria Tarsia, Carla Gaggiano, Elisa Gessaroli, Salvatore Grosso, Gian Marco Tosi, Bruno Frediani, Luca Cantarini, Claudia Fabiani
Summary: Posterior idiopathic scleritis is the most common type of scleritis observed in childhood, but anterior and necrotizing inflammatory scleritis can also occur. While less common than in adults, systemic disorders can be associated with scleral inflammation in children and should be promptly recognized and treated to prevent complications. A multidisciplinary diagnostic work-up is necessary to rule out infectious and autoimmune causes and tailor treatment to the specific patient.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Rheumatology
Federica Bello, Alessandra Bettiol, Elena Silvestri, Irene Mattioli, Maria Letizia Urban, Adalgisa Palermo, Matteo Mazzetti, Danilo Malandrino, Ilenia Calcaterra, Augusto Vaglio, Matteo Nicola Dario Di Minno, Giacomo Emmi, Domenico Prisco
Summary: Ultrasound markers of subclinical atherosclerosis are increased in EGPA patients as compared with controls, independently of traditional cardiovascular risk factors.
Article
Medicine, General & Internal
Sebastiano Cicco, Marco D'Abbondanza, Marco Proietti, Vincenzo Zaccone, Chiara Pes, Federica Caradio, Massimo Mattioli, Salvatore Piano, Alberto Maria Marra, Alessandro Nobili, Pier Mannuccio Mannucci, Antonello Pietrangelo, Giorgio Sesti, Elena Buzzetti, Andrea Salzano, Antonio Cimellaro
Summary: This study investigated the determinants and outcomes of antihypertensive drug prescription in older hospitalized patients. The findings suggest that adherence to guideline-recommended antihypertensive treatment is associated with a lower risk of adverse clinical outcomes.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Review
Rheumatology
Alessandra Bettiol, Fatma Alibaz-Oner, Haner Direskeneli, Gulen Hatemi, David Saadoun, Emire Seyahi, Domenico Prisco, Giacomo Emmi
Summary: Behçet syndrome is a rare chronic inflammatory disease with unknown causes, commonly characterized by mucocutaneous and ocular symptoms. Vascular involvement, including both venous and arterial thrombosis, is a unique feature of this syndrome. The pathogenesis involves impaired immune-inflammatory response and neutrophil-mediated mechanisms leading to thrombogenesis. Treatment primarily focuses on immunosuppressants rather than anticoagulation.
NATURE REVIEWS RHEUMATOLOGY
(2023)
Article
Medicine, General & Internal
Vincenzo Venerito, Andreina Manfredi, Antonio Carletto, Stefano Gentileschi, Fabiola Atzeni, Serena Guiducci, Marlea Lavista, Laura La Corte, Elisa Pedrollo, Arnaldo Scardapane, Caterina Tomassini, Bruno Frediani, Carlo Salvarani, Florenzo Iannone, Marco Sebastiani
Summary: The aim of this multicenter retrospective study was to investigate the effectiveness and safety of JAK-inhibitors (JAKi) in patients with rheumatoid arthritis (RA) and interstitial lung disease (ILD). The study suggests that JAKi therapy might be a safe therapeutic option for patients with RA-ILD in a short-term follow-up.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Rheumatology
Filippo Fagni, Alessandra Bettiol, Elena Silvestri, Roberto Fedi, Adalgisa Palermo, Maria Letizia Urban, Ruggero Mazzotta, Danilo Malandrino, Federica Bello, Irene Mattioli, David Simon, Gerardo Di Scala, Georg Schett, Domenico Prisco, Giacomo Emmi
Summary: A retrospective analysis found that enthesitis, defined as inflammation at the sites of tendon and ligament attachments to bone, is fairly common in patients with systemic lupus erythematosus (SLE). Patients with enthesitis had a distinct disease phenotype with less renal involvement, more arthritis, and a low response to anti-CD20 therapy.
Review
Immunology
Luca Quartuccio, Elena Treppo, Livio Urso, Giulia Del Frate, Federica Mescia, Federico Alberici, Augusto Vaglio, Giacomo Emmi
Summary: In recent years, there has been significant progress in clinical research and treatments for ANCA-associated vasculitis. However, there are still unanswered questions and unmet needs regarding AAV patients, such as predicting relapse and improving quality of life. Identifying predictors of relapse can optimize therapies and reduce side effects, while recognizing the long-term consequences of the disease and its treatment is crucial. This review aims to highlight achievements, challenges, and the perspectives of physicians and patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Medicine, General & Internal
Simone Perniola, Maria Sole Chimenti, Francesca Romana Spinelli, Bruno Frediani, Rosario Foti, Sara Ferrigno, Cristina Garufi, Giulia Cassone, Vincenzo Venerito, Fabiola Atzeni, Roberto Caporali, Fabrizio Conti, Ennio Giulio Favalli, Florenzo Iannone, Marco Sebastiani, Gian Franco Ferraccioli, Giovanni Lapadula, Elisa Gremese
Summary: Rheumatoid Arthritis (RA) is a complex disease with various clinical phenotypes, categorized by disease duration, seropositivity for rheumatoid factor (RF) and/or anti-citrullinated protein antibodies (ACPA), joint subtype, clinical behavior, and other subgroups. This review provides a summary of the multifaceted aspects of RA, specifically focusing on the association between autoimmune status and clinical outcomes, achievement of remission, and treatment response, as discussed in the 2022 International GISEA/OEG Symposium.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Miriana d'Alessandro, Laura Bergantini, Sara Gangi, Edoardo Conticini, Dalila Cavallaro, Paolo Cameli, Fabrizio Mezzasalma, Luca Cantarini, Bruno Frediani, Elena Bargagli
Summary: This study compared the expression of T and B cell subsets in sarcoidosis and B-mediated rheumatic diseases. They found significant differences in 15 cell subsets between sarcoidosis, rheumatic disorders, and controls. Principal components analysis and decision tree analysis were used to distinguish different diseases. This study sheds light on the immune cell profile and provides potential for biological therapies in treating sarcoidosis.
Article
Biology
Roberto D'Alessandro, Estrella Garcia Gonzalez, Paolo Falsetti, Edoardo Conticini, Miriana d'Alessandro, Enrico Selvi, Francesca Bellisai, Virginia Berlengiero, Giulia Vallifuoco, Anna Paola Pata, Marco Bardelli, Caterina Baldi, Luca Cantarini, Elena Bargagli, Bruno Frediani
Summary: This study evaluates the involvement of radial and ulnar arteries in SSc patients using ultrasound evaluation. The results show that ulnar artery occlusion is a unique feature of SSc, present in 28% of cases and associated with interstitial lung disease (ILD) and late nailfold-video-capillaroscopy (NVC) pattern.
Article
Biochemistry & Molecular Biology
Brunetta Porcelli, Miriana d'Alessandro, Latika Gupta, Silvia Grazzini, Nila Volpi, Maria Romana Bacarelli, Federica Ginanneschi, Giovanni Biasi, Francesca Bellisai, Marta Fabbroni, David Bennett, Claudia Fabiani, Luca Cantarini, Elena Bargagli, Bruno Frediani, Edoardo Conticini
Summary: This study assessed the diagnostic accuracy of anti-cN1A antibodies in patients with suspected IIM and evaluated the agreement between line immunoassay (LIA) and enzyme-linked immunoassay (ELISA). The results showed excellent concordance between LIA and ELISA for detecting anti-cN1A antibodies, suggesting that LIA could be a rapid and useful adjunct, and it could even replace ELISA for cN1A assay.
Article
Rheumatology
A. Manfredi, G. Cassone, R. Izzo, G. Dallagiacoma, M. Felicetti, A. Cariddi, A. Berti, A. Giollo, C. Nannini, S. Bettio, S. Monti, E. Conticini, M. Govoni, L. Quartuccio, L. M. Argolini, S. Kaleci, G. Emmi, C. Dejaco, R. Padoan, L. Dagna, M. Rossini, F. Cantini, C. Montecucco, B. Frediani, S. De Vita, R. Caporali, F. Muratore, M. Sebastiani, C. Salvarani
Summary: This study describes the presence of interstitial lung disease (ILD) in antineutrophil cytoplasmic antibodies-associated vasculitides (AAV). It found that non-specific interstitial pneumonia (NSIP) was the most common ILD pattern, observed in c-ANCA positive patients. The study also highlights the early complication of ILD in AAV and emphasizes the importance of early diagnosis by both pulmonologists and rheumatologists.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Edoardo Conticini, Paolo Falsetti, Claudia Fabiani, Caterina Baldi, Silvia Grazzini, Gian Marco Tosi, Luca Cantarini, Bruno Frediani
Summary: The aim of this study was to assess the role of Color Doppler Eye Ultrasound (CDEUS) in the differential diagnosis between arteritic and non-arteritic blindness. The results showed that CDEUS displayed good reliability in distinguishing between arteritic and non-arteritic central retinal artery occlusion (CRAO), but no significant difference was found in arteritic and non-arteritic anterior ischemic optic neuropathy (AION). Therefore, CDEUS is not a reliable procedure in the diagnostic work-up of giant cell arteritis (GCA) and should be restricted to the exclusion of thrombo-embolic occlusions within the territory of central retinal artery.
JOURNAL OF ULTRASOUND
(2023)
Article
Rheumatology
Caterina Matucci-Cerinic, Helene Palluy, Sulaiman Al-Mayouf, Paul A. Brogan, Luca Cantarini, Ahmet Gul, Ozgur Kasapcopur, Jasmin Kuemmerle-Deschner, Seza Ozen, David Saadoun, Farhad Shahram, Francesca Bovis, Eugenia Mosci, Nicolino Ruperto, Marco Gattorno, Isabelle Kone-Paut
Summary: The objective of this study was to validate the PEDiatric Behcet's Disease classification criteria (PEDBD) using an evidence-based approach. The results showed that the PEDBD criteria were highly specific, while the ICBD criteria were more sensitive. Further research is needed to evaluate the performance of the criteria.
