Article
Medicine, General & Internal
Rui Gao, Jingxue Ma, Zhengwei Zhang, Qingli Shang, Jialiang Duan
Summary: This study compared retinal biomarkers of choroidal neovascularization secondary to MFC, mCNV, and ICNV using OCT. The key findings were that biomarkers such as CNV diameter, sub-retinal fluids, the pitchfork sign, and choroidal thickness under CNV can help distinguish different types of CNV. There were no differences between the MFC group and ICNV group except in refractive error.
ANNALS OF MEDICINE
(2021)
Article
Engineering, Biomedical
Hao Yao, Huan Xu, Mingxing Wu, Wulong Lei, Lanjiao Li, Danning Liu, Zhigang Wang, Haitao Ran, Huafeng Ma, Xiyuan Zhou
Summary: This study developed a non-invasive treatment method for choroidal neovascularization (CNV) in wet age-related macular degeneration (AMD) using targeted nanoparticles. These nanoparticles effectively reduce neovascularization leakage and provide an alternative treatment for AMD.
ACTA BIOMATERIALIA
(2023)
Review
Biochemistry & Molecular Biology
Federico Di Staso, Mariachiara Di Pippo, Solmaz Abdolrahimzadeh
Summary: This review aims to elucidate the possible origins of choroidal neovascularization (CNV) by examining in vivo and in vitro models compared to clinical cases. It pays particular attention to histologic alterations and molecular cascades. Although the mechanisms are still partially obscure, experimental models are progressively enhancing our understanding of neovascularization etiology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Pinghui Wei, Meiqin He, Ying Wang, Guoge Han
Summary: High-fat diet accelerates choroidal neovascularization in age-related macular degeneration. This study investigates the effects of high-fat diet on retinal and retinal pigment epithelium/choroidal acylcarnitine metabolism. The results show that high-fat diet promotes weight gain, dyslipidemia, and neovascular formation, accompanied by different changes in isomerism of metabolites.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Henry T. Hsueh, Renee Ti Chou, Usha Rai, Patricia Kolodziejski, Wathsala Liyanage, Jahnavi Pejavar, Ann Mozzer, Charlotte Davison, Matthew B. Appell, Yoo Chun Kim, Kirby T. Leo, Hyeyoung Kwon, Maanasa Sista, Nicole M. Anders, Avelina Hemingway, Sri Vishnu Kiran Rompicharla, Ian Pitha, Donald J. Zack, Justin Hanes, Michael P. Cummings, Laura M. Ensign
Summary: Effective eye drop delivery systems for treating diseases of the posterior segment have yet to be clinically validated. In this study, a combination of a hypotonic gel-forming eye drop delivery system and an engineered melanin binding and cell-penetrating peptide was used to achieve effective and sustained therapeutic drug concentration, enhancing neuroprotection in a rat model of optic nerve injury.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Biochemistry & Molecular Biology
Bomina Park, Sheik Pran Babu Sardar Pasha, Kamakshi L. Sishtla, Gabriella D. Hartman, Xiaoping Qi, Michael E. Boulton, Timothy W. Corson
Summary: The study validates soluble epoxide hydrolase (sEH) as a potential therapeutic target for choroidal neovascularization (CNV) associated with wet age-related macular degeneration (nAMD). Knockdown of the sEH gene significantly reduces CNV and normalizes the expression levels of CNV-related inflammatory markers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Manjing Li, Zhaojian Xu, Lu Zhang, Mingyue Cui, Manhui Zhu, Yang Guo, Rong Sun, Junfei Han, E. Song, Yao He, Yuanyuan Su
Summary: The development of hybrid cell-membrane-cloaked nanoparticles as an alternative antiangiogenic agent for noninvasive targeted treatment of CNV has shown significantly enhanced accumulation in CNV regions and excellent therapeutic efficacy in reducing leakage and area of CNV. This biomimetic approach provides an effective strategy for the treatment of CNV.
Letter
Ophthalmology
Nikhil Bommakanti, Cagri G. Besirli, Peter Y. Zhao
Summary: This case report discusses the progression of posterior subcapsular cataract and retinal neovascularization in a patient with posterior polar annular choroidal dystrophy.
JAMA OPHTHALMOLOGY
(2023)
Article
Multidisciplinary Sciences
Daniel Duck-Jin Hwang, Hak Jun Lee
Summary: The purpose of this study was to investigate the long-term changes in choroidal thickness in central retinal vein occlusion (CRVO) after anti-vascular endothelial growth factor (VEGF) treatment. The study included 41 patients with treatment-naive unilateral CRVO. The results showed that the subfoveal choroidal thickness (SFCT) in CRVO eyes significantly decreased at 12 months and 24 months compared to baseline.
SCIENTIFIC REPORTS
(2023)
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.
Article
Medicine, General & Internal
Lisa Toto, Maria Ludovica Ruggeri, Federica Evangelista, Chiara Trivigno, Rossella D'Aloisio, Chiara De Nicola, Pasquale Viggiano, Emanuele Doronzo, Marta Di Nicola, Annamaria Porreca, Rodolfo Mastropasqua
Summary: This study investigates the parameters of optical coherence tomography (OCT) and OCT angiography (OCTA) in patients with neovascular age-related macular degeneration (nAMD) and macular neovascularization (MNV) types 1, 2, and 3. The results showed significant differences in CVI, CMT, and ORCCFA between MNV 1 and the other two groups. CVI was significantly different between MNV 1 and healthy controls and between MNV 1 and MNV 2. ORCCFA and CMT were significantly different between MNV 1 and MNV 2. There was no statistically significant difference in subfoveal choroidal thickness (SFCT) among the three groups.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Bai Xue, Mengyue Ge, Kelong Fan, Xinglu Huang, Xiyun Yan, Wei Jiang, Bing Jiang, Zhenglin Yang
Summary: This study developed an ultrasmall Pt nanozyme loaded mitochondria-targeted liposome to alleviate hypoxia and eliminate excess ROS for effective treatment of retinal neovascularization. Using an oxygen-induced retinopathy (OIR) mouse model, the nanozymes significantly suppressed abnormal neovascularization and facilitated avascular normalization of the retina.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Biochemistry & Molecular Biology
Lacramioara Samoila, Oliviu Vostinaru, Elena Dinte, Andreea Elena Bodoki, Bogdan-Cezar Iacob, Ede Bodoki, Ovidiu Samoila
Summary: The topical administration of medicines for retinal degenerative diseases is limited by the eye's barriers, but NSAIDs have shown potential for effective treatment. Other drug classes may require fine-tuning of pharmacokinetic profiles or advanced formulation strategies for improved delivery to the retina. Ultimately, developing more effective ways of delivering drugs to the posterior eye will enhance clinical efficacy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Anna Salas, Anna Badia, Laura Fontrodona, Miguel Zapata, Jose Garcia-Arumi, Anna Duarri
Summary: Through studying a mouse model of laser-induced choroidal neovascularization, we found that the progression of CNV lesions goes through an acute phase and a stable phase, and this model is suitable for screening anti-inflammatory and anti-angiogenic drugs.
Article
Ophthalmology
Yifan Feng, Liyang Wang, Chunqiong Dong, Xi Yang, Jing Wang, Xi Zhang, Yuanzhi Yuan, Jinhui Dai, Jinhai Huang, Fei Yuan
Summary: miR-376b-3p is a suppressor of glutamine metabolism in endothelial cells. It inhibits the expression of GLS1 by suppressing CEBPB, leading to the inhibition of proliferation, migration, tube formation, and the promotion of apoptosis in HRMECs. Ultimately, it restrains CNV formation and may serve as a therapeutic target for CNV-related diseases.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Biotechnology & Applied Microbiology
Shu Kachi, Katie Binley, Katsutoshi Yokoi, Naoyasu Umeda, Hideo Akiyama, Daisuke Muramatu, Sharifah Iqball, On Kan, Stuart Naylor, Peter A. Campochiaro
HUMAN GENE THERAPY
(2009)
Article
Chemistry, Medicinal
Moorthy S. S. Palanki, Hideo Akiyama, Peter Campochiaro, Jianguo Cao, Chun P. Chow, Luis Dellamary, John Doukas, Richard Fine, Colleen Gritzen, John D. Hood, Steven Hu, Shu Kachi, Xinshan Kang, Boris Klebansky, Ahmed Kousba, Dan Lohse, Chi Ching Mak, Michael Martin, Andrew McPherson, Ved P. Pathak, Joel Renick, Richard Soll, Naoyasu Umeda, Shiyin Yee, Katsutoshi Yokoi, Binqi Zeng, Hong Zhu, Glenn Noronha
JOURNAL OF MEDICINAL CHEMISTRY
(2008)
Article
Pharmacology & Pharmacy
Naoyasu Umeda, Shu Kachi, Hideo Akiyama, Grit Zahn, Doerte Vossmeyer, Roland Stragies, Peter A. Campochiaro
MOLECULAR PHARMACOLOGY
(2006)
Article
Cell Biology
H Akiyama, S Kachi, RLE Silva, N Umeda, SF Hackett, D McCauley, T McCauley, A Zoltoski, DM Epstein, PA Campochiaro
JOURNAL OF CELLULAR PHYSIOLOGY
(2006)
Article
Pharmacology & Pharmacy
H Akiyama, KA Mohamedali, RLE Silva, S Kachi, JK Shen, C Hatara, N Umeda, SF Hackett, S Aslam, M Krause, H Lai, MG Rosenblum, PA Campochiaro
MOLECULAR PHARMACOLOGY
(2005)
Article
Cell Biology
H Nambu, N Umeda, S Kachi, Y Oshima, H Akiyama, R Nambu, PA Campochiaro
JOURNAL OF CELLULAR PHYSIOLOGY
(2005)
Article
Biochemistry & Molecular Biology
Y Oshima, S Oshima, H Nambu, S Kachi, K Takahashi, N Umeda, J Shen, A Dong, RS Apte, E Duh, SF Hackett, G Okaye, K Ishibashi, J Handa, M Melia, S Weigand, G Yancopoulos, DJ Zack, PA Campochiaro
Article
Ophthalmology
N Umeda, H Ozaki, H Hayashi, K Oshima
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2004)
Article
Ophthalmology
N Umeda, H Ozaki, H Hayashi, H Miyajima-Uchida, K Oshima
OPHTHALMIC RESEARCH
(2003)
Article
Ophthalmology
N Umeda, H Ozaki, H Hayashi, H Kondo, H Uchida, K Oshima
OPHTHALMIC RESEARCH
(2002)