Review
Cell Biology
Anna Waskiel-Burnat, Marta Osinska, Anna Salinska, Leszek Blicharz, Mohamad Goldust, Malgorzata Olszewska, Lidia Rudnicka
Summary: Alopecia areata is characterized by dysregulation of various systemic cytokines including Th1, Th2, and Th17. The severity and duration of the disease are positively correlated with elevated levels of certain cytokines, while others may serve as potential predictors of therapeutic efficacy.
Article
Cell Biology
Xiaoxu Duan, Guowei Xu, Jinlong Li, Nan Yan, Xin Li, Xuping Liu, Bing Li
Summary: This study found that arsenic induces continuous immune-inflammatory responses in the liver and kidney, leading to structural damage and inflammatory infiltration. It also enhances the expression of inflammatory factors and affects the differentiation of T cells and immune balance.
MEDIATORS OF INFLAMMATION
(2022)
Article
Medicine, Research & Experimental
Le Lv, Ziyang Chen, Wenhui Bai, Jiahui Hao, Zhengang Heng, Caijin Meng, Lin Wang, Xianglan Luo, Xinmiao Wang, Yanjun Cao, Jiao He
Summary: This study aimed to explore the efficacy of THDCA on ulcerative colitis and to reveal its mechanisms of action. The results showed that THDCA can significantly alleviate colitis and exert its effects by regulating the Th1/Th2 and Th17/Treg balance.
Article
Dentistry, Oral Surgery & Medicine
S. Leng, W. Xu, L. Wu, L. Liu, J. Du, F. Yang, D. Huang, L. Zhang
Summary: Apical periodontitis is an inflammatory condition caused by immunological reaction to invading bacteria. NLRP3 plays a crucial role in the pathogenesis of this condition by disturbing the balance between Treg and Th17 cells. The dysregulation of NLRP3 exacerbates periapical inflammation and bone resorption.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Vafa Baradaran Rahimi, Saeideh Saadat, Pouria Rahmanian Devin, Ali Jebalbarezy, Maryam Moqaddam, Mohammad Hossein Boskabady, Vahid Reza Askari
Summary: Crocetin, a natural compound derived from Crocus sativus, has immunoregulatory and anti-inflammatory properties, which allow it to modulate the immune response in human lymphocytes. It can decrease pro-inflammatory cytokines and increase anti-inflammatory cytokines, promoting a shift towards a Th1 and Treg dominant response.
Article
Clinical Neurology
Yi Zhang, Chenglin Niu
Summary: The study suggests that CDC42 may be associated with the progression and cognitive decline in Alzheimer's disease, and has the potential to serve as a biomarker for estimating AD risk and progression.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2022)
Review
Microbiology
Ekaterina Martynova, Albert Rizvanov, Richard A. Urbanowicz, Svetlana Khaiboullina
Summary: This review focuses on the mechanisms of inflammasome activation and their role in the development of Th1, Th2, and Th17 lymphocytes. The contribution of cytokines released from activated inflammasomes to the immune response is summarized, along with the discussion of the role of cytokines released from tissue cells in promoting lymphocyte differentiation.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Immunology
Weihang Luo, Jindong Hu, Weifang Xu, Jingcheng Dong
Summary: The immune response in the asthmatic respiratory tract is driven by CD4(+) T helper cells, especially Th2 cells. Asthma is a heterogeneous and progressive disease, with different stages of the disease course showing different immune responses. The complex immune networks in the inflammatory airway make it challenging to find a universal treatment for all asthmatics.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Veronique Corbiere, Eleonora E. Lambert, Marine Rodesch, Jacqueline A. M. van Gaans-van den Brink, Alicja Misiak, Elles Simonetti, Anne Van Praet, Audrey Godefroid, Dimitri A. Diavatopoulos, Cecile A. C. M. van Els, Francoise Mascart
Summary: This study developed a two-step assay for evaluating the immunogenicity of pertussis vaccines. It involved stimulating fresh whole blood with pertussis antigens, cryopreserving the stimulated cells, and later analyzing cytokine production using flow cytometry. The assay demonstrated high reproducibility and sensitivity, allowing for the accurate quantification of pertussis antigen-specific Th1, Th2, and Th17-type CD4(+) T cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Lisa Hirahara, Kaoru Takase-Minegishi, Yohei Kirino, Yuki Iizuka-Iribe, Yutaro Soejima, Ryusuke Yoshimi, Hideaki Nakajima
Summary: Behcet's disease is a systemic inflammatory disease characterized by recurrent oral ulcers, genital ulcers, cutaneous inflammation, and uveitis. The pathogenesis of BD is not fully understood, but it is likely a result of genetic susceptibility and environmental factors. This review discusses the roles of monocytes and macrophages in BD and their potential as therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Hannes Lindahl, Tomas Olsson
Summary: IL-22 is a significant interleukin that plays a crucial role in the immune system and tissue repair, particularly in T cell-driven inflammatory diseases. Its influence on T cells has not been fully understood so far, and further research is needed to explore its role in promoting regulatory T cell responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Dermatology
Hyun Jeong Ju, Hyo Jin Park, In Hye Choi, Kyung Ho Lee, Mi Yeon Kwon, Chul Jong Park
Summary: This study found that the levels of Th1 and Th17 cytokines in tissues were increased in psoriasis patients compared to healthy controls. The increase in IFN-gamma mRNA levels in acute guttate psoriasis and the increase in IL-12 and IL-17A protein levels in chronic plaque psoriasis suggest that an imbalance between Th1 and Th17 cytokines may play a role in the phenotypic transition of psoriasis.
ANNALS OF DERMATOLOGY
(2022)
Article
Immunology
Aimaiti Yasen, Wending Li, Abudusalamu Aini, Bo Ran, Tiemin Jiang, Yingmei Shao, Tuerganaili Aji, Hao Wen
Summary: This study revealed an association between the expression of Th1/Th2/Th17-type cytokines and cyst stages in hepatic echinococcosis (CE) patients. Th1 and Th17-type cytokines were predominant in patients with inactive cysts, while Th2-type cytokines were more evident in patients with active cysts.
PARASITE IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Faruque Parvez, Fredine T. Lauer, Pam Factor-Litvak, Tariqul Islam, Mahbubul Eunus, M. Abu Horayara, Mizanour Rahman, Golam Sarwar, Habibul Ahsan, Joseph H. Graziano, Scott W. Burchiel
Summary: Limited evidence suggests that environmental exposure to arsenic affects the immune system in adults. Urinary arsenic and its metabolites have been found to modulate the number of T-helper 17 cells and IL-17A cytokine production. The associations between urinary arsenic and Th17 cell numbers are nonlinear in non-smoking women, while significant decreases in Th17 cell numbers are observed in smoking males. Vitamin D levels can modify these associations.
Article
Oncology
Zhiguo Peng, Xinyue Dong, Miao He, Yajing Zhao, Yujia Liu, Mo Li, Guosheng Li, Xiuwen Wang, Li Li, Yu Hu
Summary: This study found that the expression levels of Th22, Th17, Th1, and Th2 cell subsets were significantly increased in breast cancer patients. Th22 cells were found to be associated with molecular classification and clinical outcomes of breast cancer. These cell subsets may play a critical role in the development of breast cancer and have the potential to be used as clinical markers.
Article
Allergy
Mohammad-Reza Yazdani, Elham Aflaki, Nasser Gholijani
IRANIAN JOURNAL OF ALLERGY ASTHMA AND IMMUNOLOGY
(2020)
Article
Allergy
Kurosh Kalantar, Zahra Farzaneh, Nasser Gholijani, Seyed Younes Hosseini, Ebrahim Bani Hasan
IRANIAN JOURNAL OF ALLERGY ASTHMA AND IMMUNOLOGY
(2020)
Article
Orthopedics
Firoozeh Estakhri, Mohammad Reza Panjehshahin, Nader Tanideh, Rasoul Gheisari, Amir Mahmoodzadeh, Negar Azarpira, Nasser Gholijani
Article
Dermatology
Saeed Malek Hosseini, Naser Gholijani, Nooshafarin Chenari, Kurosh Kalantar
ANAIS BRASILEIROS DE DERMATOLOGIA
(2020)
Article
Medicine, General & Internal
Maryam Zarrabi, Mohammadali Nazarinia, Abbas Rahimi Jaberi, Nasser Gholijani, Zahra Amirghofran
Summary: The study found that serum levels of IL-38 were significantly higher in newly diagnosed or recently untreated patients with multiple sclerosis and systemic sclerosis compared to treated patients and healthy controls, suggesting a potential role of this cytokine in the development of these diseases or as part of a feedback loop to attenuate inflammation in the early stages.
MEDICAL PRINCIPLES AND PRACTICE
(2021)
Article
Microbiology
Alireza Shiri, Jamal Sarvari, Saeed Firoozi Ghahestani, Nasser Gholijani, Ali Mohammad Tamaddon, Mahroo Rastegari, Afagh Moattari, Seyed Younes Hosseini
Summary: The study found that coagulation factors have an impact on the expression of inflammatory and fibrotic genes in adenovirus, with the Ad36 complex loaded with FVII inducing a higher level of inflammation response.
CURRENT MICROBIOLOGY
(2021)
Article
Rheumatology
Saeedeh Shenavandeh, Mozhdeh Sepaskhah, Sanaz Dehghani, MohammadAli Nazarinia
Summary: Both BTX-A and prostaglandins showed clinical benefits in treating resistant digital ulcers in patients with systemic sclerosis, aiding in healing and pain control. Capillaroscopy revealed a significant reduction in microhemorrhages in both treatment groups. The cost of treatment was significantly lower in the BTX-A group.
CLINICAL RHEUMATOLOGY
(2022)
Article
Rheumatology
Saeedeh Shenavandeh, Mehrnoush Ajri, Sahand Hamidi
Summary: Capillaroscopy is a useful tool for distinguishing primary and secondary causes in patients with RP. This retrospective cohort study aimed to evaluate the causes of RP in a specific area and identify prognostic factors indicating a definite CTD or remaining a UCTD. The study found that the most prevalent causes of secondary RP were UCTD and SSc, and certain capillaroscopy and laboratory results could serve as predictive markers for the transition from UCTD to CTD.
Article
Rheumatology
Saeedeh Shenavandeh, Hamed Ghoddusi Johari, Elham Aflaki
Summary: These two cases demonstrate that both arterial and venous involvement can progress in patients with Behcet's disease, suggesting that the same inflammatory process may be responsible for both arterial and venous manifestations. Therefore, early immunosuppressive treatment should be considered to improve the prognosis.
CURRENT RHEUMATOLOGY REVIEWS
(2022)
Article
Rheumatology
Saeedeh Shenavandeh, Arash Mani, Mehdi Eazadnegahdar, Ali Nekooeian
Summary: Patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) commonly exhibit medication non-adherence due to factors such as depression. In SLE patients, depression and poor prognostic factors impact adherence, while in RA patients, comorbid diseases, depression, and higher pill numbers play a significant role in non-adherence. Factors like income, health insurance, disease duration, and health literacy do not have a significant effect on medication adherence.
CURRENT RHEUMATOLOGY REVIEWS
(2021)
Article
Pharmacology & Pharmacy
Peyman Bemani, Sajad Jalili, Kazem Hassanpour, Fouziyeh Faraji, Nasser Gholijani, Mahdi Barazesh, Mozafar Mohammadi, Gholamreza Farnoosh
Summary: In this study, a multi-epitope vaccine based on Tregitope was designed to induce tolerance in pathogenic myelin-specific T cells in multiple sclerosis. Computational predictions showed that this vaccine can regulate disease progression and prevent relapse by controlling the activation of pathogenic T cells.
CURRENT DRUG SAFETY
(2023)
Article
Immunology
Pooriya Fazeli, Atefe Ghamar Talepoor, Zahra Faghih, Nasser Gholijani, Mohammad Reza Ataollahi, Mohammad Ali-Hassanzadeh, Hossein Moravej, Kurosh Kalantar
Summary: In patients with T1D, the frequency of CD4(+) TSCM is increased, while the percentage of CD8(+) T naive cells is also higher. Moreover, increased PD-1 expression is observed on CD4(+)TCM and TCMhi cells in LT patients, as well as on CD8(+) TCM and TCMhi cells in both NC and LT patients.
IMMUNITY INFLAMMATION AND DISEASE
(2022)
Article
Immunology
Paria Heydarinejad, Nasser Gholijani, Zahra Habibagahi, Mohammad Reza Malekmakan, Zahra Amirghofran
Summary: The study found that FOXP3 polymorphisms are associated with systemic lupus erythematosus (SLE) susceptibility and patients' characteristics. The rs3761548 C/- genotype was associated with disease susceptibility in male patients, while both SNPs were associated with the risk of abortion in female patients. Additionally, there were correlations between these SNPs and several clinical features of the patients.
IRANIAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Firoozeh Estakhri, Mohammad Reza Panjehshahin, Nader Tanideh, Rasoul Gheisari, Negar Azarpira, Nasser Gholijani
Summary: This study investigated the effect of co-injection of apigenin and synovial membrane-derived mesenchymal stem cells (SMMSCs) on osteoarthritis in male rats' knee joints. The results suggest that apigenin may have additional beneficial effects on cell therapy by reducing oxidative stress, suppressing inflammation, and promoting the production of extracellular matrix (ECM) components.
IRANIAN JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Medicine, General & Internal
Elham Aflaki, Saman Farahangiz, Alireza Salehi
IRANIAN JOURNAL OF MEDICAL SCIENCES
(2020)
