Article
Clinical Neurology
Jorge J. Llibre-Guerra, Jing Li, Yuting Qian, Juan de Jesus Llibre-Rodriguez, Ivonne Z. Jimenez-Velazquez, Daisy Acosta, Aquiles Salas, Juan Carlos Llibre-Guerra, Adolfo Valvuerdi, Amal Harrati, Jordan Weiss, Mao-Mei Liu, William H. Dow
Summary: This study investigated the role of the major susceptibility gene for Alzheimer's disease, APOE, in diverse Hispanic populations. The study found that APOEε4 carriers had higher dementia prevalence and lower memory performance in all subsamples.
ALZHEIMERS & DEMENTIA
(2023)
Article
Nutrition & Dietetics
Meng-Yu Li, Man-Ki Kwok, Catherine Mary Schooling
Summary: The study suggests that plasma apoE2 and apoE4 may play a role in lipid modulation and ischemic heart disease, while further clarification is needed on the potential therapeutic targets once larger genetic studies of apoE isoforms are available.
Article
Biochemistry & Molecular Biology
Michel Satya Naslavsky, Claudia K. Suemoto, Luciano Abreu Brito, Marilia Oliveira Scliar, Renata Eloah Ferretti-Rebustini, Roberta Diehl Rodriguez, Renata E. P. Leite, Nathalia Matta Araujo, Victor Borda, Eduardo Tarazona-Santos, Wilson Jacob-Filho, Carlos Pasqualucci, Ricardo Nitrini, Kristine Yaffe, Mayana Zatz, Lea T. Grinberg
Summary: Dementia is more common in Blacks than in Whites, possibly due to a combination of environmental and biological factors. Interestingly, studies have shown a lower risk of dementia associated with APOE epsilon 4 in individuals of African ancestry. However, the underlying biological factors are not well understood. This study found that African ancestry was associated with a lower burden of neuropathology, but in individuals with severe neuropathology, it was associated with worse clinical symptoms of dementia.
MOLECULAR PSYCHIATRY
(2022)
Article
Cell Biology
Aylin Dincer, Charles D. Chen, Nicole S. McKay, Lauren N. Koenig, Austin McCullough, Shaney Flores, Sarah J. Keefe, Stephanie A. Schultz, Rebecca L. Feldman, Nelly Joseph-Mathurin, Russ C. Hornbeck, Carlos Cruchaga, Suzanne E. Schindler, David M. Holtzman, John C. Morris, Anne M. Fagan, Tammie L. S. Benzinger, Brian A. Gordon
Summary: This study investigated the relationship between the APOE ε4 allele and beta-amyloid and tau proteins. The results showed that APOE ε4 carriers had higher tau PET signals in the temporal regions, but there was no interaction with MRI volumes or CSF ptau181. Sex had a greater impact on the effects of APOE genotype, although it was not strongly correlated with mRNA expression.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Neurosciences
Mitsuru Shinohara, Kaoru Suzuki, Guojun Bu, Naoyuki Sato
Summary: The study found that the effects of diabetes on longevity vary among APOE genotype, particularly in nondemented individuals, and may be associated with activity status during their lifespan.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Neurosciences
Tamara Shiner, Anat Mirelman, Yevgenia Rosenblum, Gitit Kave, Mali Gana Weisz, Anat Bar-Shira, Orly Goldstein, Avner Thaler, Tanya Gurevich, Avi Orr-Urtreger, Nir Giladi, Noa Bregman
Summary: The study found high frequencies of GBA mutations and the APOE epsilon 4 allele among AJ patients with DLB, with distinct effects on the clinical disease phenotype separately and in combination. GBA mutation carriers had earlier onset age, poorer cognition, and more severe parkinsonism compared to non-carriers. There were significant interactions between the two genetic factors, with patients carrying both mutations showing more severe cognitive and motor dysfunction.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Neurosciences
Michelle M. Dunk, Ira Driscoll
Summary: This study investigates the relationship between total cholesterol and APOE-related AD risk. The results show that higher total cholesterol may be a significant contributor to AD risk, particularly in APOE4 carriers. These findings highlight a possible mechanism by which APOE confers AD risk and indicate the potential for AD risk modification through maintenance of healthy total cholesterol levels.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Biochemical Research Methods
Paige E. Lawler, James G. Bollinger, Suzanne E. Schindler, Cynthia R. Hodge, Nicolas J. Iglesias, Vishal Krishnan, John B. Coulton, Iran Li, David M. Holtzman, Randall J. Bateman
Summary: Although the APOE 4 allele is highly associated with sporadic Alzheimer's disease, the mechanism of apolipoprotein (apoE) and AD pathophysiology remains unclear. This study developed a LC-MS/MS assay to measure both unmodified and O-glycosylated apoE peptides in plasma and cerebrospinal fluid (CSF). The results indicate that plasma apoE glycosylation levels correlate with total apoE levels, APOE genotype, and amyloid status, suggesting it could be a marker of brain amyloidosis and may contribute to the pathophysiology of AD.
ANALYTICAL BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Paolo Abondio, Francesco Bruno, Donata Luiselli
Summary: Human APOE is a protein that plays a role in lipid metabolism, with specific activities related to cholesterol transport. It has three main variants, which impact lipid metabolism differently and are associated with diseases like Alzheimer's and cardiovascular disease. This study analyzes the distribution of these variants and haplotypes among different populations and suggests their potential for ancestry-informed screenings in medicine and public health.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Neurosciences
John Andersson, Anna Sundstrom, Maria Nordin, David Segersson, Bertil Forsberg, Rolf Adolfsson, Anna Oudin
Summary: This study aimed to investigate the association between PM2.5 exposure and dementia in a low exposure area, and the role of olfaction and the APOE epsilon 4 allele in these associations.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Nutrition & Dietetics
Minwoo Lee, Jae-Sung Lim, Yerim Kim, Soo Hyun Park, Sang-Hwa Lee, Chulho Kim, Byung-Chul Lee, Kyung-Ho Yu, Jae-Jun Lee, Mi Sun Oh
Summary: The ApoB/ApoA-I ratio in the acute stage of stroke independently predicts the development of post-stroke cognitive impairment (PSCI) at 3-6 months after stroke due to large artery atherosclerosis. Specifically, a high ApoB/ApoA-I ratio is associated with dysfunction in the frontal domain.
Article
Neurosciences
Lenique K. L. Huggins, Se Hee Min, Samantha Kaplan, Jingkai Wei, Kathleen Welsh-Bohmer, Hanzhang Xu
Summary: There are racial and ethnic variations in the association between the APOE epsilon 4 allele and the risk of developing Alzheimer's disease and related dementias (ADRD). This study examined this association among global Hispanic populations and found that APOE epsilon 4 was significantly associated with increased risk of ADRD for the South American subgroup, while the association was not significant for other Hispanic subgroups.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Clinical Neurology
Yume Imahori, Davide L. Vetrano, Petter Ljungman, Erika J. Laukka, Jing Wu, Giulia Grande, Debora Rizzuto, Laura Fratiglioni, Chengxuan Qiu
Summary: This study reveals the independent and joint effects of ischemic heart disease and coexisting atrial fibrillation and heart failure on dementia risk. Ischemic heart disease is associated with an increased risk of dementia and cognitive decline in older adults, independent of atrial fibrillation, heart failure, and cerebrovascular disease.
ALZHEIMERS & DEMENTIA
(2023)
Article
Cardiac & Cardiovascular Systems
Katrine L. Rasmussen, Jiao Luo, Borge G. Nordestgaard, Anne Tybjaerg-Hansen, Ruth Frikke-Schmidt
Summary: The structural genetic variations in the APOE gene are associated with vascular diseases. APOE variants with high apoE, triglycerides, and remnant cholesterol are associated with peripheral arterial disease (PAD), while common APOE variants with high LDL cholesterol, triglycerides, and remnant cholesterol are associated with ischemic heart disease (IHD). APOE variants with low apoE are associated with increased risk of ischemic cerebrovascular disease (ICVD).
Article
Clinical Neurology
Amin Gharbi-Meliani, Aline Dugravot, Severine Sabia, Melina Regy, Aurore Fayosse, Alexis Schnitzler, Mika Kivimaki, Archana Singh-Manoux, Julien Dumurgier
Summary: The study found that APOE ε4 carriers have poorer cognition and higher risk of dementia in old age. Heterozygous ε4 carriers have cognitive advantage in midlife and show poorer cognitive scores after the age of 75.
ALZHEIMERS RESEARCH & THERAPY
(2021)