The Role of LGR4 (GPR48) in Normal and Cancer Processes

LGR4 overexpression is associated with clinical parameters and poor prognosis of serous ovarian cancer

(2020) Zhaoyang Zeng et al.   Cancer Biomarkers

MicroRNA‑137 regulates hypoxia‑mediated migration and epithelial‑mesenchymal transition in prostate cancer by targeting LGR4 via the EGFR/ERK signaling pathway

(2020) Hao Zhang et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

LGR4, Not LGR5, Enhances hPSC Hematopoiesis by Facilitating Mesoderm Induction via TGF-Beta Signaling Activation

(2020) Yu Wang et al.   Cell Reports

Targeting RSPO3-LGR4 Signaling for Leukemia Stem Cell Eradication in Acute Myeloid Leukemia

(2020) Basit Salik et al.   CANCER CELL

Lgr4 Governs a Pro-Inflammatory Program in Macrophages to Antagonize Post-Infarction Cardiac Repair

(2020) Chunkai Huang et al.   CIRCULATION RESEARCH

LGR4 deficiency results in delayed puberty through impaired Wnt/β-catenin signaling

(2020) Alessandra Mancini et al.   JCI Insight

Rspo1/Rspo3-LGR4 signaling inhibits hepatic cholesterol synthesis through the AMPKα-SREBP2 pathway

(2020) Shiying Liu et al.   FASEB JOURNAL

LGR4 maintains HGSOC cell epithelial phenotype and stem-like traits

(2020) Zhuo Wang et al.   GYNECOLOGIC ONCOLOGY

Ablation of LGR4 signaling enhances radiation sensitivity of prostate cancer cells

(2020) Fang Liang et al.   LIFE SCIENCES

LGR4 is essential for R-spondin1-mediated suppression of food intake via pro-opiomelanocortin

(2019) Ayano Otsuka et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Uterine Gαq/11 signaling, in a progesterone-dependent manner, critically regulates the acquisition of uterine receptivity in the female mouse

(2019) Vanessa de Oliveira et al.   FASEB JOURNAL

Understanding the role of the R-spondin 2-LGR4 system in tongue squamous cell carcinoma progression

(2019) Ahmed Al-Samadi et al.   EBioMedicine

R-spondin 2-LGR4 system regulates growth, migration and invasion, epithelial-mesenchymal transition and stem-like properties of tongue squamous cell carcinoma via Wnt/β-catenin signaling

(2019) Liping Zhang et al.   EBioMedicine

circLgr4 drives colorectal tumorigenesis and invasion through Lgr4‐targeting peptide

(2019) Xiaofei Zhi et al.   INTERNATIONAL JOURNAL OF CANCER

MicroRNA-34 family enhances wound inflammation by targeting LGR4

(2019) Jianmin Wu et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

R-spondin3-LGR4 signaling protects hepatocytes against DMOG-induced hypoxia/reoxygenation injury through activating β-catenin

(2018) Shiying Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibition of Rspo-Lgr4 facilitates checkpoint blockade therapy by switching macrophage polarization

(2018) Binghe Tan et al.   CANCER RESEARCH

Myocardial-specific R-spondin3 drives proliferation of the coronary stems primarily through the Leucine Rich Repeat G Protein coupled receptor LGR4

(2018) Fabio Da Silva et al.   DEVELOPMENTAL BIOLOGY

LGR4 modulates breast cancer initiation, metastasis, and cancer stem cells

(2018) Zhiying Yue et al.   FASEB JOURNAL

MicroRNA-137 dysregulation predisposes to osteoporotic fracture by impeding ALP activity and expression via suppression of leucine-rich repeat-containing G-protein-coupled receptor 4 expression

(2018) Xiangjun Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

LGR4 protects hepatocytes from injury in mouse

(2018) Ziru Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Type 2 diabetes with hypertensive patients results in changes to features of adipocytokines: Leptin, Irisin, LGR4, and Sfrp5

(2018) Baoxin Li et al.   CLINICAL AND EXPERIMENTAL HYPERTENSION

R-spondins: Multi-mode WNT signaling regulators in adult stem cells

(2018) Ahmed A. Raslan et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

An overview of microRNAs: Biology, functions, therapeutics, and analysis methods

(2018) Kioomars Saliminejad et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Loss of Lgr4 inhibits differentiation, migration and apoptosis, and promotes proliferation in bone mesenchymal stem cells

(2018) Peng Sun et al.   JOURNAL OF CELLULAR PHYSIOLOGY

MicroRNA-34c promotes osteoclast differentiation through targeting LGR4

(2017) Fei Cong et al.   GENE

Evidence of the Role of R-Spondin 1 and Its Receptor Lgr4 in the Transmission of Mechanical Stimuli to Biological Signals for Bone Formation

(2017) Gui-Xun Shi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Leucine-rich repeat–containing G protein–coupled receptor 4 (Lgr4) is necessary for prostate cancer metastasis via epithelial–mesenchymal transition

(2017) Weijia Luo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Blockade of LGR4 inhibits proliferation and odonto/osteogenic differentiation of stem cells from apical papillae

(2017) Meng Zhou et al.   JOURNAL OF MOLECULAR HISTOLOGY

Upregulation of RSPO2-GPR48/LGR4 signaling in papillary thyroid carcinoma contributes to tumor progression

(2017) Yea Eun Kang et al.   Oncotarget

RSPO3-LGR4 Regulates Osteogenic Differentiation Of Human Adipose-Derived Stem Cells Via ERK/FGF Signalling

(2017) Min Zhang et al.   Scientific Reports

RANK-RANKL signalling in cancer

(2016) N. Renema et al.   BIOSCIENCE REPORTS

Lgr4 is crucial for skin carcinogenesis by regulating MEK/ERK and Wnt/β-catenin signaling pathways

(2016) Peng Xu et al.   CANCER LETTERS

LGR4 acts as a key receptor for R-spondin 2 to promote osteogenesis through Wnt signaling pathway

(2016) Chao Zhu et al.   CELLULAR SIGNALLING

The Wnt signaling pathway in cancer

(2016) Yann Duchartre et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Lgr4 promotes prostate tumorigenesis through the Jmjd2a/AR signaling pathway

(2016) Jianwei Zhang et al.   EXPERIMENTAL CELL RESEARCH

MicroRNA let-7b induces lens epithelial cell apoptosis by targeting leucine-rich repeat containing G protein-coupled receptor 4 (Lgr4) in age-related cataract

(2016) Yuchen Dong et al.   EXPERIMENTAL EYE RESEARCH

Lgr4 Expression in Osteoblastic Cells Is Suppressed by Hydrogen Peroxide Treatment

(2016) Chantida Pawaputanon Na Mahasarakham et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The RSPO–LGR4/5–ZNRF3/RNF43 module controls liver zonation and size

(2016) Lara Planas-Paz et al.   NATURE CELL BIOLOGY

LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption

(2016) Jian Luo et al.   NATURE MEDICINE

Association of a gain-of-function variant in LGR4 with central obesity

(2016) Yaoyu Zou et al.   Obesity

miR-218 impedes IL-6-induced prostate cancer cell proliferation and invasion via suppression of LGR4 expression

(2016) FUJUN LI et al.   ONCOLOGY REPORTS

Ascending aortic adventitial remodeling and fibrosis are ameliorated with Apelin-13 in rats after TAC via suppression of the miRNA-122 and LGR4-β-catenin signaling

(2016) Ran Xu et al.   PEPTIDES

LGR4 and LGR5 Regulate Hair Cell Differentiation in the Sensory Epithelium of the Developing Mouse Cochlea

(2016) Magdalena Żak et al.   Frontiers in Cellular Neuroscience

LGR4 Is a Direct Target of MicroRNA-34a and Modulates the Proliferation and Migration of Retinal Pigment Epithelial ARPE-19 Cells

(2016) Qiang Hou et al.   PLoS One

Ablation of Lgr4 enhances energy adaptation in skeletal muscle via activation of Ampk/Sirt1/Pgc1α pathway

(2015) Yingkai Sun et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lgr4 Controls Specialization of Female Gonads in Mice1

(2015) Masae Koizumi et al.   BIOLOGY OF REPRODUCTION

BMP-2 Enhances Lgr4 Gene Expression in Osteoblastic Cells

(2015) Chantida Pawaputanon Na Mahasarakham et al.   JOURNAL OF CELLULAR PHYSIOLOGY

GPCR48/LGR4 promotes tumorigenesis of prostate cancer via PI3K/Akt signaling pathway

(2015) Fang Liang et al.   MEDICAL ONCOLOGY

Targeted Deletion of the Murine Lgr4 Gene Decreases Lens Epithelial Cell Resistance to Oxidative Stress and Induces Age-Related Cataract Formation

(2015) Jun Zhu et al.   PLoS One

In a Class of Their Own – RXFP1 and RXFP2 are Unique Members of the LGR Family

(2015) Emma J. Petrie et al.   Frontiers in Endocrinology

LGR4 and Its Role in Intestinal Protection and Energy Metabolism

(2015) Ziru Li et al.   Frontiers in Endocrinology

Lgr4 is required for endometrial receptivity acquired through ovarian hormone signaling

(2014) Tomoyo Kida et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Functional roles of Lgr4 and Lgr5 in embryonic gut, kidney and skin development in mice

(2014) Bernd Kinzel et al.   DEVELOPMENTAL BIOLOGY

Lgr4Gene Regulates Corpus Luteum Maturation Through Modulation of the WNT-Mediated EGFR-ERK Signaling Pathway

(2014) Hongjie Pan et al.   ENDOCRINOLOGY

LGR4/GPR48 Inactivation Leads to Aniridia-Genitourinary Anomalies-Mental Retardation Syndrome Defects

(2014) Tingfang Yi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lgr4 Protein Deficiency Induces Ataxia-like Phenotype in Mice and Impairs Long Term Depression at Cerebellar Parallel Fiber-Purkinje Cell Synapses

(2014) Xin Guan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aberrant RSPO3-LGR4 signaling in Keap1-deficient lung adenocarcinomas promotes tumor aggressiveness

(2014) X Gong et al.   ONCOGENE

Gpr48 Deficiency Induces Polycystic Kidney Lesions and Renal Fibrosis in Mice by Activating Wnt Signal Pathway

(2014) Yongyan Dang et al.   PLoS One

RSPO–LGR4 functions via IQGAP1 to potentiate Wnt signaling

(2014) Kendra S. Carmon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GPR48 Promotes Multiple Cancer Cell Proliferation via Activation of Wnt Signaling

(2013) Yong-Bin Zhu et al.   Asian Pacific Journal of Cancer Prevention

Lgr4 Promotes Glioma Cell Proliferation through Activation of Wnt Signaling

(2013) Chun-Yong Yu et al.   Asian Pacific Journal of Cancer Prevention

Reconstitution of R-Spondin:LGR4:ZNRF3 Adult Stem Cell Growth Factor Signaling Complexes with Recombinant Proteins Produced in Escherichia coli

(2013) Heather E. Moad et al.   BIOCHEMISTRY

GPR48, a poor prognostic factor, promotes tumor metastasis and activates β-catenin/TCF signaling in colorectal cancer

(2013) Jinhua Wu et al.   CARCINOGENESIS

Lgr4-mediated Wnt/ -catenin signaling in peritubular myoid cells is essential for spermatogenesis

(2013) Y. Qian et al.   DEVELOPMENT

GPR87 Is an Overexpressed G-Protein Coupled Receptor in Squamous Cell Carcinoma of the Lung

(2013) Mathias Gugger et al.   DISEASE MARKERS

Interaction with both ZNRF3 and LGR4 is required for the signalling activity of R-spondin

(2013) Yang Xie et al.   EMBO REPORTS

LGR4 and Its Ligands, R-Spondin 1 and R-Spondin 3, Regulate Food Intake in the Hypothalamus of Male Rats

(2013) Ji-Yao Li et al.   ENDOCRINOLOGY

LGR4 expressed in uterine epithelium is necessary for uterine gland development and contributes to decidualization in mice

(2013) Mizuki Sone et al.   FASEB JOURNAL

Structural basis for R-spondin recognition by LGR4/5/6 receptors

(2013) D. Wang et al.   GENES & DEVELOPMENT

An mRNA atlas of G protein-coupled receptor expression during primary human monocyte/macrophage differentiation and lipopolysaccharide-mediated activation identifies targetable candidate regulators of inflammation

(2013) Daniel M. Hohenhaus et al.   IMMUNOBIOLOGY

Lgr4Gene Deficiency Increases Susceptibility and Severity of Dextran Sodium Sulfate-induced Inflammatory Bowel Disease in Mice

(2013) Shijie Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lgr4/Gpr48 Negatively Regulates TLR2/4-associated Pattern Recognition and Innate Immunity by Targeting CD14 Expression

(2013) Bing Du et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multi-functional norrin is a ligand for the LGR4 receptor

(2013) C. Deng et al.   JOURNAL OF CELL SCIENCE

LGR4 acts as a link between the peripheral circadian clock and lipid metabolism in liver

(2013) Feng Wang et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Regulation of the Follistatin Gene by RSPO-LGR4 Signaling via Activation of the WNT/ -Catenin Pathway in Skeletal Myogenesis

(2013) X. H. Han et al.   MOLECULAR AND CELLULAR BIOLOGY

Nonsense mutation in the LGR4 gene is associated with several human diseases and other traits

(2013) Unnur Styrkarsdottir et al.   NATURE

Analysis of LGR4 Receptor Distribution in Human and Mouse Tissues

(2013) Jing Yi et al.   PLoS One

Structures of Wnt-Antagonist ZNRF3 and Its Complex with R-Spondin 1 and Implications for Signaling

(2013) Weng Chuan Peng et al.   PLoS One

Lgr4 is a key regulator of prostate development and prostate stem cell differentiation

(2013) Weijia Luo et al.   STEM CELLS

Lgr4 regulates mammary gland development and stem cell activity through the pluripotency transcription factor Sox2

(2013) Ying Wang et al.   STEM CELLS

Identification of Lgr5-Independent Spheroid-Generating Progenitors of the Mouse Fetal Intestinal Epithelium

(2013) Roxana C. Mustata et al.   Cell Reports

Lgr4 in Ocular Development and Glaucoma

(2013) Stefan Siwko et al.   Journal of Ophthalmology

Stat3 Upregulates Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 4 Expression in Osteosarcoma Cells

(2013) Jia Liu et al.   Biomed Research International

LGR4 Is Required for the Cell Survival of the Peripheral Mesenchyme at the Embryonic Stages of Nephrogenesis

(2012) Yasuaki MOHRI et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Redundant Sources of Wnt Regulate Intestinal Stem Cells and Promote Formation of Paneth Cells

(2012) Henner F. Farin et al.   GASTROENTEROLOGY

The R-spondin family of proteins: Emerging regulators of WNT signaling

(2012) Yong-Ri Jin et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

(2012) Huai-Xiang Hao et al.   NATURE

R-Spondin Potentiates Wnt/β-Catenin Signaling through Orphan Receptors LGR4 and LGR5

(2012) Heinz Ruffner et al.   PLoS One

LGR4 and LGR6 are differentially expressed and of putative tumor biological significance in gastric carcinoma

(2012) Jan Simon Steffen et al.   VIRCHOWS ARCHIV

Lgr4-deficient mice showed premature differentiation of ureteric bud with reduced expression of Wnt effector Lef1 and Gata3

(2011) Yasuaki Mohri et al.   DEVELOPMENTAL DYNAMICS

Lgr4 is required for Paneth cell differentiation and maintenance of intestinal stem cells ex vivo

(2011) Roxana C Mustata et al.   EMBO REPORTS

LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling

(2011) Andrei Glinka et al.   EMBO REPORTS

GPR48 Increases Mineralocorticoid Receptor Gene Expression

(2011) J. Wang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

(2011) Wim de Lau et al.   NATURE

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/ -catenin signaling

(2011) K. S. Carmon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conditional Knockout of Lgr4 Leads to Impaired Ductal Elongation and Branching Morphogenesis in Mouse Mammary Glands

(2011) K. Oyama et al.   Sexual Development

GPR48-Induced keratinocyte proliferation occurs through HB-EGF mediated EGFR transactivation

(2010) Zhenlian Wang et al.   FEBS LETTERS

Reduced fertility with impairment of early-stage embryos observed in mice lacking Lgr4 in epithelial tissues

(2010) Yasuaki Mohri et al.   FERTILITY AND STERILITY

Wnt signal transduction pathways

(2010) Yuko Komiya et al.   Organogenesis

Three-Dimensional Reconstruction of Efferent Ducts in Wild-Type andLgr4Knock-Out Mice

(2009) Marie-Alexandra H. Lambot et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Regulation of bone formation and remodeling by G-protein-coupled receptor 48

(2009) J. Luo et al.   DEVELOPMENT

Defective development of the gall bladder and cystic duct in Lgr4- hypomorphic mice

(2009) Ryo Yamashita et al.   DEVELOPMENTAL DYNAMICS

Impaired hair placode formation with reduced expression of hair follicle-related genes in mice lacking Lgr4

(2008) Yasuaki Mohri et al.   DEVELOPMENTAL DYNAMICS

Inactivation of G-protein-coupled Receptor 48 (Gpr48/Lgr4) Impairs Definitive Erythropoiesis at Midgestation through Down-regulation of the ATF4 Signaling Pathway

(2008) Huiping Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deletion of G protein-coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down-regulation of Pitx2

(2008) J. Weng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparative genomics of leucine-rich repeats containing G protein-coupled receptors and their ligands

(2007) Tom Van Loy et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY