LGR4 overexpression is associated with clinical parameters and poor prognosis of serous ovarian cancer

Expression and clinical significance of Transcription factor 4 (TCF4) in epithelial ovarian cancer

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VPS33B negatively modulated by nicotine functions as a tumor suppressor in colorectal cancer

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VPS33B interacts with NESG1 to modulate EGFR/PI3K/AKT/c-Myc/P53/miR-133a-3p signaling and induce 5-fluorouracil sensitivity in nasopharyngeal carcinoma

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circLgr4 drives colorectal tumorigenesis and invasion through Lgr4‐targeting peptide

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miR-296-3p Negatively Regulated by Nicotine Stimulates Cytoplasmic Translocation of c-Myc via MK2 to Suppress Chemotherapy Resistance

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Dual roles of miR-374a by modulated c-Jun respectively targets CCND1-inducing PI3K/AKT signal and PTEN-suppressing Wnt/β-catenin signaling in non-small-cell lung cancer

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Inflammation is a key contributor to ovarian cancer cell seeding

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miR-374a-CCND1-pPI3K/AKT-c-JUN feedback loop modulated by PDCD4 suppresses cell growth, metastasis and sensitizes nasopharyngeal carcinoma to cisplatin

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miR-3188 regulates nasopharyngeal carcinoma proliferation and chemosensitivity through a FOXO1-modulated positive feedback loop with mTOR–p-PI3K/AKT-c-JUN

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microRNA-374a suppresses colon cancer progression by directly reducing CCND1 to inactivate the PI3K/AKT pathway

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GPCR48/LGR4 promotes tumorigenesis of prostate cancer via PI3K/Akt signaling pathway

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Ovarian cancer

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GPR48 Promotes Multiple Cancer Cell Proliferation via Activation of Wnt Signaling

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GPR48, a poor prognostic factor, promotes tumor metastasis and activates β-catenin/TCF signaling in colorectal cancer

(2013) Jinhua Wu et al.   CARCINOGENESIS

Regulation of the Follistatin Gene by RSPO-LGR4 Signaling via Activation of the WNT/ -Catenin Pathway in Skeletal Myogenesis

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Lgr4 is a key regulator of prostate development and prostate stem cell differentiation

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Lgr4 regulates mammary gland development and stem cell activity through the pluripotency transcription factor Sox2

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R-Spondin Potentiates Wnt/β-Catenin Signaling through Orphan Receptors LGR4 and LGR5

(2012) Heinz Ruffner et al.   PLoS One

LGR4 and LGR6 are differentially expressed and of putative tumor biological significance in gastric carcinoma

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LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling

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GPR48 Increases Mineralocorticoid Receptor Gene Expression

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Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

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Targeting genetic and epigenetic alterations in the treatment of serous ovarian cancer

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Regulation of bone formation and remodeling by G-protein-coupled receptor 48

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Regulation of GSK-3 beta in the proliferation and apoptosis of human thyrocytes investigated using a GSK-3 beta-targeting RNAi adenovirus expression vector: involvement the Wnt/beta-catenin pathway

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Inactivation of G-protein-coupled Receptor 48 (Gpr48/Lgr4) Impairs Definitive Erythropoiesis at Midgestation through Down-regulation of the ATF4 Signaling Pathway

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Deletion of G protein-coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down-regulation of Pitx2

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