Mechanotransduction of matrix stiffness in regulation of focal adhesion size and number: reciprocal regulation of caveolin-1 and β1 integrin

PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis

(2016) Katherine Martin et al.   Nature Communications

Kindlin-2 cooperates with talin to activate integrins and induces cell spreading by directly binding paxillin

(2016) Marina Theodosiou et al.   eLife

Distinct Structural Domains of Caveolin-1 Independently Regulate Ca2+Release-Activated Ca2+Channels and Ca2+Microdomain-Dependent Gene Expression

(2015) Yi-Chun Yeh et al.   MOLECULAR AND CELLULAR BIOLOGY

Mechanical phenotype of cancer cells: cell softening and loss of stiffness sensing

(2015) Hsi-Hui Lin et al.   Oncotarget

ADAP interactions with talin and kindlin promote platelet integrin  IIb 3 activation and stable fibrinogen binding

(2014) A. Kasirer-Friede et al.   BLOOD

Caveolin-1 Alters the Pattern of Cytoplasmic Ca2+Oscillations and Ca2+-dependent Gene Expression by Enhancing Leukotriene Receptor Desensitization

(2014) Yi-Chun Yeh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression

(2014) Janna K Mouw et al.   NATURE MEDICINE

Talin and kindlin: the one-two punch in integrin activation

(2014) Feng Ye et al.   Frontiers of Medicine

Lipid raft regulates the initial spreading of melanoma A375 cells by modulating β1 integrin clustering

(2013) Ruifei Wang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Talins and kindlins: partners in integrin-mediated adhesion

(2013) David A. Calderwood et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Differential Effect of Actomyosin Relaxation on the Dynamic Properties of Focal Adhesion Proteins

(2013) Irena Lavelin et al.   PLoS One

The Influence of Physical and Physiological Cues on Atomic Force Microscopy-Based Cell Stiffness Assessment

(2013) Yu-Wei Chiou et al.   PLoS One

Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation

(2012) C. T. Lefort et al.   BLOOD

Coordinated Mechanosensitivity of Membrane Rafts and Focal Adhesions

(2012) Daniela E. Fuentes et al.   Cellular and Molecular Bioengineering

Distinct Roles of Talin and Kindlin in Regulating Integrin α5β1 Function and Trafficking

(2012) Coert Margadant et al.   CURRENT BIOLOGY

Phosphocaveolin-1 is a mechanotransducer that induces caveola biogenesis via Egr1 transcriptional regulation

(2012) Bharat Joshi et al.   JOURNAL OF CELL BIOLOGY

Negative regulators of integrin activity

(2012) J. Pouwels et al.   JOURNAL OF CELL SCIENCE

Matrix rigidity regulates a switch between TGF-β1–induced apoptosis and epithelial–mesenchymal transition

(2012) Jennifer L. Leight et al.   MOLECULAR BIOLOGY OF THE CELL

Biomechanical Remodeling of the Microenvironment by Stromal Caveolin-1 Favors Tumor Invasion and Metastasis

(2011) Jacky G. Goetz et al.   CELL

Actomyosin-generated tension controls the molecular kinetics of focal adhesions

(2011) H. Wolfenson et al.   JOURNAL OF CELL SCIENCE

Talin-1 and Kindlin-3 Regulate α 4 β 1 Integrin-Mediated Adhesion Stabilization, but Not G Protein-Coupled Receptor-Induced Affinity Upregulation

(2011) Sharon J. Hyduk et al.   JOURNAL OF IMMUNOLOGY

Transforming Growth Factor-β1 Induces Smad3-Dependent β1 Integrin Gene Expression in Epithelial-to-Mesenchymal Transition during Chronic Tubulointerstitial Fibrosis

(2010) Yi-Chun Yeh et al.   AMERICAN JOURNAL OF PATHOLOGY

Breast Cancer Cells in Three-dimensional Culture Display an Enhanced Radioresponse after Coordinate Targeting of Integrin  5 1 and Fibronectin

(2010) J.-M. Nam et al.   CANCER RESEARCH

Integrin expression profiling identifies integrin alpha5 and beta1 as prognostic factors in early stage non-small cell lung cancer

(2010) Anne-Marie C Dingemans et al.   Molecular Cancer

Mechanical regulation of cell function with geometrically modulated elastomeric substrates

(2010) Jianping Fu et al.   NATURE METHODS

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Genetic and cell biological analysis of integrin outside-in signaling

(2009) K. R. Legate et al.   GENES & DEVELOPMENT

The mechanical integrin cycle

(2009) E. Puklin-Faucher et al.   JOURNAL OF CELL SCIENCE

Mechanically Activated Integrin Switch Controls  5 1 Function

(2009) J. C. Friedland et al.   SCIENCE

Mechanosensing machinery for cells under low substratum rigidity

(2008) Wei-Chun Wei et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Phosphorylated Caveolin-1 Regulates Rho/ROCK-Dependent Focal Adhesion Dynamics and Tumor Cell Migration and Invasion

(2008) B. Joshi et al.   CANCER RESEARCH

Caveolin-1 Up-regulation during Epithelial to Mesenchymal Transition Is Mediated by Focal Adhesion Kinase

(2008) Kelly M. Bailey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Concerted regulation of focal adhesion dynamics by galectin-3 and tyrosine-phosphorylated caveolin-1

(2008) Jacky G. Goetz et al.   JOURNAL OF CELL BIOLOGY