Lgr4 Governs a Pro-Inflammatory Program in Macrophages to Antagonize Post-Infarction Cardiac Repair

Dectin-1 Contributes to Myocardial Ischemia/Reperfusion Injury by Regulating Macrophage Polarization and Neutrophil Infiltration

(2019) Qin Fan et al.   CIRCULATION

Transcription factor Fra-1 targets arginase-1 to enhance macrophage-mediated inflammation in arthritis

(2019) Nicole Hannemann et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of Rspo-Lgr4 facilitates checkpoint blockade therapy by switching macrophage polarization

(2018) Binghe Tan et al.   CANCER RESEARCH

Cytosolic DNA Sensing Promotes Macrophage Transformation and Governs Myocardial Ischemic Injury

(2018) Dian J. Cao et al.   CIRCULATION

Myocardial-specific R-spondin3 drives proliferation of the coronary stems primarily through the Leucine Rich Repeat G Protein coupled receptor LGR4

(2018) Fabio Da Silva et al.   DEVELOPMENTAL BIOLOGY

Mechanisms involved in enhancement of matrix metalloproteinase-9 expression in macrophages by interleukin-33

(2017) Wataru Ariyoshi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The infarcted myocardium solicits GM-CSF for the detrimental oversupply of inflammatory leukocytes

(2017) Atsushi Anzai et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Trends in GPCR drug discovery: new agents, targets and indications

(2017) Alexander S. Hauser et al.   NATURE REVIEWS DRUG DISCOVERY

Loss of Macrophage Wnt Secretion Improves Remodeling and Function After Myocardial Infarction in Mice

(2017) Dahlia Palevski et al.   Journal of the American Heart Association

Myeloid-Epithelial-Reproductive Receptor Tyrosine Kinase and Milk Fat Globule Epidermal Growth Factor 8 Coordinately Improve Remodeling After Myocardial Infarction via Local Delivery of Vascular Endothelial Growth FactorCLINICAL PERSPECTIVE

(2016) Kiave-Yune Howangyin et al.   CIRCULATION

Abandoning M1/M2 for a Network Model of Macrophage Function

(2016) Matthias Nahrendorf et al.   CIRCULATION RESEARCH

The Biological Basis for Cardiac Repair After Myocardial Infarction

(2016) Sumanth D. Prabhu et al.   CIRCULATION RESEARCH

The TLR4–NOS1–AP1 signaling axis regulates macrophage polarization

(2016) Mansi Srivastava et al.   INFLAMMATION RESEARCH

LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption

(2016) Jian Luo et al.   NATURE MEDICINE

Lp-PLA2Antagonizes Left Ventricular Healing After Myocardial Infarction by Impairing the Appearance of Reparative MacrophagesCLINICAL PERSPECTIVE

(2015) Shun He et al.   Circulation-Heart Failure

Macrophage Targeted Theranostics as Personalized Nanomedicine Strategies for Inflammatory Diseases

(2015) Sravan Kumar Patel et al.   Theranostics

Ly-6C high Monocytes Depend on Nr4a1 to Balance Both Inflammatory and Reparative Phases in the Infarcted Myocardium

(2014) Ingo Hilgendorf et al.   CIRCULATION RESEARCH

LGR4/GPR48 Inactivation Leads to Aniridia-Genitourinary Anomalies-Mental Retardation Syndrome Defects

(2014) Tingfang Yi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small Molecule Inhibitors Targeting Activator Protein 1 (AP-1)

(2014) Na Ye et al.   JOURNAL OF MEDICINAL CHEMISTRY

Anti-Inflammatory Strategies for Ventricular Remodeling Following ST-Segment Elevation Acute Myocardial Infarction

(2014) Ignacio M. Seropian et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Myofibroblasts and the extracellular matrix network in post-myocardial infarction cardiac remodeling

(2014) Yonggang Ma et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

RSPO–LGR4 functions via IQGAP1 to potentiate Wnt signaling

(2014) Kendra S. Carmon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Erratum: A statin-loaded reconstituted high-density lipoprotein nanoparticle inhibits atherosclerotic plaque inflammation

(2014) Raphaël Duivenvoorden et al.   Nature Communications

Transcriptional Control of Macrophage Polarization

(2013) Derin Tugal et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Temporal dynamics of cardiac immune cell accumulation following acute myocardial infarction

(2013) Xiaoxiang Yan et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Ablation of LGR4 promotes energy expenditure by driving white-to-brown fat switch

(2013) Jiqiu Wang et al.   NATURE CELL BIOLOGY

Lgr4 is required for Paneth cell differentiation and maintenance of intestinal stem cells ex vivo

(2011) Roxana C Mustata et al.   EMBO REPORTS

LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling

(2011) Andrei Glinka et al.   EMBO REPORTS

GPR48 Increases Mineralocorticoid Receptor Gene Expression

(2011) J. Wang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Modulation of cardiac macrophages by phosphatidylserine-presenting liposomes improves infarct repair

(2011) Tamar Harel-Adar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/ -catenin signaling

(2011) K. S. Carmon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cardiomyocyte death: mechanisms and translational implications

(2011) M Chiong et al.   Cell Death & Disease

Fatal myocardial rupture after acute myocardial infarction complicated by heart failure, left ventricular dysfunction, or both: The VALsartan In Acute myocardial iNfarcTion Trial (VALIANT)

(2010) Faisal Shamshad et al.   AMERICAN HEART JOURNAL

TIMP2 Deficiency Accelerates Adverse Post–Myocardial Infarction Remodeling Because of Enhanced MT1-MMP Activity Despite Lack of MMP2 Activation

(2010) Vijay Kandalam et al.   CIRCULATION RESEARCH

Activation of the Transcription Factor FosB/Activating Protein-1 (AP-1) Is a Prominent Downstream Signal of the Extracellular Nucleotide Receptor P2RX7 in Monocytic and Osteoblastic Cells

(2010) Monica L. Gavala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DEGseq: an R package for identifying differentially expressed genes from RNA-seq data

(2009) Likun Wang et al.   BIOINFORMATICS

Anakinra, a Recombinant Human Interleukin-1 Receptor Antagonist, Inhibits Apoptosis in Experimental Acute Myocardial Infarction

(2008) Antonio Abbate et al.   CIRCULATION

The nucleotide receptor P2RX7 mediates ATP-induced CREB activation in human and murine monocytic cells

(2008) Monica L. Gavala et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Deletion of G protein-coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down-regulation of Pitx2

(2008) J. Weng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA