Article
Medicine, General & Internal
Yang Zhang, Chao Ning, Huijie Zhou, Yingjie Yan, Fulai Liu, Yayun Huang
Summary: This study identified serum IL-1 beta, IL-6, and IL-17A as indicators for predicting clinical response to celecoxib in AS patients, which may assist with optimizing personalized treatment.
IRISH JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Cell Biology
Shanjun Shi, Wubing Lu, Yinxin Zhou, Jieru Pang, Yan Li, Mingcai Li
Summary: This study investigated the levels of serum IL-36 gamma in patients with ankylosing spondylitis (AS) and their association with the disease. The results showed that serum IL-36 gamma levels were elevated in AS patients and correlated with disease activity. IL-36 gamma may be involved in the progression of AS disease and could potentially serve as a biomarker for AS.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Review
Medicine, General & Internal
Mingguang Yan, Xiao Fang, Jianjun Guo, Weibing Yin
Summary: This protocol aims to evaluate the efficacy and safety of IL-17A inhibitors in patients with ankylosing spondylitis through systematic review and meta-analysis. By searching multiple electronic databases, the current evidence will be synthesized. The results of this protocol can provide strong evidence for clinicians in managing ankylosing spondylitis.
Article
Rheumatology
Bon San Koo, Seunghun Lee, Ji Seon Oh, Seo Young Park, Ga Young Ahn, Ji Hui Shin, Kyung Bin Joo, Tae-Hwan Kim
Summary: The study investigated the relationship between changes in CRP levels and spinal radiographic progression in patients with radiographic axial spondyloarthritis. Controlled CRP levels after 3 months of initial non-biologic treatment were significantly associated with a slower rate of spinal radiographic change. CRP levels at 3 months may be a good predictor of radiographic progression in these patients.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2022)
Article
Immunology
Charalampos Papagoras, Akrivi Chrysanthopoulou, Alexandros Mitsios, Maria Ntinopoulou, Victoria Tsironidou, Aristea K. Batsali, Helen A. Papadaki, Panagiotis Skendros, Konstantinos Ritis
Summary: The research found that neutrophil extracellular traps (NETs) formation was enhanced in patients with ankylosing spondylitis. NETs decorated with interleukin-17A (IL-17A) stimulated the differentiation of bone marrow mesenchymal stem cells (MSCs) towards bone-forming cells. The expression of IL-17A was regulated by IL-1 beta, and blocking the IL-1 beta signaling pathway disrupted osteogenesis driven by IL-17A-bearing NETs.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Immunology
Dominique Baeten, Iannis E. Adamopoulos
Summary: This article discusses the pathobiology of axial spondyloarthritis, particularly the role of IL-23/IL-17 axis, and shares relevant lessons learned for translating emerging biological insights into clinical therapeutics.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Holly L. Rosenzweig, Emily E. Vance, Kofi Asare-Konadu, Kylie Koney, Ellen J. Lee, Atul A. Deodhar, Rouhin Sen, Liron Caplan, Ruth J. Napier
Summary: This study reveals a novel neutrophil-intrinsic role for Card9 in arthritogenic Th17 responses and the pathogenesis of AS. These data provide valuable utility in our future understanding of CARD9-specific mechanisms in spondyloarthritis.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Cell Biology
Joanna Wielinska, Jerzy Swierkot, Katarzyna Kolossa, Bartosz Bugaj, Monika Chaszczewska-Markowska, Slawomir Jeka, Katarzyna Bogunia-Kubik
Summary: IL-17A and IL-17F, together with their coreceptor, play a significant role in the pathogenesis of spondyloarthritis, with IL-17F rs763780 polymorphism potentially serving as a promising biomarker of disease activity and anti-TNF treatment outcome. The IL-17RA rs48419554 G allele may be a potential marker of disease severity in Polish AS patients.
MEDIATORS OF INFLAMMATION
(2021)
Article
Rheumatology
Ergun Soysal, Firdevs Ulutas, Emre Tepeli, Serdar Kaymaz, Veli Cobankara
Summary: This study found that in the South Aegean region of Turkey, nine analyzed IL-23R gene polymorphisms were more frequently seen in rheumatoid arthritis patients compared to healthy controls, with some SNPs being related to higher acute phase reactants and higher disease activity scores.
RHEUMATOLOGY INTERNATIONAL
(2022)
Article
Rheumatology
Jinhyun Kim, Min Jung Kim, Geun Young Oh, Sun Kyung Lee, Taeeun Kim, Kichul Shin
Summary: The study found that ASDAS is a better assessment tool for disease activity in AS patients during biologic therapy, and a low ASDAS after 1 year may indicate long-term drug survival of TNFi therapy.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2023)
Article
Rheumatology
V. I. Mazurov, T. V. Dubinina, S. Erdes, S. A. Lapshina, N. F. Soroka, E. V. Kunder, A. V. Smirnov, A. V. Eremeeva, A. V. Zinkina-Orikhan, M. A. Morozova, I. Z. Gaydukova
Summary: The study shows that Netakimab is effective in treating patients with active radiographic axial spondyloarthritis (r-axSpA), regardless of baseline C-reactive protein (CRP) and inflammation on sacroiliac joint (SIJ) MRI. The benefit is more pronounced in patients with high CRP (>20 mg/L).
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Article
Medicine, General & Internal
B. Elbey, O. Ayyildiz, U. C. Yazgan, R. Cevik, I Kaplan, M. A. Sariyildiz
Summary: The study aimed to investigate the relationship between interleukin 23 and ankylosing spondylitis, finding significantly higher levels of IL-23 in AS patients compared to healthy controls, and a correlation between IL-23 levels and disease severity. IL-23 may play a role in the progression and pathogenesis of AS and joint problems independent of classic inflammatory markers.
WEST INDIAN MEDICAL JOURNAL
(2021)
Article
Pharmacology & Pharmacy
Yutong Jiang, Mingcan Yang, Yanli Zhang, Yefei Huang, Jialing Wu, Ya Xie, Qiujing Wei, Zetao Liao, Jieruo Gu
Summary: Anti-IL-17A therapy can effectively reverse immune cell imbalance in AS patients, specifically altering the distribution of T cell and B cell subsets.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Medicine, General & Internal
Giuseppe Scalise, Antonio Ciancio, Daniele Mauro, Francesco Ciccia
Summary: Ankylosing spondylitis is a chronic inflammatory disease characterized by inflammation of axial joints and the pelvis. Intestinal dysbiosis may play a role in the pathogenesis of the disease, with microbial metabolism potentially influencing disease onset.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Genetics & Heredity
Hongyan Liao, Zhuochun Huang, Junlong Zhang, Bin Yang
Summary: Our study for the first time demonstrated significant associations of rs7517847 in IL-23R and rs2275913 in IL-17A with the risk of IgAN in the Chinese Han population.
GENES AND IMMUNITY
(2022)
Article
Medical Laboratory Technology
Zhuochun Huang, Weihua Feng, Wei Wei, Bin Yang, Lanlan Wang
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2019)
Article
Biology
Lin Chen, Zhuochun Huang, Yun Liao, Bin Yang, Junlong Zhang
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2019)
Article
Medicine, General & Internal
Qian Niu, Wei Wei, Zhuochun Huang, Junlong Zhang, Bin Yang, Lanlan Wang
Article
Immunology
Lei Zhang, Jianzhao Zhai, Lu Wang, Zhuochun Huang, Jing Hu, Lixin Li, Junlong Zhang, Honghu Tang, Min Yang, Yongkang Wu
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2020)
Article
Medicine, General & Internal
Zhenzhen Su, Qian Niu, Zhuochun Huang, Bin Yang, Junlong Zhang
Article
Medicine, General & Internal
Lin Chen, Qian Niu, Zhuochun Huang, Bin Yang, Yongkang Wu, Junlong Zhang
Article
Medicine, General & Internal
Bin Yang, Limei Luo, Lin Chen, Qian Niu, Junlong Zhang, Huan Xu, Yifeng Wu, Zhuochun Huang
Summary: The study found an association between ETS1 rs73013527 and serum RANKL levels in patients with rheumatoid arthritis (RA), but not with clinical characteristics and laboratory markers in patients. Univariate analysis showed a significant association between the CT/TT genotype of ETS1 rs73013527 and elevated RANKL levels in RA patients, suggesting that ETS1 may be an indirect factor involved in RANKL regulation in RA.
Article
Biophysics
Xianming Li, Hang Yang, Jialun He, Bin Yang, Yi Zhao, Peng Wu
Summary: The study demonstrates that nuclease digestion results in almost complete liberation of 2-AP mononucleotides, independent of labeling site and neighboring bases. Additionally, nuclease digestion can lead to increased sensitivity through higher numbers of 2-AP labeling, which is not achievable in traditional sensors without full liberation of 2-AP.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Genetics & Heredity
Hongyan Liao, Zhuochun Huang, Junlong Zhang, Bin Yang
Summary: Our study for the first time demonstrated significant associations of rs7517847 in IL-23R and rs2275913 in IL-17A with the risk of IgAN in the Chinese Han population.
GENES AND IMMUNITY
(2022)
Article
Medical Laboratory Technology
Keyi Zhang, Zhenzhen Su, Jing Hu, Zhuochun Huang, Chaojun Hu, Bin Yang
Summary: The DFS pattern is rare in Chinese population and predominantly associated with inflammatory, infectious, mental diseases, and various systemic autoimmune rheumatic diseases. It is not wise to exclude the diagnosis of SARDs solely based on the presence of the DFS pattern, but rather should consider autoimmune diseases-related antibodies and clinical information of patients.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Allergy
Zhenzhen Su, Lin Chen, Qian Niu, Bin Yang, Zhuochun Huang
Summary: This study found that polymorphisms of the CXCR5 gene are associated with the development and progression of rheumatoid arthritis (RA). In particular, the rs630923 A allele is associated with an increased risk of RA, while the rs497916 T allele is associated with a decreased risk. Additionally, different genotypes are significantly associated with specific laboratory values.
IRANIAN JOURNAL OF ALLERGY ASTHMA AND IMMUNOLOGY
(2022)
Article
Hematology
Zhenzhen Su, Zhuochun Huang, Jiuliang Zhao, Mengtao Li, Jing Hu, Xiaofeng Zeng, Chaojun Hu, Bin Yang
Summary: This study assessed the prevalence of various aPL in the Chinese population and found that IgA aPL may not enhance the classification ability of established laboratory criteria for thrombotic APS.
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
(2022)
Review
Chemistry, Medicinal
Rui Shi, Xinle Liu
Summary: The development of tyrosine kinase inhibitors has been successful in treating CML, but challenges such as relapse, drug resistance, and LSC persistence remain. CD44 plays a crucial role in tumor microenvironment communication and signaling, offering potential for CML management.
