Cellular death, reactive oxygen species (ROS) and diabetic complications

A novel damage mechanism: Contribution of the interaction between necroptosis and ROS to high glucose-induced injury and inflammation in H9c2 cardiac cells

(2017) Weijie Liang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Methylglyoxal-induced apoptosis is dependent on the suppression of c-FLIPL expression via down-regulation of p65 in endothelial cells

(2017) Ji Hoon Jang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Autophagy in Diabetic Retinopathy

(2016) Michelino Di Rosa et al.   Current Neuropharmacology

Hyperglycemic Conditions Prime Cells for RIP1-dependent Necroptosis

(2016) Timothy J. LaRocca et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ruboxistaurin attenuates diabetic nephropathy via modulation of TGF-β1/Smad and GRAP pathways

(2016) Asma S. AL-Onazi et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

R59949, a diacylglycerol kinase inhibitor, inhibits inducible nitric oxide production through decreasing transplasmalemmal l-arginine uptake in vascular smooth muscle cells

(2016) Tomoko Shimomura et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Pancreatic β Cell Mass Death

(2016) Husnia I. Marrif et al.   Frontiers in Pharmacology

Blockage of ROS and NF-κB-mediated inflammation by a new chalcone L6H9 protects cardiomyocytes from hyperglycemia-induced injuries

(2015) Peng Zhong et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Exogenous Hydrogen Sulfide Attenuates Cardiac Fibrosis Through Reactive Oxygen Species Signal Pathways in Experimental Diabetes Mellitus Models

(2015) Dan Zheng et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Novel N-pyrimidin-4-yl-3-amino-pyrrolo [3, 4-C] pyrazole derivatives as PKC kinase inhibitors: a patent evaluation of US2015099743 (A1)

(2015) Joydip Das   EXPERT OPINION ON THERAPEUTIC PATENTS

The novel NADPH oxidase 4 inhibitor GLX351322 counteracts glucose intolerance in high-fat diet-treated C57BL/6 mice

(2015) E. Anvari et al.   FREE RADICAL RESEARCH

AST IV inhibits H2O2-induced human umbilical vein endothelial cell apoptosis by suppressing Nox4 expression through the TGF-β1/Smad2 pathway

(2015) MA YUHONG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Inflammasome, mTORC1 activation, and metabolic derangement contribute to the susceptibility of diabetics to infections

(2015) Teresa Krakauer   MEDICAL HYPOTHESES

Protein kinase C-β inhibitor treatment attenuates hepatic ischemia and reperfusion injury in diabetic rats

(2015) GUANG-XING MENG et al.   Experimental and Therapeutic Medicine

TRAIL protects against endothelium injury in diabetes via Akt-eNOS signaling

(2014) Min Liu et al.   ATHEROSCLEROSIS

Investigating the Protective Effect of Lithium Against High Glucose-Induced Neurotoxicity in PC12 Cells: Involvements of ROS, JNK and P38 MAPKs, and Apoptotic Mitochondria Pathway

(2014) A. Aminzadeh et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Protein kinase RNA- like endoplasmic reticulum kinase (PERK) signaling pathway plays a major role in reactive oxygen species (ROS)- mediated endoplasmic reticulum stress- induced apoptosis in diabetic cardiomyopathy

(2013) Zhong-Wei Liu et al.   Cardiovascular Diabetology

Mammalian Target of Rapamycin (mTOR) Inhibition with Rapamycin Improves Cardiac Function in Type 2 Diabetic Mice

(2013) Anindita Das et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of metformin on markers of oxidative stress and antioxidant reserve in patients with newly diagnosed type 2 diabetes: A randomized clinical trial

(2012) Alireza Esteghamati et al.   CLINICAL NUTRITION

Diallyl trisufide (DATS) suppresses high glucose-induced cardiomyocyte apoptosis by inhibiting JNK/NFκB signaling via attenuating ROS generation

(2012) Wei-Wen Kuo et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

The emerging role of autophagy in the pathophysiology of diabetes mellitus

(2010) Claudio D. Gonzalez et al.   Autophagy

Comparative pharmacology of chemically distinct NADPH oxidase inhibitors

(2010) S Wind et al.   BRITISH JOURNAL OF PHARMACOLOGY

NADPH Oxidases Regulate CD44 and Hyaluronic Acid Expression in Thrombin-treated Vascular Smooth Muscle Cells and in Atherosclerosis

(2010) Aleksandr E. Vendrov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

First in Class, Potent, and Orally Bioavailable NADPH Oxidase Isoform 4 (Nox4) Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis

(2010) Benoı̂t Laleu et al.   JOURNAL OF MEDICINAL CHEMISTRY

NADPH Oxidase 2-Derived Reactive Oxygen Species Mediate FFAs-Induced Dysfunction and Apoptosis of β-Cells via JNK, p38 MAPK and p53 Pathways

(2010) Huiping Yuan et al.   PLoS One

Post-Stroke Inhibition of Induced NADPH Oxidase Type 4 Prevents Oxidative Stress and Neurodegeneration

(2010) Christoph Kleinschnitz et al.   PLOS BIOLOGY

Small-Molecule NOX Inhibitors: ROS-Generating NADPH Oxidases as Therapeutic Targets

(2009) Vincent Jaquet et al.   ANTIOXIDANTS & REDOX SIGNALING

Role and regulation of autophagy in cancer

(2009) Ning Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The NADPH oxidase inhibitor diphenyleneiodonium is also a potent inhibitor of cholinesterases and the internal Ca2+ pump

(2009) T Tazzeo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Losartan Metabolite EXP3179 Blocks NADPH Oxidase-Mediated Superoxide Production by Inhibiting Protein Kinase C

(2009) Ana Fortuño et al.   HYPERTENSION

Analytical Review of the Evidence for Renoprotection by Renin-Angiotensin-Aldosterone System Blockade in Chronic Kidney Disease – A Call for Caution

(2009) Macaulay A. Onuigbo   NEPHRON CLINICAL PRACTICE

Extracellular High-Mobility Group Box 1 Acts as an Innate Immune Mediator to Enhance Autoimmune Progression and Diabetes Onset in NOD Mice

(2008) J. Han et al.   DIABETES

High Glucose Induces Toll-Like Receptor Expression in Human Monocytes: Mechanism of Activation

(2008) M. R. Dasu et al.   DIABETES

From hyperglycemia to AGE-RAGE interaction on the cell surface: A dangerous metabolic route for diabetic patients

(2008) José Augusto Nogueira-Machado et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Unknown

(2008) John Klune et al.   MOLECULAR MEDICINE