Carborane-containing amino acids and peptides: Synthesis, properties and applications

Boron Chemistry for Medical Applications

(2020) Fayaz Ali et al.   MOLECULES

Boron Neutron Capture Therapy and Photodynamic Therapy for High-Grade Meningiomas

(2020) Yukiko Nakahara et al.   Cancers

Boron neutron capture therapy for malignant brain tumors

(2020) Shin-Ichi Miyatake et al.   JOURNAL OF NEURO-ONCOLOGY

Targeting of peptide‐binding receptors on cancer cells with peptide‐drug conjugates

(2020) Dennis J. Worm et al.   Peptide Science

Boron neutron capture therapy: Current status and future perspectives

(2020) Mayya Alexandrovna Dymova et al.   Cancer Communications

4-Borono-2-18F-fluoro-l-phenylalanine PET for boron neutron capture therapy-oriented diagnosis: overview of a quarter century of research

(2019) Kiichi Ishiwata   ANNALS OF NUCLEAR MEDICINE

11Boron Delivery Agents for Boron Proton-capture Enhanced Proton Therapy

(2019) KATALIN HIDEGHÉTY et al.   ANTICANCER RESEARCH

Boron neutron capture therapy (BNCT): a unique role in radiotherapy with a view to entering the accelerator-based BNCT era

(2019) Minoru Suzuki   International Journal of Clinical Oncology

Metallacarboranes as a tool for enhancing the activity of therapeutic peptides

(2019) Krzysztof Fink et al.   Annals of the New York Academy of Sciences

Synthesis and Initial Biological Evaluation of Boron-Containing Prostate-Specific Membrane Antigen Ligands for Treatment of Prostate Cancer Using Boron Neutron Capture Therapy

(2019) Sinan Wang et al.   MOLECULAR PHARMACEUTICS

Selective Neuropeptide Y Conjugates with Maximized Carborane Loading as Promising Boron Delivery Agents for Boron Neutron Capture Therapy

(2019) Dennis J. Worm et al.   JOURNAL OF MEDICINAL CHEMISTRY

De Novo Carborane-Containing Macrocyclic Peptides Targeting Human Epidermal Growth Factor Receptor

(2019) Yizhen Yin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Boron neutron capture therapy at the crossroads - Where do we go from here?

(2019) Rolf F. Barth et al.   APPLIED RADIATION AND ISOTOPES

Boron agents for neutron capture therapy

(2019) Kuan Hu et al.   COORDINATION CHEMISTRY REVIEWS

A Selective Carborane-Functionalized Gastrin-Releasing Peptide Receptor Agonist as Boron Delivery Agent for Boron Neutron Capture Therapy

(2019) Paul Hoppenz et al.   JOURNAL OF ORGANIC CHEMISTRY

Direct carborane-peptide conjugates: Synthesis and evaluation as non-natural lipopeptide mimetics

(2018) Tamara Lützenburg et al.   CHEMISTRY AND PHYSICS OF LIPIDS

RGD Peptide–mediated Molecular Imaging for Targeting Integrin Alpha(v) Beta(3) in Tumors: A Review

(2018) Su Hu et al.   Current Medical Imaging Reviews

Towards carborane-functionalised structures for the treatment of brain cancer

(2018) Gianpiero Calabrese et al.   DRUG DISCOVERY TODAY

An innovative therapeutic approach for malignant mesothelioma treatment based on the use of Gd/boron multimodal probes for MRI guided BNCT

(2018) Diego Alberti et al.   JOURNAL OF CONTROLLED RELEASE

Gadolinium nanoparticles as diagnostic and therapeutic agents: Their delivery systems in magnetic resonance imaging and neutron capture therapy

(2018) Asghar Narmani et al.   JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

closo-Dodecaborate-conjugated human serum albumins: preparation and in vivo selective boron delivery to tumor

(2018) Hiroyuki Nakamura et al.   PURE AND APPLIED CHEMISTRY

Advances in targeting the folate receptor in the treatment/imaging of cancers

(2018) Marcos Fernández et al.   Chemical Science

First experimental proof of Proton Boron Capture Therapy (PBCT) to enhance protontherapy effectiveness

(2018) G. A. P. Cirrone et al.   Scientific Reports

Piezoactive amino acid derivatives containing fragments of planar-chiral ortho-carboranes

(2018) Dmitry A. Gruzdev et al.   Journal of Materials Chemistry C

Icosahedral boron clusters as modifying entities for biomolecules

(2018) Tomasz M. Goszczyński et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Preparation of enantiomerically pure derivatives of (3-amino-1,2-dicarba-closo-dodecaboran-1-yl)acetic acid

(2018) Dmitry A. Gruzdev et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

A stable meta -carborane enables the generation of boron-rich peptide agonists targeting the ghrelin receptor

(2018) Dennis J. Worm et al.   JOURNAL OF PEPTIDE SCIENCE

Synthesis and Biological Activity of Thymosin β4-Anionic Boron Cluster Conjugates

(2018) Krzysztof Fink et al.   BIOCONJUGATE CHEMISTRY

Synthesis of meta-Carboranyl-(S)-homocysteine Sulfoxide

(2018) D. A. Gruzdev et al.   RUSSIAN JOURNAL OF ORGANIC CHEMISTRY

Development of Albumin-closo -Dodecaborate Conjugates as Boron Carriers for Neutron-Capture Therapy by Ru(bpy)3 -Photocatalyzed Modification of Tyrosine

(2017) Shinichi Sato et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Morphology and piezoelectric characterization of thin films and microcrystals of ortho-carboranyl derivatives of (S)-glutamine and (S)-asparagine

(2017) A. S. Nuraeva et al.   FERROELECTRICS

The versatility of boron in biological target engagement

(2017) Diego B. Diaz et al.   Nature Chemistry

Evaluation of a novel sodium borocaptate-containing unnatural amino acid as a boron delivery agent for neutron capture therapy of the F98 rat glioma

(2017) Gen Futamura et al.   Radiation Oncology

Synthesis of ortho-carboranyl derivatives of (S)-asparagine and (S)-glutamine

(2017) D. A. Gruzdev et al.   RUSSIAN JOURNAL OF ORGANIC CHEMISTRY

“Carboranyl-cysteine”—Synthesis, Structure and Self-Assembly Behavior of a Novel α-Amino Acid

(2017) Tianyu He et al.   Scientific Reports

Charge-Compensated Metallacarborane Building Blocks for Conjugation with Peptides

(2016) René Frank et al.   CHEMBIOCHEM

Enantioselective synthesis of adamantylalanine and carboranylalanine and their incorporation into the proteasome inhibitor bortezomib

(2016) Gerjan de Bruin et al.   CHEMICAL COMMUNICATIONS

Electrochemistry and Photoluminescence of Icosahedral Carboranes, Boranes, Metallacarboranes, and Their Derivatives

(2016) Rosario Núñez et al.   CHEMICAL REVIEWS

Icosahedral boron clusters: a perfect tool for the enhancement of polymer features

(2016) R. Núñez et al.   CHEMICAL SOCIETY REVIEWS

Metal boranes: Progress and applications

(2016) Bjarne R.S. Hansen et al.   COORDINATION CHEMISTRY REVIEWS

Piezoelectric and ferroelectric properties of organic single crystals and films derived from chiral 2-methoxy and 2-amino acids

(2016) A. S. Nuraeva et al.   FERROELECTRICS

Insights into the use of gadolinium and gadolinium/boron-based agents in imaging-guided neutron capture therapy applications

(2016) Annamaria Deagostino et al.   Future Medicinal Chemistry

Challenges and Opportunities for the Application of Boron Clusters in Drug Design

(2016) Zbigniew J. Leśnikowski   JOURNAL OF MEDICINAL CHEMISTRY

Boron Neutron Capture Therapy for Malignant Brain Tumors

(2016) Shin-Ichi MIYATAKE et al.   NEUROLOGIA MEDICO-CHIRURGICA

Luminescent metal complexes featuring photophysically innocent boron cluster ligands

(2016) Kent O. Kirlikovali et al.   Chemical Science

Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor

(2016) Abigail S. Krall et al.   Nature Communications

N,O-Type Carborane-Based Materials

(2016) José Planas et al.   Crystals

Tumor-specific delivery of BSH-3R for boron neutron capture therapy and positron emission tomography imaging in a mouse brain tumor model

(2015) Yoshiya Iguchi et al.   BIOMATERIALS

Carborane-containing urea-based inhibitors of glutamate carboxypeptidase II: Synthesis and structural characterization

(2015) Sihyun Youn et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis, characterization, and preliminary fluorescence study of a mixed-ligand bis(dicarbollyl)nickel complex bearing a tryptophan-BODIPY FRET couple

(2015) Natalia I. Shlyakhtina et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Retinoic acid receptors: From molecular mechanisms to cancer therapy

(2015) Alessandra di Masi et al.   MOLECULAR ASPECTS OF MEDICINE

A theranostic approach based on the use of a dual boron/Gd agent to improve the efficacy of Boron Neutron Capture Therapy in the lung cancer treatment

(2015) Diego Alberti et al.   Nanomedicine-Nanotechnology Biology and Medicine

Advancements in Tumor Targeting Strategies for Boron Neutron Capture Therapy

(2015) Micah John Luderer et al.   PHARMACEUTICAL RESEARCH

Carbaboranes – more than just phenyl mimetics

(2015) René Frank et al.   PURE AND APPLIED CHEMISTRY

Synthesis and evaluation of boron folates for Boron-Neutron-Capture-Therapy (BNCT)

(2015) Kathrin Kettenbach et al.   RADIOCHIMICA ACTA

Carborane–β-cyclodextrin complexes as a supramolecular connector for bioactive surfaces

(2015) P. Neirynck et al.   Journal of Materials Chemistry B

Synthesis of new acids based on bis(dicarbollide)cobalt

(2015) A. V. Shmal’ko et al.   RUSSIAN CHEMICAL BULLETIN

Synthesis and in vitro evaluation of thiododecaborated α, α- cycloalkylamino acids for the treatment of malignant brain tumors by boron neutron capture therapy

(2014) Yoshihide Hattori et al.   AMINO ACIDS

The acceleration of boron neutron capture therapy using multi-linked mercaptoundecahydrododecaborate (BSH) fused cell-penetrating peptide

(2014) Hiroyuki Michiue et al.   BIOMATERIALS

Diastereoselective Acylation of Racemic Heterocyclic Amines with N-Tosyl-(S)-Prolyl Chloride and its Structural Analogs

(2014) S. A. Vakarov et al.   Chemistry of Heterocyclic Compounds

Receptor-Mediated Uptake of Boron-Rich Neuropeptide Y Analogues for Boron Neutron Capture Therapy

(2014) Verena M. Ahrens et al.   ChemMedChem

Preparation and evaluation of carborane-derived inhibitors of prostate specific membrane antigen (PSMA)

(2014) Mohamed E. El-Zaria et al.   DALTON TRANSACTIONS

Synthesis, Structure, and Catalytic Applications for ortho- and meta-Carboranyl Based NBN Pincer-Pd Complexes

(2014) Min Ying Tsang et al.   INORGANIC CHEMISTRY

Direct Observation of Bis(dicarbollyl)nickel Conformers in Solution by Fluorescence Spectroscopy: An Approach to Redox-Controlled Metallacarborane Molecular Motors

(2014) Alexander V. Safronov et al.   INORGANIC CHEMISTRY

Synthesis of a carborane-containing cholesterol derivative and evaluation as a potential dual agent for MRI/BNCT applications

(2014) Diego Alberti et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Critical review, with an optimistic outlook, on Boron Neutron Capture Therapy (BNCT)

(2013) Raymond L. Moss   APPLIED RADIATION AND ISOTOPES

Evaluation of unnatural cyclic amino acids as boron delivery agents for treatment of melanomas and gliomas

(2013) Rolf F. Barth et al.   APPLIED RADIATION AND ISOTOPES

The Functions and Applications of RGD in Tumor Therapy and Tissue Engineering

(2013) Fen Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Boron neutron capture therapy outcomes for advanced or recurrent head and neck cancer

(2013) M. Suzuki et al.   JOURNAL OF RADIATION RESEARCH

Manipulating Y receptor subtype activation of short neuropeptide Y analogs by introducing carbaboranes

(2013) S. Hofmann et al.   NEUROPEPTIDES

Synthesis of new carborane-based amino acids

(2013) Marina Yu. Stogniy et al.   POLYHEDRON

Biological Evaluation of Dodecaborate-Containing l-Amino Acids for Boron Neutron Capture Therapy

(2012) Yoshihide Hattori et al.   JOURNAL OF MEDICINAL CHEMISTRY

RGD-Based Strategies To Target Alpha(v) Beta(3) Integrin in Cancer Therapy and Diagnosis

(2012) Fabienne Danhier et al.   MOLECULAR PHARMACEUTICS

Boron neutron capture therapy (BNCT) in Finland: Technological and physical prospects after 20 years of experiences

(2012) Sauli Savolainen et al.   Physica Medica-European Journal of Medical Physics

Current status of boron neutron capture therapy of high grade gliomas and recurrent head and neck cancer

(2012) Rolf F Barth et al.   Radiation Oncology

Synthesis of boron-containing tyrosine derivatives based on the closo-decaborate and closo-dodecaborate anions

(2012) A. V. Prikaznov et al.   RUSSIAN CHEMICAL BULLETIN

Retinoids, Retinoic Acid Receptors, and Cancer

(2011) Xiao-Han Tang et al.   Annual Review of Pathology-Mechanisms of Disease

Synthesis of optically active dodecaborate-containing l-amino acids for BNCT

(2011) Shintaro Kusaka et al.   APPLIED RADIATION AND ISOTOPES

Synthesis of conjugates of polyhedral boron compounds with tumor-seeking molecules for neutron capture therapy

(2011) V. Bregadze et al.   APPLIED RADIATION AND ISOTOPES

Reagents for Astatination of Biomolecules. 5. Evaluation of Hydrazone Linkers in211At- and125I-Labeledcloso-Decaborate(2-) Conjugates of Fab′ as a Means of Decreasing Kidney Retention

(2011) D. Scott Wilbur et al.   BIOCONJUGATE CHEMISTRY

Synthesis and evaluation of cyclic RGD-boron cluster conjugates to develop tumor-selective boron carriers for boron neutron capture therapy

(2011) Sadaaki Kimura et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and Biological Data of ortho-Carborane Analogs from 4-Aminobenzoic Acid and 4-Hydroxybenzoic Acid as a Potential Boron Neutron Capture Therapy Agent

(2011) Seung-Hwan Lee et al.   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

Carbaboranes as Pharmacophores: Properties, Synthesis, and Application Strategies

(2011) Matthias Scholz et al.   CHEMICAL REVIEWS

Boron in Drug Discovery: Carboranes as Unique Pharmacophores in Biologically Active Compounds

(2011) Fatiah Issa et al.   CHEMICAL REVIEWS

MRI-Guided Neutron Capture Therapy by Use of a Dual Gadolinium/Boron Agent Targeted at Tumour Cells through Upregulated Low-Density Lipoprotein Transporters

(2011) Simonetta Geninatti-Crich et al.   CHEMISTRY-A EUROPEAN JOURNAL

Nonenzymatic Acylative Kinetic Resolution of Racemic Amines and Related Compounds

(2011) Victor P. Krasnov et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Incorporation ofortho-Carbaboranyl-Nε-Modifiedl-Lysine into Neuropeptide Y Receptor Y1- and Y2-Selective Analogues

(2011) Verena M. Ahrens et al.   JOURNAL OF MEDICINAL CHEMISTRY

Polyhedral boron clusters in materials science

(2011) Barada Prasanna Dash et al.   NEW JOURNAL OF CHEMISTRY

The use of a new carboranylamidophosphite ligand in the asymmetric Rh-catalyzed hydrogenation of α- and β-dehydroamino acid derivatives

(2011) Sergey E. Lyubimov et al.   POLYHEDRON

A novel approach to the synthesis of amino acids based on cobalt bis(dicarbollide)

(2011) I. A. Lobanova et al.   RUSSIAN CHEMICAL BULLETIN

Synthesis of closo-1,7-carboranyl alkyl amines

(2011) Hitesh K. Agarwal et al.   TETRAHEDRON LETTERS

Determination of enantiomeric purity of 1-substituted 3-amino-1,2-dicarba-closo-dodecaboranes by HPLC on chiral stationary phases

(2010) V. P. Krasnov et al.   RUSSIAN CHEMICAL BULLETIN

Synthesis of novel carboranyl derivatives of α-amino acids

(2010) D. A. Gruzdev et al.   RUSSIAN CHEMICAL BULLETIN

Biological evaluation of boronated unnatural amino acids as new boron carriers

(2009) G.W. Kabalka et al.   APPLIED RADIATION AND ISOTOPES

Insect neuropeptides: Structures, chemical modifications and potential for insect control

(2009) Jürgen Scherkenbeck et al.   BIOORGANIC & MEDICINAL CHEMISTRY

General Access to Aminobenzyl-o-carboranes as a New Class of Carborane Derivatives: Entry to Enantiopure Carborane-Amine Combinations

(2009) Vincent Terrasson et al.   CHEMISTRY-A EUROPEAN JOURNAL

Polyhedral Boranes for Medical Applications: Current Status and Perspectives

(2009) Igor B. Sivaev et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Towards improved boron neutron capture therapy agents: evaluation of in vitro cellular uptake of a glutamine-functionalized carborane

(2009) Antonella Crivello et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

closo-Borane Conjugated Regulatory Peptides Retain High Biological Affinity: Synthesis ofcloso-Borane Conjugated Tyr3-Octreotate Derivatives for BNCT

(2008) Thomas Betzel et al.   BIOCONJUGATE CHEMISTRY

Synthesis of Gd(III)-C-palmitamidomethyl-C′-DOTAMA-C6-o-carborane: a new dual agent for innovative MRI/BNCT applications

(2008) Silvio Aime et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Discovery and Development of Folic-Acid-Based Receptor Targeting for Imaging and Therapy of Cancer and Inflammatory Diseases

(2007) Philip S. Low et al.   ACCOUNTS OF CHEMICAL RESEARCH