Journal
EXPERT OPINION ON BIOLOGICAL THERAPY
Volume 18, Issue -, Pages 205-213Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14712598.2018.1473369
Keywords
Boron clusters; boron neutron capture therapy; conjugates; dicarbollides; metallacarboranes
Funding
- National Science Centre, Poland [2016/23/D/NZ1/02611, 2015/19/N/NZ7/02726]
- SciClone Pharmaceuticals
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Introduction: Icosahedral boron clusters have unique properties useful in medicinal chemistry: rigidity, chemical stability, and three-dimensional aromaticity. Furthermore, these abiotic compounds have low toxicity and are stable in the biological environment. All these features ultimately give them the ability to interact with biological molecules in a different mode than organic compounds.Areas covered: In the present article, we aim to introduce boron clusters as a class of entities suitable for modifications of biomolecules to obtain a specific biological effect. We will focus on icosahedral boron clusters, as well as metallacarboranes, and their biological activity and interaction with the biological environment.Expert opinion: Boron clusters are suitable for altering structural and functional features of biomolecules and can be used in the development of new drugs and drug delivery systems. The high affinity of boron clusters, especially metallacarboranes, to albumin creates a new possibility to use them to optimize the pharmacokinetics of biologically active peptides. Boron clusters have high potential in biological and medicinal applications. Due to their peculiar properties, they can be used to optimize parameters critical for the biological activity of therapeutic substances and their affinity toward biological targets.
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