4.1 Article

A novel approach to the synthesis of amino acids based on cobalt bis(dicarbollide)

Journal

RUSSIAN CHEMICAL BULLETIN
Volume 59, Issue 12, Pages 2302-2308

Publisher

SPRINGER
DOI: 10.1007/s11172-010-0392-9

Keywords

cobalt complexes; carboranes; oxonium compounds; amino acids; tyrosine; boron neutron capture therapy of cancer

Funding

  1. Russian Foundation for Basic Research [08-03-00463, 09-03-00701, 10-03-00698]
  2. Presidium of the Russian Academy of Sciences

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A novel approach to the synthesis of boron-containing amino acids based on ring opening of cyclic oxonium derivatives of polyhedral boron hydrides under the action of the terminal functional groups of natural amino acids was proposed. This approach was successfully implemented for the synthesis of cobalt bis(dicarbollide) - tyrosine conjugate.

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