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Single-Cell Transcriptome Atlas of Murine Endothelial Cells

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Diabetes-Induced Inflammation and Vascular Alterations in the Goto–Kakizaki Rat Retina

(2020) Soumaya Hachana et al.   CURRENT EYE RESEARCH

Neuroimaging in Vascular Cognitive Impairment and Dementia: A Systematic Review

(2020) Viviana Frantellizzi et al.   JOURNAL OF ALZHEIMERS DISEASE

Metabolic compartmentalization between astroglia and neurons in physiological and pathophysiological conditions of the neurovascular unit

(2020) Shinichi Takahashi   NEUROPATHOLOGY

An epigenetic clock for human skeletal muscle

(2020) Sarah Voisin et al.   Journal of Cachexia Sarcopenia and Muscle

Vascular Integrity and Signaling Determining Brain Development, Network Excitability, and Epileptogenesis

(2020) Jugajyoti Baruah et al.   Frontiers in Physiology

Neurovascular unit dysregulation, white matter disease, and executive dysfunction: the shared triad of vascular cognitive impairment and Alzheimer disease

(2020) Alexander Levit et al.   GeroScience

Metabolic Coordination of Pericyte Phenotypes: Therapeutic Implications

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APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline

(2020) Axel Montagne et al.   NATURE

Brain Endothelial Cells Are Exquisite Sensors of Age-Related Circulatory Cues

(2020) Michelle B. Chen et al.   Cell Reports

BIN1 protein isoforms are differentially expressed in astrocytes, neurons, and microglia: neuronal and astrocyte BIN1 are implicated in tau pathology

(2020) Mariko Taga et al.   Molecular Neurodegeneration

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(2020) Hannah W. Song et al.   Scientific Reports

Differential expression of receptors mediating receptor-mediated transcytosis (RMT) in brain microvessels, brain parenchyma and peripheral tissues of the mouse and the human

(2020) Wandong Zhang et al.   Fluids and Barriers of the CNS

Pharmacologically reversible zonation-dependent endothelial cell transcriptomic changes with neurodegenerative disease associations in the aged brain

(2020) Lei Zhao et al.   Nature Communications

Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction

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Understanding and overcoming the pitfalls and biases of next-generation sequencing (NGS) methods for use in the routine clinical microbiological diagnostic laboratory

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Veins and Arteries Build Hierarchical Branching Patterns Differently: Bottom-Up versus Top-Down

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The receptor for advanced glycation end-products (RAGE) is an important pattern recognition receptor (PRR) for inflammaging

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Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1

(2019) Hanadie Yousef et al.   NATURE MEDICINE

Therapeutic Potential of Oxytocin in Atherosclerotic Cardiovascular Disease: Mechanisms and Signaling Pathways

(2019) Ping Wang et al.   Frontiers in Neuroscience

Oxysterols and the NeuroVascular Unit (NVU): A far true love with bright and dark sides

(2019) Julien Saint-Pol et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Homeobox B9 integrates bone morphogenic protein 4 with inflammation at atheroprone sites

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Amyloid-beta impairs insulin signaling by accelerating autophagy-lysosomal degradation of LRP-1 and IR-β in blood-brain barrier endothelial cells in vitro and in 3XTg-AD mice

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ApoER2 (Apolipoprotein E Receptor-2) Deficiency Accelerates Smooth Muscle Cell Senescence via Cytokinesis Impairment and Promotes Fibrotic Neointima After Vascular Injury

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Profiling the mouse brain endothelial transcriptome in health and disease models reveals a core blood–brain barrier dysfunction module

(2019) Roeben Nocon Munji et al.   NATURE NEUROSCIENCE

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Thyroid Hormones in the Brain and Their Impact in Recovery Mechanisms After Stroke

(2019) Daniela Talhada et al.   Frontiers in Neurology

Novel Genetic Locus Influencing Retinal Venular Tortuosity Is Also Associated With Risk of Coronary Artery Disease

(2019) Abirami Veluchamy et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Microvascular Dysfunction Is Associated With Worse Cognitive Performance

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Cerebral small vessel disease and the risk of Alzheimer’s disease: A systematic review

(2018) Yue Liu et al.   AGEING RESEARCH REVIEWS

KLF4 protects brain microvascular endothelial cells from ischemic stroke induced apoptosis by transcriptionally activating MALAT1

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Relationship between Cytotoxicity in the Hippocampus and an Abnormal High Intensity Area on the Diffusion-weighted Images of Three Patients with Transient Global Amnesia

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The Role of Low-Density Lipoprotein Receptor-Related Protein 1 in Lipid Metabolism, Glucose Homeostasis and Inflammation

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(2018) Kenneth H. Gouin et al.   MICROCIRCULATION

Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

(2018) Steven E. Arnold et al.   Nature Reviews Neurology

Effects of aging, hypertension and diabetes on the mouse brain and heart vasculomes

(2018) Shuzhen Guo et al.   NEUROBIOLOGY OF DISEASE

Strategies to Annotate and Characterize Long Noncoding RNAs: Advantages and Pitfalls

(2018) Huifen Cao et al.   TRENDS IN GENETICS

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(2018) Caroline Maria Oliveira Volpe et al.   Cell Death & Disease

Influence of Glucose Availability and CRP Acetylation on the Genome-Wide Transcriptional Response of Escherichia coli: Assessment by an Optimized Factorial Microarray Analysis

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The Orphan Nuclear Receptor 4A1: A Potential New Therapeutic Target for Metabolic Diseases

(2018) Lei Zhang et al.   Journal of Diabetes Research

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Neurovascular Defects and Faulty Amyloid-β Vascular Clearance in Alzheimer's Disease

(2018) Abhay P. Sagare et al.   JOURNAL OF ALZHEIMERS DISEASE

A molecular atlas of cell types and zonation in the brain vasculature

(2018) Michael Vanlandewijck et al.   NATURE

The role of brain vasculature in neurodegenerative disorders

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The Role of Hepatocyte Growth Factor (HGF) in Insulin Resistance and Diabetes

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The Reelin Receptors Apolipoprotein E receptor 2 (ApoER2) and VLDL Receptor

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Nailfold Capillary Morphology in Alzheimer’s Disease Dementia

(2018) Clara C. Cousins et al.   JOURNAL OF ALZHEIMERS DISEASE

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(2018) Shawez Khan et al.   NUCLEIC ACIDS RESEARCH

Dysfunction of Cerebrovascular Endothelial Cells: Prelude to Vascular Dementia

(2018) Feixue Wang et al.   Frontiers in Aging Neuroscience

Hippocampal vascularization patterns: A high-resolution 7 Tesla time-of-flight magnetic resonance angiography study

(2018) Marco Spallazzi et al.   NeuroImage-Clinical

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Relevance of the cerebral collateral circulation in ischaemic stroke: time is brain, but collaterals set the pace

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Oxytocin inhibits ox-LDL-induced adhesion of monocytic THP-1 cells to human brain microvascular endothelial cells

(2017) Shuyan Liu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Endothelial LRP1 regulates metabolic responses by acting as a co-activator of PPARγ

(2017) Hua Mao et al.   Nature Communications

Apolipoprotein E Receptor 2 Mediates Activated Protein C–Induced Endothelial Akt Activation and Endothelial Barrier StabilizationSignificance

(2016) Ranjeet K. Sinha et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

NET-GE: a web-server for NETwork-based human gene enrichment

(2016) Samuele Bovo et al.   BIOINFORMATICS

Altered interleukin-18 levels are associated with cognitive impairment in chronic schizophrenia

(2016) Jing Qin Wu et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Nuclear receptor 4A (NR4A) family – orphans no more

(2016) Stephen Safe et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Q-GDEMAR: a general method for the identification of differentially expressed genes in microarrays with unbalanced groups

(2016) Daniel V. Guebel et al.   Molecular BioSystems

FOXO1 couples metabolic activity and growth state in the vascular endothelium

(2016) Kerstin Wilhelm et al.   NATURE

PANTHER version 11: expanded annotation data from Gene Ontology and Reactome pathways, and data analysis tool enhancements

(2016) Huaiyu Mi et al.   NUCLEIC ACIDS RESEARCH

KEGG: new perspectives on genomes, pathways, diseases and drugs

(2016) Minoru Kanehisa et al.   NUCLEIC ACIDS RESEARCH

IL-4 Causes Hyperpermeability of Vascular Endothelial Cells through Wnt5A Signaling

(2016) Tom Skaria et al.   PLoS One

Loss of Reelin protects against atherosclerosis by reducing leukocyte–endothelial cell adhesion and lesion macrophage accumulation

(2016) Yinyuan Ding et al.   Science Signaling

Sexual Dimorphism and Aging in the Human Hyppocampus: Identification, Validation, and Impact of Differentially Expressed Genes by Factorial Microarray and Network Analysis

(2016) Daniel V. Guebel et al.   Frontiers in Aging Neuroscience

Interferon‐β Modulates Inflammatory Response in Cerebral Ischemia

(2016) Ping‐Chang Kuo et al.   Journal of the American Heart Association

Loss of Reelin protects against atherosclerosis by reducing leukocyte–endothelial cell adhesion and lesion macrophage accumulation

(2016) Yinyuan Ding et al.   Science Signaling

Endothelial Progenitor Cells Physiology and Metabolic Plasticity in Brain Angiogenesis and Blood-Brain Barrier Modeling

(2016) Natalia A. Malinovskaya et al.   Frontiers in Physiology

Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance

(2015) Zhen Zhao et al.   NATURE NEUROSCIENCE

Blood-Brain Barrier Breakdown in the Aging Human Hippocampus

(2015) Axel Montagne et al.   NEURON

Venous Endothelial Marker COUP-TFII Regulates the Distinct Pathologic Potentials of Adult Arteries and Veins

(2015) Xiaofeng Cui et al.   Scientific Reports

Cholesterol metabolism and homeostasis in the brain

(2015) Juan Zhang et al.   Protein & Cell

Blood–brain barrier dysfunction developed during normal aging is associated with inflammation and loss of tight junctions but not with leukocyte recruitment

(2015) Mina Elahy et al.   Immunity & Ageing

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Trafficking regulation of proteins in Alzheimer’s disease

(2014) Shangtong Jiang et al.   Molecular Neurodegeneration

APOE2 enhances neuroprotection against Alzheimer’s disease through multiple molecular mechanisms

(2014) C Conejero-Goldberg et al.   MOLECULAR PSYCHIATRY

Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation

(2014) Lior Mayo et al.   NATURE MEDICINE

Brain gene expression patterns differentiate mild cognitive impairment from normal aged and Alzheimer's disease

(2014) Nicole C. Berchtold et al.   NEUROBIOLOGY OF AGING

Transcript Analysis Reveals a Specific HOX Signature Associated with Positional Identity of Human Endothelial Cells

(2014) Mark Toshner et al.   PLoS One

Sphingosine-1-Phosphate Receptor 3 Mediates Sphingosine-1-Phosphate Induced Release of Weibel-Palade Bodies from Endothelial Cells

(2014) Kathinka W. E. M. van Hooren et al.   PLoS One

Deletion of Krüppel‐Like Factor 4 in Endothelial and Hematopoietic Cells Enhances Neointimal Formation Following Vascular Injury

(2014) Tadashi Yoshida et al.   Journal of the American Heart Association

Leptomeningeal collaterals are associated with modifiable metabolic risk factors

(2013) Bijoy K. Menon et al.   ANNALS OF NEUROLOGY

HMGB1 induces an inflammatory response in endothelial cells via the RAGE-dependent endoplasmic reticulum stress pathway

(2013) Ying Luo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Linking endothelial dysfunction with endothelial cell activation

(2013) James K. Liao   JOURNAL OF CLINICAL INVESTIGATION

Microglia are the major source of TNF-α and TGF-β1 in postnatal glial cultures; regulation by cytokines, lipopolysaccharide, and vitronectin

(2013) Jennifer V. Welser-Alves et al.   NEUROCHEMISTRY INTERNATIONAL

Inhibition of Tumorigenesis by the Thyroid Hormone Receptor β in Xenograft Models

(2013) Won Gu Kim et al.   THYROID

The Role of Endothelial Progenitor Cells in Postnatal Vasculogenesis: Implications for Therapeutic Neovascularization and Wound Healing

(2013) Swathi Balaji et al.   Advances in Wound Care

Pathophysiology of Vascular Remodeling in Hypertension

(2013) Nicolás F. Renna et al.   International Journal of Hypertension

The Alarmin IL-33 Is a Notch Target in Quiescent Endothelial Cells

(2012) Eirik Sundlisæter et al.   AMERICAN JOURNAL OF PATHOLOGY

NetWalker: a contextual network analysis tool for functional genomics

(2012) Kakajan Komurov et al.   BMC GENOMICS

LRP1-Dependent Endocytic Mechanism Governs the Signaling Output of the Bmp System in Endothelial Cells and in Angiogenesis

(2012) Xinchun Pi et al.   CIRCULATION RESEARCH

A multimodal RAGE-specific inhibitor reduces amyloid β–mediated brain disorder in a mouse model of Alzheimer disease

(2012) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

Twisted Blood Vessels: Symptoms, Etiology and Biomechanical Mechanisms

(2012) Hai-Chao Han   JOURNAL OF VASCULAR RESEARCH

Analysis of cell adhesion during early stages of colon cancer based on an extended multi-valued logic approach

(2012) Daniel V. Guebel et al.   Molecular BioSystems

Aging-Related Changes in Blood-Brain Barrier Integrity and the Effect of Dietary Fat

(2012) R. Takechi et al.   Neurodegenerative Diseases

Changing topographic Hox expression in blood vessels results in regionally distinct vessel wall remodeling

(2012) N. D. Pruett et al.   Biology Open

Analysis of alternative splicing associated with aging and neurodegeneration in the human brain

(2011) J. R. Tollervey et al.   GENOME RESEARCH

Whole Transcriptome Sequencing Reveals Gene Expression and Splicing Differences in Brain Regions Affected by Alzheimer's Disease

(2011) Natalie A. Twine et al.   PLoS One

Epidermal growth factor receptor transactivation by endogenous vasoactive peptides contributes to hyperproliferation of vascular smooth muscle cells of SHR

(2010) Yuan Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Capillary enlargement, not sprouting angiogenesis, determines beneficial therapeutic effects and side effects of angiogenic gene therapy

(2010) Petra Korpisalo et al.   EUROPEAN HEART JOURNAL

Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice

(2010) Mitomu Kioi et al.   JOURNAL OF CLINICAL INVESTIGATION

Expression of interleukin-15 and its receptor on the surface of stimulated human umbilical vein endothelial cells

(2010) Xiuping Liu et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

Microglial activation state exerts a biphasic influence on brain endothelial cell proliferation by regulating the balance of TNF and TGF-β1

(2010) Jennifer V Welser et al.   Journal of Neuroinflammation

Collateral Capillary Arterialization following Arteriolar Ligation in Murine Skeletal Muscle

(2010) FEILIM MAC GABHANN et al.   MICROCIRCULATION

Lactosylceramide promotes cell migration and proliferation through activation of ERK1/2 in human aortic smooth muscle cells

(2009) Hong Mu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

VEGF recruits lactosylceramide to induce endothelial cell adhesion molecule expression and angiogenesis in vitro and in vivo

(2009) Antonina Kolmakova et al.   GLYCOCONJUGATE JOURNAL

The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress

(2009) Truyen Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LRP1 shedding in human brain: roles of ADAM10 and ADAM17

(2009) Qiang Liu et al.   Molecular Neurodegeneration

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Upregulation of Interleukin-8/CXCL8 in Vascular Smooth Muscle Cells from Spontaneously Hypertensive Rats

(2008) Hyo Young KIM et al.   HYPERTENSION RESEARCH

Vascular and inflammatory stresses mediate atherosclerosis via RAGE and its ligands in apoE–/– mice

(2008) Evis Harja et al.   JOURNAL OF CLINICAL INVESTIGATION

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(2008) Vikas Chandra et al.   NATURE

Gene expression changes in the course of normal brain aging are sexually dimorphic

(2008) N. C. Berchtold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA