Article
Multidisciplinary Sciences
Ka Lung Cheung, Anbalagan Jaganathan, Yuan Hu, Feihong Xu, Alannah Lejeune, Rajal Sharma, Cristina I. Caescu, Jamel Meslamani, Adam Vincek, Fan Zhang, Kyung Lee, Nilesh Zaware, Amina Abdul Qayum, Chunyan Ren, Mark H. Kaplan, John Cijiang He, Huabao Xiong, Ming-Ming Zhou
Summary: This study uncovers a previously unrecognized mechanism of self-directed cell type-specific regulation of the master transcription factor Stat3 through its own transcriptional target Hipk2 in Th17 cell differentiation. These findings provide insights into the regulation of Th17 cell immune functions and suggest a therapeutic strategy for developing targeted therapies for Th17-associated inflammatory disorders.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Cell Biology
Vojo Deretic, Guido Kroemer
Summary: Autophagy is both a metabolic process and a quality control process, involving specific receptors that selectively remove various intracellular targets. It is regulated by master regulators of cellular metabolism such as MTOR and AMPK, making the system responsive to amino acid and glucose starvation.
Article
Chemistry, Medicinal
Yao-Jun Liu, Wei-Heng Xu, Li-Ming Fan, Yu-Qin Zhang, Wen Xu, Ya-Ping Chen, Lin-Lin Chen, Li Chen, Wei Xu, Yan Wang, Ke-Dan Chu, Jun-Ping Zhang
Summary: This study found that polydatin can inhibit the differentiation of Th17 cells and alleviate inflammatory bowel disease. By inhibiting the phosphorylation of STAT3, polydatin reduces the number of Th17 cells and relieves colitis.
PHYTOTHERAPY RESEARCH
(2022)
Article
Multidisciplinary Sciences
Lachlan P. Deimel, Zheyi Li, Sreeja Roy, Charani Ranasinghe
Summary: The production of IL-4 is associated with low-avidity, poorly cytotoxic T cell induction, which contributes to viral immune evasion and the failure of T cell-based vaccines. Research indicates that cells can dynamically alter their IL-4/IL-13 receptor signature to modulate downstream immune outcomes. The findings suggest that IL-4 stimulation down-regulates the expression of TGF-beta 1 and IFN-gamma R1 on naive T cells, affecting lineage commitment decisions.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Nicholas W. Chavkin, Gael Genet, Mathilde Poulet, Erin D. Jeffery, Corina Marziano, Nafiisha Genet, Hema Vasavada, Elizabeth A. Nelson, Bipul R. Acharya, Anupreet Kour, Jordon Aragon, Stephanie P. McDonnell, Mahalia Huba, Gloria M. Sheynkman, Kenneth Walsh, Karen K. Hirschi
Summary: Different endothelial cell cycle states provide distinct windows of opportunity for the molecular induction of arterial vs. venous fate during blood vessel development.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Annachiara Tesoriere, Alberto Dinarello, Francesco Argenton
Summary: STAT3 is a crucial transcription factor regulating cell growth and proliferation by controlling gene transcription; it plays significant roles in cancer progression, with different post-translational modifications having opposite effects in different cellular models; the extensive results from various studies show that post-translational modifications drastically alter STAT3 activities, necessitating further analysis to fully elucidate its multifaceted functions.
Article
Immunology
Li-Ming Fan, Yu-Qin Zhang, Ya-Ping Chen, Lin-Lin Chen, Wei-Heng Xu, Li-Hong Nan, Wei Xu, Bin Lu, Yan Wang, Ke-Dan Chu, Jun-Ping Zhang
Summary: The study demonstrates that cryptotanshinone (CTS) can alleviate acute and chronic ulcerative colitis (UC) by suppressing STAT3 activation and Th17 cell differentiation, suggesting it as a promising candidate drug for UC treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Cell Biology
Xinxin Chi, Wei Jin, Xue Bai, Xiaohong Zhao, Jing Shao, Jiaqi Li, Qinli Sun, Bing Su, Xiaohu Wang, Xuexian O. Yang, Chen Dong
Summary: The study found that RORα is highly expressed in active UC patients, especially in those non-responsive to anti-TNF treatment. RORα plays a crucial role in promoting IBD development in CD4(+) T cells by regulating T cell infiltration, inhibiting T cell apoptosis, and promoting mTORC1 activation. This indicates that the RORα-mTORC1 axis may be a potential therapeutic target for human patients with IBD.
Article
Cell Biology
Leticia Soriano-Baguet, Melanie Grusdat, Henry Kurniawan, Mohaned Benzarti, Carole Binsfeld, Anouk Ewen, Joseph Longworth, Lynn Bonetti, Luana Guerra, Davide G. Franchina, Takumi Kobayashi, Veronika Horkova, Charlene Verschueren, Sergio Helgueta, Deborah Gerard, Tushar H. More, Antonia Henne, Catherine Dostert, Sophie Farinelle, Antoine Lesur, Jean-Jacques Gerardy, Christian Jager, Michel Mittelbronn, Lasse Sinkkonen, Karsten Hiller, Johannes Meiser, Dirk Brenner
Summary: Pyruvate dehydrogenase (PDH) plays a crucial role in the metabolism and function of T helper 17 (Th17) cells. PDH is necessary for the generation of a glucose-derived citrate pool, which is essential for Th17 cell proliferation, survival, and effector function. In the absence of PDH, Th17 cells exhibit increased glutaminolysis, glycolysis, and lipid uptake, but critically low levels of cellular citrate, leading to impaired oxidative phosphorylation, lipid synthesis, and histone acetylation.
Article
Oncology
Marco Rossi, Emanuela Altomare, Cirino Botta, Maria Eugenia Gallo Cantafio, Sarai Sarvide, Daniele Caracciolo, Caterina Riillo, Marco Gaspari, Domenico Taverna, Francesco Conforti, Paola Critelli, Bernardo Bertucci, Michelangelo Iannone, Nicoletta Polera, Domenica Scumaci, Mariamena Arbitrio, Nicola Amodio, Maria Teresa Di Martino, Bruno Paiva, Pierosandro Tagliaferri, Pierfrancesco Tassone
Summary: The study demonstrated that miR-21 plays a crucial role in Th17-mediated tumor growth and bone disease in multiple myeloma, with inhibition of miR-21 leading to reduced pathology. Early inhibition of miR-21 in T cells (miR-21i-T cells) was found to impair Th17 differentiation, thereby decreasing MM cell proliferation and osteoclast activity.
Article
Immunology
Yuye Yin, Xinyi Yang, Shusheng Wu, Xinyu Ding, Huamin Zhu, Xuehui Long, Yuliang Wang, Sulan Zhai, Yun Chen, Nan Che, Jingjing Chen, Xiaoming Wang
Summary: This study reveals the critical role of Jmjd1c in regulating plasma cell differentiation and rheumatoid arthritis (RA) in B cells. Jmjd1c demethylates STAT3, maintains its normal activity, and restrains plasma cell generation.
Article
Multidisciplinary Sciences
Sang-A Park, Yun-Ji Lim, Wai Lim Ku, Dunfang Zhang, Kairong Cui, Liu-Ya Tang, Cheryl Chia, Peter Zanvit, Zuojia Chen, Wenwen Jin, Dandan Wang, Junji Xu, Ousheng Liu, Fu Wang, Alexander Cain, Nancy Guo, Hiroko Nakatsukasa, Chuan Wu, Ying E. Zhang, Keji Zhao, WanJun Chen
Summary: This study reveals that the differentiation of IL-9-producing Th9 cells is regulated by TGF-beta and IL-4 signals through pSmad3L-Ser(213), and the transcription factors DBP and E2F8 have opposing effects on Il9 gene transcription.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Alexandre Larange, Ikuo Takazawa, Kiyokazu Kakugawa, Nicolas Thiault, Soomun Ngoi, Meagan E. Olive, Hitoshi Iwaya, Laetitia Seguin, Ildefonso Vicente-Suarez, Stephane Becart, Greet Verstichel, Ann Balancio, Amnon Altman, John T. Chang, Ichiro Taniuchi, Bjorn Lillemeier, Mitchell Kronenberg, Samuel A. Myers, Hilde Cheroutre
Summary: This study uncovers the role of retinoic acid receptor alpha (RARa) in T cells. Retinoic acid (RA) promotes immune activation and tolerance through regulation of RARa transcriptional activity, and RARa is also found to function in the cytoplasm. Extranuclear RARa is rapidly phosphorylated and recruited to the TCR signalosome upon TCR stimulation. RA interferes with extranuclear RARa signaling, leading to suboptimal TCR activation and enhanced FOXP3+ regulatory T cell conversion. TCR activation induces the expression of CRABP2, which transports RA to the nucleus. Deletion of CRABP2 increases cytoplasmic RA and disrupts signalosome-associated RARa, resulting in impaired immune response.
Article
Biochemistry & Molecular Biology
Le Sun, Yu Yan, Heng Lv, Jianlong Li, Zhiyuan Wang, Kun Wang, Lin Wang, Yunxia Li, Hong Jiang, Yaoyang Zhang
Summary: This study discovered STAT3 as a direct functional protein target of rapamycin using a chemical proteomics strategy. Rapamycin inhibits tumor growth in hepatocellular carcinoma by suppressing c-Myc-regulated gene expression. These findings provide important information for the development of STAT3 inhibitors for cancer therapy.
CELL CHEMICAL BIOLOGY
(2022)
Article
Immunology
Magalie Michee-Cospolite, Marina Boudigou, Alexis Grasseau, Quentin Simon, Olivier Mignen, Jacques-Olivier Pers, Divi Cornec, Laetitia Le Pottier, Sophie Hillion
Summary: Regulatory B cells (Bregs) play important roles in various pathological conditions by producing IL-10 and utilizing multiple suppressing mechanisms to modulate immune response. The molecular regulation of Bregs is not fully understood, and this manuscript provides detailed insights into the role of transcription factors STAT3 and c-MAF in controlling IL-10 production in B cells and their significance in the Breg response.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Youn Sook Lee, Jin Seok Park, Su Myung Jung, Sang-Doo Kim, Jun Hwan Kim, Jae Young Lee, Kyeong Cheon Jung, Mizuko Mamura, Sangho Lee, Seong-Jin Kim, Yoe-Sik Bae, Seok Hee Park
EMBO MOLECULAR MEDICINE
(2015)
Article
Allergy
[Anonymous]
WORLD ALLERGY ORGANIZATION JOURNAL
(2016)
Article
Medicine, Research & Experimental
Jeong-Hwan Yoon, Su Myung Jung, Seok Hee Park, Mitsuyasu Kato, Tadashi Yamashita, In-Kyu Lee, Katsuko Sudo, Susumu Nakae, Jin Soo Han, Ok-Hee Kim, Byung-Chul Oh, Takayuki Sumida, Masahiko Kuroda, Ji-Hyeon Ju, Kyeong Cheon Jung, Seong Hoe Park, Dae-Kee Kim, Mizuko Mamura
EMBO MOLECULAR MEDICINE
(2013)
Correction
Medicine, Research & Experimental
Jeong-Hwan Yoon, Su Myung Jung, Seok Hee Park, Mitsuyasu Kato, Tadashi Yamashita, In-Kyu Lee, Katsuko Sudo, Susumu Nakae, Jin Soo Han, Ok-Hee Kim, Byung-Chul Oh, Takayuki Sumida, Masahiko Kuroda, Ji-Hyeon Ju, Kyeong Cheon Jung, Seong Hoe Park, Dae-Kee Kim, Mizuko Mamura
EMBO MOLECULAR MEDICINE
(2014)
Article
Biochemistry & Molecular Biology
Ok-Hee Kim, Gun-Hyung Kang, Hyungjoon Noh, Ji-Young Cha, Ho-Jae Lee, Jeong-Hwan Yoon, Mizuko Mamura, Jeong-Seok Nam, Dae Ho Lee, Young A. Kim, Young Joo Park, Hyeonjin Kim, Byung-Chul Oh
MOLECULES AND CELLS
(2013)
Correction
Biochemistry & Molecular Biology
Ok-Hee Kim, Gun-Hyung Kang, Hyungjoon Noh, Ji-Young Cha, Ho-Jae Lee, Jeong-Hwan Yoon, Mizuko Mamura, Jeong-Seok Nam, Dae Ho Lee, Young A. Kim, Young Joo Park, Hyeonjin Kim, Byung-Chul Oh
MOLECULES AND CELLS
(2014)
Editorial Material
Immunology
Jong-Young Kwak, Mizuko Mamura, Jana Barlic-Dicen, Evelin Grage-Griebenow
JOURNAL OF IMMUNOLOGY RESEARCH
(2014)
Review
Immunology
Seung Min Jung, Kyoung Woon Kim, Chul-Woo Yang, Sung-Hwan Park, Ji Hyeon Ju
JOURNAL OF IMMUNOLOGY RESEARCH
(2014)
Article
Cell Biology
Jae Won Lee, Ee Taek Hwang, Jin Soo Han
Summary: This study demonstrates that topical application of nitrite can attenuate testicular ischemia-reperfusion injury in rats by reducing oxidative stress and apoptosis levels.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Agriculture, Dairy & Animal Science
Dong Jin Baek, Hyoun Chul Kwon, Ah Lyum Mun, Joo Ri Lim, Sung Won Park, Jin Soo Han
Summary: The objective of this study was to obtain an objective index for establishing an animal welfare certification standard in Korea. The study compared rumen pH, ruminating time, milk yield, milk quality, and blood components in cows reared in farms with different forage levels. The results showed that cows on the welfare farm had longer rumination time, healthier rumen pH, and higher milk production efficiency compared to those on the conventional farm.
Article
Medicine, Research & Experimental
Eun Jung Jo, Eunjin Bae, Jeong-Hwan Yoon, Ji Yeon Kim, Jin Soo Han
Summary: The study compared the effects of RP and FV blood collection methods on mice, with results showing that the FV method not only reduces collection time, pain, and tissue damage, but also decreases stress and lasting harm without the use of anesthesia.
LABORATORY ANIMAL RESEARCH
(2021)
Article
Veterinary Sciences
Yong Jae Lee, Eun Jung Jo, Hye Won Lee, Bo Ram Hwang, Yong Hyun Kim, Byoung Joo Park, Yoon Ju Cho, Young Ah Lee, In Soo Choi, Jin Soo Han
JOURNAL OF VETERINARY SCIENCE
(2019)
Article
Biochemistry & Molecular Biology
Yojiro Makino, Jeong-Hwan Yoon, Eunjin Bae, Mitsuyasu Kato, Keiji Miyazawa, Tatsuo Ohira, Norihiko Ikeda, Masahiko Kuroda, Mizuko Mamura
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2017)
