Therapeutic targeting of the angiopoietin–TIE pathway

Blue Rubber Bleb Nevus (BRBN) Syndrome Is Caused by Somatic TEK (TIE2) Mutations

(2017) Julie Soblet et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Structural basis of Tie2 activation and Tie2/Tie1 heterodimerization

(2017) Veli-Matti Leppänen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dimerization of Tie2 mediated by its membrane-proximal FNIII domains

(2017) Jason O. Moore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual angiopoietin-2 and VEGFA inhibition elicits antitumor immunity that is enhanced by PD-1 checkpoint blockade

(2017) Martina Schmittnaegel et al.   Science Translational Medicine

High-circulating Tie2 Is Associated With Pathologic Complete Response to Chemotherapy and Antiangiogenic Therapy in Breast Cancer

(2016) Issam Makhoul et al.   AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS

Plasma angiopoietin-2 outperforms other markers of endothelial injury in prognosticating pediatric ARDS mortality

(2016) Matt S. Zinter et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Vascular Growth Factors and Glomerular Disease

(2016) Christina S. Bartlett et al.   Annual Review of Physiology

Normalization of Tumor Vessels by Tie2 Activation and Ang2 Inhibition Enhances Drug Delivery and Produces a Favorable Tumor Microenvironment

(2016) Jin-Sung Park et al.   CANCER CELL

Tie2 Expression on Macrophages Is Required for Blood Vessel Reconstruction and Tumor Relapse after Chemotherapy

(2016) Lin Chen et al.   CANCER RESEARCH

Targeting key angiogenic pathways with a bispecific CrossMAb optimized for neovascular eye diseases

(2016) Jörg T Regula et al.   EMBO Molecular Medicine

Final results of a phase 3 study of trebananib plus weekly paclitaxel in recurrent ovarian cancer (TRINOVA-1): Long-term survival, impact of ascites, and progression-free survival-2

(2016) Bradley J. Monk et al.   GYNECOLOGIC ONCOLOGY

Opposing actions of angiopoietin-2 on Tie2 signaling and FOXO1 activation

(2016) Minah Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Tie1 controls angiopoietin function in vascular remodeling and inflammation

(2016) Emilia A. Korhonen et al.   JOURNAL OF CLINICAL INVESTIGATION

Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity

(2016) Tomokazu Souma et al.   JOURNAL OF CLINICAL INVESTIGATION

FOXO1 couples metabolic activity and growth state in the vascular endothelium

(2016) Kerstin Wilhelm et al.   NATURE

Endothelial exocytosis of angiopoietin-2 resulting from CCM3 deficiency contributes to cerebral cavernous malformation

(2016) Huanjiao Jenny Zhou et al.   NATURE MEDICINE

Ten years of anti-vascular endothelial growth factor therapy

(2016) Napoleone Ferrara et al.   NATURE REVIEWS DRUG DISCOVERY

Enhanced Benefit in Diabetic Macular Edema from AKB-9778 Tie2 Activation Combined with Vascular Endothelial Growth Factor Suppression

(2016) Peter A. Campochiaro et al.   OPHTHALMOLOGY

Gene control of tyrosine kinaseTIE2and vascular manifestations of infections

(2016) Chandra C. Ghosh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages

(2016) Teresa E. Peterson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival

(2016) Jonas Kloepper et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Self-renewal of a purified Tie2+ hematopoietic stem cell population relies on mitochondrial clearance

(2016) K. Ito et al.   SCIENCE

Somatic activating mutations in Pik3ca cause sporadic venous malformations in mice and humans

(2016) Sandra D. Castillo et al.   Science Translational Medicine

Amelioration of sepsis by TIE2 activation–induced vascular protection

(2016) Sangyeul Han et al.   Science Translational Medicine

Somatic PIK3CA mutations as a driver of sporadic venous malformations

(2016) Pau Castel et al.   Science Translational Medicine

Synchronization of endothelial Dll4-Notch dynamics switch blood vessels from branching to expansion

(2016) Benedetta Ubezio et al.   eLife

Association of Angiopoietin-2 and Ki-67 Expression with Vascular Density and Sunitinib Response in Metastatic Renal Cell Carcinoma

(2016) Juhana Rautiola et al.   PLoS One

Constitutive Association of Tie1 and Tie2 with Endothelial Integrins is Functionally Modulated by Angiopoietin-1 and Fibronectin

(2016) Annamarie C. Dalton et al.   PLoS One

Nucleoside diphosphate kinase B deficiency causes a diabetes-like vascular pathology via up-regulation of endothelial angiopoietin-2 in the retina

(2015) Yi Qiu et al.   ACTA DIABETOLOGICA

Somatic Activating PIK3CA Mutations Cause Venous Malformation

(2015) Nisha Limaye et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Synergistic Actions of Blocking Angiopoietin-2 and Tumor Necrosis Factor-α in Suppressing Remodeling of Blood Vessels and Lymphatics in Airway Inflammation

(2015) Catherine T.K. Le et al.   AMERICAN JOURNAL OF PATHOLOGY

Donor Heart Treatment With COMP-Ang1 Limits Ischemia-Reperfusion Injury and Rejection of Cardiac Allografts

(2015) S. O. Syrjälä et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Angiopoietin-2 blocking antibodies reduce early atherosclerotic plaque development in mice

(2015) Thomas L. Theelen et al.   ATHEROSCLEROSIS

Arterial stiffness in diabetes mellitus

(2015) Stuart B. Prenner et al.   ATHEROSCLEROSIS

Prognostic Value of Angiopoietin-2 for Death Risk Stratification in Patients with Metastatic Colorectal Carcinoma

(2015) M. Jary et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

A Phase I First-in-Human Study of Nesvacumab (REGN910), a Fully Human Anti-Angiopoietin-2 (Ang2) Monoclonal Antibody, in Patients with Advanced Solid Tumors

(2015) K. P. Papadopoulos et al.   CLINICAL CANCER RESEARCH

Drug Repurposing Screen Identifies Foxo1-Dependent Angiopoietin-2 Regulation in Sepsis*

(2015) Chandra C. Ghosh et al.   CRITICAL CARE MEDICINE

Angiopoietin-2 associations with the underlying infection and sepsis severity

(2015) Korina Lymperopoulou et al.   CYTOKINE

Intravitreal AAV2.COMP-Ang1 Prevents Neurovascular Degeneration in a Murine Model of Diabetic Retinopathy

(2015) Judd M. Cahoon et al.   DIABETES

Angiopoietin-2 in acute myocardial infarction complicated by cardiogenic shock-a biomarker substudy of the IABP-SHOCK II-Trial

(2015) Janine Pöss et al.   EUROPEAN JOURNAL OF HEART FAILURE

Common and specific effects of TIE2 mutations causing venous malformations

(2015) Marjut Nätynki et al.   HUMAN MOLECULAR GENETICS

Recent insights into the cellular biology of atherosclerosis

(2015) Ira Tabas et al.   JOURNAL OF CELL BIOLOGY

Rapamycin improves TIE2-mutated venous malformation in murine model and human subjects

(2015) Elisa Boscolo et al.   JOURNAL OF CLINICAL INVESTIGATION

Trebananib (AMG 386) in Combination With Sunitinib in Patients With Metastatic Renal Cell Cancer: An Open-Label, Multicenter, Phase II Study

(2015) Michael B. Atkins et al.   JOURNAL OF CLINICAL ONCOLOGY

Serum angiopoietin-2 is associated with angiopathy in type 2 diabetes mellitus

(2015) Li Li et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

MicroRNA-30 mediates anti-inflammatory effects of shear stress and KLF2 via repression of angiopoietin 2

(2015) Shemsi Demolli et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Clinical and Genetic Aspects of the Segmental Overgrowth Spectrum Due to Somatic Mutations in PIK3CA

(2015) Hoon-Chul Kang et al.   JOURNAL OF PEDIATRICS

Lymphatic and Other Vascular Malformative/Overgrowth Disorders Are Caused by Somatic Mutations in PIK3CA

(2015) Valerie L. Luks et al.   JOURNAL OF PEDIATRICS

High Angiopoietin-1 levels predict a good functional outcome within 72h of an aneurysmal subarachnoid hemorrhage: A prospective study from a single center

(2015) Yi Wang et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Circulating Angiopopietin-1 Correlates With the Clinical Course of Multiple Organ Dysfunction Syndrome and Mortality in Patients With Severe Sepsis

(2015) Shu-Min Lin et al.   MEDICINE

Altiratinib Inhibits Tumor Growth, Invasion, Angiogenesis, and Microenvironment-Mediated Drug Resistance via Balanced Inhibition of MET, TIE2, and VEGFR2

(2015) B. D. Smith et al.   MOLECULAR CANCER THERAPEUTICS

Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation

(2015) Tea Pemovska et al.   NATURE

Treatment of Diabetic Macular Edema with an Inhibitor of Vascular Endothelial-Protein Tyrosine Phosphatase That Activates Tie2

(2015) Peter A. Campochiaro et al.   OPHTHALMOLOGY

The Angiopoietin-1 Variant COMP-Ang1 Enhances BMP2-Induced Bone Regeneration with Recruiting Pericytes in Critical Sized Calvarial Defects

(2015) Hyuck Choi et al.   PLoS One

Angiopoietin-2 as a Prognostic Biomarker of Major Adverse Cardiovascular Events and All-Cause Mortality in Chronic Kidney Disease

(2015) Yi-Chun Tsai et al.   PLoS One

Molecular pathogenesis of retinal and choroidal vascular diseases

(2015) Peter A. Campochiaro   PROGRESS IN RETINAL AND EYE RESEARCH

Yes-associated protein regulates endothelial cell contact-mediated expression of angiopoietin-2

(2015) Hyun-Jung Choi et al.   Nature Communications

Endothelial destabilization by angiopoietin-2 via integrin β1 activation

(2015) Laura Hakanpaa et al.   Nature Communications

Real-Time Imaging Reveals Local, Transient Vascular Permeability, and Tumor Cell Intravasation Stimulated by TIE2hi Macrophage-Derived VEGFA

(2015) A. S. Harney et al.   Cancer Discovery

Designed angiopoietin-1 variant, COMP-angiopoietin-1, rescues erectile function through healthy cavernous angiogenesis in a hypercholesterolemic mouse

(2015) Ji-Kan Ryu et al.   Scientific Reports

A Designed Angiopoietin-1 Variant, Dimeric CMP-Ang1 Activates Tie2 and Stimulates Angiogenesis and Vascular Stabilization in N-glycan Dependent Manner

(2015) Nuri Oh et al.   Scientific Reports

Prospective evaluation of plasma levels of ANGPT2, TuM2PK, and VEGF in patients with renal cell carcinoma

(2015) Bishoy A Gayed et al.   BMC Urology

The Orphan Receptor Tie1 Controls Angiogenesis and Vascular Remodeling by Differentially Regulating Tie2 in Tip and Stalk Cells

(2015) Soniya Savant et al.   Cell Reports

Targeting Vascular Pericytes in Hypoxic Tumors Increases Lung Metastasis via Angiopoietin-2

(2015) Doruk Keskin et al.   Cell Reports

A phase 1b, open-label study of trebananib plus bevacizumab or motesanib in patients with solid tumours

(2015) David S. Hong et al.   Oncotarget

Poor glycemic control associates with high intravitreal angiopoietin-2 levels in patients with diabetic retinopathy

(2014) Raimo Tuuminen et al.   ACTA OPHTHALMOLOGICA

Evaluation of angiopoietin 1 and 2, vascular endothelial growth factor, and tumor necrosis factor alpha levels in asthmatic children

(2014) Burcu Tahire Köksal et al.   ALLERGY AND ASTHMA PROCEEDINGS

Angiopoietin-2 Inhibition Prevents Transplant Ischemia-Reperfusion Injury and Chronic Rejection in Rat Cardiac Allografts

(2014) S. O. Syrjälä et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Predictive Value of Circulating Angiopoietin-2 for Endothelial Damage–Related Complications in Allogeneic Hematopoietic Stem Cell Transplantation

(2014) Norihiro Ueda et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Postsurgical Adjuvant Tumor Therapy by Combining Anti-Angiopoietin-2 and Metronomic Chemotherapy Limits Metastatic Growth

(2014) Kshitij Srivastava et al.   CANCER CELL

Investigation of novel circulating proteins, germ line single-nucleotide polymorphisms, and molecular tumor markers as potential efficacy biomarkers of first-line sunitinib therapy for advanced renal cell carcinoma

(2014) Robert J. Motzer et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Neurons Limit Angiogenesis by Titrating VEGF in Retina

(2014) Keisuke Okabe et al.   CELL

A Phase I Study of Oral ARRY-614, a p38 MAPK/Tie2 Dual Inhibitor, in Patients with Low or Intermediate-1 Risk Myelodysplastic Syndromes

(2014) G. Garcia-Manero et al.   CLINICAL CANCER RESEARCH

Angiopoietin-2 and outcome in patients with acute decompensated heart failure

(2014) Janine Pöss et al.   Clinical Research in Cardiology

Lung-Targeted RNA Interference Against Angiopoietin-2 Ameliorates Multiple Organ Dysfunction and Death in Sepsis

(2014) Thomas Stiehl et al.   CRITICAL CARE MEDICINE

Disturbed Balance between Serum Levels of Receptor Tyrosine Kinases Tie-1, Tie-2 and Angiopoietins in Systemic Sclerosis

(2014) Zofia Gerlicz et al.   DERMATOLOGY

Angiopoietin 2 Induces Pericyte Apoptosis via  3 1 Integrin Signaling in Diabetic Retinopathy

(2014) S. W. Park et al.   DIABETES

Activating PIK3CA alleles and lymphangiogenic phenotype of lymphatic endothelial cells isolated from lymphatic malformations

(2014) Alexander J. Osborn et al.   HUMAN MOLECULAR GENETICS

Gln-362 of Angiopoietin-2 Mediates Migration of Tumor and Endothelial Cells through Association with α5β1 Integrin

(2014) Hyo Seon Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prognostic impact of angiopoietin-2 in multiple myeloma

(2014) Constantina A. Pappa et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy

(2014) Gabriela D’Amico et al.   JOURNAL OF CLINICAL INVESTIGATION

A lymphatic defect causes ocular hypertension and glaucoma in mice

(2014) Benjamin R. Thomson et al.   JOURNAL OF CLINICAL INVESTIGATION

Lymphatic regulator PROX1 determines Schlemm’s canal integrity and identity

(2014) Dae-Young Park et al.   JOURNAL OF CLINICAL INVESTIGATION

The Schlemm’s canal is a VEGF-C/VEGFR-3–responsive lymphatic-like vessel

(2014) Aleksanteri Aspelund et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting VE-PTP activates TIE2 and stabilizes the ocular vasculature

(2014) Jikui Shen et al.   JOURNAL OF CLINICAL INVESTIGATION

Serum angiopoietin-2 and soluble VEGF receptor 2 are surrogate markers for plasma leakage in patients with acute dengue virus infection

(2014) Cornelia A.M. van de Weg et al.   JOURNAL OF CLINICAL VIROLOGY

Angiopoietin-2-Induced Arterial Stiffness in CKD

(2014) F.-C. Chang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Tumor Microenvironment of Metastasis and Risk of Distant Metastasis of Breast Cancer

(2014) Thomas E. Rohan et al.   JNCI-Journal of the National Cancer Institute

Anti-angiopoietin therapy with trebananib for recurrent ovarian cancer (TRINOVA-1): a randomised, multicentre, double-blind, placebo-controlled phase 3 trial

(2014) Bradley J Monk et al.   LANCET ONCOLOGY

Overexpression of angiopoietin-2 in rats and patients with liver fibrosis. Therapeutic consequences of its inhibition

(2014) Montse Pauta et al.   LIVER INTERNATIONAL

Recurrent PTPRB and PLCG1 mutations in angiosarcoma

(2014) Sam Behjati et al.   NATURE GENETICS

Leukocyte extravasation and vascular permeability are each controlled in vivo by different tyrosine residues of VE-cadherin

(2014) Florian Wessel et al.   NATURE IMMUNOLOGY

Circulating Ang-2 mRNA Expression Levels: Looking Ahead to a New Prognostic Factor for NSCLC

(2014) Ana L. Coelho et al.   PLoS One

COMP-Angiopoietin1 Potentiates the Effects of Bone Morphogenic Protein-2 on Ischemic Necrosis of the Femoral Head in Rats

(2014) Lu Zhou et al.   PLoS One

Host genetic diversity enables Ebola hemorrhagic fever pathogenesis and resistance

(2014) A. L. Rasmussen et al.   SCIENCE

Plasma Angiopoietin-1 Is Lower After Ischemic Stroke and Associated With Major Disability But Not Stroke Incidence

(2014) Jonathan Golledge et al.   STROKE

The Role of Angiopoietins as Potential Therapeutic Targets in Renal Cell Carcinoma

(2014) Xiaoen Wang et al.   Translational Oncology

Circulating Angiopoietin-2 levels predict mortality in kidney transplant recipients: a 4-year prospective case-cohort study

(2014) Miklos Z. Molnar et al.   TRANSPLANT INTERNATIONAL

Role of Angiopoietin-2 in Adaptive Tumor Resistance to VEGF Signaling Blockade

(2014) Nicolò Rigamonti et al.   Cell Reports

Pro-angiogenic cytokines for prediction of outcomes in patients with advanced hepatocellular carcinoma

(2013) K Miyahara et al.   BRITISH JOURNAL OF CANCER

Vascular Endothelial Growth Factor-Angiopoietin Chimera With Improved Properties for Therapeutic Angiogenesis

(2013) Andrey Anisimov et al.   CIRCULATION

Ang-2-VEGF-A CrossMab, a Novel Bispecific Human IgG1 Antibody Blocking VEGF-A and Ang-2 Functions Simultaneously, Mediates Potent Antitumor, Antiangiogenic, and Antimetastatic Efficacy

(2013) Y. Kienast et al.   CLINICAL CANCER RESEARCH

Serum Angiopoietin-2 and CRP Levels During COPD Exacerbations

(2013) Sofia Nikolakopoulou et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Circulating angiopoietin-2, its soluble receptor Tie-2, and mortality in the general population

(2013) Roberto Lorbeer et al.   EUROPEAN JOURNAL OF HEART FAILURE

Angiopoietin signaling in the vasculature

(2013) Lauri Eklund et al.   EXPERIMENTAL CELL RESEARCH

Increased intravitreal angiopoietin-2 levels associated with rhegmatogenous retinal detachment

(2013) Sirpa Loukovaara et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Incidence and management of edema associated with trebananib (AMG 386)

(2013) Bradley J. Monk et al.   GYNECOLOGIC ONCOLOGY

The flow dependency of Tie2 expression in endotoxemia

(2013) Neng F. Kurniati et al.   INTENSIVE CARE MEDICINE

Angiopoietin 2 mediates microvascular and hemodynamic alterations in sepsis

(2013) Tilman Ziegler et al.   JOURNAL OF CLINICAL INVESTIGATION

Recent molecular discoveries in angiogenesis and antiangiogenic therapies in cancer

(2013) Jonathan Welti et al.   JOURNAL OF CLINICAL INVESTIGATION

Effect of Intracavernous Administration of Angiopoietin‐4 on Erectile Function in the Streptozotocin‐Induced Diabetic Mouse

(2013) Mi‐Hye Kwon et al.   Journal of Sexual Medicine

Early Angiopoietin-2 Levels after Onset Predict the Advent of Severe Pancreatitis, Multiple Organ Failure, and Infectious Complications in Patients with Acute Pancreatitis

(2013) Karel T. Buddingh et al.   JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS

Targeted Glomerular Angiopoietin-1 Therapy for Early Diabetic Kidney Disease

(2013) C. Dessapt-Baradez et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Effects of Vascular-Endothelial Protein Tyrosine Phosphatase Inhibition on Breast Cancer Vasculature and Metastatic Progression

(2013) Shom Goel et al.   JNCI-Journal of the National Cancer Institute

Synergistic effect of vascular endothelial growth factor and angiopoietin-2 on progression free survival in multiple myeloma

(2013) Archana Bhaskar et al.   LEUKEMIA RESEARCH

Neovascularization in diabetes and its complications. Unraveling the angiogenic paradox

(2013) Paulo Zoé Costa et al.   LIFE SCIENCES

A clinicopathological correlation of the expression of the angiopoietin-Tie-2 receptor pathway in the brain of adults with Plasmodium falciparum malaria

(2013) Panote Prapansilp et al.   MALARIA JOURNAL

The Temporal Kinetics of Circulating Angiopoietin Levels in Children With Sepsis

(2013) John S. Giuliano et al.   Pediatric Critical Care Medicine

A Novel Angiopoietin-2 Selective Fully Human Antibody with Potent Anti-Tumoral and Anti-Angiogenic Efficacy and Superior Side Effect Profile Compared to Pan-Angiopoietin-1/-2 Inhibitors

(2013) Markus Thomas et al.   PLoS One

Platelet Activation Determines Angiopoietin-1 and VEGF Levels in Malaria: Implications for Their Use as Biomarkers

(2013) Judith Brouwers et al.   PLoS One

Angiopoietin-2 Serum Levels Improve Noninvasive Fibrosis Staging in Chronic Hepatitis C: A Fibrogenic-Angiogenic Link

(2013) Ángel Hernández-Bartolomé et al.   PLoS One

Angiopoietin-2 in Adults with Congenital Heart Disease and Heart Failure

(2013) Alexander Lukasz et al.   PLoS One

Angiopoietin-2 Is Critical for Cytokine-Induced Vascular Leakage

(2013) Andrew V. Benest et al.   PLoS One

Structural basis for angiopoietin-1-mediated signaling initiation

(2013) X. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Angiopoietin-1 Guides Directional Angiogenesis Through Integrin  v 5 Signaling for Recovery of Ischemic Retinopathy

(2013) J. Lee et al.   Science Translational Medicine

VE-PTP regulates VEGFR2 activity in stalk cells to establish endothelial cell polarity and lumen formation

(2013) Makoto Hayashi et al.   Nature Communications

Dysregulation of the angiopoietin–Tie-2 axis in sepsis and ARDS

(2013) Samir M Parikh   Virulence

The Calcineurin-NFAT-Angiopoietin-2 Signaling Axis in Lung Endothelium Is Critical for the Establishment of Lung Metastases

(2013) Takashi Minami et al.   Cell Reports

The Complex Role of Angiopoietin-2 in the Angiopoietin-Tie Signaling Pathway

(2013) G. Thurston et al.   Cold Spring Harbor Perspectives in Medicine

The effects of designed angiopoietin-1 variant on lipid droplet diameter, vascular endothelial cell density and metabolic parameters in diabetic db/db mice

(2012) Yu Jin Jung et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Vascular endothelial hyperpermeability induces the clinical symptoms of Clarkson disease (the systemic capillary leak syndrome)

(2012) Z. Xie et al.   BLOOD

Angiopoietin-2 Functions as a Tie2 Agonist in Tumor Models, Where It Limits the Effects of VEGF Inhibition

(2012) C. Daly et al.   CANCER RESEARCH

Angiopoietin-2 in acute liver failure*

(2012) Johannes Hadem et al.   CRITICAL CARE MEDICINE

Plasma angiopoietin-2 in clinical acute lung injury

(2012) Carolyn S. Calfee et al.   CRITICAL CARE MEDICINE

Angiopoietin-2 may contribute to multiple organ dysfunction and death in sepsis*

(2012) Sascha David et al.   CRITICAL CARE MEDICINE

Angiopoietin-2 levels are associated with retinopathy and predict mortality in Malawian children with cerebral malaria

(2012) Andrea L. Conroy et al.   CRITICAL CARE MEDICINE

G-CSF rescues tumor growth and neo-angiogenesis during liver metastasis under host angiopoietin-2 deficiency

(2012) Jae Hong Im et al.   INTERNATIONAL JOURNAL OF CANCER

Ligand oligomerization state controls Tie2 receptor trafficking and angiopoietin-2-specific responses

(2012) R. Pietila et al.   JOURNAL OF CELL SCIENCE

Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling

(2012) Moritz Felcht et al.   JOURNAL OF CLINICAL INVESTIGATION

Effects of Angiopoietin-2-Blocking Antibody on Endothelial Cell–Cell Junctions and Lung Metastasis

(2012) Tanja Holopainen et al.   JNCI-Journal of the National Cancer Institute

Efficacy and safety of regorafenib for advanced gastrointestinal stromal tumours after failure of imatinib and sunitinib (GRID): an international, multicentre, randomised, placebo-controlled, phase 3 trial

(2012) George D Demetri et al.   LANCET

Simultaneous targeting of TNF and Ang2 with a novel bispecific antibody enhances efficacy in an in vivo model of arthritis

(2012) Palanisamy Kanakaraj et al.   mAbs

COMP-Angiopoietin-1 Recovers Molecular Biomarkers of Neuropathy and Improves Vascularisation in Sciatic Nerve of ob/ob Mice

(2012) Joanna Kosacka et al.   PLoS One

The Molecular Balance between Receptor Tyrosine Kinases Tie1 and Tie2 Is Dynamically Controlled by VEGF and TNFα and Regulates Angiopoietin Signalling

(2012) Harprit Singh et al.   PLoS One

Orchestral actions of angiopoietin-1 in vascular regeneration

(2012) Gou Young Koh   TRENDS IN MOLECULAR MEDICINE

Angiopoietin-1 Requires IQ Domain GTPase-Activating Protein 1 to Activate Rac1 and Promote Endothelial Barrier Defense

(2011) Sascha David et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

COMP-Ang1 stimulates HIF-1 -mediated SDF-1 overexpression and recovers ischemic injury through BM-derived progenitor cell recruitment

(2011) S.-W. Youn et al.   BLOOD

Angiopoietin-1 is associated with cerebral vasospasm and delayed cerebral ischemia in subarachnoid hemorrhage

(2011) Marlene Fischer et al.   BMC Neurology

Targeting the ANG2/TIE2 Axis Inhibits Tumor Growth and Metastasis by Impairing Angiogenesis and Disabling Rebounds of Proangiogenic Myeloid Cells

(2011) Roberta Mazzieri et al.   CANCER CELL

Acute administration of recombinant Angiopoietin-1 ameliorates multiple-organ dysfunction syndrome and improves survival in murine sepsis

(2011) Sascha David et al.   CYTOKINE

Intracavernous Delivery of a Designed Angiopoietin-1 Variant Rescues Erectile Function by Enhancing Endothelial Regeneration in the Streptozotocin-Induced Diabetic Mouse

(2011) Hai-Rong Jin et al.   DIABETES

Tie1 attenuation reduces murine atherosclerosis in a dose-dependent and shear stress–specific manner

(2011) Kel Vin Woo et al.   JOURNAL OF CLINICAL INVESTIGATION

Angiopoietin-1 is essential in mouse vasculature during development and in response to injury

(2011) Marie Jeansson et al.   JOURNAL OF CLINICAL INVESTIGATION

Randomized, Double-Blind, Placebo-Controlled Phase II Study of AMG 386 Combined With Weekly Paclitaxel in Patients With Recurrent Ovarian Cancer

(2011) Beth Y. Karlan et al.   JOURNAL OF CLINICAL ONCOLOGY

Dissociation of VE-PTP from VE-cadherin is required for leukocyte extravasation and for VEGF-induced vascular permeability in vivo

(2011) Andre Broermann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Somatic mutations in exon 17 of the TEK gene in vascular tumors and vascular malformations

(2011) Caisheng Ye et al.   JOURNAL OF VASCULAR SURGERY

Plasma levels of angiopoietin-1 and -2 predict cerebral malaria outcome in Central India

(2011) Vidhan Jain et al.   MALARIA JOURNAL

Unknown

(2011) Sae-Won Lee et al.   MOLECULAR MEDICINE

Angiopoietin-2 levels predict mortality in CKD patients

(2011) Sascha David et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

VEGF and angiopoietin signaling in tumor angiogenesis and metastasis

(2011) Pipsa Saharinen et al.   TRENDS IN MOLECULAR MEDICINE

Angiopoietin-2, a Regulator of Vascular Permeability in Inflammation, Is Associated With Persistent Organ Failure in Patients With Acute Pancreatitis From the United States and Germany

(2010) David C Whitcomb et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Vitreous Levels of Angiopoietin-1 and Angiopoietin-2 in Eyes With Retinopathy of Prematurity

(2010) Tatsuhiko Sato et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Angiopoietin-2-Driven Vascular Remodeling in Airway Inflammation

(2010) Sebastien P. Tabruyn et al.   AMERICAN JOURNAL OF PATHOLOGY

Angiopoietin-2 plasma dosage predicts time to first treatment and overall survival in chronic lymphocytic leukemia

(2010) R. Maffei et al.   BLOOD

Identification and functional analysis of endothelial tip cell-enriched genes

(2010) R. del Toro et al.   BLOOD

COMP–angiopoietin-1 accelerates bone formation during distraction osteogenesis

(2010) Byung-Hyun Park et al.   BONE

Identification of serum angiopoietin-2 as a biomarker for clinical outcome of colorectal cancer patients treated with bevacizumab-containing therapy

(2010) V Goede et al.   BRITISH JOURNAL OF CANCER

Double Antiangiogenic Protein, DAAP, Targeting VEGF-A and Angiopoietins in Tumor Angiogenesis, Metastasis, and Vascular Leakage

(2010) Young Jun Koh et al.   CANCER CELL

Complementary Actions of Inhibitors of Angiopoietin-2 and VEGF on Tumor Angiogenesis and Growth

(2010) H. Hashizume et al.   CANCER RESEARCH

Ratio of angiopoietin-2 to angiopoietin-1 as a predictor of mortality in acute lung injury patients

(2010) Thida Ong et al.   CRITICAL CARE MEDICINE

High glucose and elevated fatty acids suppress signaling by the endothelium protective ligand angiopoietin-1

(2010) Harprit Singh et al.   MICROVASCULAR RESEARCH

A Human Monoclonal Anti-ANG2 Antibody Leads to Broad Antitumor Activity in Combination with VEGF Inhibitors and Chemotherapy Agents in Preclinical Models

(2010) J. L. Brown et al.   MOLECULAR CANCER THERAPEUTICS

Context-Dependent Role of Angiopoietin-1 Inhibition in the Suppression of Angiogenesis and Tumor Growth: Implications for AMG 386, an Angiopoietin-1/2-Neutralizing Peptibody

(2010) A. Coxon et al.   MOLECULAR CANCER THERAPEUTICS

Angiopoietin-2 is highly correlated with inflammation and disease activity in recent-onset rheumatoid arthritis and could be predictive for cardiovascular disease

(2010) J. Westra et al.   RHEUMATOLOGY

Retinal overexpression of angiopoietin-2 mimics diabetic retinopathy and enhances vascular damages in hyperglycemia

(2009) Frederick Pfister et al.   ACTA DIABETOLOGICA

Contrasting Actions of Selective Inhibitors of Angiopoietin-1 and Angiopoietin-2 on the Normalization of Tumor Blood Vessels

(2009) Beverly L. Falcón et al.   AMERICAN JOURNAL OF PATHOLOGY

COMP-angiopoietin-1 enhances skeletal muscle blood flow and insulin sensitivity in mice

(2009) Hoon Ki Sung et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Angiopoietin-2, Marker and Mediator of Endothelial Activation With Prognostic Significance Early After Trauma?

(2009) Michael T. Ganter et al.   ANNALS OF SURGERY

COMP-Ang1, a chimeric form of Angiopoietin 1, enhances BMP2-induced osteoblast differentiation and bone formation

(2009) Byung-Chul Jeong et al.   BONE

Angiopoietin-1 alters microvascular permeability coefficients in vivo via modification of endothelial glycocalyx

(2009) Andrew H.J. Salmon et al.   CARDIOVASCULAR RESEARCH

Autocrine and Paracrine Angiopoietin 1/Tie-2 Signaling Promotes Muscle Satellite Cell Self-Renewal

(2009) Rana Abou-Khalil et al.   Cell Stem Cell

Decreased Hypoxia-Induced Neovascularization in Angiopoietin-2 Heterozygous Knockout Mouse through Reduced MMP Activity

(2009) Yuxi Feng et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Angiopoietin-2 Levels Are Associated with Disease Progression in Metastatic Malignant Melanoma

(2009) I. Helfrich et al.   CLINICAL CANCER RESEARCH

Hereditary cutaneomucosal venous malformations are caused by TIE2 mutations with widely variable hyper-phosphorylating effects

(2009) Vinciane Wouters et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Suppression of Tie-1 in endothelial cells in vitro induces a change in the genome-wide expression profile reflecting an inflammatory function

(2009) Barden Chan et al.   FEBS LETTERS

Angiopoietin-2 is increased in septic shock: Evidence for the existence of a circulating factor stimulating its release from human monocytes

(2009) Hariklia Kranidioti et al.   IMMUNOLOGY LETTERS

Angiopoietin-2 in patients requiring renal replacement therapy in the ICU: relation to acute kidney injury, multiple organ dysfunction syndrome and outcome

(2009) Philipp Kümpers et al.   INTENSIVE CARE MEDICINE

VE-PTP controls blood vessel development by balancing Tie-2 activity

(2009) Mark Winderlich et al.   JOURNAL OF CELL BIOLOGY

Safety, Pharmacokinetics, and Antitumor Activity of AMG 386, a Selective Angiopoietin Inhibitor, in Adult Patients With Advanced Solid Tumors

(2009) Roy S. Herbst et al.   JOURNAL OF CLINICAL ONCOLOGY

Overall Survival and Updated Results for Sunitinib Compared With Interferon Alfa in Patients With Metastatic Renal Cell Carcinoma

(2009) Robert J. Motzer et al.   JOURNAL OF CLINICAL ONCOLOGY

COMP-Angiopoietin-1 decreases lipopolysaccharide-induced acute kidney injury

(2009) Duk Hoon Kim et al.   KIDNEY INTERNATIONAL

Angiopoietin 2 Is a Partial Agonist/Antagonist of Tie2 Signaling in the Endothelium

(2009) H. T. Yuan et al.   MOLECULAR AND CELLULAR BIOLOGY

Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system

(2009) Hellmut G. Augustin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Intravitreal Bevacizumab and Ranibizumab for Age-Related Macular Degeneration

(2009) Donald S. Fong et al.   OPHTHALMOLOGY

Regulation of angiopoietin expression by bacterial lipopolysaccharide

(2008) Mahroo Mofarrahi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Receptor tyrosine kinase Tie-1 overexpression in endothelial cells upregulates adhesion molecules

(2008) Barden Chan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Angiopoietin-2 Deficiency Decelerates Age-Dependent Vascular Changes in the Mouse Retina

(2008) Yuxi Feng et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Angiopoietin-1 gene transfer improves impaired wound healing in genetically diabetic mice without increasing VEGF expression

(2008) Alessandra Bitto et al.   CLINICAL SCIENCE

Angiopoietin-1 Prevents VEGF-Induced Endothelial Permeability by Sequestering Src through mDia

(2008) Julie Gavard et al.   DEVELOPMENTAL CELL

Pericyte Migration: A Novel Mechanism of Pericyte Loss in Experimental Diabetic Retinopathy

(2008) F. Pfister et al.   DIABETES

Angiopoietin-1 variant, COMP-Ang1 attenuates hydrogen peroxide-induced acute lung injury

(2008) So Ri Kim et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Angiopoietin-1 Induces Krüppel-like Factor 2 Expression through a Phosphoinositide 3-Kinase/AKT-dependent Activation of Myocyte Enhancer Factor 2

(2008) Keisuke Sako et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The angiopoietin-2 gene of endothelial cells is up-regulated in hypoxia by a HIF binding site located in its first intron and by the central factors GATA-2 and Ets-1

(2008) Marie-Pierre Simon et al.   JOURNAL OF CELLULAR PHYSIOLOGY

VE-PTP maintains the endothelial barrier via plakoglobin and becomes dissociated from VE-cadherin by leukocytes and by VEGF

(2008) Astrid F. Nottebaum et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Differential function of Tie2 at cell–cell contacts and cell–substratum contacts regulated by angiopoietin-1

(2008) Shigetomo Fukuhara et al.   NATURE CELL BIOLOGY

Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell–cell and cell–matrix contacts

(2008) Pipsa Saharinen et al.   NATURE CELL BIOLOGY

Somatic mutations in angiopoietin receptor gene TEK cause solitary and multiple sporadic venous malformations

(2008) Nisha Limaye et al.   NATURE GENETICS

Expression of angiopoietins and vascular endothelial growth factors and their clinical significance in acute myeloid leukemia

(2007) Hsin-An Hou et al.   LEUKEMIA RESEARCH