Article
Psychology, Clinical
Joscha Boehnlein, Elisabeth J. Leehr, Kati Roesmann, Teresa Sappelt, Ole Platte, Dominik Grotegerd, Lisa Sindermann, Jonathan Repple, Nils Opel, Susanne Meinert, Hannah Lemke, Tiana Borgers, Katharina Dohm, Verena Enneking, Janik Goltermann, Lena Waltemate, Carina Huelsmann, Katharina Thiel, Nils Winter, Jochen Bauer, Ulrike Lueken, Thomas Straube, Markus Junghoefer, Udo Dannlowski
Summary: Patients with specific phobia (SP) showed altered brain activation when presented with phobia-specific stimuli, but no differences were found in response to nonspecific aversive facial stimuli compared to healthy controls. However, machine learning techniques were able to differentiate between the two groups with a high accuracy rate. This suggests that patients with SP may have subtle differences in processing nonspecific emotional stimuli.
DEPRESSION AND ANXIETY
(2021)
Review
Psychology
Emiliana Tonini, Yann Quide, Manreena Kaur, Thomas J. Whitford, Melissa J. Green
Summary: This systematic review explores the association between schizotypy and structural and functional brain changes, suggesting schizotypy may be a potential intermediate phenotype in the developmental path to psychosis. The study found that schizotypy is related to changes in gray matter, brain activation, and connectivity, particularly in the default mode and frontoparietal networks. However, due to methodological differences, consistent patterns of brain aberration associated with schizotypy were not identified, highlighting the need for greater methodological concordance in future neuroimaging research.
PSYCHOLOGICAL BULLETIN
(2021)
Article
Neurosciences
Elijah Mak, Maria-Eleni Dounavi, Audrey Low, Stephen F. Carter, Elizabeth McKiernan, Guy B. Williams, P. Simon Jones, Isabelle Carriere, Graciela Terrera Muniz, Karen Ritchie, Craig Ritchie, Li Su, John T. O'Brien
Summary: This study found that a shorter estimated years to onset of dementia may be associated with incipient brain abnormalities in cognitively normal midlife adults, particularly among APOE-epsilon 4 carriers. The research also suggests that EYO could serve as a potential stage marker of preclinical progression in sporadic dementia.
Article
Radiology, Nuclear Medicine & Medical Imaging
Francesca B. Pizzini, Enrico Conti, Angelo Bianchetti, Alessandra Splendiani, Domenico Fusco, Ferdinando Caranci, Alessandro Bozzao, Francesco Landi, Nicoletta Gandolfo, Lisa Farina, Vittorio Miele, Marco Trabucchi, Giovanni B. Frisoni, Stefano Bastianello
Summary: This article presents a disease-oriented protocol for radiological image evaluation and reporting, aiming to increase diagnostic accuracy and effectiveness of interdisciplinary dialogue for radiologists.
Review
Medicine, General & Internal
Shailendra Mohan Tripathi, Naif Ali Majrashi, Ali S. Alyami, Wael A. Ageeli, Turkey A. Refaee
Summary: Extensive research on crossed cerebellar diaschisis (CCD) in neurodegenerative disorders is lacking. While PET is commonly used to detect CCD, advanced MRI techniques have also emerged for this purpose. This study aimed to evaluate whether PET provides additional value compared to MRI or advanced MRI techniques in detecting CCD. Eight articles involving 1246 participants were included in this review, with six using PET imaging and two using MRI and hybrid imaging. PET studies showed decreased cerebral metabolism in various cortices, while MRI studies showed decreased cerebellar volumes. The study concluded that PET is a common and sensitive technique for detecting CCD in neurodegenerative diseases, while MRI is better for measuring brain volume.
Article
Biochemical Research Methods
Xingzhong Zhao, Jingqi Chen, Peipei Xiao, Jianfeng Feng, Qing Nie, Xing-Ming Zhao
Summary: Using the TCA method, age-specific cortex (ASC) gene signatures were identified, showing significant correlations with cortical thickness and myelination. These gene signatures also help elucidate the molecular mechanisms of neuropsychiatric disorders.
BRIEFINGS IN BIOINFORMATICS
(2021)
Review
Behavioral Sciences
Mary Clare McKenna, Jasmin Lope, Peter Bede, Ee Ling Tan
Summary: Frontotemporal dementia (FTD) phenotypes are characterized by cortical atrophy and regional hypometabolism, but the cognitive and behavioral manifestations in FTD result from dysfunction in multisynaptic networks. The thalamus plays a key role in several important circuits involved in FTD. This paper reviews evidence for thalamic pathology in FTD and outlines future research directions and priorities.
BRAIN AND BEHAVIOR
(2023)
Article
Biology
Botond Antal, Liam P. McMahon, Syed Fahad Sultan, Andrew Lithen, Deborah J. Wexler, Bradford Dickerson, Eva-Maria Ratai, Lilianne R. Mujica-Parodi
Summary: This study analyzed neuroimaging and cognitive data from a large cohort of individuals with type 2 diabetes mellitus (T2DM) and healthy controls. The findings show that T2DM is associated with significant cognitive deficits and structural and functional brain changes, with overlap with aging effects. The duration of the disease is linked to more severe neurodegeneration. Treatment with metformin does not improve neurocognitive outcomes.
Article
Psychology, Developmental
Carolina Badke D'Andrea, Jeanette K. Kenley, David F. Montez, Amy E. Mirro, Ryland L. Miller, Eric A. Earl, Jonathan M. Koller, Sooyeon Sung, Essa Yacoub, Jed T. Elison, Damien A. Fair, Nico U. F. Dosenbach, Cynthia E. Rogers, Christopher D. Smyser, Deanna J. Greene
Summary: Imaging the infant brain with MRI has improved our understanding of early neurodevelopment. However, head motion during MRI acquisition is detrimental to both functional and structural MRI scan quality. Providing MRI technicians with real-time motion estimates via FIRMM software can help obtain high-quality, low motion fMRI data in infants. The addition of FIRMM significantly increased the amount of usable fMRI data acquired per infant, demonstrating its value for research and clinical infant neuroimaging.
DEVELOPMENTAL COGNITIVE NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Marta Pengo, Enrico Premi, Barbara Borroni
Summary: Frontotemporal dementia (FTD) is a complex disorder with diverse pathological features, requiring further research and diagnosis. Advanced neuroimaging techniques have played a significant role in understanding FTD, supporting clinical diagnosis, and other aspects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Clinical Neurology
Sait Ashina, Enrico Bentivegna, Paolo Martelletti, Katharina Eikermann-Haerter
Summary: Individuals with migraine exhibit structural and functional changes in the brain, including white matter abnormalities, silent infarct-like lesions, and volumetric changes. Neuroimaging studies have helped characterize these changes, but limitations such as small sample sizes and poorly defined control groups exist.
Review
Clinical Neurology
Emily L. Ball, Mahnoor Shah, Eilidh Ross, Rachel Sutherland, Charlotte Squires, Gillian E. Mead, Joanna M. Wardlaw, Terence J. Quinn, Dorota Religa, Erik Lundstrom, Joshua Cheyne, Susan D. Shenkin
Summary: This systematic review investigates the associations between magnetic resonance imaging (MRI) features performed at stroke diagnosis and post-stroke cognitive impairment in stroke survivors. The findings suggest that cerebral atrophy, microbleeds, and severity of white matter hyperintensities are associated with cognitive outcomes, while the association between increasing cerebral small vessel disease score and cognitive outcomes is inconclusive. These findings can help identify stroke patients at risk of cognitive problems, but the clinical utility of acute MRI in predicting cognitive problems remains uncertain.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Review
Neurosciences
Olga Tymofiyeva, Robert Gaschler
Summary: Experience-dependent neural plasticity is high in the developing brain, with most studies showing significant changes in brain activation, structure, and connectivity with different types of training. Some studies also demonstrate a significant correlation between performance improvement and neural changes. However, a portion of the studies lack control conditions, highlighting the need for more empirical and methodological support in future research.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Geriatrics & Gerontology
Lichuang Wu, Xiang Wang, Yiheng Ye, Cailong Liu
Summary: This study found that while no significant differences were observed in structural neuroimaging markers between osteoarthritis (OA) and non-OA groups in the cross-sectional analysis, a steeper decline in volumes of gray matter of the whole brain was associated with OA in non-demented older adults in the longitudinal analysis.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Neurosciences
Caroline Demro, Bryon A. Mueller, Jerillyn S. Kent, Philip C. Burton, Cheryl A. Olman, Michael-Paul Schallmo, Kelvin O. Lim, Scott R. Sponheim
Summary: This paper describes an investigation within the Human Connectome Project focusing on psychotic psychopathology, with data collected from clinical assessments, cognitive assessments, motor assessments, blood specimens, and MRI data. The goal is to provide information on data acquisition process for researchers planning to use the publicly available data, with a companion paper detailing the study's 7 Tesla image acquisition protocol.
Article
Immunology
Malgorzata Lysek-Gladysinska, Magdalena Starz, Agnieszka Borowiec-Sek, Iwona Sufin, Anna Wieczorek, Magdalena Chrapek, Dorota Zarebska-Michaluk, Patrycja Sufin, Stanislaw Gluszek, Wioletta Adamus-Bialek
Summary: This study analyzed the correlation between the third dose of COVID-19 vaccination and the dynamics of IgG anti-SARS-CoV-2 spike protein antibody levels in a group of healthy individuals. The results showed that IgG levels were significantly higher and less variable after the second booster vaccination compared to the first booster. The antibody levels were positively correlated with females, healthcare workers, the elderly, and participants with a negative COVID-19 history.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Review
Medicine, General & Internal
Luca Filippi, Viviana Frantellizzi, Giuseppe De Vincentis, Orazio Schillaci, Laura Evangelista
Summary: The aim of this study was to provide a comprehensive overview of the clinical applications of PET with radiopharmaceuticals targeting TSPO in gliomas. Ten selected articles involving 314 glioma patients demonstrated the usefulness of TSPO PET in identifying anaplastic transformation and prognostic stratification. TSPO PET with [F-18]-GE-180 showed superior image quality compared to amino-acid PET, with larger and partially non-overlapping PET-based volumes.
Review
Medicine, General & Internal
Luca Filippi, Viviana Frantellizzi, Paola Bartoletti, Giuseppe De Vincentis, Orazio Schillaci, Laura Evangelista
Summary: The aim of this study is to compare F-18-fluorodeoxyglucose (FDG) and C-11-methionine (MET) for positron emission computed tomography (PET/CT) imaging in multiple myeloma (MM), based on a systematic review of relevant studies. MET showed higher sensitivity and better performance in detecting focal lesions, diffuse bone marrow involvement, and mixed patterns compared to FDG. MET also had stronger correlation and inter-observer agreement and higher PET-derived parameters than FDG. Preliminary findings suggest that MET-PET should be preferred or used as a complementary modality for MM imaging.
Review
Medicine, General & Internal
Miriam Conte, Maria Silvia De Feo, Marko Magdi Abdou Sidrak, Ferdinando Corica, Joana Gorica, Giorgia Maria Granese, Luca Filippi, Giuseppe De Vincentis, Viviana Frantellizzi
Summary: This article provides a systematic review of current and novel PET tracers for tauopathies. The results indicate that PET imaging can serve as a valuable tool for diagnosis, although further research on promising ligands is needed for differential diagnosis.
Article
Biochemistry & Molecular Biology
Maria Silvia De Feo, Viviana Frantellizzi, Matteo Bauckneht, Alessio Farcomeni, Luca Filippi, Elisa Lodi Rizzini, Valentina Lavelli, Maria Lina Stazza, Tania Di Raimondo, Giuseppe Fornarini, Sara Elena Rebuzzi, Mammini Filippo, Paolo Mammucci, Andrea Marongiu, Fabio Monari, Giuseppe Rubini, Angela Spanu, Giuseppe De Vincentis
Summary: This multicenter study aimed to assess the impact of baseline bone scan index (BSI) on overall survival (OS) in mCRPC patients treated with (RaCl2)-Ra-223. The results showed that baseline BSI significantly predicts OS in mCRPC treated with (RaCl2)-Ra-223.
Review
Biochemistry & Molecular Biology
Miriam Tomaciello, Miriam Conte, Francesca Romana Montinaro, Arianna Sabatini, Giorgia Cunicella, Federico Di Giammarco, Paolo Tini, Giovanni Luca Gravina, Enrico Cortesi, Giuseppe Minniti, Giuseppe De Vincentis, Viviana Frantellizzi, Francesco Marampon
Summary: The abscopal effect (AE) refers to the ability of radiotherapy (RT) to induce immune-mediated responses in nonirradiated distant metastases. Bone metastases (BMs) are common and provide an immunologically favorable environment for cancer cell proliferation. This study reviewed the literature and evaluated the incidence of AE involving BMs in patients receiving palliative RT.
Review
Chemistry, Medicinal
Marko Magdi Abdou Sidrak, Maria Silvia De Feo, Joana Gorica, Ferdinando Corica, Miriam Conte, Luca Filippi, Giuseppe De Vincentis, Viviana Frantellizzi
Summary: Coronary artery disease (CAD) is the leading cause of death, and myocardial perfusion imaging (MPI) plays a central role in risk stratification and prognosis for CAD patients. However, there are limitations to MPI that the referring clinician and managing team must be aware of and use to their advantage.
Review
Chemistry, Medicinal
Joana Gorica, Maria Silvia De Feo, Ferdinando Corica, Marko Magdi Abdou Sidrak, Miriam Conte, Luca Filippi, Orazio Schillaci, Giuseppe De Vincentis, Viviana Frantellizzi
Summary: This systematic review focuses on the clinical and preclinical applications of the CCR4 receptor as a target for theranostics. The review provides a comprehensive overview of CCR4 expression and its role in various tumors. The study finds that the development of new radionuclides and radiopharmaceuticals targeting CCR4 shows promising results in the theranostics of CCR4-sensitive tumors. However, further translation of preclinical to clinical data is needed to expand its use in clinical practice.
Review
Cardiac & Cardiovascular Systems
Marco Alfonso Perrone, Andrea Cimini, Maria Ricci, Milena Pizzoferro, Maria Carmen Garganese, Massimiliano Raponi, Orazio Schillaci
Summary: The role of nuclear medicine in pediatric cardiology has become increasingly important, providing valuable functional and prognostic information in the evaluation of cardiac diseases. This review summarizes the clinical applications, advantages, and limitations of nuclear medicine techniques in pediatric cardiology, with a special focus on minimizing radiation exposure.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)