Targeting RGD-binding integrins as an integrative therapy for diabetic retinopathy and neovascular age-related macular degeneration

Microglia control vascular architecture via a TGFβ1 dependent paracrine mechanism linked to tissue mechanics

(2020) Tejasvi Dudiki et al.   Nature Communications

Do Genomic Factors Play a Role in Diabetic Retinopathy?

(2020) Andrea P. Cabrera et al.   Journal of Clinical Medicine

Risuteganib—a novel integrin inhibitor for the treatment of non-exudative (dry) age-related macular degeneration and diabetic macular edema

(2020) Lincoln T. Shaw et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Angiopoietin-2 blockade ameliorates autoimmune neuroinflammation by inhibiting leukocyte recruitment into the CNS

(2020) Zhilin Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Single-cell transcriptome analysis of the Akimba mouse retina reveals cell-type-specific insights into the pathobiology of diabetic retinopathy

(2020) Inge Van Hove et al.   DIABETOLOGIA

The retinal tyrosine kinome of diabetic Akimba mice highlights potential for specific Src family kinase inhibition in retinal vascular disease

(2020) Jurgen Sergeys et al.   EXPERIMENTAL EYE RESEARCH

Anti-Integrin therapy for retinovascular diseases

(2020) Ashay D. Bhatwadekar et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Suppression of Ocular Vascular Inflammation through Peptide-Mediated Activation of Angiopoietin-Tie2 Signaling

(2020) Adam C. Mirando et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Members of the Highly Diverse Crassostrea gigas Integrin Family Cooperate for the Generation of Various Immune Responses

(2020) Zhao Lv et al.   Frontiers in Immunology

Dietary Nutrient Intake and Progression to Late Age-Related Macular Degeneration in the Age-Related Eye Disease Studies 1 and 2

(2020) Elvira Agrón et al.   OPHTHALMOLOGY

Revisiting the role of factor H in age-related macular degeneration: Insights from complement-mediated renal disease and rare genetic variants

(2020) Nikolaos Tzoumas et al.   SURVEY OF OPHTHALMOLOGY

Recombinant RGD-disintegrin DisBa-01 blocks integrin αvβ3 and impairs VEGF signaling in endothelial cells

(2019) Taís M. Danilucci et al.   Cell Communication and Signaling

VEGF in Signaling and Disease: Beyond Discovery and Development

(2019) Rajendra S. Apte et al.   CELL

Role of Angiopoietin-2 in Vascular Physiology and Pathophysiology

(2019) Racheal G. Akwii et al.   Cells

Integrin αvβ6 mediates epithelial-mesenchymal transition in human bronchial epithelial cells induced by lipopolysaccharides of Pseudomonas aeruginosa via TGF-β1-Smad2/3 signaling pathway

(2019) Weiming Liu et al.   FOLIA MICROBIOLOGICA

The Role of Genetic Variants (rs869109213 and rs2070744) Of the eNOS Gene and BglII in the α2 Subunit of the α2β1 Integrin Gene in Diabetic Retinopathy in a Tunisian Population

(2019) Fatma Midani et al.   Seminars in Ophthalmology

Tellurium Compounds Prevent and Reverse Type-1 Diabetes in NOD Mice by Modulating α4β7 Integrin Activity, IL-1β, and T Regulatory Cells

(2019) Tom Eitan Yossipof et al.   Frontiers in Immunology

Overexpression of α5β1 integrin and angiopoietin-1 co-operatively promote blood-brain barrier integrity and angiogenesis following ischemic stroke

(2019) Lu Wang et al.   EXPERIMENTAL NEUROLOGY

Higher matrix stiffness as an independent initiator triggers epithelial-mesenchymal transition and facilitates HCC metastasis

(2019) Yinying Dong et al.   Journal of Hematology & Oncology

Age-related macular degeneration: A two-level model hypothesis

(2019) Maarten P. Rozing et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Non-canonical (non-SMAD2/3) TGF-β signaling in fibrosis: Mechanisms and targets

(2019) Kenneth W. Finnson et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

SNAI1, an endothelial–mesenchymal transition transcription factor, promotes the early phase of ocular neovascularization

(2018) Jia-Xing Sun et al.   ANGIOGENESIS

Distinct CD40L receptors mediate inflammasome activation and secretion of IL-1β and MCP-1 in cultured human retinal pigment epithelial cells

(2018) Zong-Mei Bian et al.   EXPERIMENTAL EYE RESEARCH

Inhibition of integrin α5β1 ameliorates VEGF-induced retinal neovascularization and leakage by suppressing NLRP3 inflammasome signaling in a mouse model

(2018) Ailing Sui et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Beyond the Matrix: The Many Non-ECM Ligands for Integrins

(2018) Bryce LaFoya et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Molecular Pharmacology of VEGF-A Isoforms: Binding and Signalling at VEGFR2

(2018) Chloe Peach et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ocular Distribution and Pharmacodynamics of SF0166, a Topically Administeredαvβ3Integrin Antagonist, for the Treatment of Retinal Diseases

(2018) Ben C. Askew et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Targeting β1-integrin inhibits vascular leakage in endotoxemia

(2018) Laura Hakanpaa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrin β3 Mediates the Endothelial-to-Mesenchymal Transition via the Notch Pathway

(2018) Weisen Wang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The NLRP3 Inflammasome May Contribute to Pathologic Neovascularization in the Advanced Stages of Diabetic Retinopathy

(2018) Shyam S. Chaurasia et al.   Scientific Reports

Roles of integrins and extracellular matrix in stroke

(2018) Danielle Edwards et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Comparison of Surgically Excised Premacular Membranes in Eyes with Macular Pucker and Proliferative Vitreoretinopathy

(2018) Stefanie R. Guenther et al.   CURRENT EYE RESEARCH

IL-1β promotes transendothelial migration of PBMCs by upregulation of the FN/α5β1 signalling pathway in immortalised human brain microvascular endothelial cells

(2018) Josephine Labus et al.   EXPERIMENTAL CELL RESEARCH

Angiopoietin-2 exacerbates cardiac hypoxia and inflammation after myocardial infarction

(2018) Seung-Jun Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

The role of placental growth factor (PlGF) and its receptor system in retinal vascular diseases

(2018) Tine Van Bergen et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Myofibroblasts in macular fibrosis secondary to neovascular age-related macular degeneration - the potential sources and molecular cues for their recruitment and activation

(2018) Karis Little et al.   EBioMedicine

Initiation of fibrosis in the integrin Αvβ6 knockout mice

(2018) Wenjing Wu et al.   EXPERIMENTAL EYE RESEARCH

The potent small molecule integrin antagonist THR-687 is a promising next-generation therapy for retinal vascular disorders

(2018) Tjing-Tjing Hu et al.   EXPERIMENTAL EYE RESEARCH

The role of integrins in glaucoma

(2017) Mark S. Filla et al.   EXPERIMENTAL EYE RESEARCH

Lebecetin, a C-type lectin, inhibits choroidal and retinal neovascularization

(2017) Fadoua Montassar et al.   FASEB JOURNAL

Direct binding to integrins and loss of disulfide linkage in interleukin-1β (IL-1β) are involved in the agonistic action of IL-1β

(2017) Yoko K. Takada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Talin – the master of integrin adhesions

(2017) Benjamin Klapholz et al.   JOURNAL OF CELL SCIENCE

αVβ3 Integrin regulates astrocyte reactivity

(2017) Raúl Lagos-Cabré et al.   Journal of Neuroinflammation

Therapeutic targeting of the angiopoietin–TIE pathway

(2017) Pipsa Saharinen et al.   NATURE REVIEWS DRUG DISCOVERY

High Circulating Levels of ANGPTL2: Beyond a Clinical Marker of Systemic Inflammation

(2017) Nathalie Thorin-Trescases et al.   Oxidative Medicine and Cellular Longevity

Mechanotransduction of matrix stiffness in regulation of focal adhesion size and number: reciprocal regulation of caveolin-1 and β1 integrin

(2017) Yi-Chun Yeh et al.   Scientific Reports

Early and intermediate age-related macular degeneration: update and clinical review

(2017) Alfredo Garcia-Layana et al.   Clinical Interventions in Aging

Extracellular matrix structure

(2016) Achilleas D. Theocharis et al.   ADVANCED DRUG DELIVERY REVIEWS

Retinal Ganglion Cell Layer Change in Patients Treated With Anti–Vascular Endothelial Growth Factor for Neovascular Age-related Macular Degeneration

(2016) Marco Beck et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Tat PTD-Endostatin-RGD: A novel protein with anti-angiogenesis effect in retina via eye drops

(2016) Yan Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

αv integrins: key regulators of tissue fibrosis

(2016) Kylie P. Conroy et al.   CELL AND TISSUE RESEARCH

Angiopoietin-Tie signalling in the cardiovascular and lymphatic systems

(2016) L. Eklund et al.   CLINICAL SCIENCE

Minireview: Fibronectin in retinal disease

(2016) Charles G Miller et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Retinal fibrosis in diabetic retinopathy

(2016) Sayon Roy et al.   EXPERIMENTAL EYE RESEARCH

Molecular mechanisms of subretinal fibrosis in age-related macular degeneration

(2016) Keijiro Ishikawa et al.   EXPERIMENTAL EYE RESEARCH

Current and investigational drugs for the treatment of diabetic retinopathy

(2016) Michael Steven Tolentino et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Risk of geographic atrophy in age-related macular degeneration patients treated with intravitreal anti-VEGF agents

(2016) M Gemenetzi et al.   EYE

Angiopoietin-like Protein 2 Is a Multistep Regulator of Inflammatory Neovascularization in a Murine Model of Age-related Macular Degeneration

(2016) Manabu Hirasawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mice deficient in endothelial α5 integrin are profoundly resistant to experimental ischemic stroke

(2016) Jill Roberts et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cyclic RGD peptides target human trabecular meshwork cells while ameliorating connective tissue growth factor-induced fibrosis

(2016) Robert Hennig et al.   JOURNAL OF DRUG TARGETING

ANGPTL4-αvβ3 interaction counteracts hypoxia-induced vascular permeability by modulating Src signalling downstream of vascular endothelial growth factor receptor 2

(2016) Elisa Gomez Perdiguero et al.   JOURNAL OF PATHOLOGY

Quantitative Proteomics Reveals β2 Integrin-mediated Cytoskeletal Rearrangement in Vascular Endothelial Growth Factor (VEGF)-induced Retinal Vascular Hyperpermeability

(2016) Dong Hyun Jo et al.   MOLECULAR & CELLULAR PROTEOMICS

Candidate gene studies of diabetic retinopathy in human

(2016) Petra Priščáková et al.   MOLECULAR BIOLOGY REPORTS

Joint Antiangiogenic Effect of ATN-161 and Anti-VEGF Antibody in a Rat Model of Early Wet Age-Related Macular Degeneration

(2016) Wen-Qiu Wang et al.   MOLECULAR PHARMACEUTICS

Mechanisms and regulation of endothelial VEGF receptor signalling

(2016) Michael Simons et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The progress in understanding and treatment of diabetic retinopathy

(2016) Alan W. Stitt et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Angiopoietin 2 induces astrocyte apoptosis via αvβ5-integrin signaling in diabetic retinopathy

(2016) J-H Yun et al.   Cell Death & Disease

Research advances on structure and biological functions of integrins

(2016) Li Pan et al.   SpringerPlus

Constitutive Association of Tie1 and Tie2 with Endothelial Integrins is Functionally Modulated by Angiopoietin-1 and Fibronectin

(2016) Annamarie C. Dalton et al.   PLoS One

Angiopoietin-like protein 2 induces proinflammatory responses in peritoneal cells

(2015) Masato Umikawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Effects of IGFBP-1 and IGFBP-2 and their fragments on migration and IGF-induced proliferation of human dermal fibroblasts

(2015) Katrin Brandt et al.   GROWTH HORMONE & IGF RESEARCH

The integrin expression profile modulates orientation and dynamics of force transmission at cell-matrix adhesions

(2015) H. E. Balcioglu et al.   JOURNAL OF CELL SCIENCE

Insulin-Like Growth Factor Binding Protein-2 Promotes Adhesion of Endothelial Progenitor Cells to Endothelial Cells via Integrin α5β1

(2015) Nianping Feng et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Interactions of DPP-4 and integrin β1 influences endothelial-to-mesenchymal transition

(2015) Sen Shi et al.   KIDNEY INTERNATIONAL

The Proteome of Native Adult Müller Glial Cells From Murine Retina

(2015) Antje Grosche et al.   MOLECULAR & CELLULAR PROTEOMICS

Leukocyte integrins: Role in leukocyte recruitment and as therapeutic targets in inflammatory disease

(2015) Ioannis Mitroulis et al.   PHARMACOLOGY & THERAPEUTICS

αvβ5 Integrin/FAK/PGC-1α Pathway Confers Protective Effects on Retinal Pigment Epithelium

(2015) Murilo F. Roggia et al.   PLoS One

The α v β 1 integrin plays a critical in vivo role in tissue fibrosis

(2015) Nilgun I. Reed et al.   Science Translational Medicine

RGD Peptides Protects Against Acute Lung Injury in Septic Mice Through Wisp1-Integrin β6 Pathway Inhibition

(2015) Xibing Ding et al.   SHOCK

High prevalence of diabetic retinopathy and lack of association with integrin α2 gene polymorphisms in patients with type 2 diabetes from Northeastern Mexico

(2015) ANA CECILIA CEPEDA-NIETO et al.   Experimental and Therapeutic Medicine

Integrin β1 controls VE-cadherin localization and blood vessel stability

(2015) Hiroyuki Yamamoto et al.   Nature Communications

Endothelial destabilization by angiopoietin-2 via integrin β1 activation

(2015) Laura Hakanpaa et al.   Nature Communications

Future Therapies of Wet Age-Related Macular Degeneration

(2015) Makoto Ishikawa et al.   Journal of Ophthalmology

Influence of Extracellular Matrix Components on the Expression of Integrins and Regeneration of Adult Retinal Ganglion Cells

(2015) Elena Vecino et al.   PLoS One

Thyroid hormone regulates adhesion, migration and matrix metalloproteinase 9 activity via αvβ3 integrin in myeloma cells

(2015) Keren Cohen et al.   Oncotarget

Integrin-directed modulation of macrophage responses to biomaterials

(2014) Toral D. Zaveri et al.   BIOMATERIALS

Association of Platelet Glycoprotein Receptor Alpha2beta1 Integrin and Glycoprotein IIIa Gene Polymorphisms with Diabetic Retinopathy: Evidence from 3007 Subjects

(2014) Jian-Yang Gong et al.   CURRENT EYE RESEARCH

Angiopoietin 2 Induces Pericyte Apoptosis via  3 1 Integrin Signaling in Diabetic Retinopathy

(2014) S. W. Park et al.   DIABETES

Therapeutic efficacy of a novel non-peptide αvβ3 integrin antagonist for pathological retinal angiogenesis in mice

(2014) Yong-Jie Li et al.   EXPERIMENTAL EYE RESEARCH

Gln-362 of Angiopoietin-2 Mediates Migration of Tumor and Endothelial Cells through Association with α5β1 Integrin

(2014) Hyo Seon Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Matrix metalloproteinase 2 and membrane type 1 matrix metalloproteinase co-regulate axonal outgrowth of mouse retinal ganglion cells

(2014) Djoere Gaublomme et al.   JOURNAL OF NEUROCHEMISTRY

Dual Targeting of Integrin  v 3 and Matrix Metalloproteinase-2 for Optical Imaging of Tumors and Chemotherapeutic Delivery

(2014) J. L. Crisp et al.   MOLECULAR CANCER THERAPEUTICS

Osteopontin Is Induced by TGF-β2 and Regulates Metabolic Cell Activity in Cultured Human Optic Nerve Head Astrocytes

(2014) Carolin Neumann et al.   PLoS One

Cyr61 induces the expression of monocyte chemoattractant protein-1 via the integrin ανβ3, FAK, PI3K/Akt, and NF-κB pathways in retinal vascular endothelial cells

(2013) Jian-Jang You et al.   CELLULAR SIGNALLING

Advances in our understanding of diabetic retinopathy

(2013) Alan W. Stitt et al.   CLINICAL SCIENCE

Effective Treatment of Mouse Sepsis With an Inhibitory Antibody Targeting Integrin αvβ5*

(2013) George Su et al.   CRITICAL CARE MEDICINE

CCN2 promotes keratinocyte adhesion and migration via integrin α5β1

(2013) Elizabeth Kiwanuka et al.   EXPERIMENTAL CELL RESEARCH

Increased Activation of Latent TGF-β1 by αVβ3 in Human Crohnʼs Disease and Fibrosis in TNBS Colitis Can Be Prevented by Cilengitide

(2013) Chao Li et al.   INFLAMMATORY BOWEL DISEASES

Proteolytic Processing Regulates Placental Growth Factor Activities

(2013) Daniel C. Hoffmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TNF-α promotes cerebral pericyte remodeling in vitro, via a switch from α1 to α2 integrins

(2013) Ulrich Tigges et al.   Journal of Neuroinflammation

Signalling pathways linking integrins with cell cycle progression

(2013) Paulina Moreno-Layseca et al.   MATRIX BIOLOGY

A Urokinase Receptor-Derived Peptide Inhibiting VEGF-Dependent Directional Migration and Vascular Sprouting

(2013) K. Bifulco et al.   MOLECULAR CANCER THERAPEUTICS

Integrin inactivators: balancing cellular functions in vitro and in vivo

(2013) Daniel Bouvard et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tellurium Compound AS101 Ameliorates Experimental Autoimmune Encephalomyelitis by VLA-4 Inhibition and Suppression of Monocyte and T Cell Infiltration into the CNS

(2013) Jun-Ho Lee et al.   NEUROMOLECULAR MEDICINE

Clinical Classification of Age-related Macular Degeneration

(2013) Frederick L. Ferris et al.   OPHTHALMOLOGY

Risk of Scar in the Comparison of Age-related Macular Degeneration Treatments Trials

(2013) Ebenezer Daniel et al.   OPHTHALMOLOGY

Angiopoietin-1 Guides Directional Angiogenesis Through Integrin  v 5 Signaling for Recovery of Ischemic Retinopathy

(2013) J. Lee et al.   Science Translational Medicine

uPAR

(2013) Pavel Uhrin et al.   Cell Adhesion & Migration

Current treatments in diabetic macular oedema: systematic review and meta-analysis

(2013) John Alexander Ford et al.   BMJ Open

Vascular Hyperpermeability, Angiogenesis, and Stroma Generation

(2013) J. A. Nagy et al.   Cold Spring Harbor Perspectives in Medicine

Integrin Activation States and Eosinophil Recruitment in Asthma

(2013) Mats W. Johansson et al.   Frontiers in Pharmacology

Endothelial endoglin is involved in inflammation: role in leukocyte adhesion and transmigration

(2012) E. Rossi et al.   BLOOD

VEGF-induced endothelial cell migration requires urokinase receptor (uPAR)-dependent integrin redistribution

(2012) Revu Ann Alexander et al.   CARDIOVASCULAR RESEARCH

DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88

(2012) Valeria Tarallo et al.   CELL

Integrin α5β1 Activates the NLRP3 Inflammasome by Direct Interaction with a Bacterial Surface Protein

(2012) Hye-Kyoung Jun et al.   IMMUNITY

N-acetylglucosaminyltransferase V negatively regulates integrin α5β1-mediated monocyte adhesion and transmigration through vascular endothelium

(2012) HUO-MEI YANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling

(2012) Moritz Felcht et al.   JOURNAL OF CLINICAL INVESTIGATION

Defective Retinal Vascular Endothelial Cell Development As a Consequence of Impaired Integrin  V 8-Mediated Activation of Transforming Growth Factor- 

(2012) T. D. Arnold et al.   JOURNAL OF NEUROSCIENCE

Angiopoietin-like protein 2 mediates endotoxin-induced acute inflammation in the eye

(2012) Atsuhiro Kanda et al.   LABORATORY INVESTIGATION

Age-related macular degeneration

(2012) Laurence S Lim et al.   LANCET

Mechanisms of Age-Related Macular Degeneration

(2012) Jayakrishna Ambati et al.   NEURON

Ranibizumab for Diabetic Macular Edema

(2012) Quan Dong Nguyen et al.   OPHTHALMOLOGY

Integrins as receptor targets for neurological disorders

(2012) Xin Wu et al.   PHARMACOLOGY & THERAPEUTICS

β1 Integrin-Focal Adhesion Kinase (FAK) Signaling Modulates Retinal Ganglion Cell (RGC) Survival

(2012) Andrea Rachelle C. Santos et al.   PLoS One

Pericyte-endothelial cell interaction

(2012) Sharmila Chatterjee et al.   Cell Adhesion & Migration

Absence of Integrin αvβ3 Enhances Vascular Leak in Mice by Inhibiting Endothelial Cortical Actin Formation

(2011) George Su et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Potentiation of Platelet-Derived Growth Factor Receptor-β Signaling Mediated by Integrin-Associated MFG-E8

(2011) Sei-ichiro Motegi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Notch promotes vascular maturation by inducing integrin-mediated smooth muscle cell adhesion to the endothelial basement membrane

(2011) L. Scheppke et al.   BLOOD

Angiopoietin-like Protein 2 Is an Important Facilitator of Inflammatory Carcinogenesis and Metastasis

(2011) J. Aoi et al.   CANCER RESEARCH

Retinal Pigment Epithelium Cell Alignment on Nanostructured Collagen Matrices

(2011) Stefan Ulbrich et al.   CELLS TISSUES ORGANS

αVβ3-integrin expression through ERK activation mediates cell attachment and is necessary for production of tumor necrosis factor alpha in monocytic THP-1 cells stimulated by phorbol myristate acetate

(2011) Yuichi Kurihara et al.   CELLULAR IMMUNOLOGY

The astrocyte-expressed integrin  v 8 governs blood vessel sprouting in the developing retina

(2011) S. Hirota et al.   DEVELOPMENT

Integrin-dependent and -independent functions of astrocytic fibronectin in retinal angiogenesis

(2011) D. Stenzel et al.   DEVELOPMENT

Inhibition of pathological retinal angiogenesis by the integrin αvβ3 antagonist tetraiodothyroacetic acid (tetrac)

(2011) Takeshi Yoshida et al.   EXPERIMENTAL EYE RESEARCH

Roles of αvβ5, FAK and MerTK in oxidative stress inhibition of RPE cell phagocytosis

(2011) Suofu Qin et al.   EXPERIMENTAL EYE RESEARCH

TGF-β signaling in fibrosis

(2011) Anna Biernacka et al.   GROWTH FACTORS

Evidence of association ofAPOEwith age-related macular degeneration - a pooled analysis of 15 studies

(2011) Gareth J. McKay et al.   HUMAN MUTATION

Müller Glial Cells in Retinal Disease

(2011) Andreas Bringmann et al.   OPHTHALMOLOGICA

Cholesterol-enriched diet causes age-related macular degeneration-like pathology in rabbit retina

(2011) Bhanu Dasari et al.   BMC Ophthalmology

Endothelial  1 integrins regulate sprouting and network formation during vascular development

(2010) D. Malan et al.   DEVELOPMENT

Diabetic Retinopathy: Targeting Vasoregression

(2010) H.-P. Hammes et al.   DIABETES

Angiopoietin-2 Stimulation of Endothelial Cells Induces αvβ3 Integrin Internalization and Degradation

(2010) Markus Thomas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Involvement of β1-Integrin Up-regulation in Basic Fibroblast Growth Factor- and Epidermal Growth Factor-induced Proliferation of Mouse Neuroepithelial Cells

(2010) Yusuke Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

αVβ3 integrin regulates macrophage inflammatory responses via PI3 kinase/Akt-dependent NF-κB activation

(2010) Alexander S. Antonov et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Improvements in endotoxemic syndromes using a disintegrin, rhodostomin, through integrin αvβ3-dependent pathway

(2010) C.-C. HSU et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Turning Müller Glia into Neural Progenitors in the Retina

(2010) Andy J. Fischer et al.   MOLECULAR NEUROBIOLOGY

Two-Year Outcomes of the Ranibizumab for Edema of the mAcula in Diabetes (READ-2) Study

(2010) Quan Dong Nguyen et al.   OPHTHALMOLOGY

Vascular Cellular Adhesion Molecule-1 (VCAM-1) Expression in Mice Retinal Vessels Is Affected by Both Hyperglycemia and Hyperlipidemia

(2010) Carin Gustavsson et al.   PLoS One

Transforming Growth Factor-β Upregulates the Expression of Integrin and Related Proteins in MRC-5 Human Myofibroblasts

(2010) Eiko Honda et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Cooperation between integrin ανβ3 and VEGFR2 in angiogenesis

(2009) Payaningal R. Somanath et al.   ANGIOGENESIS

Single and combined effects of αvβ3- and α5β1-integrins on capillary tube formation in a human fibrinous matrix

(2009) Nancy Laurens et al.   ANGIOGENESIS

Preclinical Evaluation of the Novel Small-Molecule Integrin α5β1 Inhibitor JSM6427 in Monkey and Rabbit Models of Choroidal Neovascularization

(2009) Grit Zahn   ARCHIVES OF OPHTHALMOLOGY

Angiopoietin-like Protein 2 Promotes Chronic Adipose Tissue Inflammation and Obesity-Related Systemic Insulin Resistance

(2009) Mitsuhisa Tabata et al.   Cell Metabolism

Microvascular lesions of diabetic retinopathy: clues towards understanding pathogenesis?

(2009) T M Curtis et al.   EYE

Conditional deletion of β1-integrin in astroglia causes partial reactive gliosis

(2009) Stefanie Robel et al.   GLIA

Nanoparticle–integrin antagonist C16Y peptide treatment of choroidal neovascularization in rats

(2009) Hyuncheol Kim et al.   JOURNAL OF CONTROLLED RELEASE

The Integrin Antagonist Cilengitide Activates αVβ3, Disrupts VE-Cadherin Localization at Cell Junctions and Enhances Permeability in Endothelial Cells

(2009) Gian Carlo Alghisi et al.   PLoS One

Cellular signaling and factors involved in Müller cell gliosis: Neuroprotective and detrimental effects

(2009) Andreas Bringmann et al.   PROGRESS IN RETINAL AND EYE RESEARCH

The Tail of Integrins, Talin, and Kindlins

(2009) M. Moser et al.   SCIENCE

Feedback Mechanism Between Blood Vessels and Astrocytes in Retinal Vascular development

(2009) Yoshiaki Kubota et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Molecular dissection of reactive astrogliosis and glial scar formation

(2009) Michael V. Sofroniew   TRENDS IN NEUROSCIENCES

Integrins

(2008) Rita Silva et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Integrin activation

(2008) Asoka Banno et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The urokinase receptor and integrins in cancer progression

(2008) C.-H. Tang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Interleukin-1β Causes Acute Lung Injury via αvβ5 and αvβ6 Integrin–Dependent Mechanisms

(2008) Michael T. Ganter et al.   CIRCULATION RESEARCH

Integrin binding angiopoietin-1 monomers reduce cardiac hypertrophy

(2008) Susan M. Dallabrida et al.   FASEB JOURNAL

Intravitreal bevacizumab in active progressive proliferative diabetic retinopathy

(2008) Siamak Moradian et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Direct Binding of Integrin αvβ3 to FGF1 Plays a Role in FGF1 Signaling

(2008) Seiji Mori et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rab-coupling protein coordinates recycling of α5β1 integrin and EGFR1 to promote cell migration in 3D microenvironments

(2008) Patrick T. Caswell et al.   JOURNAL OF CELL BIOLOGY

Topical administration of a multi-targeted kinase inhibitor suppresses choroidal neovascularization and retinal edema

(2008) John Doukas et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Review of the activation of TGF-  in immunity

(2008) A. W. Taylor   JOURNAL OF LEUKOCYTE BIOLOGY

Characterization of the Vitreous Proteome in Diabetes without Diabetic Retinopathy and Diabetes with Proliferative Diabetic Retinopathy

(2008) Ben-Bo Gao et al.   JOURNAL OF PROTEOME RESEARCH

The CXC-Chemokine CXCL4 Interacts with Integrins Implicated in Angiogenesis

(2008) Sallouha Aidoudi et al.   PLoS One

Inhibition of Integrin αvβ6, an Activator of Latent Transforming Growth Factor-β, Prevents Radiation-induced Lung Fibrosis

(2007) Khalid Puthawala et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Partial Inhibition of Integrin αvβ6 Prevents Pulmonary Fibrosis without Exacerbating Inflammation

(2007) Gerald S. Horan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE