Article
Genetics & Heredity
Nevin Karakus, Serbulent Yigit, Nursah Basol, Onur Incealtin
Summary: This study investigated the relationship between MTHFR and ACE gene polymorphisms and acute ischemic stroke. The results showed a significant correlation between MTHFR gene A1298C polymorphism and acute ischemic stroke. Additionally, genotype combinations of MTHFR and ACE gene polymorphisms were also associated with an increased risk of acute ischemic stroke. Further research is needed to validate these findings and utilize these genetic variations as alternative treatments for ischemic stroke.
JOURNAL OF GENETICS
(2023)
Article
Neurosciences
Chunyang Wang, Fenghe Zhang, Xiaojing Zhang, Chao Zhang, He Li
Summary: In this meta-analysis, we found that the phosphodiesterase 4D (PDE4D) rs966221 variant is associated with ischemic stroke (IS) risk in the Caucasian population but not consistently in Chinese populations. However, subgroup analysis revealed a significant association between rs966221 and IS susceptibility in the Northeast Chinese populations.
Article
Developmental Biology
Guifeng Ding, Yan Li, Jianrong Gao, Wenxia Wang, Huijuan Wang, Guiqin Bai
Summary: This study investigated the associations between angiotensinogen, methylenetetrahydrofolate reductase, vascular endothelial growth factor gene polymorphisms, and preeclampsia in the Han Chinese population. The results suggest that a specific variant in the MTHFR gene may increase the risk of preeclampsia in pregnant women, while polymorphisms in the AGT and VEGF genes may not play a significant role in the development of preeclampsia.
Article
Nutrition & Dietetics
Mong-Liang Lu, Wei-Chi Ku, Nailis Syifa, Shu-Chin Hu, Chia-Te Chou, Yi-Hsio Wu, Po-Hsiu Kuo, Chun-Hsin Chen, Wei J. Chen, Tzu-Hua Wu
Summary: Inadequate levels of 5-methyltetrahydrofolate (5-MTHF) and the T variant of MTHFR C677T have been suggested to be associated with an increased risk of developing mental illness, whereas the PON1 SNP variant provides a protective role. This study used a sensitive LC-MS/MS system to measure 5-MTHF levels in schizophrenia patients and healthy controls in Taiwan. The results showed that schizophrenia patients had significantly lower levels of 5-MTHF compared to the healthy controls. Lower plasma 5-MTHF concentrations were observed in male subjects.
Article
Neurosciences
Liangyan Pei, Xiaofan Xu, Tianqi Yuan
Summary: This study found that circ_0101874 plays an important role in ischemic stroke, and its knockdown can alleviate OGD-induced neuronal cell injury by suppressing PDE4D and regulating miR-335-5p.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2022)
Article
Neurosciences
Mehrdokht Mazdeh, Mojtaba Khazaie, Mir Davood Omrani, Rezvan Noroozi, Alireza Komaki, Masoud Karimi, Mohammad Taheri, Soudeh Ghafouri-Fard
Summary: The study revealed an association between MTHFR gene rs1801133 and rs1801131 SNPs with the risk of ischemic stroke in the Iranian population, especially with rs1801133 showing significant association in the recessive model.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2021)
Article
Endocrinology & Metabolism
Lamia M'barek, Salma Sakka, Fatma Meghdiche, Dhaker Turki, Khadija Maalla, Mariem Dammak, Choumous Kallel, Chokri Mhiri
Summary: The study confirmed the involvement of MTHFR polymorphisms as important risk factors for AIS, while the presence of FVL polymorphism or prothrombin G20210A mutation alone is not correlated with stroke occurrence. Patients with both MTHFR and FVL polymorphisms have a synergistic effect, increasing the risk of AIS.
METABOLIC BRAIN DISEASE
(2021)
Article
Multidisciplinary Sciences
Jinghong Rao, Youfang Chen, Xuan Chen, Ruoying Wu, Shimu Luo, Qingfan Lin, Zhenzhu Dong, Jingying Huang
Summary: This study investigated the impact of polymorphisms in the eNOS and MTHFR genes on preeclampsia. The results showed that the frequency of the eNOS -786 C C genotype and MTHFR 677 TT genotype were higher in women with preeclampsia, leading to lower NO levels and higher Hcy levels.
Review
Genetics & Heredity
Lili Zhao, Tao Li, Meijuan Dang, Ye Li, Hong Fan, Qian Hao, Dingli Song, Jialiang Lu, Ziwei Lu, Yating Jian, Heying Wang, Xiaoya Wang, Yulun Wu, Guilian Zhang
Summary: This study found a significant association between the MTHFR rs1801133 (677C > T) gene mutation and an increased risk of ischemic stroke, particularly in the Asian, Hispanic, or Latin population and middle-aged and elderly individuals.
FRONTIERS IN GENETICS
(2023)
Article
Biochemistry & Molecular Biology
Amrit Sudershan, Agar Chander Pushap, Hardeep Kumar, Parvinder Kumar
Summary: The present meta-analysis found that MTHFR-C677T is significantly associated with an increased risk of migraine and its clinical subtype. ACE I/D also significantly increases the risk of overall migraine and both clinical subtypes. MTHFR A1289C only increases the risk of migraine in certain genetic models.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2023)
Review
Clinical Neurology
Manabesh Nath, Priyanka Swarnkar, Shubham Misra, Pradeep Kumar
Summary: This meta-analysis aimed to evaluate the relationship between phosphodiesterase 4 D (PDE4D) gene polymorphism and the risk of ischemic stroke (IS). The results showed that SNP45, SNP83, and SNP89 polymorphisms were significantly associated with increased risk of IS in Asians, but not in the Caucasian population.
ACTA NEUROLOGICA BELGICA
(2023)
Article
Neurosciences
Ankit Goyal, Alvee Saluja, Kallur N. Saraswathy, Priya Bansal, Rajinder K. Dhamija
Summary: The study demonstrates a strong association between ACE insertion/deletion polymorphism and the risk of acute ischemic stroke (AIS), with the DD genotype independently associated with an increased risk. This finding suggests the potential of ACE polymorphism as a genetic risk factor for AIS.
Article
Health Care Sciences & Services
Alexandra Mastaleru, Sabina Alexandra Cojocariu, Andra Oancea, Maria Magdalena Leon Constantin, Mihai Roca, Ioana Madalina Zota, Irina Abdulan, Cristina Rusu, Roxana Popescu, Lucian Mihai Antoci, Cristian Gabriel Ciobanu, Alexandru Dan Costache, Elena Cojocaru, Florin Mitu
Summary: This study found that polymorphisms in PAI-1, ACE, ApoB-100, MTHFR A1298C, and C677T genes are associated with atherosclerosis, atherosclerotic cardiovascular disease, and metabolic syndrome in patients with familial hypercholesterolemia.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Medicine, Research & Experimental
Caixia Zhou, Yashu Kuang, Qinyu Li, Yunhao Duan, Xiuxiang Liu, Jinnan Yue, Xiaoli Chen, Jie Liu, Yuzhen Zhang, Lin Zhang
Summary: This study demonstrates that EC-expressing S1pr2 tightly controls post-ischemic angiogenesis and blood flow perfusion recovery. The inhibition of S1pr2 can enhance post-ischemic angiogenesis and improve blood flow in peripheral artery disease, offering a novel therapeutic intervention.
Review
Clinical Neurology
Michelle C. Johansen
Summary: Accurate determination and diagnosis of ischemic stroke are crucial for providing excellent cerebrovascular care. It helps initiate appropriate prevention strategies, educate patients about specific risk factors, and predict patient outcomes. It also provides an opportunity for patients to participate in research studies and targeted treatments. Advances in research, imaging techniques, biomarkers, and genetic sequencing have challenged the traditional classification of stroke, leading to the identification of new entities and limitations in current diagnostic algorithms. This article reviews the steps for accurate classification and discusses emerging research and future directions in stroke diagnostics and classification.
Article
Genetics & Heredity
Minju Choi, Chaeyoung Lee
INTERNATIONAL JOURNAL OF HUMAN GENETICS
(2019)
Article
Biotechnology & Applied Microbiology
Shen-Yin Lim, Keat Wei Loo, Wey-Lim Wong
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2020)
Article
Biology
Loo Keat Wei, Leong Shi Quan
COMPUTATIONAL BIOLOGY AND CHEMISTRY
(2019)
Review
Pharmacology & Pharmacy
Yit-Lai Chow, Lai Kuan Teh, Loh Huey Chyi, Li Fang Lim, Chin Chu Yee, Loo Keat Wei
CURRENT PHARMACEUTICAL DESIGN
(2020)
Article
Genetics & Heredity
Jihye Ryu, Chaeyoung Lee
FRONTIERS IN GENETICS
(2020)
Article
Neurosciences
Orwa Albitar, Sabariah Noor Harun, Nur Ezzati Abidin, Balamurugan Tangiisuran, Hadzliana Zainal, Irene Looi, Khairul Azmi Ibrahim, Norsima Nazifah Sidek, Keat Wei Loo, Keng Yee Lee, Zariah Abdul Aziz, Siti Maisharah Sheikh Ghadzi
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2020)
Review
Multidisciplinary Sciences
Yee Teng Lee, Nor Ismaliza Mohd Ismail, Loo Keat Wei
Summary: The relationship between microbiome and ischemic stroke is a novel and important research area. Aging, inflammation, and different microbial compositions may have an impact on the development of ischemic stroke.
Review
Neurosciences
Li Min Wong, Lee Quen Phoon, Loo Keat Wei
Summary: This study highlighted the epigenetic mechanisms associated with the occurrence of large-artery atherosclerosis (LAA), showing that hypomethylation of miRNAs and lncRNAs may serve as potential biomarkers for LAA.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2021)
Article
Genetics & Heredity
Chaeyoung Lee
Summary: This paper discusses the importance and challenges of discovering expression quantitative trait loci (eQTLs), focusing on the complexity of eTraits and the voluminous work required for eQTL profiles. It presents the properties and prospects of statistical methods, including the mixed model method, Bayesian inference, deep learning, and integration methods, as future directions for eQTL discovery.
Article
Engineering, Chemical
Jihye Ryu, Chaeyoung Lee
Summary: The study revealed significant heritability underestimation for molecules from an infinitesimal model in mixed model analysis, emphasizing the importance of using an optimal number of nucleotide variants to accurately estimate heritability and identify expression quantitative trait loci (eQTLs). Additionally, a heterogeneous covariance structure based on gene identity and the molecular layers of the gene expression process is essential for better understanding polygenic effects and minimizing errors in identifying eQTLs.
Article
Biology
Yeeun An, Chaeyoung Lee
Summary: In this study, a transcriptome-wide analysis was conducted to identify target genes associated with gender imbalance. The results suggest that these genes play important roles in sex determination and spermatogenesis.
COMPUTATIONAL BIOLOGY AND CHEMISTRY
(2022)
Article
Agronomy
Huei-Huei Kong, Loo Keat Wei, Wei Lim Goh
Summary: This study reported the existence of a new hybrid bamboo species at a new locality in Peninsular Malaysia and analyzed the population genetic structure of the hybrid and parental populations. The hybrid population showed a high degree of genetic variability and did not adversely affect the population structure of the parental populations. Opportunities for new hybrid populations are anticipated to emerge in the wild.
GENETIC RESOURCES AND CROP EVOLUTION
(2023)
Article
Genetics & Heredity
Yeeun An, Chaeyoung Lee
Summary: In this study, transcriptome-wide analysis of expression quantitative trait loci (eQTL) was conducted to identify target genes associated with Hodgkin lymphoma (HL) genome-wide association studies (GWAS) signals. A total of 80 eGenes were identified to be associated with 20 HL GWAS signals. Enrichment analysis revealed the functions of these eGenes involved apoptosis, immune responses, and cytoskeletal processes. Further investigation on two specific eGenes suggested that their minor alleles could be genetic risk factors for HL susceptibility.
Article
Chemistry, Multidisciplinary
Younyoung Kim, Chaeyoung Lee
Summary: This study utilized GWAS and tissue-specific eQTL data to identify regulatory elements and enriched pathways associated with type 2 diabetes. The findings highlight the potential importance of the lysosomal pathway in autophagic termination and provide insights into the pathogenesis of T2DM.
APPLIED SCIENCES-BASEL
(2023)
Article
Genetics & Heredity
Jooyeon Han, Chaeyoung Lee
Summary: This study found heterogeneity in expression quantitative trait locus (eQTL) effects across gene expression processes. Multiple functional variants were shown to exert their regulatory functions at different points in the gene expression process, resulting in complexity of single eQTLs.
Article
Neurosciences
Adam Vacek, Grant Mair, Philip White, Philip M. Bath, Keith W. Muir, Rustam Al-Shahi Salman, Chloe Martin, David Dye, Francesca M. Chappell, Ruediger von Kummer, Malcolm Macleod, Nikola Sprigg, Joanna M. Wardlaw
Summary: This study evaluated the performance of e-ASPECTS software in delineating the extent of intracranial hemorrhage (ICH) on brain CT scans. The results showed that the software achieved excellent or good delineation of ICH extent in 71% of cases. However, it was more likely to over- or under-estimate the extent when ICH was more extensive, intraventricular, or extra-axial.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Mathias Jacobsen Bach, Audrone Jakubauskaite, Ian Law, Otto Molby Henriksen, Inger Havsteen, Alexander Cuculiza Henriksen, Sverre Rosenbaum, Lisbeth Marner
Summary: This study found that the rCBFacz value after ACZ challenge can serve as an important indicator for predicting future cerebrovascular events, with high accuracy and prognostic value.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Tak Kyu Oh, Saeyeon Kim, In-Ae Song
Summary: The study found that many survivors of nontraumatic intracranial hemorrhage in South Korea experience unemployment, decreased household income, and newly acquired disability after intensive care unit admission. However, these changes are not associated with 2-year all-cause mortality.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Eduardo Sousa de Melo, Rodrigo de Paiva Bezerra, Arthur Cesario de Holanda, Maria Junia Lira e Silva, Paloma Peter Travassos, Tayne Fernanda Lemos da Silva, Genova Maria de Azevedo Oliveira, Silvia Marinho Martins Alves, Carolina de Araujo Medeiros, Maria das Neves Dantas da Silveira Barros, Wilson Alves de Oliveira, Gisele Sampaio Silva, Luciana Patrizia Alves de Andrade Valenca
Summary: Cardiac involvement has been found to be the predominant factor correlated with stroke in Chagas disease. While atherosclerosis-related risk factors are prevalent, their influence on ischemic stroke in Chagas disease appears limited.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Pingping Zheng, Ning Zhang, Zixi Chen
Summary: This case presents a rare infectious cause of stroke and air embolism involving a pulmonary abscess and pulmonary vein thrombosis. Early detection, diagnosis, and appropriate treatment of infected systemic embolism in young patients are crucial to prevent serious complications.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Filippo Luca Gurgoglione, Luigi Vignali, Maria Alberta Cattabiani, Emilia Solinas, Giorgio Benatti, Iacopo Tadonio, Federico Barocelli, Chiara Dizdari, Domenico Tuttolomondo, Diego Ardissino, Francesco Nicolini, Giampaolo Niccoli
Summary: The incidence of recurrent ischemic neurological events after transcatheter patent foramen ovale closure is relatively low. Obesity, Risk of Paradoxical Embolism score < 7, and migraine are independent positive predictors of recurrent stroke or transient ischemic attack.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Angelo Cascio Rizzo, Ghil Schwarz, Amedeo Cervo, Giuditta Giussani, Chiara Ceresa, Antonella Gatti, Fausto De Angeli, Cristina Motto, Angelo Guccione, Rachele Tortorella, Giuseppe Granata, Claudia Rollo, Antonio Macera, Mariangela Piano, Guglielmo Pero, Elio Clemente Agostoni
Summary: This study aimed to evaluate the efficacy and safety of endovascular treatment (EVT) in primary and EVT-induced secondary medium-vessel occlusions (MeVO). The results showed that primary MeVO had poorer outcomes in terms of complications, EVT efficacy, and the proportion of patients with a modified Rankin Scale (mRS) of 0-2 at 3 months compared to exclusive large-vessel occlusion (LVO). However, EVT-induced secondary MeVO showed similar safety and efficacy outcomes as exclusive LVO and had better outcomes in terms of mRS 0-2 compared to primary MeVO.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Jing Zhang, Chenming Wei, Jian Wu
Summary: This case report describes a patient with Bloom syndrome who developed acute cerebral infarction along with elevated antiphospholipid antibodies, suggesting a possible association between immune and coagulation abnormalities caused by Bloom syndrome and the development of acute cerebral infarction.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Yunxia Zhou, Shenglan He, Yanhong Hu
Summary: Compared with clopidogrel, DAPT with ticagrelor plus aspirin was associated with significantly lower thromboembolic events without an increase in hemorrhagic events in the treatment of intracranial aneurysms, according to the one-year clinical outcome analysis. However, larger upcoming trials are needed to confirm the effectiveness and safety of ticagrelor-associated DAPT.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Edvania Andrade de Moura Silva, Ludmilla Ribeiro Batista, Marcela Aline Fernandes Braga, Luci Fuscaldi Teixeira-Salmela, Christina Danielli Coelho de Morais Faria, Iza Faria-Fortini
Summary: The study found that stroke severity is the best predictor of self-perceived manual ability at both three and six months after stroke. Age, although significant, contributes little to the prediction of manual ability.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Sidarrth Prasad, Erica M. Jones, Mehari Gebreyohanns, Veronica Aguilera, DaiWai M. Olson, Jane A. Anderson, Sean I. Savitz, Salvador C. Flores, Steven J. Warach, Charlotte E. Rhodes, Mark P. Goldberg, Nneka L. Ifejika
Summary: This study identified the barriers and facilitators to adopting tenecteplase (TNK) as a thrombolytic treatment for acute ischemic stroke (AIS) by conducting qualitative research with stroke clinicians in Texas. The findings suggest that providing evidence and identifying key change processes can help clinicians achieve consensus on adopting TNK for AIS treatment.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Jeshma Jayan, Sunil K. Narayan, Yasmin Nesha Haniffa, Navin Kumar
Summary: This study investigated the effects of transcranial electrical and magnetic stimulation on somatosensory evoked potentials in chronic ischemic stroke patients, finding that the real tDCS and rTMS combination results in significant improvement and is safe for use.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Phoebe M. Tran, Cenjing Zhu, William T. Harris II, Sajeesh K. Kamala Raghavan, Agricola Odoi, Liem Tran
Summary: This study assessed the geographic accessibility of stroke rehabilitation facilities in Tennessee. The study found that rural counties had significantly longer travel distances and times compared to urban counties. Counties with high and medium stroke prevalence also had higher travel times and distances compared to low stroke prevalence counties. Therefore, addressing transportation barriers and implementing tele-rehabilitation are crucial for improving access to stroke aftercare in these areas.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Lili Xu, Shuaiyu Chen, Jing Xu, Yanyan Shi, Zhihang Huang, Meng Wang, Ziqiao Wei, Hui Cao, Junshan Zhou, Wei Wang, Mingyang Du
Summary: This study found that the Chinese Visceral Adiposity Index (CVAI) is positively correlated with 90-day poor outcome in Chinese ischemic stroke patients after endovascular thrombectomy (EVT).
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Guangying Wu, Shuhua Li, Min Luo, Xiaotian Li, Xinghua Zhu, Junhuai Zhang, Qian He, Qian Yang, Guojiang Zhao, Shasha Luo, Zhijie Yang
Summary: The study aimed to investigate the relationship between serum alkaline phosphatase (ALP) levels and the severity and prognosis of intracerebral hemorrhage (ICH). The results showed that serum ALP levels in ICH patients were significantly elevated and correlated with hematoma volume and Glasgow coma scale (GCS) score. High serum ALP levels may serve as a potential predictor for the severity and unfavorable prognosis of ICH.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)