LGR4 and LGR5 Regulate Hair Cell Differentiation in the Sensory Epithelium of the Developing Mouse Cochlea

Characterization of Lgr5+ progenitor cell transcriptomes in the apical and basal turns of the mouse cochlea

(2016) Muhammad Waqas et al.   Oncotarget

Lgr5+amacrine cells possess regenerative potential in the retina of adult mice

(2015) Mengfei Chen et al.   AGING CELL

Molecular cloning and functional characterisation of chicken Atonal homologue 1: A comparison with human Atoh1

(2015) Joanna F. Mulvaney et al.   BIOLOGY OF THE CELL

Sensory hair cell development and regeneration: similarities and differences

(2015) P. J. Atkinson et al.   DEVELOPMENT

Neurog1 can partially substitute for Atoh1 function in hair cell differentiation and maintenance during organ of Corti development

(2015) I. Jahan et al.   DEVELOPMENT

The Wnt and Notch signalling pathways in the developing cochlea: Formation of hair cells and induction of regenerative potential

(2015) Magdalena Żak et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

LGR5/GPR49 is implicated in motor neuron specification in nervous system

(2015) Shao-jun Song et al.   NEUROSCIENCE LETTERS

Dynamic expression of Lgr6 in the developing and mature mouse cochlea

(2015) Yanping Zhang et al.   Frontiers in Cellular Neuroscience

Making sense of Wnt signaling—linking hair cell regeneration to development

(2015) Lina Jansson et al.   Frontiers in Cellular Neuroscience

Functional roles of Lgr4 and Lgr5 in embryonic gut, kidney and skin development in mice

(2014) Bernd Kinzel et al.   DEVELOPMENTAL BIOLOGY

R-spondins/Lgrs expression in tooth development

(2014) Maiko kawasaki et al.   DEVELOPMENTAL DYNAMICS

Wnt-Responsive Lgr5+ Globose Basal Cells Function as Multipotent Olfactory Epithelium Progenitor Cells

(2014) M. Chen et al.   JOURNAL OF NEUROSCIENCE

 -Catenin Is Required for Hair-Cell Differentiation in the Cochlea

(2014) F. Shi et al.   JOURNAL OF NEUROSCIENCE

Transcription Factors with Conserved Binding Sites Near ATOH1 on the POU4F3 Gene Enhance the Induction of Cochlear Hair Cells

(2014) Ryoukichi Ikeda et al.   MOLECULAR NEUROBIOLOGY

Lgr5 marks stem/progenitor cells in ovary and tubal epithelia

(2014) Annie Ng et al.   NATURE CELL BIOLOGY

Lgr5 Marks Post-Mitotic, Lineage Restricted Cerebellar Granule Neurons during Postnatal Development

(2014) Tyler E. Miller et al.   PLoS One

RSPO–LGR4 functions via IQGAP1 to potentiate Wnt signaling

(2014) Kendra S. Carmon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single Lgr5- or Lgr6-expressing taste stem/progenitor cells generate taste bud cells ex vivo

(2014) Wenwen Ren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lgr5-Positive Supporting Cells Generate New Hair Cells in the Postnatal Cochlea

(2014) Naomi F. Bramhall et al.   Stem Cell Reports

Tympanic border cells are Wnt-responsive and can act as progenitors for postnatal mouse cochlear cells

(2013) T. A. Jan et al.   DEVELOPMENT

The role of Wnt/β-catenin signaling in proliferation and regeneration of the developing basilar papilla and lateral line

(2013) Bonnie E. Jacques et al.   Developmental Neurobiology

The Lgr5 transgene is expressed specifically in glycinergic amacrine cells in the mouse retina

(2013) Kumar Sukhdeo et al.   EXPERIMENTAL EYE RESEARCH

LGR4 expressed in uterine epithelium is necessary for uterine gland development and contributes to decidualization in mice

(2013) Mizuki Sone et al.   FASEB JOURNAL

Lgr5 Identifies Progenitor Cells Capable of Taste Bud Regeneration after Injury

(2013) Norifumi Takeda et al.   PLoS One

Generation of hair cells in neonatal mice by β-catenin overexpression in Lgr5-positive cochlear progenitors

(2013) Fuxin Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lgr4 regulates mammary gland development and stem cell activity through the pluripotency transcription factor Sox2

(2013) Ying Wang et al.   STEM CELLS

Lgr5-EGFP Marks Taste Bud Stem/Progenitor Cells in Posterior Tongue

(2013) Karen K. Yee et al.   STEM CELLS

Lgr5-Expressing Cells Are Sufficient and Necessary for Postnatal Mammary Gland Organogenesis

(2013) Vicki Plaks et al.   Cell Reports

A dual function for canonical Wnt/ -catenin signaling in the developing mammalian cochlea

(2012) B. E. Jacques et al.   DEVELOPMENT

Secreted Factor R-Spondin 2 is Involved in Refinement of Patterning of the Mammalian Cochlea

(2012) J. F. Mulvaney et al.   DEVELOPMENTAL DYNAMICS

Wnt-Responsive Lgr5-Expressing Stem Cells Are Hair Cell Progenitors in the Cochlea

(2012) F. Shi et al.   JOURNAL OF NEUROSCIENCE

R-Spondin Potentiates Wnt/β-Catenin Signaling through Orphan Receptors LGR4 and LGR5

(2012) Heinz Ruffner et al.   PLoS One

Wnt signaling induces proliferation of sensory precursors in the postnatal mouse cochlea

(2012) R. Chai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p27Kip1is required to maintain proliferative quiescence in the adult cochlea and pituitary

(2011) Elizabeth C. Oesterle et al.   CELL CYCLE

Lgr4 is required for Paneth cell differentiation and maintenance of intestinal stem cells ex vivo

(2011) Roxana C Mustata et al.   EMBO REPORTS

LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling

(2011) Andrei Glinka et al.   EMBO REPORTS

Dynamic Expression of Lgr5, a Wnt Target Gene, in the Developing and Mature Mouse Cochlea

(2011) Renjie Chai et al.   JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY

Notch Signaling Alters Sensory or Neuronal Cell Fate Specification of Inner Ear Stem Cells

(2011) S.-J. Jeon et al.   JOURNAL OF NEUROSCIENCE

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

(2011) Wim de Lau et al.   NATURE

Regulation of POU4F3 gene expression in hair cells by 5′ DNA in mice

(2011) M. Masuda et al.   NEUROSCIENCE

In vivo Atoh1 targetome reveals how a proneural transcription factor regulates cerebellar development

(2011) T. J. Klisch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/ -catenin signaling

(2011) K. S. Carmon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell cycle regulation in hair cell development and regeneration in the mouse cochlea

(2010) Zhiyong Liu et al.   CELL CYCLE

Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro

(2010) Nick Barker et al.   Cell Stem Cell

Hair cell fate decisions in cochlear development and regeneration

(2010) Douglas A. Cotanche et al.   HEARING RESEARCH

Neurod1 Suppresses Hair Cell Differentiation in Ear Ganglia and Regulates Hair Cell Subtype Development in the Cochlea

(2010) Israt Jahan et al.   PLoS One

Lgr6 Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skin

(2010) H. J. Snippert et al.   SCIENCE

LGR5 deficiency deregulates Wnt signaling and leads to precocious Paneth cell differentiation in the fetal intestine

(2009) Marie Isabelle Garcia et al.   DEVELOPMENTAL BIOLOGY

Cell cycle regulation in the inner ear sensory epithelia: Role of cyclin D1 and cyclin-dependent kinase inhibitors

(2009) Heidi Laine et al.   DEVELOPMENTAL BIOLOGY

Hey2 Regulation by FGF Provides a Notch-Independent Mechanism for Maintaining Pillar Cell Fate in the Organ of Corti

(2009) Angelika Doetzlhofer et al.   DEVELOPMENTAL CELL

β-Catenin Up-regulatesAtoh1Expression in Neural Progenitor Cells by Interaction with anAtoh13′ Enhancer

(2009) Fuxin Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lgr5 marks cycling, yet long-lived, hair follicle stem cells

(2008) Viljar Jaks et al.   NATURE GENETICS

Sox2 signaling in prosensory domain specification and subsequent hair cell differentiation in the developing cochlea

(2008) A. Dabdoub et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA