Rspo1/Rspo3-LGR4 signaling inhibits hepatic cholesterol synthesis through the AMPKα-SREBP2 pathway

Glycogen synthase kinase 3β promotes liver innate immune activation by restraining AMP-activated protein kinase activation

(2018) Haoming Zhou et al.   JOURNAL OF HEPATOLOGY

LGR4 protects hepatocytes from injury in mouse

(2018) Ziru Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Association of a gain-of-function variant in LGR4 with central obesity

(2016) Yaoyu Zou et al.   Obesity

Irisin Inhibits Hepatic Cholesterol Synthesis via AMPK-SREBP2 Signaling

(2016) Hong Tang et al.   EBioMedicine

Ablation of Lgr4 enhances energy adaptation in skeletal muscle via activation of Ampk/Sirt1/Pgc1α pathway

(2015) Yingkai Sun et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Statin use and non-alcoholic steatohepatitis in at risk individuals

(2015) Paola Dongiovanni et al.   JOURNAL OF HEPATOLOGY

AICAR-Induced Activation of AMPK Inhibits TSH/SREBP-2/HMGCR Pathway in Liver

(2015) Shudong Liu et al.   PLoS One

LGR4 and Its Role in Intestinal Protection and Energy Metabolism

(2015) Ziru Li et al.   Frontiers in Endocrinology

The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength

(2014) W. de Lau et al.   GENES & DEVELOPMENT

Nonalcoholic fatty liver disease: an emerging threat to obese and diabetic individuals

(2013) Howard C. Masuoka et al.   Annals of the New York Academy of Sciences

LGR4 and Its Ligands, R-Spondin 1 and R-Spondin 3, Regulate Food Intake in the Hypothalamus of Male Rats

(2013) Ji-Yao Li et al.   ENDOCRINOLOGY

LGR4 acts as a link between the peripheral circadian clock and lipid metabolism in liver

(2013) Feng Wang et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Inhibition of AMPK Catabolic Action by GSK3

(2013) Tsukasa Suzuki et al.   MOLECULAR CELL

Ablation of LGR4 promotes energy expenditure by driving white-to-brown fat switch

(2013) Jiqiu Wang et al.   NATURE CELL BIOLOGY

Analysis of LGR4 Receptor Distribution in Human and Mouse Tissues

(2013) Jing Yi et al.   PLoS One

Increased Hepatic Synthesis and Dysregulation of Cholesterol Metabolism Is Associated with the Severity of Nonalcoholic Fatty Liver Disease

(2012) Hae-Ki Min et al.   Cell Metabolism

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice

(2011) Yu Li et al.   Cell Metabolism

Efficacy of ezetimibe for the treatment of non-alcoholic steatohepatitis: An open-label, pilot study

(2010) Masato Yoneda et al.   HEPATOLOGY RESEARCH