The Reelin Receptors Apolipoprotein E receptor 2 (ApoER2) and VLDL Receptor

Decreased generation of C-terminal fragments of ApoER2 and increased reelin expression in Alzheimer’s disease

(2018) Trinidad Mata-Balaguer et al.   FASEB JOURNAL

Reelin Depletion is an Early Phenomenon of Alzheimer's Pathology

(2018) Arne Herring et al.   JOURNAL OF ALZHEIMERS DISEASE

Endothelial Dab1 signaling orchestrates neuro-glia-vessel communication in the central nervous system

(2018) Marta Segarra et al.   SCIENCE

Aberrant Wnt signaling: a special focus in CNS diseases

(2017) Mercedes Arnés et al.   JOURNAL OF NEUROGENETICS

Presenilin 1 mutations influence processing and trafficking of the ApoE receptor apoER2

(2017) Wei Wang et al.   NEUROBIOLOGY OF AGING

Loss of clusterin shifts amyloid deposition to the cerebrovasculature via disruption of perivascular drainage pathways

(2017) Aleksandra M. Wojtas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of clusterin in the brain vascular clearance of amyloid-β

(2017) Amy R. Nelson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GRIP1 Binds to ApoER2 and EphrinB2 to Induce Activity-Dependent AMPA Receptor Insertion at the Synapse

(2017) Sylvia Pfennig et al.   Cell Reports

The E3 ubiquitin ligase IDOL regulates synaptic ApoER2 levels and is important for plasticity and learning

(2017) Jie Gao et al.   eLife

Nonneuronal roles for the reelin signaling pathway

(2016) Elvira Khialeeva et al.   DEVELOPMENTAL DYNAMICS

Therapeutic correction of ApoER2 splicing in Alzheimer's disease mice using antisense oligonucleotides

(2016) A. J. Hinrich et al.   EMBO Molecular Medicine

Reelin in Alzheimer’s Disease, Increased Levels but Impaired Signaling: When More is Less

(2016) Inmaculada Cuchillo-Ibañez et al.   JOURNAL OF ALZHEIMERS DISEASE

Functional Differences of Very-Low-Density Lipoprotein Receptor Splice Variants in Regulating Wnt Signaling

(2016) Qian Chen et al.   MOLECULAR AND CELLULAR BIOLOGY

Structural Insights into Reelin Function: Present and Future

(2016) Fanomezana M. Ranaivoson et al.   Frontiers in Cellular Neuroscience

Canonical and Non-canonical Reelin Signaling

(2016) Hans H. Bock et al.   Frontiers in Cellular Neuroscience

The β-amyloid peptide compromises Reelin signaling in Alzheimer’s disease

(2016) Inmaculada Cuchillo-Ibañez et al.   Scientific Reports

ApoER2 and Reelin are expressed in regenerating peripheral nerve and regulate Schwann cell migration by activating the Rac1 GEF protein, Tiam1

(2015) Consuelo Pasten et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

LRP8-Reelin-Regulated Neuronal Enhancer Signature Underlying Learning and Memory Formation

(2015) Francesca Telese et al.   NEURON

Reelin protects against amyloid β toxicity in vivo

(2015) Courtney Lane-Donovan et al.   Science Signaling

Notch1 Regulates Hippocampal Plasticity Through Interaction with the Reelin Pathway, Glutamatergic Transmission and CREB Signaling

(2015) Emanuele Brai et al.   Frontiers in Cellular Neuroscience

Reelin protects against amyloid β toxicity in vivo

(2015) Courtney Lane-Donovan et al.   Science Signaling

Impaired Src signaling and post-synaptic actin polymerization in Alzheimer's disease mice hippocampus — Linking NMDA receptors and the reelin pathway

(2014) Sandra I. Mota et al.   EXPERIMENTAL NEUROLOGY

Selenoprotein P and apolipoprotein E receptor-2 interact at the blood-brain barrier and also within the brain to maintain an essential selenium pool that protects against neurodegeneration

(2014) Raymond F. Burk et al.   FASEB JOURNAL

Clusterin Is a Ligand for Apolipoprotein E Receptor 2 (ApoER2) and Very Low Density Lipoprotein Receptor (VLDLR) and Signals via the Reelin-signaling Pathway

(2014) Christian Leeb et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Isoform-specific Binding of Selenoprotein P to the β-Propeller Domain of Apolipoprotein E Receptor 2 Mediates Selenium Supply

(2014) Suguru Kurokawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Receptor heterodimerization as a novel mechanism for the regulation of Wnt/ -catenin signaling

(2014) K. Lee et al.   JOURNAL OF CELL SCIENCE

Reelin receptors ApoER2 and VLDLR are expressed in distinct spatiotemporal patterns in developing mouse cerebral cortex

(2014) Yuki Hirota et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Alzheimer’s Disease Genetics: From the Bench to the Clinic

(2014) Celeste M. Karch et al.   NEURON

Sorting Nexin 17 Regulates ApoER2 Recycling and Reelin Signaling

(2014) Pablo Sotelo et al.   PLoS One

Differential splicing and glycosylation of Apoer2 alters synaptic plasticity and fear learning

(2014) C. R. Wasser et al.   Science Signaling

Reelin delays amyloid-beta fibril formation and rescues cognitive deficits in a model of Alzheimer’s disease

(2014) Lluís Pujadas et al.   Nature Communications

ApoER2 processing by presenilin-1 modulates reelin expression

(2013) Valeria Balmaceda et al.   FASEB JOURNAL

Reduced Reelin Expression Accelerates Amyloid-  Plaque Formation and Tau Pathology in Transgenic Alzheimer's Disease Mice

(2013) S. Kocherhans et al.   JOURNAL OF NEUROSCIENCE

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

Reelin Mobilizes a VAMP7-Dependent Synaptic Vesicle Pool and Selectively Augments Spontaneous Neurotransmission

(2013) Manjot Bal et al.   NEURON

Beta-Amyloid Impairs Reelin Signaling

(2013) Inmaculada Cuchillo-Ibáñez et al.   PLoS One

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk

(2012) Karolien Bettens et al.   Molecular Neurodegeneration

Regulated Proteolytic Processing of Reelin through Interplay of Tissue Plasminogen Activator (tPA), ADAMTS-4, ADAMTS-5, and Their Modulators

(2012) Dimitrije Krstic et al.   PLoS One

Reelin-dependent ApoER2 downregulation uncouples newborn neurons from progenitor cells

(2012) F. J. Perez-Martinez et al.   Biology Open

Clusterin facilitates in vivo clearance of extracellular misfolded proteins

(2011) Amy R. Wyatt et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Functional Importance of Covalent Homodimer of Reelin Protein Linked via Its Central Region

(2011) Norihisa Yasui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Similarities and differences in structure, expression, and functions of VLDLR and ApoER2

(2011) Sunil S Reddy et al.   Molecular Neurodegeneration

Ephrin Bs are essential components of the Reelin pathway to regulate neuronal migration

(2011) Aycan Sentürk et al.   NATURE

The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β1−40 peptide

(2011) Priyanka Narayan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Alzheimer's Disease: The Challenge of the Second Century

(2011) D. M. Holtzman et al.   Science Translational Medicine

The E3 Ubiquitin Ligase IDOL Induces the Degradation of the Low Density Lipoprotein Receptor Family Members VLDLR and ApoER2

(2010) Cynthia Hong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alzheimer disease pathology in cognitively healthy elderly: A genome-wide study

(2010) Patricia L. Kramer et al.   NEUROBIOLOGY OF AGING

ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling

(2010) Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

Role for Reelin in stabilizing cortical architecture

(2010) Michael Frotscher   TRENDS IN NEUROSCIENCES

A neuronal VLDLR variant lacking the third complement-type repeat exhibits high capacity binding of apoE containing lipoproteins

(2009) Keiko Sakai et al.   BRAIN RESEARCH

Advances and Challenges in Basic and Translational Research on Clusterin

(2009) I. P. Trougakos et al.   CANCER RESEARCH

Accumulation of reelin-positive plaques is accompanied by a decline in basal forebrain projection neurons during normal aging

(2009) Amrita Madhusudan et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The cytoplasmic adaptor protein X11α and extracellular matrix protein Reelin regulate ApoE receptor 2 trafficking and cell movement

(2009) S. Sakura Minami et al.   FASEB JOURNAL

Differential Functions of ApoER2 and Very Low Density Lipoprotein Receptor in Reelin Signaling Depend on Differential Sorting of the Receptors

(2009) Sarah Duit et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

(2009) Jean-Charles Lambert et al.   NATURE GENETICS

β-amyloid controls altered Reelin expression and processing in Alzheimer's disease

(2009) Arancha Botella-López et al.   NEUROBIOLOGY OF DISEASE

An Overview of APP Processing Enzymes and Products

(2009) Vivian W. Chow et al.   NEUROMOLECULAR MEDICINE

Splicing variations in the ligand-binding domain of ApoER2 results in functional differences in the binding properties to Reelin

(2009) Terumasa Hibi et al.   NEUROSCIENCE RESEARCH

Reelin signaling antagonizes  -amyloid at the synapse

(2009) M. S. Durakoglugil et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reelin and apolipoprotein E receptor 2 in the embryonic and mature brain: effects of an evolutionary change in the apoER2 gene

(2009) N. B. Myant   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Identification and characterization of glycosylation sites in human serum clusterin

(2009) James T. Kapron et al.   PROTEIN SCIENCE

Thrombospondin-1 binds to ApoER2 and VLDL receptor and functions in postnatal neuronal migration

(2008) Sophia M Blake et al.   EMBO JOURNAL

Cerebellar hypoplasia, with quadrupedal locomotion, caused by mutations in the very low-density lipoprotein receptor gene

(2008) S Türkmen et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

apoE isoform–specific disruption of amyloid β peptide clearance from mouse brain

(2008) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

Mutations in the very low-density lipoprotein receptor VLDLR cause cerebellar hypoplasia and quadrupedal locomotion in humans

(2008) T. Ozcelik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Age-related accumulation of Reelin in amyloid-like deposits

(2007) Irene Knuesel et al.   NEUROBIOLOGY OF AGING