Tumor-related stress regulates functional plasticity of MDSCs

Anti-VEGF therapy resistance in ovarian cancer is caused by GM-CSF-induced myeloid-derived suppressor cell recruitment

(2020) Naoki Horikawa et al.   BRITISH JOURNAL OF CANCER

Valproic acid attenuates CCR2-dependent tumor infiltration of monocytic myeloid-derived suppressor cells, limiting tumor progression

(2020) Zhiqi Xie et al.   OncoImmunology

Myeloid-Derived Suppressor Cells as a Therapeutic Target for Cancer

(2020) Andrew M. K. Law et al.   Cells

Tumor-derived prostaglandin E2 promotes p50 NF-κB-dependent differentiation of monocytic MDSC

(2020) Chiara Porta et al.   CANCER RESEARCH

The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors through Inhibition of STING Signaling

(2020) Eslam Mohamed et al.   IMMUNITY

Myeloid Cell-Derived Arginase in Cancer Immune Response

(2020) Tomasz M. Grzywa et al.   Frontiers in Immunology

Metabolic Regulation of Myeloid-Derived Suppressor Cell Function in Cancer

(2020) Yufei Wang et al.   Cells

Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases

(2019) Antonio Cuadrado et al.   NATURE REVIEWS DRUG DISCOVERY

Tim-3/galectin-9 pathway and mMDSC control primary and secondary resistances to PD-1 blockade in lung cancer patients

(2019) Emeric Limagne et al.   OncoImmunology

Suppression of Myeloid Cell Arginase Activity leads to Therapeutic Response in a NSCLC Mouse Model by Activating Anti-Tumor Immunity

(2019) Juan J. Miret et al.   Journal for ImmunoTherapy of Cancer

Cachexia induced by cancer and chemotherapy yield distinct perturbations to energy metabolism

(2019) Fabrizio Pin et al.   Journal of Cachexia Sarcopenia and Muscle

Hypoxia-induced VISTA promotes the suppressive function of myeloid- derived suppressor cells in the tumor microenvironment

(2019) Jie Deng et al.   Cancer Immunology Research

Nrf2 in cancers: A double‐edged sword

(2019) Shijia Wu et al.   Cancer Medicine

The STAT3 inhibitor galiellalactone inhibits the generation of MDSC‐like monocytes by prostate cancer cells and decreases immunosuppressive and tumorigenic factors

(2019) Rebecka Hellsten et al.   PROSTATE

Lipid Metabolic Pathways Confer the Immunosuppressive Function of Myeloid-Derived Suppressor Cells in Tumor

(2019) Dehong Yan et al.   Frontiers in Immunology

AMPK Alpha-1 Intrinsically Regulates the Function and Differentiation of Tumor Myeloid-Derived Suppressor Cells

(2019) Jimena Trillo-Tinoco et al.   CANCER RESEARCH

Epacadostat plus pembrolizumab versus placebo plus pembrolizumab in patients with unresectable or metastatic melanoma (ECHO-301/KEYNOTE-252): a phase 3, randomised, double-blind study

(2019) Georgina V Long et al.   LANCET ONCOLOGY

Cellular Stress Responses in Radiotherapy

(2019) Kim et al.   Cells

Tumor Inflammation and Myeloid Derived Suppressor Cells Reduce the Efficacy of CD19 CAR T Cell Therapy in Lymphoma

(2019) Michael D. Jain et al.   BLOOD

More Than Just Attractive: How CCL2 Influences Myeloid Cell Behavior Beyond Chemotaxis

(2019) Martha Gschwandtner et al.   Frontiers in Immunology

GCN2 drives macrophage and MDSC function and immunosuppression in the tumor microenvironment

(2019) Marie Jo Halaby et al.   Science Immunology

Blockade of myeloid-derived suppressor cell expansion with all-trans retinoic acid increases the efficacy of anti-angiogenic therapy

(2018) Raimund Bauer et al.   CANCER RESEARCH

LXR/ApoE Activation Restricts Innate Immune Suppression in Cancer

(2018) Masoud F. Tavazoie et al.   CELL

“Keaping” a lid on lung cancer: the Keap1-Nrf2 pathway

(2018) Sarah A. Best et al.   CELL CYCLE

Aerobic Glycolysis Controls Myeloid-Derived Suppressor Cells and Tumor Immunity via a Specific CEBPB Isoform in Triple-Negative Breast Cancer

(2018) Wei Li et al.   Cell Metabolism

Blockade of CCR5-mediated myeloid derived suppressor cell accumulation enhances anti-PD1 efficacy in gastric cancer

(2018) Liu Yang et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

STAT3 in Tumor-Associated Myeloid Cells: Multitasking to Disrupt Immunity

(2018) Yu-Lin Su et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Frontline Science: High fat diet and leptin promote tumor progression by inducing myeloid-derived suppressor cells

(2018) Virginia K. Clements et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Bevacizumab Reduces S100A9-Positive MDSCs Linked to Intracranial Control in Patients with EG FR -Mutant Lung Adenocarcinoma

(2018) Po-Hao Feng et al.   Journal of Thoracic Oncology

Immunosuppressive effects of hypoxia-induced glioma exosomes through myeloid-derived suppressor cells via the miR-10a/Rora and miR-21/Pten Pathways

(2018) Xiaofan Guo et al.   ONCOGENE

Myeloid-Derived Suppressor Cells Hinder the Anti-Cancer Activity of Immune Checkpoint Inhibitors

(2018) Rebekka Weber et al.   Frontiers in Immunology

Targeting Myeloid-Derived Suppressor Cells to Bypass Tumor-Induced Immunosuppression

(2018) Viktor Fleming et al.   Frontiers in Immunology

Nrf2 Is a Central Regulator of Metabolic Reprogramming of Myeloid-Derived Suppressor Cells in Steady State and Sepsis

(2018) Kim Ohl et al.   Frontiers in Immunology

Targeting myeloid-derived suppressor cells using all-trans retinoic acid in melanoma patients treated with Ipilimumab

(2018) Richard P. Tobin et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

STAT3 inhibition induces Bax-dependent apoptosis in liver tumor myeloid-derived suppressor cells

(2018) Prajna Guha et al.   ONCOGENE

Myeloid-derived suppressor cells inhibit T cell activation through nitrating LCK in mouse cancers

(2018) Shan Feng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic screen in myeloid cells identifies TNF-α autocrine secretion as a factor increasing MDSC suppressive activity via Nos2 up-regulation

(2018) Matthias Schröder et al.   Scientific Reports

Immunotherapy and molecular role of T-cell in PD-1 antibody treated resectable lung cancer patients

(2018) Samaresh Sau et al.   Journal of Thoracic Disease

Protective role of all-trans retinoic acid (ATRA) against hypoxia-induced malignant potential of non-invasive breast tumor derived cells

(2018) Yasamin Al-Qassab et al.   BMC CANCER

Prognostic role of myeloid-derived suppressor cells in cancers: a systematic review and meta-analysis

(2018) Lisha Ai et al.   BMC CANCER

Activated ATF6 Induces Intestinal Dysbiosis and Innate Immune Response to Promote Colorectal Tumorigenesis

(2018) Olivia I. Coleman et al.   GASTROENTEROLOGY

ER stress signaling has an activating transcription factor 6α (ATF6)-dependent “off-switch”

(2018) Franziska Walter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxaliplatin regulates myeloid-derived suppressor cell-mediated immunosuppression via downregulation of nuclear factor-κB signaling

(2018) Na-Rae Kim et al.   Cancer Medicine

Reactive Oxygen Species as Regulators of MDSC-Mediated Immune Suppression

(2018) Kim Ohl et al.   Frontiers in Immunology

Protein kinase CK2 regulates redox homeostasis through NF-κB and Bcl-xL in cardiomyoblasts

(2017) Susanne Schaefer et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

CAR T Cells Administered in Combination with Lymphodepletion and PD-1 Inhibition to Patients with Neuroblastoma

(2017) Andras Heczey et al.   MOLECULAR THERAPY

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Myeloid-derived suppressor cells are increased and correlated with type 2 immune responses, malnutrition, inflammation, and poor prognosis in patients with breast cancer

(2017) Kenji Gonda et al.   Oncology Letters

Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma

(2017) David Kung-Chun Chiu et al.   Nature Communications

Phosphodiesterase type 5 and cancers: progress and challenges

(2017) Ines Barone et al.   Oncotarget

Surgery-induced monocytic myeloid-derived suppressor cells expand regulatory T cells in lung cancer

(2017) Jun Wang et al.   Oncotarget

Dual negative roles of C/EBPα in the expansion and pro-tumor functions of MDSCs

(2017) John R. Mackert et al.   Scientific Reports

CCR5 Directs the Mobilization of CD11b + Gr1 + Ly6C low Polymorphonuclear Myeloid Cells from the Bone Marrow to the Blood to Support Tumor Development

(2017) Elias Hawila et al.   Cell Reports

LMP1-mediated glycolysis induces myeloid-derived suppressor cell expansion in nasopharyngeal carcinoma

(2017) Ting-Ting Cai et al.   PLoS Pathogens

Endoplasmic reticulum stress signaling and chemotherapy resistance in solid cancers

(2017) T Avril et al.   Oncogenesis

Amino Acid Sensing via General Control Nonderepressible-2 Kinase and Immunological Programming

(2017) Srikanth Battu et al.   Frontiers in Immunology

Interleukin-6 Trans-Signaling Pathway Promotes Immunosuppressive Myeloid-Derived Suppressor Cells via Suppression of Suppressor of Cytokine Signaling 3 in Breast Cancer

(2017) Mengmeng Jiang et al.   Frontiers in Immunology

Regulation of T Cell Trafficking by Enzymatic Synthesis of O-Glycans

(2017) Samuel J. Hobbs et al.   Frontiers in Immunology

Targeting myeloid derived suppressor cells with all-trans retinoic acid is highly time-dependent in therapeutic tumor vaccination

(2017) Annkristin Heine et al.   OncoImmunology

Arginase inhibition suppresses lung metastasis in the 4T1 breast cancer model independently of the immunomodulatory and anti-metastatic effects of VEGFR-2 blockade

(2017) Chiara Secondini et al.   OncoImmunology

Unfolding anti-tumor immunity: ER stress responses sculpt tolerogenic myeloid cells in cancer

(2017) Juan R. Cubillos-Ruiz et al.   Journal for ImmunoTherapy of Cancer

ASP9853, an inhibitor of inducible nitric oxide synthase dimerization, in combination with docetaxel: preclinical investigation and a Phase I study in advanced solid tumors

(2016) Jason J. Luke et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Histone deacetylase inhibitors deplete myeloid-derived suppressor cells induced by 4T1 mammary tumors in vivo and in vitro

(2016) Hai-Fang Wang et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Hypoxia induces myeloid-derived suppressor cell recruitment to hepatocellular carcinoma through chemokine (C-C motif) ligand 26

(2016) David Kung-Chun Chiu et al.   HEPATOLOGY

Cancer metabolism at a glance

(2016) Alexei Vazquez et al.   JOURNAL OF CELL SCIENCE

Hypoxia-inducible factors: a central link between inflammation and cancer

(2016) Daniel Triner et al.   JOURNAL OF CLINICAL INVESTIGATION

Damage-associated molecular patterns in cancer: a double-edged sword

(2016) C Hernandez et al.   ONCOGENE

Sunitinib: the antiangiogenic effects and beyond

(2016) Zhonglin Hao et al.   OncoTargets and Therapy

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

(2016) Vincenzo Bronte et al.   Nature Communications

Tumor refractoriness to anti-VEGF therapy

(2016) Domenico Ribatti   Oncotarget

On the origin of myeloid-derived suppressor cells

(2016) Camilla Rydberg Millrud et al.   Oncotarget

Targeting the CCL2-CCR2 signaling axis in cancer metastasis

(2016) Su Yin Lim et al.   Oncotarget

Reduction of MDSCs with All-trans Retinoic Acid Improves CAR Therapy Efficacy for Sarcomas

(2016) A. H. Long et al.   Cancer Immunology Research

Targeting myeloid-derived suppressor cells with colony stimulating factor-1 receptor blockade can reverse immune resistance to immunotherapy in indoleamine 2,3-dioxygenase-expressing tumors

(2016) Rikke B. Holmgaard et al.   EBioMedicine

Hypoxia: a key player in antitumor immune response. A Review in the Theme: Cellular Responses to Hypoxia

(2015) Muhammad Zaeem Noman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Endoplasmic Reticulum Stress in Immunity

(2015) Sarah E. Bettigole et al.   Annual Review of Immunology

Chemotherapy-Derived Inflammatory Responses Accelerate the Formation of Immunosuppressive Myeloid Cells in the Tissue Microenvironment of Human Pancreatic Cancer

(2015) S. Takeuchi et al.   CANCER RESEARCH

ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis

(2015) Juan R. Cubillos-Ruiz et al.   CELL

All- trans retinoic acid prevents oxidative stress-induced loss of renal tight junction proteins in type-1 diabetic model

(2015) Eduardo Molina-Jijón et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

The transcription factor XBP1 is selectively required for eosinophil differentiation

(2015) Sarah E Bettigole et al.   NATURE IMMUNOLOGY

Inflammation and cancer: advances and new agents

(2015) Shanthini M. Crusz et al.   Nature Reviews Clinical Oncology

Diversity and selectivity in mRNA translation on the endoplasmic reticulum

(2015) David W. Reid et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Critical role of PPARγ in myeloid-derived suppressor cell-stimulated cancer cell proliferation and metastasis

(2015) Ting Zhao et al.   Oncotarget

Human CD4+ T cells require exogenous cystine for glutathione and DNA synthesis

(2015) Trine B. Levring et al.   Oncotarget

Ex vivo generation of myeloid-derived suppressor cells that model the tumor immunosuppressive environment in colorectal cancer

(2015) Inès Dufait et al.   Oncotarget

Inhibition of Fatty Acid Oxidation Modulates Immunosuppressive Functions of Myeloid-Derived Suppressor Cells and Enhances Cancer Therapies

(2015) F. Hossain et al.   Cancer Immunology Research

Myeloid cells in the tumor microenvironment: Role of adenosine

(2015) Silvana Morello et al.   OncoImmunology

Sunitinib depletes myeloid-derived suppressor cells and synergizes with a cancer vaccine to enhance antigen-specific immune responses and tumor eradication

(2015) Oana Draghiciu et al.   OncoImmunology

Systemic Monocytic-MDSCs Are Generated from Monocytes and Correlate with Disease Progression in Breast Cancer Patients

(2015) Caroline Bergenfelz et al.   PLoS One

Elevated endoplasmic reticulum stress reinforced immunosuppression in the tumor microenvironment via myeloid-derived suppressor cells

(2015) Bo-Ra Lee et al.   Oncotarget

Combination of an agonistic anti-CD40 monoclonal antibody and the COX-2 inhibitor celecoxib induces anti-glioma effects by promotion of type-1 immunity in myeloid cells and T-cells

(2014) Akemi Kosaka et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Immunosuppressive Myeloid Cells Induced by Chemotherapy Attenuate Antitumor CD4+ T-Cell Responses through the PD-1-PD-L1 Axis

(2014) Z.-C. Ding et al.   CANCER RESEARCH

The Stress-Response Sensor Chop Regulates the Function and Accumulation of Myeloid-Derived Suppressor Cells in Tumors

(2014) Paul T. Thevenot et al.   IMMUNITY

ER stress regulates myeloid-derived suppressor cell fate through TRAIL-R–mediated apoptosis

(2014) Thomas Condamine et al.   JOURNAL OF CLINICAL INVESTIGATION

PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation

(2014) Muhammad Zaeem Noman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Proinflammatory S100 Proteins Regulate the Accumulation of Myeloid-Derived Suppressor Cells

(2014) P. Sinha et al.   JOURNAL OF IMMUNOLOGY

The NRF2-KEAP1 Pathway Is an Early Responsive Gene Network in Arsenic Exposed Lymphoblastoid Cells

(2014) Emilio J. Córdova et al.   PLoS One

Increased Levels of Granulocytic Myeloid-Derived Suppressor Cells in Peripheral Blood and Tumour Tissue of Pancreatic Cancer Patients

(2014) Yazan S. Khaled et al.   Journal of Immunology Research

Targeting CCL5 in inflammation

(2013) Rafael Elias Marques et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Regulation of Nrf2—an update

(2013) Suryakant K. Niture et al.   FREE RADICAL BIOLOGY AND MEDICINE

Increased circulating Lin−/lowCD33+HLA-DR−myeloid-derived suppressor cells in hepatocellular carcinoma patients

(2013) Peng Shen et al.   HEPATOLOGY RESEARCH

STAT3 regulates arginase-I in myeloid-derived suppressor cells from cancer patients

(2013) David Vasquez-Dunddel et al.   JOURNAL OF CLINICAL INVESTIGATION

The Combination of a Low-Dose Chemotherapeutic Agent, 5-Fluorouracil, and an Adenoviral Tumor Vaccine Has a Synergistic Benefit on Survival in a Tumor Model System

(2013) Sean M. Geary et al.   PLoS One

IRE1: ER stress sensor and cell fate executor

(2013) Yani Chen et al.   TRENDS IN CELL BIOLOGY

Role of the PD-1 Pathway in the Immune Response

(2012) L. V. Riella et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Chemokine C-C motif receptor 5 and C-C motif ligand 5 promote cancer cell migration under hypoxia

(2012) Sensen Lin et al.   CANCER SCIENCE

Blockade of Myeloid-Derived Suppressor Cells after Induction of Lymphopenia Improves Adoptive T Cell Therapy in a Murine Model of Melanoma

(2012) K. N. Kodumudi et al.   JOURNAL OF IMMUNOLOGY

Paclitaxel promotes differentiation of myeloid-derived suppressor cells into dendritic cellsin vitroin a TLR4-independent manner

(2012) Tillmann Michels et al.   Journal of Immunotoxicology

Multipeptide immune response to cancer vaccine IMA901 after single-dose cyclophosphamide associates with longer patient survival

(2012) Steffen Walter et al.   NATURE MEDICINE

Inhibition of Casein Kinase 2 Modulates XBP1-GRP78 Arm of Unfolded Protein Responses in Cultured Glial Cells

(2012) Toru Hosoi et al.   PLoS One

Cancer Cell Metabolism: One Hallmark, Many Faces

(2012) Jason R. Cantor et al.   Cancer Discovery

Activated human CD4+ T cells express transporters for both cysteine and cystine

(2012) Trine Bøegh Levring et al.   Scientific Reports

Myeloid-derived suppressor cells: mechanisms of action and recent advances in their role in transplant tolerance

(2012) Nahzli Dilek et al.   Frontiers in Immunology

Monocytic CCR2+ Myeloid-Derived Suppressor Cells Promote Immune Escape by Limiting Activated CD8 T-cell Infiltration into the Tumor Microenvironment

(2011) A. M. Lesokhin et al.   CANCER RESEARCH

MDSC as a mechanism of tumor escape from sunitinib mediated anti-angiogenic therapy

(2011) James Finke et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Histone deacetylase inhibition facilitates GM-CSF-mediated expansion of myeloid-derived suppressor cells in vitro and in vivo

(2011) Brian R. Rosborough et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The unfolded protein response controls induction and activation of ADAM17/TACE by severe hypoxia and ER stress

(2011) T Rzymski et al.   ONCOGENE

COX-2 inhibition improves immunotherapy and is associated with decreased numbers of myeloid-derived suppressor cells in mesothelioma. Celecoxib influences MDSC function

(2010) Joris D Veltman et al.   BMC CANCER

IL-1β regulates a novel myeloid-derived suppressor cell subset that impairs NK cell development and function

(2010) Moshe Elkabets et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Reactive oxygen species in cancer

(2010) Geou-Yarh Liou et al.   FREE RADICAL RESEARCH

HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment

(2010) Cesar A. Corzo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Control of the Metabolic Switch in Cancers by Oncogenes and Tumor Suppressor Genes

(2010) A. J. Levine et al.   SCIENCE

Endotoxin-Induced Myeloid-Derived Suppressor Cells Inhibit Alloimmune Responses via Heme Oxygenase-1

(2009) V. De Wilde et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Sunitinib Mediates Reversal of Myeloid-Derived Suppressor Cell Accumulation in Renal Cell Carcinoma Patients

(2009) J. S. Ko et al.   CLINICAL CANCER RESEARCH

HIF at a glance

(2009) M. C. Brahimi-Horn et al.   JOURNAL OF CELL SCIENCE

Inflammation enhances myeloid-derived suppressor cell cross-talk by signaling through Toll-like receptor 4

(2009) Stephanie K. Bunt et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Acetylation of Nrf2 by p300/CBP Augments Promoter-Specific DNA Binding of Nrf2 during the Antioxidant Response

(2009) Z. Sun et al.   MOLECULAR AND CELLULAR BIOLOGY

Phosphorylation of Nrf2 at Multiple Sites by MAP Kinases Has a Limited Contribution in Modulating the Nrf2-Dependent Antioxidant Response

(2009) Zheng Sun et al.   PLoS One