Article
Chemistry, Inorganic & Nuclear
Lukas Greifenstein, Tilmann Grus, Johannes Nagel, Jean Phillip Sinnes, Frank Roesch
APPLIED RADIATION AND ISOTOPES
(2020)
Review
Chemistry, Inorganic & Nuclear
Zsolt Baranyai, Gyula Tircso, Frank Roesch
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Vasko Kramer, Carlos Juri, Patrick J. Riss, Rossana Pruzzo, Cristian Soza-Ried, Jonathan Flores, Ana Hurtado, Frank Roesch, Pedro Chana-Cuevas, Horacio Amaral
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Divya Yadav, Sanjana Ballal, Madhav Prasad Yadav, Madhavi Tripathi, Frank Roesch, Chandrasekhar Bal
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2020)
Article
Chemistry, Medicinal
Lukas Greifenstein, Nils Engelbogen, Hanane Lahnif, Jean-Philippe Sinnes, Ralf Bergmann, Michael Bachmann, Frank Roesch
Article
Biochemistry & Molecular Biology
Giulia Orteca, Jean-Philippe Sinnes, Sara Rubagotti, Michele Iori, Pier Cesare Capponi, Markus Piel, Frank Roesch, Erika Ferrari, Mattia Asti
JOURNAL OF INORGANIC BIOCHEMISTRY
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ismaheel O. Lawal, Kgomotso M. G. Mokoala, Johncy Mahapane, Janke Kleyhans, Marian Meckel, Mariza Vorster, Thomas Ebenhan, Frank Roesch, Mike M. Sathekge
Summary: This study compared the lesion detection rate of [Ga-68]Ga-PSMA-11 PET/CT, [Ga-68]Ga-NODAGA(ZOL) PET/CT, and [Tc-99m]Tc-MDP bone scan in assessing bone metastases in patients with advanced prostate cancer. The results showed that in the staging of skeletal metastases, [Ga-68]Ga-PSMA-11 PET/CT may detect more lesions than [Ga-68]Ga-NODAGA(ZOL) PET/CT and [Tc-99m]Tc-MDP bone scan.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rene Fernandez, Elisabeth Eppard, Wencke Lehnert, Luis David Jimenez-Franco, Cristian Soza-Ried, Matias Ceballos, Jessica Ribbeck, Andreas Kluge, Frank Roesch, Marian Meckel, Konstantin Zhernosekov, Vasko Kramer, Horacio Amaral
Summary: The study evaluated the safety and dosimetry of a new therapeutic radiopharmaceutical, 177Lu-DOTA-ZOL, for bone metastasis through a series of SPECT/CT images and blood samples. Results showed fast uptake and high retention in bone lesions, with a stable average retention rate in tumor lesions after injection. The red marrow was identified as the dose-limiting organ for all patients, suggesting personalized dosimetry should be considered to prevent severe hematotoxicity.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Daniel Zakowiecki, Maja Frankiewicz, Tobias Hess, Krzysztof Cal, Maciej Gajda, Justyna Dabrowska, Bartlomiej Kubiak, Jadwiga Paszkowska, Marcela Wiater, Dagmara Hoc, Grzegorz Garbacz, Dorota Haznar-Garbacz
Summary: The study used novel calcium phosphate-based starter pellets to develop a biphasic-release multiple-unit pellet system containing drug-layered pellets with delayed-release and extended-release characteristics. Comparative dissolution testing showed similar results to an equivalent commercial product prepared using direct pelletization technique.
Article
Chemistry, Medicinal
Michael Wagner, Tobias Hess, Daniel Zakowiecki
Summary: Calcium phosphate-based pharmaceutical excipients have been widely used in pharmaceutical technology and have beneficial biocompatible and biodegradable properties. However, there is limited information on their solubility under different pH conditions.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Daniel Zakowiecki, Tobias Hess, Krzysztof Cal, Barbara Mikolaszek, Grzegorz Garbacz, Dorota Haznar-Garbacz
Summary: Reliable and stable tablet formulations for rosuvastatin calcium have been developed, providing good mechanical properties, rapid disintegration, and dissolution rate, as well as satisfactory chemical stability.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Panagiotis Kanellopoulos, Berthold A. A. Nock, Lukas Greifenstein, Richard P. P. Baum, Frank Roesch, Theodosia Maina
Summary: In this study, a new hybrid chelator DATA(5m) was introduced for PET/CT imaging of SST2R-positive tumors. The [Ga-68]Ga-DATA(5m)-LM4 tracer showed excellent binding affinity in cell and mouse models, and accurately visualized tumor lesions in a patient.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Krzysztof Cal, Barbara Mikolaszek, Tobias Hess, Markos Papaioannou, Joanna Lenik, Patrycja Ciosek-Skibinska, Helene Wall, Jadwiga Paszkowska, Svitlana Romanova, Grzegorz Garbacz, Daniel Zakowiecki
Summary: Sprinkle formulations are developed as a solution for patients with swallowing difficulties. In this study, immediate-release sprinkle MUPS containing rosuvastatin calcium were successfully developed. The formulation showed uniform distribution of coating layers thickness and fast dissolution rate. The taste-masking efficiency of the formulation was found to be particle size-dependent.
Article
Pharmacology & Pharmacy
Daniel Zakowiecki, Peter Edinger, Tobias Hess, Jadwiga Paszkowska, Marcela Staniszewska, Svitlana Romanova, Grzegorz Garbacz
Summary: Tableting of biomolecules is challenging, but in this study, pancreatin tablets formulated with a combination of brittle and plastic excipients can be successfully manufactured at varying compaction pressures without adversely affecting pancreatin content and enzymatic activity.
Article
Radiology, Nuclear Medicine & Medical Imaging
Vasko Kramer, Agnete Dyssegaard, Jonathan Flores, Cristian Soza-Ried, Frank Roesch, Gitte Moos Knudsen, Horacio Amaral, Matthias M. Herth
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2020)