How age and infection history shape the antigen‐specific CD8 + T‐cell repertoire: Implications for vaccination strategies in older adults

Primary and secondary anti-viral response captured by the dynamics and phenotype of individual T cell clones

(2020) Anastasia A Minervina et al.   eLife

Reverse TCR repertoire evolution toward dominant low-affinity clones during chronic CMV infection

(2020) Kilian Schober et al.   NATURE IMMUNOLOGY

Back to the Future for Influenza Preimmunity—Looking Back at Influenza Virus History to Infer the Outcome of Future Infections

(2019) Magen Francis et al.   Viruses-Basel

Impact of CMV upon immune aging: facts and fiction

(2019) Mladen Jergović et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

The hallmarks of CMV-specific CD8 T-cell differentiation

(2019) Sara P. H. van den Berg et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Promising Cytomegalovirus-Based Vaccine Vector Induces Robust CD8+ T-Cell Response

(2019) Jian Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Stochastic Expansions Maintain the Clonal Stability of CD8+ T Cell Populations Undergoing Memory Inflation Driven by Murine Cytomegalovirus

(2019) Corinne J. Smith et al.   JOURNAL OF IMMUNOLOGY

Adjuvant strategies to improve vaccination of the elderly population

(2018) Birgit Weinberger   CURRENT OPINION IN PHARMACOLOGY

Predicting the spectrum of TCR repertoire sharing with a data-driven model of recombination

(2018) Yuval Elhanati et al.   IMMUNOLOGICAL REVIEWS

Lifelong CMV infection improves immune defense in old mice by broadening the mobilized TCR repertoire against third-party infection

(2018) Megan J. Smithey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vaccines for the elderly: current use and future challenges

(2018) Birgit Weinberger   Immunity & Ageing

The Contribution of Cytomegalovirus Infection to Immune Senescence Is Set by the Infectious Dose

(2018) Anke Redeker et al.   Frontiers in Immunology

Single-Cell Approach to Influenza-Specific CD8+ T Cell Receptor Repertoires Across Different Age Groups, Tissues, and Following Influenza Virus Infection

(2018) Sneha Sant et al.   Frontiers in Immunology

The Changing Landscape of Naive T Cell Receptor Repertoire With Human Aging

(2018) Evgeny S. Egorov et al.   Frontiers in Immunology

Cytomegalovirus Exposure in the Elderly Does Not Reduce CD8 T Cell Repertoire Diversity

(2018) Paul Lindau et al.   JOURNAL OF IMMUNOLOGY

Major TCR Repertoire Perturbation by Immunodominant HLA-B*44:03-Restricted CMV-Specific T Cells

(2018) Meriem Attaf et al.   Frontiers in Immunology

Aging-related changes in human T-cell repertoire over 20 years delineated by deep sequencing of peripheral T-cell receptors

(2017) Kengo Yoshida et al.   EXPERIMENTAL GERONTOLOGY

Unique influenza A cross-reactive memory CD8 T-cell receptor repertoire has a potential to protect against EBV seroconversion

(2017) Levi B. Watkin et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Quantifiable predictive features define epitope-specific T cell receptor repertoires

(2017) Pradyot Dash et al.   NATURE

Identifying specificity groups in the T cell receptor repertoire

(2017) Jacob Glanville et al.   NATURE

Immunosequencing identifies signatures of cytomegalovirus exposure history and HLA-mediated effects on the T cell repertoire

(2017) Ryan O Emerson et al.   NATURE GENETICS

Aged-associated cytomegalovirus and Epstein-Barr virus reactivation and cytomegalovirus relationship with the frailty syndrome in older women

(2017) Ronaldo Luis Thomasini et al.   PLoS One

Sequence and Structural Analyses Reveal Distinct and Highly Diverse Human CD8 + TCR Repertoires to Immunodominant Viral Antigens

(2017) Guobing Chen et al.   Cell Reports

Cytomegalovirus persistence and T-cell immunosenescence in people aged fifty and older: A systematic review

(2016) Marlies Weltevrede et al.   EXPERIMENTAL GERONTOLOGY

Dynamics of Individual T Cell Repertoires: From Cord Blood to Centenarians

(2016) Olga V. Britanova et al.   JOURNAL OF IMMUNOLOGY

How many TCR clonotypes does a body maintain?

(2016) Grant Lythe et al.   JOURNAL OF THEORETICAL BIOLOGY

Heightened self-reactivity associated with selective survival, but not expansion, of naïve virus-specific CD8+T cells in aged mice

(2016) Kylie M. Quinn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Robust estimates of overall immune-repertoire diversity from high-throughput measurements on samples

(2016) Joseph Kaplinsky et al.   Nature Communications

Mechanisms Underlying T Cell Immunosenescence: Aging and Cytomegalovirus Infection

(2016) Wenjuan Tu et al.   Frontiers in Microbiology

T-Cell Immunity to Influenza in Older Adults: A Pathophysiological Framework for Development of More Effective Vaccines

(2016) Janet E. McElhaney et al.   Frontiers in Immunology

A Single 17D Yellow Fever Vaccination Provides Lifelong Immunity; Characterization of Yellow-Fever-Specific Neutralizing Antibody and T-Cell Responses after Vaccination

(2016) Rosanne W. Wieten et al.   PLoS One

Chemical Modification of Influenza CD8+ T-Cell Epitopes Enhances Their Immunogenicity Regardless of Immunodominance

(2016) Sietske K. Rosendahl Huber et al.   PLoS One

Reduced naïve CD8+T-cell priming efficacy in elderly adults

(2015) Olivia Briceño et al.   AGING CELL

Narrowing of Human Influenza A Virus-Specific T Cell Receptor α and β Repertoires with Increasing Age

(2015) Anna Gil et al.   JOURNAL OF VIROLOGY

Dynamics of the Cytotoxic T Cell Response to a Model of Acute Viral Infection

(2015) William S. DeWitt et al.   JOURNAL OF VIROLOGY

Estimating T-cell repertoire diversity: limitations of classical estimators and a new approach

(2015) Daniel J. Laydon et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Heterologous immunity between viruses

(2015) Raymond M. Welsh et al.   IMMUNOLOGICAL REVIEWS

Age-associated Epstein-Barr virus-specific T cell responses in seropositive healthy adults

(2014) D. Cárdenas Sierra et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

The interplay between Epstein–Barr virus and B lymphocytes: implications for infection, immunity, and disease

(2014) Olivia L. Hatton et al.   IMMUNOLOGIC RESEARCH

A population biological approach to understanding the maintenance and loss of the T-cell repertoire during aging

(2014) Philip L. F. Johnson et al.   IMMUNOLOGY

In vitro expansion of antigen-specific CD8+ T cells distorts the T-cell repertoire

(2014) Dan Koning et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Multiple Glycines in TCR  -Chains Determine Clonally Diverse Nature of Human T Cell Memory to Influenza A Virus

(2014) Y. N. Naumov et al.   JOURNAL OF IMMUNOLOGY

Naive Precursor Frequencies and MHC Binding Rather Than the Degree of Epitope Diversity Shape CD8+ T Cell Immunodominance

(2014) M. F. Kotturi et al.   JOURNAL OF IMMUNOLOGY

Age-Related Decrease in TCR Repertoire Diversity Measured with Deep and Normalized Sequence Profiling

(2014) O. V. Britanova et al.   JOURNAL OF IMMUNOLOGY

Aging and Cytomegalovirus Infection Differentially and Jointly Affect Distinct Circulating T Cell Subsets in Humans

(2014) A. M. Wertheimer et al.   JOURNAL OF IMMUNOLOGY

Clonal Evolution of CD8+T Cell Responses against Latent Viruses: Relationship among Phenotype, Localization, and Function

(2014) Ester B. M. Remmerswaal et al.   JOURNAL OF VIROLOGY

Reproducible selection of high avidity CD8+ T-cell clones following secondary acute virus infection

(2014) T. Cukalac et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diversity and clonal selection in the human T-cell repertoire

(2014) Q. Qi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CMV-, EBV- and ADV-Specific T Cell Immunity: Screening and Monitoring of Potential Third-Party Donors to Improve Post-Transplantation Outcome

(2013) Cinja Sukdolak et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Cross-Reactivity of T Cells and Its Role in the Immune System

(2013) Galina Petrova et al.   CRITICAL REVIEWS IN IMMUNOLOGY

Persistence of EBV Antigen-Specific CD8 T Cell Clonotypes during Homeostatic Immune Reconstitution in Cancer Patients

(2013) Emanuela M. Iancu et al.   PLoS One

Interrogating the relationship between naïve and immune antiviral T cell repertoires

(2013) Nicole L La Gruta et al.   Current Opinion in Virology

Functional Avidity: A Measure to Predict the Efficacy of Effector T Cells?

(2012) Selena Viganò et al.   Clinical & Developmental Immunology

Lifelong Persistent Viral Infection Alters the Naive T Cell Pool, Impairing CD8 T Cell Immunity in Late Life

(2012) M. J. Smithey et al.   JOURNAL OF IMMUNOLOGY

Evidence for Antigenic Seniority in Influenza A (H3N2) Antibody Responses in Southern China

(2012) Justin Lessler et al.   PLoS Pathogens

Deep Sequencing of Antiviral T-Cell Responses to HCMV and EBV in Humans Reveals a Stable Repertoire That Is Maintained for Many Years

(2012) P. L. Klarenbeek et al.   PLoS Pathogens

Cytomegalovirus Infection Impairs Immune Responses and Accentuates T-cell Pool Changes Observed in Mice with Aging

(2012) Luka Cicin-Sain et al.   PLoS Pathogens

Bias in the αβ T-cell repertoire: implications for disease pathogenesis and vaccination

(2011) John J Miles et al.   IMMUNOLOGY AND CELL BIOLOGY

Selective T Cell Expansion during Aging of CD8 Memory Repertoires to Influenza Revealed by Modeling

(2011) Y. N. Naumov et al.   JOURNAL OF IMMUNOLOGY

Evolution of the Antigen-Specific CD8+ TCR Repertoire across the Life Span: Evidence for Clonal Homogenization of the Old TCR Repertoire

(2011) B. D. Rudd et al.   JOURNAL OF IMMUNOLOGY

Influenza vaccine responses in older adults

(2010) Janet E. McElhaney   AGEING RESEARCH REVIEWS

CD8 T Cell Cross-Reactivity Networks Mediate Heterologous Immunity in Human EBV and Murine Vaccinia Virus Infections

(2010) M. Cornberg et al.   JOURNAL OF IMMUNOLOGY

Broad Cross-Reactive TCR Repertoires Recognizing Dissimilar Epstein-Barr and Influenza A Virus Epitopes

(2010) S. C. Clute et al.   JOURNAL OF IMMUNOLOGY

Overlap and Effective Size of the Human CD8+ T Cell Receptor Repertoire

(2010) H. S. Robins et al.   Science Translational Medicine

Comprehensive assessment of T-cell receptor  -chain diversity in    T cells

(2009) H. S. Robins et al.   BLOOD

Functional implications of T cell receptor diversity

(2009) Stephen J Turner et al.   CURRENT OPINION IN IMMUNOLOGY

Biomarkers of human immunosenescence: impact of Cytomegalovirus infection

(2009) Evelyna Derhovanessian et al.   CURRENT OPINION IN IMMUNOLOGY

Public clonotype usage identifies protective Gag-specific CD8+T cell responses in SIV infection

(2009) David A. Price et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Clonotype Selection and Composition of Human CD8 T Cells Specific for Persistent Herpes Viruses Varies with Differentiation but Is Stable Over Time

(2009) E. M. Iancu et al.   JOURNAL OF IMMUNOLOGY

Two Compensatory Pathways Maintain Long-Term Stability and Diversity in CD8 T Cell Memory Repertoires

(2009) E. N. Naumova et al.   JOURNAL OF IMMUNOLOGY

Attrition of memory CD8 T cells

(2009) Raymond M. Welsh et al.   NATURE

Impact of clonal competition for peptide-MHC complexes on the CD8+ T-cell repertoire selection in a persistent viral infection

(2008) K. K. Wynn et al.   BLOOD

T-cell receptor bias and immunity

(2008) Stephanie Gras et al.   CURRENT OPINION IN IMMUNOLOGY

Vaccine Adjuvants Alter TCR-Based Selection Thresholds

(2008) Laurent Malherbe et al.   IMMUNITY

Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus

(2008) Eric J. Yager et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Age-related appearance of a CMV-specific high-avidity CD8+ T cell clonotype which does not occur in young adults

(2008) Angelika Schwanninger et al.   Immunity & Ageing