Endothelial LRP1 regulates metabolic responses by acting as a co-activator of PPARγ

LRP in Endothelial Cells

(2016) Dudley K. Strickland et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

LRP1 Regulates Retinal Angiogenesis by Inhibiting PARP-1 Activity and Endothelial Cell ProliferationSignificance

(2015) Hua Mao et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Distinct regulatory mechanisms governing embryonic versus adult adipocyte maturation

(2015) Qiong A. Wang et al.   NATURE CELL BIOLOGY

The lipoprotein receptor LRP1 modulates sphingosine-1-phosphate signaling and is essential for vascular development

(2014) C. Nakajima et al.   DEVELOPMENT

Minireview: Challenges and Opportunities in Development of PPAR Agonists

(2014) Matthew B. Wright et al.   MOLECULAR ENDOCRINOLOGY

Genetic Inactivation of Pyruvate Dehydrogenase Kinases Improves Hepatic Insulin Resistance Induced Diabetes

(2013) Rongya Tao et al.   PLoS One

LRP1-Dependent Endocytic Mechanism Governs the Signaling Output of the Bmp System in Endothelial Cells and in Angiogenesis

(2012) Xinchun Pi et al.   CIRCULATION RESEARCH

Hypoxia Stimulates Low-Density Lipoprotein Receptor–Related Protein-1 Expression Through Hypoxia-Inducible Factor-1α in Human Vascular Smooth Muscle Cells

(2011) Jose Castellano et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Safety of PPAR Agonists

(2011) P. Home   DIABETES CARE

Hepatic Deficiency of Low Density Lipoprotein Receptor-related Protein-1 Reduces High Density Lipoprotein Secretion and Plasma Levels in Mice

(2011) Joshua E. Basford et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipoprotein Receptor LRP1 Regulates Leptin Signaling and Energy Homeostasis in the Adult Central Nervous System

(2011) Qiang Liu et al.   PLOS BIOLOGY

Signaling through LRP1: Protection from atherosclerosis and beyond

(2010) Philippe Boucher et al.   BIOCHEMICAL PHARMACOLOGY

Reduction of Brain β-Amyloid (Aβ) by Fluvastatin, a Hydroxymethylglutaryl-CoA Reductase Inhibitor, through Increase in Degradation of Amyloid Precursor Protein C-terminal Fragments (APP-CTFs) and Aβ Clearance

(2010) Mitsuru Shinohara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIV-1-induced amyloid beta accumulation in brain endothelial cells is attenuated by simvastatin

(2009) Ibolya E. András et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Pyruvate dehydrogenase kinase-4 deficiency lowers blood glucose and improves glucose tolerance in diet-induced obese mice

(2008) Nam Ho Jeoung et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

In Vivo Imaging Reveals Selective Peroxisome Proliferator Activated Receptor Modulator Activity of the Synthetic Ligand 3-(1-(4-Chlorobenzyl)-3-t-butylthio-5-isopropylindol-2-yl)-2,2-dimethylpropanoic acid (MK-886)

(2008) A. Biserni et al.   MOLECULAR PHARMACOLOGY

LDL Receptor-Related Protein 1: Unique Tissue-Specific Functions Revealed by Selective Gene Knockout Studies

(2008) Anna P. Lillis et al.   PHYSIOLOGICAL REVIEWS

 -Secretase Limits the Inflammatory Response Through the Processing of LRP1

(2008) K. Zurhove et al.   Science Signaling