IL-6, IL-12, and IL-23 STAT-Pathway Genetic Risk and Responsiveness of Lymphocytes in Patients with Multiple Sclerosis

TheSTAT4SLE risk allele rs7574865[T] is associated with increased IL-12-induced IFN-γ production in T cells from patients with SLE

(2018) Niklas Hagberg et al.   ANNALS OF THE RHEUMATIC DISEASES

The regulation of JAKs in cytokine signaling and its breakdown in disease

(2018) Henrik M. Hammarén et al.   CYTOKINE

Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity

(2016) C. A. Dendrou et al.   Science Translational Medicine

Immunology of Multiple Sclerosis

(2016) Mireia Sospedra et al.   SEMINARS IN NEUROLOGY

Opportunities for Translation from the Bench: Therapeutic Intervention of the JAK/STAT Pathway in Neuroinflammatory Diseases

(2015) Yudong Liu et al.   CRITICAL REVIEWS IN IMMUNOLOGY

Interleukin-12: Functional activities and implications for disease

(2015) Sebastian Zundler et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Retinoic Acid Increases Foxp3+ Regulatory T Cells and Inhibits Development of Th17 Cells by Enhancing TGF- -Driven Smad3 Signaling and Inhibiting IL-6 and IL-23 Receptor Expression

(2014) S. Xiao et al.   JOURNAL OF IMMUNOLOGY

Therapeutic Efficacy of Suppressing the JAK/STAT Pathway in Multiple Models of Experimental Autoimmune Encephalomyelitis

(2013) Y. Liu et al.   JOURNAL OF IMMUNOLOGY

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

(2013) Ashley H Beecham et al.   NATURE GENETICS

Stat1 activation attenuates IL-6 induced Stat3 activity but does not alter apoptosis sensitivity in multiple myeloma

(2012) Lina Y Dimberg et al.   BMC CANCER

Environmental Risk Factors for Multiple Sclerosis: A Review with a Focus on Molecular Mechanisms

(2012) Cullen O’Gorman et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Serum level of interleukin-6 in Chinese patients with multiple sclerosis

(2012) Ying-Chun Chen et al.   JOURNAL OF NEUROIMMUNOLOGY

Diagnostic criteria for multiple sclerosis: 2010 Revisions to the McDonald criteria

(2011) Chris H. Polman et al.   ANNALS OF NEUROLOGY

Tyrosine kinase 2 variant influences T lymphocyte polarization and multiple sclerosis susceptibility

(2011) N. Couturier et al.   BRAIN

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

(2011) Stephen Sawcer et al.   NATURE

Molecular Antagonism and Plasticity of Regulatory and Inflammatory T Cell Programs

(2008) Xuexian O. Yang et al.   IMMUNITY

Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging study

(2008) Benjamin M Segal et al.   LANCET NEUROLOGY