Naive T Cell Maintenance and Function in Human Aging

Lymphocyte maintenance during healthy aging requires no substantial alterations in cellular turnover

(2015) Liset Westera et al.   AGING CELL

Age-associated telomere attrition of lymphocytesin vivois co-ordinated with changes in telomerase activity, composition of lymphocyte subsets and health conditions

(2015) Yun Lin et al.   CLINICAL SCIENCE

Spatial Map of Human T Cell Compartmentalization and Maintenance over Decades of Life

(2014) Joseph J.C. Thome et al.   CELL

Mechanisms shaping the naïve T cell repertoire in the elderly — Thymic involution or peripheral homeostatic proliferation?

(2014) Qian Qi et al.   EXPERIMENTAL GERONTOLOGY

A population biological approach to understanding the maintenance and loss of the T-cell repertoire during aging

(2014) Philip L. F. Johnson et al.   IMMUNOLOGY

p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8+ T cells

(2014) Sian M. Henson et al.   JOURNAL OF CLINICAL INVESTIGATION

Homeostasis of the Naive CD4+ T Cell Compartment during Aging

(2014) R. D. Kilpatrick et al.   JOURNAL OF IMMUNOLOGY

Age-Related Decrease in TCR Repertoire Diversity Measured with Deep and Normalized Sequence Profiling

(2014) O. V. Britanova et al.   JOURNAL OF IMMUNOLOGY

Aging and Cytomegalovirus Infection Differentially and Jointly Affect Distinct Circulating T Cell Subsets in Humans

(2014) A. M. Wertheimer et al.   JOURNAL OF IMMUNOLOGY

Aging of the T Cell Compartment in Mice and Humans: From No Naive Expectations to Foggy Memories

(2014) Janko Nikolich-Žugich   JOURNAL OF IMMUNOLOGY

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

(2014) C. Franceschi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Inflamm-aging does not simply reflect increases in pro-inflammatory markers

(2014) Vincent Morrisette-Thomas et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Chaperone-mediated autophagy regulates T cell responses through targeted degradation of negative regulators of T cell activation

(2014) Rut Valdor et al.   NATURE IMMUNOLOGY

Autophagy is essential for effector CD8+ T cell survival and memory formation

(2014) Xiaojin Xu et al.   NATURE IMMUNOLOGY

Diversity and clonal selection in the human T-cell repertoire

(2014) Q. Qi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Age-related variations in the methylome associated with gene expression in human monocytes and T cells

(2014) Lindsay M. Reynolds et al.   Nature Communications

Metabolic Regulation of T Lymphocytes

(2013) Nancie J. MacIver et al.   Annual Review of Immunology

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Virus-Specific CD4+ Memory-Phenotype T Cells Are Abundant in Unexposed Adults

(2013) Laura F. Su et al.   IMMUNITY

Causes, consequences, and reversal of immune system aging

(2013) Encarnacion Montecino-Rodriguez et al.   JOURNAL OF CLINICAL INVESTIGATION

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

(2013) Tamara Tchkonia et al.   JOURNAL OF CLINICAL INVESTIGATION

Postthymic Expansion in Human CD4 Naive T Cells Defined by Expression of Functional High-Affinity IL-2 Receptors

(2013) M. L. Pekalski et al.   JOURNAL OF IMMUNOLOGY

Two Separate Defects Affecting True Naive or Virtual Memory T Cell Precursors Combine To Reduce Naive T Cell Responses with Aging

(2013) K. R. Renkema et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Central Memory CD8 T Cells in Aged Mice Are Virtual Memory Cells

(2013) B.-C. Chiu et al.   JOURNAL OF IMMUNOLOGY

Quantifying T lymphocyte turnover

(2013) Rob J. De Boer et al.   JOURNAL OF THEORETICAL BIOLOGY

Understanding immunosenescence to improve responses to vaccines

(2013) Jörg J Goronzy et al.   NATURE IMMUNOLOGY

Molecular regulation of stem cell quiescence

(2013) Tom H. Cheung et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MicroRNAs in T helper cell differentiation and plasticity

(2013) Silvia Monticelli   SEMINARS IN IMMUNOLOGY

The Janus Head of T Cell Aging – Autoimmunity and Immunodeficiency

(2013) Jörg J. Goronzy et al.   Frontiers in Immunology

Mathematical Model of Naive T Cell Division and Survival IL-7 Thresholds

(2013) Joseph Reynolds et al.   Frontiers in Immunology

T Cell Aging: A Review of the Transcriptional Changes Determined from Genome-Wide Analysis

(2013) Guobing Chen et al.   Frontiers in Immunology

The Effect of Age on Thymic Function

(2013) Donald B. Palmer   Frontiers in Immunology

The role of DNA damage and repair in aging through the prism of Koch-like criteria

(2012) Alexey A. Moskalev et al.   AGEING RESEARCH REVIEWS

A Differentiation Checkpoint Limits Hematopoietic Stem Cell Self-Renewal in Response to DNA Damage

(2012) Jianwei Wang et al.   CELL

Immune aging and autoimmunity

(2012) Jörg J. Goronzy et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Immune senescence and vaccines to prevent herpes zoster in older persons

(2012) Myron J Levin   CURRENT OPINION IN IMMUNOLOGY

Chronic inflammation and aging: DNA damage tips the balance

(2012) Mary M Cavanagh et al.   CURRENT OPINION IN IMMUNOLOGY

Distinct energy requirements for human memory CD4 T-cell homeostatic functions

(2012) Dennis D. Taub et al.   FASEB JOURNAL

Maintenance of Peripheral Naive T Cells Is Sustained by Thymus Output in Mice but Not Humans

(2012) Ineke den Braber et al.   IMMUNITY

Lymphopenia-Driven Homeostatic Regulation of Naive T Cells in Elderly and Thymectomized Young Adults

(2012) D. Sauce et al.   JOURNAL OF IMMUNOLOGY

Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity

(2012) Guangjin Li et al.   NATURE MEDICINE

DNA damage checkpoints in stem cells, ageing and cancer

(2012) Tobias Sperka et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Peripheral selection rather than thymic involution explains sudden contraction in naive CD4 T-cell diversity with age

(2012) P. L. F. Johnson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signal inhibition by the dual-specific phosphatase 4 impairs T cell-dependent B-cell responses with age

(2012) M. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Removal of Shelterin Reveals the Telomere End-Protection Problem

(2012) A. Sfeir et al.   SCIENCE

Signaling pathways in aged T cells – A reflection of T cell differentiation, cell senescence and host environment

(2012) Jörg J. Goronzy et al.   SEMINARS IN IMMUNOLOGY

Changes in primary lymphoid organs with aging

(2012) Ivan K. Chinn et al.   SEMINARS IN IMMUNOLOGY

B cell maintenance and function in aging

(2012) Igor Kogut et al.   SEMINARS IN IMMUNOLOGY

The narrowing of the CD8 T cell repertoire in old age

(2011) Marcia A Blackman et al.   CURRENT OPINION IN IMMUNOLOGY

Exhaustive T-cell repertoire sequencing of human peripheral blood samples reveals signatures of antigen selection and a directly measured repertoire size of at least 1 million clonotypes

(2011) R. L. Warren et al.   GENOME RESEARCH

Tumor Suppressor and Aging Biomarker p16INK4aInduces Cellular Senescence without the Associated Inflammatory Secretory Phenotype

(2011) Jean-Philippe Coppé et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial DNA mutations in disease and aging

(2011) Chan Bae Park et al.   JOURNAL OF CELL BIOLOGY

Telomere dysfunction induces metabolic and mitochondrial compromise

(2011) Ergün Sahin et al.   NATURE

Normal T cell homeostasis: the conversion of naive cells into memory-phenotype cells

(2011) Jonathan Sprent et al.   NATURE IMMUNOLOGY

T-cell receptor ligation induces distinct signaling pathways in naive vs. antigen-experienced T cells

(2011) K. Adachi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nonrandom attrition of the naive CD8+ T-cell pool with aging governed by T-cell receptor:pMHC interactions

(2011) B. D. Rudd et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human cytomegalovirus-specific CD8+ T-cell expansions contain long-lived cells that retain functional capacity in both young and elderly subjects

(2010) Diana L. Wallace et al.   IMMUNOLOGY

Linking functional decline of telomeres, mitochondria and stem cells during ageing

(2010) Ergün Sahin et al.   NATURE

Progeria syndromes and ageing: what is the connection?

(2010) Christopher R. Burtner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

Expression ofp16INK4ain peripheral blood T-cells is a biomarker of human aging

(2009) Yan Liu et al.   AGING CELL

Comprehensive assessment of T-cell receptor  -chain diversity in    T cells

(2009) H. S. Robins et al.   BLOOD

Evidence of premature immune aging in patients thymectomized during early childhood

(2009) Delphine Sauce et al.   JOURNAL OF CLINICAL INVESTIGATION

Deficiency of the DNA repair enzyme ATM in rheumatoid arthritis

(2009) Lan Shao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The antigen-specific CD8+T cell repertoire in unimmunized mice includes memory phenotype cells bearing markers of homeostatic expansion

(2009) Catherine Haluszczak et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Rejuvenating the immune system in rheumatoid arthritis

(2009) Cornelia M. Weyand et al.   Nature Reviews Rheumatology

Telomerase insufficiency in rheumatoid arthritis

(2009) H. Fujii et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD28− T cells: their role in the age-associated decline of immune function

(2009) Nan-ping Weng et al.   TRENDS IN IMMUNOLOGY

Life after the thymus: CD31+ and CD31- human naive CD4+ T-cell subsets

(2008) S. Kohler et al.   BLOOD

T cell subset-specific susceptibility to aging

(2008) Marta Czesnikiewicz-Guzik et al.   CLINICAL IMMUNOLOGY

Homeostasis of Naive and Memory T Cells

(2008) Charles D. Surh et al.   IMMUNITY