Journal
JOURNAL OF CONTROLLED RELEASE
Volume 280, Issue -, Pages 31-38Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jconrel.2018.04.043
Keywords
Mesothelioma; Boron Neutron Capture Therapy; Magnetic Resonance Imaging (MRI); Low Density Lipoproteins
Funding
- Italian National Institute of Nuclear Physics project NeTTuNO
Ask authors/readers for more resources
The aim of this study is to develop an innovative imaging guided approach based on Boron Neutron Capture Therapy, for the treatment of mesothelioma, assisted by the quantification of the in vivo boron distribution by MRI. The herein reported results demonstrate that overexpressed Low Density Lipoproteins receptors can be successfully exploited to deliver to mesothelioma cells a therapeutic dose of boron (26 mu g/g), significantly higher than in the surrounding tissue (3.5 mu g/g). Boron and Gd cells uptake was assessed by ICP-MS and MRI on two mesothelioma (ZL34, AE17) and two healthy (MRC-5 and NMuMg) cell lines. An in vivo model was prepared by subcutaneous injection of ZL34 cells in Nu/Nu mice. After irradiation with thermal neutrons, tumor growth was evaluated for 40 days by MRI. Tumor masses of boron treated mice showed a drastic reduction of about 80-85%. The obtained results appear very promising providing patients affected by this rare disease with an improved therapeutic option, exploiting LDL transporters.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available