Treatment with the poly(ADP-ribose) polymerase inhibitor PJ-34 improves cerebromicrovascular endothelial function, neurovascular coupling responses and cognitive performance in aged mice, supporting the NAD+ depletion hypothesis of neurovascular aging

Role of endothelial NAD+ deficiency in age-related vascular dysfunction

(2019) Anna Csicsar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Nicotinamide mononucleotide (NMN) treatment attenuates oxidative stress and rescues angiogenic capacity in aged cerebromicrovascular endothelial cells: a potential mechanism for the prevention of vascular cognitive impairment

(2019) Tamas Kiss et al.   GeroScience

Augmentation of cellular NAD + by NQO1 enzymatic action improves age‐related hearing impairment

(2019) Hyung‐Jin Kim et al.   AGING CELL

Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice

(2019) Stefano Tarantini et al.   Redox Biology

Age-related impairment of neurovascular coupling responses: a dynamic vessel analysis (DVA)-based approach to measure decreased flicker light stimulus-induced retinal arteriolar dilation in healthy older adults

(2019) Agnes Lipecz et al.   GeroScience

Treatment with the mitochondrial-targeted antioxidant peptide SS-31 rescues neurovascular coupling responses and cerebrovascular endothelial function and improves cognition in aged mice

(2018) Stefano Tarantini et al.   AGING CELL

Impairment of an Endothelial NAD + -H 2 S Signaling Network Is a Reversible Cause of Vascular Aging

(2018) Abhirup Das et al.   CELL

NAD + Intermediates: The Biology and Therapeutic Potential of NMN and NR

(2018) Jun Yoshino et al.   Cell Metabolism

Rapamycin increases oxidative metabolism and enhances metabolic flexibility in human cardiac fibroblasts

(2018) Timothy Nacarelli et al.   GeroScience

PACAP deficiency as a model of aging

(2018) D. Reglodi et al.   GeroScience

Impaired neurovascular coupling in aging and Alzheimer's disease: Contribution of astrocyte dysfunction and endothelial impairment to cognitive decline

(2017) Stefano Tarantini et al.   EXPERIMENTAL GERONTOLOGY

Rapamycin treatment attenuates age-associated periodontitis in mice

(2017) Jonathan Y. An et al.   GeroScience

IGF-1 has sexually dimorphic, pleiotropic, and time-dependent effects on healthspan, pathology, and lifespan

(2017) Nicole M. Ashpole et al.   GeroScience

Role of DNA methylation in the dietary restriction mediated cellular memory

(2017) Archana Unnikrishnan et al.   GeroScience

Pharmacologically induced impairment of neurovascular coupling responses alters gait coordination in mice

(2017) Stefano Tarantini et al.   GeroScience

Differential effects of early-life nutrient restriction in long-lived GHR-KO and normal mice

(2017) Yimin Fang et al.   GeroScience

The GH/IGF-1 axis in a critical period early in life determines cellular DNA repair capacity by altering transcriptional regulation of DNA repair-related genes: implications for the developmental origins of cancer

(2017) Andrej Podlutsky et al.   GeroScience

Cerebromicrovascular dysfunction predicts cognitive decline and gait abnormalities in a mouse model of whole brain irradiation-induced accelerated brain senescence

(2017) Zoltan Ungvari et al.   GeroScience

A new mouse model of frailty: the Cu/Zn superoxide dismutase knockout mouse

(2017) Sathyaseelan S. Deepa et al.   GeroScience

Demonstration of impaired neurovascular coupling responses in TG2576 mouse model of Alzheimer’s disease using functional laser speckle contrast imaging

(2017) Stefano Tarantini et al.   GeroScience

Why NAD + Declines during Aging: It’s Destroyed

(2016) Michael B. Schultz et al.   Cell Metabolism

Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice

(2016) Kathryn F. Mills et al.   Cell Metabolism

Bioenergetic Impairment in Animal and Cellular Models of Alzheimer’s Disease: PARP-1 Inhibition Rescues Metabolic Dysfunctions

(2016) Sara Martire et al.   JOURNAL OF ALZHEIMERS DISEASE

Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds

(2016) Michael S. Bonkowski et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

IGF-1 deficiency impairs neurovascular coupling in mice: implications for cerebromicrovascular aging

(2015) Peter Toth et al.   AGING CELL

Purinergic glio-endothelial coupling during neuronal activity: role of P2Y1 receptors and eNOS in functional hyperemia in the mouse somatosensory cortex

(2015) Peter Toth et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Pharmacologically-Induced Neurovascular Uncoupling is Associated with Cognitive Impairment in Mice

(2015) Stefano Tarantini et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

PARP-1 involvement in neurodegeneration: A focus on Alzheimer’s and Parkinson’s diseases

(2015) Sara Martire et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Resveratrol treatment rescues neurovascular coupling in aged mice: role of improved cerebromicrovascular endothelial function and downregulation of NADPH oxidase

(2013) Peter Toth et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

(2013) Ana P. Gomes et al.   CELL

Age-related changes of blood-oxygen-level–dependent signal dynamics during optokinetic stimulation

(2013) Iskra Stefanova et al.   NEUROBIOLOGY OF AGING

Neurovascular coupling in normal aging: A combined optical, ERP and fMRI study

(2013) Monica Fabiani et al.   NEUROIMAGE

Neurovascular coupling, cerebral white matter integrity, and response to cocoa in older people

(2013) F. A. Sorond et al.   NEUROLOGY

Activation of PARP by Oxidative Stress Induced by β-Amyloid: Implications for Alzheimer’s Disease

(2012) Rosella Abeti et al.   NEUROCHEMICAL RESEARCH

Age-Associated Changes In Oxidative Stress and NAD+ Metabolism In Human Tissue

(2012) Hassina Massudi et al.   PLoS One

Neurovascular coupling is impaired in slow walkers: The MOBILIZE Boston Study

(2011) Farzaneh A. Sorond et al.   ANNALS OF NEUROLOGY

PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation

(2011) Péter Bai et al.   Cell Metabolism

Growth Hormone and IGF-1 Deficiency Exacerbate High-Fat Diet-Induced Endothelial Impairment in Obese Lewis Dwarf Rats: Implications for Vascular Aging

(2011) L. C. Bailey-Downs et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Age Related Changes in NAD+ Metabolism Oxidative Stress and Sirt1 Activity in Wistar Rats

(2011) Nady Braidy et al.   PLoS One

Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: Role of circulating factors and SIRT1

(2009) Anna Csiszar et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Occipital cortex activation studied with simultaneous recordings of functional transcranial Doppler ultrasound (fTCD) and visual evoked potential (VEP) in cognitively normal human subjects: Effect of healthy aging

(2009) M. Akif Topcuoglu et al.   NEUROSCIENCE LETTERS

Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations

(2008) Anna Csiszar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Endothelial function and vascular oxidative stress in long-lived GH/IGF-deficient Ames dwarf mice

(2008) Anna Csiszar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span

(2008) Kevin J. Pearson et al.   Cell Metabolism