Advancements in Tumor Targeting Strategies for Boron Neutron Capture Therapy

Toward a full understanding of the EPR effect in primary and metastatic tumors as well as issues related to its heterogeneity

(2015) Hiroshi Maeda   ADVANCED DRUG DELIVERY REVIEWS

Nanomedicine in cancer therapy: Challenges, opportunities, and clinical applications

(2015) Andreas Wicki et al.   JOURNAL OF CONTROLLED RELEASE

The acceleration of boron neutron capture therapy using multi-linked mercaptoundecahydrododecaborate (BSH) fused cell-penetrating peptide

(2014) Hiroyuki Michiue et al.   BIOMATERIALS

Alpha (α-) and beta (β-carboranyl-C-deoxyribosides: Syntheses, structures and biological evaluation

(2014) Ivan Šnajdr et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Therapeutic efficacy of boron neutron capture therapy mediated by boron-rich liposomes for oral cancer in the hamster cheek pouch model

(2014) Elisa M. Heber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Correlation of 18F-BPA and 18F-FDG uptake in head and neck cancers

(2014) Hitomi Tani et al.   RADIOTHERAPY AND ONCOLOGY

Boron neutron capture therapy and 18F-labelled borophenylalanine positron emission tomography: A critical and clinical overview of theliterature

(2013) Laura Evangelista et al.   APPLIED RADIATION AND ISOTOPES

Fractionated BNCT for locally recurrent head and neck cancer: Experience from a phase I/II clinical trial at Tsing Hua Open-Pool Reactor

(2013) Ling-Wei Wang et al.   APPLIED RADIATION AND ISOTOPES

Towards boron neutron capture therapy: The formulation and preliminary in vitro evaluation of liposomal vehicles for the therapeutic delivery of the dequalinium salt of bis-nido-carborane

(2013) Dimitrios Theodoropoulos et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Targeted delivery of antibody-based therapeutic and imaging agents to CNS tumors: crossing the blood–brain barrier divide

(2013) Ann-Marie Chacko et al.   Expert Opinion on Drug Delivery

N3-substituted thymidine bioconjugates for cancer therapy and imaging

(2013) Ahmed Khalil et al.   Future Medicinal Chemistry

“Click” Star-Shaped and Dendritic PEGylated Gold Nanoparticle-Carborane Assemblies

(2013) Na Li et al.   INORGANIC CHEMISTRY

Biocompatibility of functionalized boron phosphate (BPO4) nanoparticles for boron neutron capture therapy (BNCT) application

(2013) Cesare Achilli et al.   Nanomedicine-Nanotechnology Biology and Medicine

Predominant contribution of L-type amino acid transporter to 4-borono-2-18F-fluoro-phenylalanine uptake in human glioblastoma cells

(2013) Mitsuyoshi Yoshimoto et al.   NUCLEAR MEDICINE AND BIOLOGY

Biodistribution and Subcellular Localization of an Unnatural Boron-Containing Amino Acid (Cis-ABCPC) by Imaging Secondary Ion Mass Spectrometry for Neutron Capture Therapy of Melanomas and Gliomas

(2013) Subhash Chandra et al.   PLoS One

Boron neutron capture therapy demonstrated in mice bearing EMT6 tumors following selective delivery of boron by rationally designed liposomes

(2013) P. J. Kueffer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Boron neutron capture therapy (BNCT) for liver metastasis in an experimental model: dose–response at five-week follow-up based on retrospective dose assessment in individual rats

(2013) Emiliano C. C. Pozzi et al.   RADIATION AND ENVIRONMENTAL BIOPHYSICS

New classes of carborane-appended 5-thio-d-glucopyranose derivatives

(2012) Rashmirekha Satapathy et al.   DALTON TRANSACTIONS

Boron neutron capture therapy for glioblastoma multiforme: enhanced drug delivery and antitumor effect following blood–brain barrier disruption induced by focused ultrasound

(2012) Feng-Yi Yang et al.   Future Oncology

Boron neutron capture therapy (BNCT) for liver metastasis: therapeutic efficacy in an experimental model

(2012) Emiliano C. C. Pozzi et al.   RADIATION AND ENVIRONMENTAL BIOPHYSICS

Determination of boron concentration in blood and tissue samples from patients with liver metastases of colorectal carcinoma using Prompt Gamma Ray Activation Analysis (PGAA)

(2011) T. Schmitz et al.   APPLIED RADIATION AND ISOTOPES

Comparison of intracerebral delivery of carboplatin and photon irradiation with an optimized regimen for boron neutron capture therapy of the F98 rat glioma

(2011) Rolf F. Barth et al.   APPLIED RADIATION AND ISOTOPES

Sodium mercaptoundecahydro-closo-dodecaborate (BSH), a boron carrier that merits more attention

(2011) Andrea Wittig et al.   APPLIED RADIATION AND ISOTOPES

BNCT for locally recurrent head and neck cancer: Preliminary clinical experience from a phase I/II trial at Tsing Hua Open-Pool Reactor

(2011) L.W. Wang et al.   APPLIED RADIATION AND ISOTOPES

l-Boronophenylalanine-Mediated Boron Neutron Capture Therapy for Malignant Glioma Progressing After External Beam Radiation Therapy: A Phase I Study

(2011) Leena Kankaanranta et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Boron Neutron Capture Therapy in the Treatment of Locally Recurred Head-and-Neck Cancer: Final Analysis of a Phase I/II Trial

(2011) Leena Kankaanranta et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

In Vitro Studies on Stability of L-p-boronophenylalanine–fructose Complex (BPA-F)

(2011) Sami HEIKKINEN et al.   JOURNAL OF RADIATION RESEARCH

Could nanoparticle systems have a role in the treatment of cerebral gliomas?

(2011) Gerardo Caruso et al.   Nanomedicine-Nanotechnology Biology and Medicine

The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect

(2010) Jun Fang et al.   ADVANCED DRUG DELIVERY REVIEWS

Boron neutron capture therapy (BNCT) for the treatment of liver metastases: biodistribution studies of boron compounds in an experimental model

(2010) Marcela A. Garabalino et al.   RADIATION AND ENVIRONMENTAL BIOPHYSICS

Boron Neutron Capture Therapy for glioblastoma multiforme: advantage of prolonged infusion of BPA-f

(2009) K. Sköld et al.   ACTA NEUROLOGICA SCANDINAVICA

Boronophenylalanine uptake in C6 glioma model is dramatically increased by l-DOPA preloading

(2009) S. Capuani et al.   APPLIED RADIATION AND ISOTOPES

Suitability of boron carriers for BNCT: Accumulation of boron in malignant and normal liver cells after treatment with BPA, BSH and BA

(2009) F.I. Chou et al.   APPLIED RADIATION AND ISOTOPES

Survival benefit of boron neutron capture therapy for recurrent malignant gliomas

(2009) Shin-Ichi Miyatake et al.   APPLIED RADIATION AND ISOTOPES

Comparison of BNCT and GdNCT efficacy in treatment of canine cancer

(2009) V.N. Mitin et al.   APPLIED RADIATION AND ISOTOPES

Boron neutron capture therapy of EGFR or EGFRvIII positive gliomas using either boronated monoclonal antibodies or epidermal growth factor as molecular targeting agents

(2009) W. Yang et al.   APPLIED RADIATION AND ISOTOPES

Early clinical trial concept for boron neutron capture therapy: A critical assessment of the EORTC trial 11001

(2009) A. Wittig et al.   APPLIED RADIATION AND ISOTOPES

Survival benefit from boron neutron capture therapy for the newly diagnosed glioblastoma patients

(2009) Shinji Kawabata et al.   APPLIED RADIATION AND ISOTOPES

Biological evaluation of boronated unnatural amino acids as new boron carriers

(2009) G.W. Kabalka et al.   APPLIED RADIATION AND ISOTOPES

Extra-corporeal liver BNCT for the treatment of diffuse metastases: What was learned and what is still to be learned

(2009) A. Zonta et al.   APPLIED RADIATION AND ISOTOPES

EORTC trial 11001: distribution of two10B-compounds in patients with squamous cell carcinoma of head and neck, a translational research/phase 1 trial

(2009) Andrea Wittig et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Carborane Derivatives Loaded into Liposomes as Efficient Delivery Systems for Boron Neutron Capture Therapy†

(2009) S. Altieri et al.   JOURNAL OF MEDICINAL CHEMISTRY

Molecular Targeting and Treatment of Composite EGFR and EGFRvIII-Positive Gliomas Using Boronated Monoclonal Antibodies

(2008) W. Yang et al.   CLINICAL CANCER RESEARCH

Boron neutron capture therapy (BNCT) for glioblastoma multiforme: A phase II study evaluating a prolonged high-dose of boronophenylalanine (BPA)

(2008) Roger Henriksson et al.   RADIOTHERAPY AND ONCOLOGY

An investigation of boron neutron capture therapy for recurrent glioblastoma multiforme

(2007) L. Pellettieri et al.   ACTA NEUROLOGICA SCANDINAVICA