Leucine-rich repeat–containing G protein–coupled receptor 4 (Lgr4) is necessary for prostate cancer metastasis via epithelial–mesenchymal transition

Lgr4 promotes prostate tumorigenesis through the Jmjd2a/AR signaling pathway

(2016) Jianwei Zhang et al.   EXPERIMENTAL CELL RESEARCH

LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption

(2016) Jian Luo et al.   NATURE MEDICINE

GPCR48/LGR4 promotes tumorigenesis of prostate cancer via PI3K/Akt signaling pathway

(2015) Fang Liang et al.   MEDICAL ONCOLOGY

Proteomic mapping of ER–PM junctions identifies STIMATE as a regulator of Ca2+ influx

(2015) Ji Jing et al.   NATURE CELL BIOLOGY

Snail as a potential marker for predicting the recurrence of prostate cancer in patients at stage T2 after radical prostatectomy

(2014) Yu-Ching Wen et al.   CLINICA CHIMICA ACTA

LGR4/GPR48 Inactivation Leads to Aniridia-Genitourinary Anomalies-Mental Retardation Syndrome Defects

(2014) Tingfang Yi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GPR48, a poor prognostic factor, promotes tumor metastasis and activates β-catenin/TCF signaling in colorectal cancer

(2013) Jinhua Wu et al.   CARCINOGENESIS

Lgr4-mediated Wnt/ -catenin signaling in peritubular myoid cells is essential for spermatogenesis

(2013) Y. Qian et al.   DEVELOPMENT

Putative prognostic epithelial-to-mesenchymal transition biomarkers for aggressive prostate cancer

(2013) Helen Whiteland et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Lgr4/Gpr48 Negatively Regulates TLR2/4-associated Pattern Recognition and Innate Immunity by Targeting CD14 Expression

(2013) Bing Du et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spondin-2, a Secreted Extracellular Matrix Protein, is a Novel Diagnostic Biomarker for Prostate Cancer

(2013) Giuseppe Lucarelli et al.   JOURNAL OF UROLOGY

Nonsense mutation in the LGR4 gene is associated with several human diseases and other traits

(2013) Unnur Styrkarsdottir et al.   NATURE

Molecular circuit involving KLK4 integrates androgen and mTOR signaling in prostate cancer

(2013) Y. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p63-expressing cells are the stem cells of developing prostate, bladder, and colorectal epithelia

(2013) J.-C. Pignon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lgr4 is a key regulator of prostate development and prostate stem cell differentiation

(2013) Weijia Luo et al.   STEM CELLS

Lgr4 regulates mammary gland development and stem cell activity through the pluripotency transcription factor Sox2

(2013) Ying Wang et al.   STEM CELLS

Epithelial-mesenchymal transition as a fundamental mechanism underlying the cancer phenotype

(2012) A. Cervantes-Arias et al.   Veterinary and Comparative Oncology

LGR4 and LGR6 are differentially expressed and of putative tumor biological significance in gastric carcinoma

(2012) Jan Simon Steffen et al.   VIRCHOWS ARCHIV

Wnt Signaling and Injury Repair

(2012) J. L. Whyte et al.   Cold Spring Harbor Perspectives in Biology

The role of Snail in prostate cancer

(2012) Bethany N. Smith et al.   Cell Adhesion & Migration

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Metastasis suppressors in human benign prostate, intraepithelial neoplasia, and invasive cancer: their prospects as therapeutic agents

(2011) Zahraa I. Khamis et al.   MEDICINAL RESEARCH REVIEWS

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

(2011) Wim de Lau et al.   NATURE

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/ -catenin signaling

(2011) K. S. Carmon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conditional Knockout of Lgr4 Leads to Impaired Ductal Elongation and Branching Morphogenesis in Mouse Mammary Glands

(2011) K. Oyama et al.   Sexual Development

ZEB1 Coordinately Regulates Laminin-332 and β4 Integrin Expression Altering the Invasive Phenotype of Prostate Cancer Cells

(2010) Justin M. Drake et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epithelial-Mesenchymal Transition in Cancer: Parallels Between Normal Development and Tumor Progression

(2010) Douglas S. Micalizzi et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

The Wnt inhibitory factor 1 restoration in prostate cancer cells was associated with reduced tumor growth, decreased capacity of cell migration and invasion and a reversal of epithelial to mesenchymal transition

(2010) David S Yee et al.   Molecular Cancer

Vimentin regulates EMT induction by Slug and oncogenic H-Ras and migration by governing Axl expression in breast cancer

(2010) K Vuoriluoto et al.   ONCOGENE

A Comprehensive Panel of Three-Dimensional Models for Studies of Prostate Cancer Growth, Invasion and Drug Responses

(2010) Ville Härmä et al.   PLoS One

Snail1 is over-expressed in prostate cancer

(2009) SARA HEEBØLL et al.   APMIS

WNT signaling regulates self-renewal and differentiation of prostate cancer cells with stem cell characteristics

(2009) Isabelle Bisson et al.   CELL RESEARCH

G protein-coupled receptor 48 upregulates estrogen receptor   expression via cAMP/PKA signaling in the male reproductive tract

(2009) X.-Y. Li et al.   DEVELOPMENT

Regulation of bone formation and remodeling by G-protein-coupled receptor 48

(2009) J. Luo et al.   DEVELOPMENT

Defective development of the gall bladder and cystic duct in Lgr4- hypomorphic mice

(2009) Ryo Yamashita et al.   DEVELOPMENTAL DYNAMICS

A luminal epithelial stem cell that is a cell of origin for prostate cancer

(2009) Xi Wang et al.   NATURE

The epithelial-mesenchymal transition-inducing factor TWIST is an attractive target in advanced and/or metastatic bladder and prostate cancers

(2009) Hervé Wallerand et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Inactivation of G-protein-coupled Receptor 48 (Gpr48/Lgr4) Impairs Definitive Erythropoiesis at Midgestation through Down-regulation of the ATF4 Signaling Pathway

(2008) Huiping Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prostate cancer stem cells

(2008) SH Lang et al.   JOURNAL OF PATHOLOGY

A Tissue Biomarker Panel Predicting Systemic Progression after PSA Recurrence Post-Definitive Prostate Cancer Therapy

(2008) Tohru Nakagawa et al.   PLoS One

Deletion of G protein-coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down-regulation of Pitx2

(2008) J. Weng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA