Review
Medicine, General & Internal
Morgane Joubert, Anne-Claire Desbois, Fanny Domont, Amine Ghembaza, Alexandre Le Joncour, Adrien Mirouse, Georgina Maalouf, Mathilde Leclercq, Sarah Touhami, Patrice Cacoub, Bahram Bodaghi, David Saadoun
Summary: Uveitis is a common and significant complication in Behcet's disease, with a high risk of blindness. It commonly presents as panuveitis, with bilateral involvement occurring after 2 years on average. Prompt management is crucial to achieve remission and preserve vision. Biologic therapies have revolutionized the treatment of uveitis in Behcet's disease.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Shizhao Yang, Zhaohao Huang, Yunwei Hu, Jian Zhang, Xiuxing Liu, He Li, Lihui Xie, Feng Wen, Dan Liang, Wenru Su
Summary: The study compared the efficacy of ADA with conventional therapy in treating retinal vasculitis in initial treatment of Behcet's Uveitis patients. The results showed significant improvements in patients in the ADA group, with fewer relapses, longer remission periods, better BCVA improvement, inflammation control, and lower glucocorticoid dosages compared to the conventional therapy group.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Tianyu Tao, Shizhao Yang, Daquan He, Zhaohuai Li, Binyao Chen, Lei Zhu, Wenru Su
Summary: This cross-sectional study investigated the efficacy and safety of dexamethasone implant, Ozurdex(R), as an adjunctive treatment for refractory Behcet's uveitis (BU). The study included 61 patients (80 eyes) divided into non-DEX and DEX groups. After >12 months of treatment, the DEX group showed significantly higher improvement in fluorescein angiography score and vitritis score compared to the non-DEX group. Despite worsening posterior capsule opacification score, the DEX group had higher usage of low-dose systemic glucocorticoid and fewer relapse times. Therefore, Ozurdex(R) is an effective and safe option for refractory BU patients, providing control of vasculitis, stabilization of vitreous inflammation, prevention of recurrence, and reduction of daily glucocorticoid doses.
CLINICAL IMMUNOLOGY
(2023)
Article
Immunology
Minghang Pei, Xinshu Liu, Peizeng Yang, Chan Zhao, Fei Gao, Yi Qu, Anyi Liang, Junyan Xiao, Meifen Zhang
Summary: IL33/ST2 gene polymorphisms are associated with the development of BDU, with specific alleles showing significant differences in BD patients with different clinical features, indicating the important role of IL33/ST2 in the pathogenesis of BDU.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Alessandra Bettiol, Filippo Fagni, Irene Mattioli, Giacomo Bagni, Gianfranco Vitiello, Alessia Grassi, Chiara Della Bella, Marisa Benagiano, Arianna Troilo, Katarzyna Stella Holownia, David Simon, Flavia Rita Argento, Jurgen Sota, Claudia Fabiani, Matteo Becatti, Claudia Fiorillo, Georg Schett, Giuseppe Lopalco, Luca Cantarini, Domenico Prisco, Elena Silvestri, Giacomo Emmi, Mario Milco D'Elios
Summary: In this study, the ability of serum interleukin (IL)-36a concentration to differentiate Behcet's syndrome (BS) from psoriatic arthritis (PsA) was investigated. The results showed significantly lower IL-36a concentrations in BS patients compared to PsA patients, although both groups had significantly higher IL-36a levels compared to healthy controls. A cut-off of 420.6 pg/mL displayed good specificity and sensitivity in discriminating PsA from BS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Julie Gueudry, Mathilde Leclercq, David Saadoun, Bahram Bodaghi
Summary: Behcet's disease is a systemic vasculitis disease primarily affecting young individuals, characterized by ocular involvement, venous and arterial occlusion, and potential rapid and severe vision loss. Early therapeutic intervention is crucial, but diagnosis remains a challenge.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Ophthalmology
Ghazala A. Datoo O'Keefe, Narsing Rao
Summary: Retinal vasculitis, involving inflammation or ischemia of the retinal vessel wall, can be associated with systemic processes or isolated to the retina. Due to limited ability for histopathological studies and lack of a gold standard for diagnosis, creating a classification system and improving diagnostic strategies are essential. This framework based on size, location, and etiology aims to provide diagnostic strategies for this complex condition.
SURVEY OF OPHTHALMOLOGY
(2021)
Article
Multidisciplinary Sciences
Mohammad Zarei, Hossein Pesarakli, Mehdi Yaseri, Hamed Etesali, Nazanin Ebrahimiadib
Summary: This study investigated the correlation of OCT parameters with fluorescein angiography in evaluating inflammatory activity in Behcet's retinal vasculitis. Results showed that parameters such as CSMT, PRT2.2, PRT3.45, and PNFLT had significant correlation with FA scores, with PRT3.45 and PNFLT showing the strongest correlation with angiographic inflammatory activity. These parameters may serve as non-invasive alternatives to FA for monitoring Behcet's retinal vasculitis.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Shizhao Yang, Zhaohao Huang, Xiuxing Liu, He Li, Lihui Xie, Xiaoqing Chen, Feng Wen, Dan Liang, Wenru Su
Summary: The study compared the effectiveness of adalimumab plus conventional therapy versus conventional therapy alone in treating patients with retinal vasculitis due to refractory Behcet's uveitis. Results showed that adalimumab plus conventional therapy outperformed conventional therapy alone in improving inflammatory parameters, reducing relapse time, and tapering daily glucocorticoid doses. Adverse events were mainly upper respiratory tract infection and gastrointestinal discomfort in the adalimumab group, while fewer adverse events were observed in the conventional therapy group.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Chun Yan, Fan Li, Min Hou, Xiaoyuan Ye, Lishi Su, Yixin Hu, Jiawen Luo, Wei Chi
Summary: The study revealed that patients with Behcet's uveitis showed significantly reduced vascular density in the peripapillary zone, especially in the inferior subfield of RPCN. There was a significant correlation between the reduction in RPCN vascular density and decreased BCVA in BU patients.
FRONTIERS IN MEDICINE
(2021)
Review
Medicine, General & Internal
Aniruddha Agarwal, Anne Ruebsam, Lynn zur Bonsen, Francesco Pichi, Piergiorgio Neri, Uwe Pleyer
Summary: In this review, the etiologies, clinical manifestations, and imaging advances in retinal vasculitis, such as OCTA and widefield imaging, have been comprehensively discussed.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Kai-Bao Ji, Zhe Hu, Qing-Lin Zhang, Hai-Feng Mei, Yi-Qiao Xing
Summary: This meta-analysis found that retinal microvasculature features, including macular whole enface vessel density (VD), foveal VD, parafoveal VD, and foveal avascular zones (FAZs), were significantly different between eyes with Behcet's disease (BD) and controls. The findings suggest that optical coherence tomography angiography (OCTA) can be useful for diagnosing and monitoring BD patients.
SCIENTIFIC REPORTS
(2022)
Review
Ophthalmology
Sruthi R. Arepalli, Akshay S. Thomas
Summary: This review discusses the causes and treatment options for occlusive retinal vasculitis (ORV), including genetic mutations associated with ORV, ORV caused by intraocular therapeutics, and ORV linked to Behcet's disease. Identifying the underlying etiology is crucial for guiding treatment, which involves treating underlying infections or autoimmune conditions, stopping any causative agents, and managing neovascular complications.
CURRENT OPINION IN OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Jurgen Sota, Stefano Gentileschi, Maria Orsetta Perfetti, Bruno Frediani, Gian Marco Tosi, Luca Cantarini, Claudia Fabiani
Summary: The study demonstrates the significant efficacy of SB5 in treating Behcet's syndrome-related uveitis, showing its ability to control inflammation relapses, resolve retinal vasculitis, and preserve visual acuity.
OPHTHALMOLOGY AND THERAPY
(2021)
Review
Medicine, General & Internal
Hanna Zajac, Anna Turno-Krecicka
Summary: Behcet's disease is a systemic vasculitis that commonly affects the oral, genital, and ocular regions, potentially leading to blindness. The first line treatment is azathioprine, with alternative immunosuppressive and biological agents used in severe or refractory cases.
JOURNAL OF CLINICAL MEDICINE
(2021)
Letter
Ophthalmology
Kubra Ozdemir Yalcinsoy, Yasemin Ozdamar Erol, Pinar Cakar Ozdal
Summary: This case report presents a case of panuveitis with granulomatous intraocular inflammation and vasculitis related to COVID-19. The patient exhibited blurred vision, anterior chamber cells, mutton fat keratic precipitates, and posterior synechiae. Retinal examinations revealed superficial retinal infiltrate lesions and periphlebitis in both eyes.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Ophthalmology
Pia Allegri, Luca Cimino, Janet L. Davis, Ilknur Tugal-Tutkun
Summary: This study investigated the effectiveness and safety of PHBC in reducing the number and intensity of HLA-B27-related AAU relapses. The results showed that compared to the placebo group, the PHBC group had fewer relapses and a higher proportion of responders, with comparable severity of attacks. Therefore, PHBC treatment may be beneficial.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Review
Rheumatology
Ilknur Tugal-Tutkun
Summary: This article reviews recently published data on Behcet disease (BD) uveitis, including the development of classification criteria and a diagnostic algorithm. It confirms the male predominance and posterior segment inflammation in the majority of BD uveitis patients, as well as the predictive factors for poor visual outcome. The article also highlights the efficacy of interferon-alpha, infliximab, and adalimumab compared to conventional therapy.
CURRENT OPINION IN RHEUMATOLOGY
(2023)
Article
Rheumatology
Rabia Deniz, Zeliha Emrence, Yasemin Yalcinkaya, Bahar Artim Esen, Murat Inanc, Mahdume Lale Ocal, Ahmet Gul
Summary: The skin pathergy test (SPT) conducted using a 20G needle prick and PS-23 antigens has been shown to have improved sensitivity in the diagnosis of Behcet disease (BD). This method can increase the diagnostic rate of BD, especially in patients with active disease.
Letter
Ophthalmology
Pinar Kaya, Pinar Cakar Ozdal
Summary: This study reports the clinical features and follow-up of a case with subretinal hypopyon due to syphilis infection. The patient, who was admitted with optic neuritis, was treated with intravenous pulse steroids without antibiotics. Subsequently, the patient was referred to the uvea clinic due to decreased vision and multiple retinitis foci. Subretinal hypopyon was diagnosed in the left eye, along with a positive TPHA test. Antibiotic therapy resulted in significant regression of retinitis and hypopyon.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Ophthalmology
Pinar Kaya, Merve Inanc Tekin, Pinar Cakar Ozdal
Summary: The purpose of this study was to identify the prognostic factors in Vogt-Koyanagi-Harada (VKH) disease. The study included 23 patients with acute-phase VKH, divided into two subgroups: acute-resolved (10 patients) and chronic-recurrent (13 patients). The results showed that older patients and/or those with extraocular findings at presentation were more likely to show recurrences. The initiation of immunomodulatory therapy did not affect the prognosis.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Rheumatology
Shirkhan Amikishiyev, M. Guven Gunver, Murat Bektas, Sarvan Aghamuradov, Burak Ince, Nevzat Koca, Ege Sinan Torun, Numune Aliyeva, Selma Sari, Cigdem Cetin, Banu C. Yalcin-Dulundu, Rabia Deniz, Fatih Kemik, Besim Fazil Agargun, Ubeyde Ayse Gulseren, Beliz Besisik, Onur Alkan, Ceren Bagriacik, Yavuz B. Tor, Naci Senkal, Yunus Catma, Gorkem Durak, Sevim Mese, Ali Agacfidan, Murat Kose, Mustafa Erelel, A. Atahan Cagatay, Serap Simsek-Yavuz, Sevgi Kalayoglu-Besisik, Figen Esen, Ahmet Guel
Summary: This study aimed to identify criteria for early detection of hyperinflammation (HI) in patients with COVID-19, and found a 12-item criteria that showed high sensitivity and specificity. The use of these criteria can help identify patients in need of treatment earlier and initiate timely interventions.
ARTHRITIS & RHEUMATOLOGY
(2023)
Letter
Ophthalmology
Pinar Kaya, Merve Inanc Tekin, Pinar Cakar Ozdal
Summary: Aggressive treatment, including immunomodulatory therapy, is crucial in preventing the development of the chronic recurrent stage in Vogt-Koyanagi-Harada (VKH) disease, but it is not the sole determinant of prognosis as there are other factors that can influence the outcome.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Editorial Material
Ophthalmology
Emmett T. T. Cunningham Jr, Mamta Agarwal, Derrick P. Smit, Ilknur Tugal-Tutkun, Jennifer E. Thorne
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Medicine, General & Internal
Elif Arslanoglu Aydin, Semanur Ozdel, Pinar Cakar Ozdal, Ilknur Bagrul, Esra Baglan, Serife Tuncez, Mehmet Bulbul
Summary: The aim of this study was to compare the clinical features of pediatric uveitis between the pandemic and pre-pandemic periods. A total of 187 children diagnosed with uveitis were included in this retrospective study. The results showed that the number of uveitis cases doubled during the pandemic period compared to the pre-pandemic period, and the frequency of anterior uveitis was significantly higher in the pandemic period.
POSTGRADUATE MEDICINE
(2023)
Review
Medicine, General & Internal
Carl P. Herbort Jr, Masaru Takeuchi, Ioannis Papasavvas, Ilknur Tugal-Tutkun, Alireza Hedayatfar, Yoshihiko Usui, Pinar C. Ozdal, Cristhian A. Urzua
Summary: The availability of dual fluorescein and indocyanine green angiography has enabled global and precise follow-up of uveitis, while additional non-invasive imaging methods, including OCT, EDI-OCT, BAF, and OCT-A, have brought value-added precision to uveitis imaging. This review examines the evidence for the potential replacement of dye angiographic methods by OCT-A and discusses its practical impact.
Article
Chemistry, Medicinal
Ozge Soylu-Eter, Zekiye Seyma Sevincli, Betul Ersoy, Bahar Hasanusta, Ugur Gatfar, Nathan A. Lack, Burak Erman, Ahmet Gul, Hakan S. Orer, Nilgun Karali
Summary: This study aimed to develop drugs with anti-interleukin-1 activity. Through evaluation and screening of compounds, as well as in vitro studies and molecular modeling, it was found that compounds 78 and 81 had the strongest IL-1 receptor inhibitory effects and the most favorable drug-like properties.
ARCHIV DER PHARMAZIE
(2023)
Article
Rheumatology
Murat Bektas, Nevzat Koca, Emin Oguz, Selma Sari, Gizem Dagci, Burak Ince, Pelin Karaca Ozer, Besim Fazil Agargun, Yasemin Yalcinkaya, Bahar Artim-Esen, Lale Ocal, Murat Inanc, Ahmet Gul
Summary: This study evaluated the clinical, laboratory, and genetic characteristics of patients with AA amyloidosis in Turkey. It found that FMF is the most common cause of AA amyloidosis and patients with homozygous or compound heterozygous MEFV exon 10 variants tend to develop the disease earlier. Patients with a low estimated glomerular filtration rate at admission had a higher risk of progressing to end-stage renal disease. The study also found that the mortality rate increased with the amyloid burden.
Article
Clinical Neurology
Seher Koeksaldi, Rahmi Tumay Ala, Ibrahim Oztura, Emre Emirbayer, Gulden Akdal, Sinan Emre, Ilknur Tugal-Tutkun, Ali Osman Saatci
Summary: This case report describes the OCTA findings of retinal lesions in a patient with SSPE. The OCTA showed flow deficit areas and reduced vessel density. The patient presented with various neurological and neuropsychological symptoms, and brain MRI revealed non-specific small foci of T2 hyperintensity.
NEURO-OPHTHALMOLOGY
(2023)
