Cycling CD4+ T cells in HIV-infected immune nonresponders have mitochondrial dysfunction

First-in-human phase 1 clinical study of the IL-15 superagonist complex ALT-803 to treat relapse after transplantation

(2018) Rizwan Romee et al.   BLOOD

Homeostatic control of metabolic and functional fitness of Treg cells by LKB1 signalling

(2017) Kai Yang et al.   NATURE

Responsiveness to IL-7 but not to IFN-α is diminished in CD4+ T cells from treated HIV infected patients who experience poor CD4+ T-cell recovery

(2016) Thao P. Nguyen et al.   AIDS

Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming

(2016) Michael D. Buck et al.   CELL

Heterodimeric IL15 Treatment Enhances Tumor Infiltration, Persistence, and Effector Functions of Adoptively Transferred Tumor-specific T Cells in the Absence of Lymphodepletion

(2016) Sinnie Sin Man Ng et al.   CLINICAL CANCER RESEARCH

The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction

(2016) Nicole E. Scharping et al.   IMMUNITY

The Proteomic Landscape of Human Ex Vivo Regulatory and Conventional T Cells Reveals Specific Metabolic Requirements

(2016) Claudio Procaccini et al.   IMMUNITY

Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8 + T Cell Exhaustion

(2016) Bertram Bengsch et al.   IMMUNITY

Inflammation Perturbs the IL-7 Axis, Promoting Senescence and Exhaustion that Broadly Characterize Immune Failure in Treated HIV Infection

(2016) Carey L. Shive et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

IL-15 promotes activation and expansion of CD8+ T cells in HIV-1 infection

(2016) Souheil-Antoine Younes et al.   JOURNAL OF CLINICAL INVESTIGATION

Correlation of transferrin receptor (CD71) with Ki67 expression on stimulated human and mouse T cells: The kinetics of expression of T cell activation markers

(2016) Melika Motamedi et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Mucosal Regulatory T Cells and T Helper 17 Cells in HIV-Associated Immune Activation

(2016) Pushpa Pandiyan et al.   Frontiers in Immunology

Essential role of mitochondrial energy metabolism in Foxp3+ T-regulatory cell function and allograft survival

(2015) Ulf H. Beier et al.   FASEB JOURNAL

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Influence of hepatitis C virus coinfection on CD4+ T cells of HIV-infected patients receiving HAART

(2014) Konstantin V. Shmagel et al.   AIDS

Type I IFN gene delivery suppresses regulatory T cells within tumors

(2014) H Hashimoto et al.   CANCER GENE THERAPY

Mitochondrial Metabolism in T Cell Activation and Senescence: A Mini-Review

(2014) Noga Ron-Harel et al.   GERONTOLOGY

Regulatory T Cells in HIV-Infected Immunological Nonresponders Are Increased in Blood but Depleted in Lymphoid Tissue and Predict Immunological Reconstitution

(2014) Julie C. Gaardbo et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Type I interferons directly inhibit regulatory T cells to allow optimal antiviral T cell responses during acute LCMV infection

(2014) Shivani Srivastava et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inflammatory Cytokines Drive CD4+ T-Cell Cycling and Impaired Responsiveness to Interleukin 7: Implications for Immune Failure in HIV Disease

(2014) Carey L. Shive et al.   JOURNAL OF INFECTIOUS DISEASES

Cycling Memory CD4+ T Cells in HIV Disease Have a Diverse T Cell Receptor Repertoire and a Phenotype Consistent with Bystander Activation

(2014) W. Jiang et al.   JOURNAL OF VIROLOGY

Regulatory T cell proliferative potential is impaired in human autoimmune disease

(2013) Fortunata Carbone et al.   NATURE MEDICINE

Incomplete Normalization of Regulatory T-Cell Frequency in the Gut Mucosa of Colombian HIV-Infected Patients Receiving Long-Term Antiretroviral Treatment

(2013) Cesar M. Rueda et al.   PLoS One

Dynamics of Immune Reconstitution and Activation Markers in HIV+ Treatment-Naïve Patients Treated with Raltegravir, Tenofovir Disoproxil Fumarate and Emtricitabine

(2013) Nicholas T. Funderburg et al.   PLoS One

Sample-level enrichment analysis unravels shared stress phenotypes among multiple cancer types

(2012) Gunes Gundem et al.   Genome Medicine

Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development

(2011) Gerritje J.W. van der Windt et al.   IMMUNITY

Immunologic Failure Despite Suppressive Antiretroviral Therapy Is Related to Activation and Turnover of Memory CD4 Cells

(2011) Michael M. Lederman et al.   JOURNAL OF INFECTIOUS DISEASES

Memory Phenotype CD4 T Cells Undergoing Rapid, Nonburst-Like, Cytokine-Driven Proliferation Can Be Distinguished from Antigen-Experienced Memory Cells

(2011) Souheil-Antoine Younes et al.   PLOS BIOLOGY

Immune activation, apoptosis, and Treg activity are associated with persistently reduced CD4+ T-cell counts during antiretroviral therapy

(2010) Stefania Piconi et al.   AIDS

Long-term mortality in HIV patients virally suppressed for more than three years with incomplete CD4 recovery: A cohort study

(2010) Frederik N Engsig et al.   BMC INFECTIOUS DISEASES

Different Proliferative Potential and Migratory Characteristics of Human CD4+ Regulatory T Cells That Express either CD45RA or CD45RO

(2010) N. J. Booth et al.   JOURNAL OF IMMUNOLOGY

Enrichment Map: A Network-Based Method for Gene-Set Enrichment Visualization and Interpretation

(2010) Daniele Merico et al.   PLoS One

Incomplete Peripheral CD4+Cell Count Restoration in HIV‐Infected Patients Receiving Long‐Term Antiretroviral Treatment

(2009) Colleen F. Kelley et al.   CLINICAL INFECTIOUS DISEASES

Incomplete Reconstitution of T Cell Subsets on Combination Antiretroviral Therapy in the AIDS Clinical Trials Group Protocol 384

(2009) Gregory K. Robbins et al.   CLINICAL INFECTIOUS DISEASES

GARP (LRRC32) is essential for the surface expression of latent TGF-  on platelets and activated FOXP3+ regulatory T cells

(2009) D. Q. Tran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD4+ count and risk of non-AIDS diseases following initial treatment for HIV infection

(2008) Jason V Baker et al.   AIDS