Journal
CURRENT MEDICAL IMAGING
Volume 14, Issue 2, Pages 186-195Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1573405613666161209102928
Keywords
Integrin; molecular probe; RGD peptide; targeted MRI; angiogenesis; endothelial cells
Funding
- National Natural Foundation of China [81171393]
- Research Innovation Program for College Graduates of Jiangsu Province [KYZZ15_0335]
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Background: RGD peptides are small peptides containing arginine-glycine-aspartic (ArgGly-Asp) acid triple-peptide motif and can specifically bind to integrin receptor on the cell surface. Discussion: The integrin receptors, especially alpha(v) beta(3), are highly expressed on the surface of activated endothelial cells and tumor cells while displaying low expression on mature endothelial cells. Molecular imaging can achieve the imaging of the biological processes at cellular and molecular levels in vivo and help in qualitative and quantitative research, making the evaluation of the expression levels of integrin possible in vivo. Conclusion: Therefore, RGD peptides show great potential in the study of specific imaging of tumor-induced angiogenesis. This study reviewed the recent research progress of RGD peptide-mediated imaging of tumor-induced angiogenesis, which can benefit the RGD peptide-targeted molecular imaging researches.
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